Review
Chemistry, Multidisciplinary
Qingsong Cheng, Qian Ma, Hebing Pei, Simin He, Rui Wang, Ruibin Guo, Nijuan Liu, Zunli Mo
Summary: This paper mainly summarizes the research status of enantioseparation membranes, including membrane materials, preparation methods, factors affecting membrane properties, and separation mechanisms. In addition, it analyzes the key problems and challenges to be solved in the research of enantioseparation membranes, and provides future development trends for chiral membranes.
Article
Multidisciplinary Sciences
Katherin Patsch, Chao Liu, Grzegorz Zapotoczny, Yuanye Sun, Harish Sura, Nolan Ung, Ren X. Sun, Bethany Haliday, Chen Yu, Mayada Aljehani, Jerry S. H. Lee, Boris A. Kashemirov, David B. Agus, Charles E. McKenna, Daniel Ruderman
Summary: This study identified a new mechanism of drug resistance in lethal prostate cancer and discovered a structurally contradictory stereoisomer in a drug compound, suggesting new strategies to overcome drug resistance mechanisms.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Chemistry, Multidisciplinary
Sreejith Sudhakaran Jayabhavan, Jonathan W. Steed, Krishna K. Damodaran
Summary: A series of bis(urea) compounds with complementary functional groups similar to the drug metronidazole and its structural isomer have been synthesized and studied for their gelation properties. It was found that drug-mimetic gels interact with the surface of the drug crystal, resulting in new crystal morphologies, while nonmimetic gels did not show this effect.
CRYSTAL GROWTH & DESIGN
(2021)
Article
Chemistry, Multidisciplinary
Lei Yang, Zhongyue Sun, Siyun Zhang, Yue Sun, Haibing Li
Summary: In this study, a facile and feasible strategy was employed to construct chiral-modified nanochannels for the transmembrane transport of chiral drugs. The results showed that the constructed nanochannels exhibited improved chiral selectivity compared to other chiral channels. This study is of significant importance for the basic theory research and the construction of artificial channels for the separation of chiral drugs.
Review
Biochemistry & Molecular Biology
Efraim Reyes, Liher Prieto, Andrea Milelli
Summary: The interaction between drugs and chiral counterparts, such as proteins, is the main mechanism. The negative impact of chirality on therapeutic outcomes is well-known. The increasing number of non-racemic chiral drugs on the market highlights the need for safe, economic, and environmentally sustainable synthesis methods.
Article
Engineering, Environmental
Kaijun Gou, Yumei Wang, Linlin Xie, Xianmou Guo, Yingyu Guo, Jia Ke, Lulu Wu, Sanming Li, Heran Li
Summary: Chiral mesoporous silica nanoparticles (CMSNs) have unique physicochemical properties and advantages in biological behavior, making them valuable in various applications such as chiral catalysis, chiral selectivity, chiral recognition, separation, drug delivery, and medical research. Studies on CMSNs have made significant progress in synthesis, chirality origination mechanisms, structural properties, and practical applications, indicating great potential in the field of pharmaceutical science and beyond.
CHEMICAL ENGINEERING JOURNAL
(2021)
Review
Chemistry, Multidisciplinary
Andrej Emanuel Cotman
Summary: Noyori-Ikariya-type ruthenium(II)-catalysts have been used for 25 years in asymmetric transfer hydrogenation for the synthesis of chiral secondary alcohols. Recent progress has been made in understanding the asymmetric reduction of complex ketones, controlling up to four stereocenters in a single transformation. Intriguing multi-chiral molecular architectures can be prepared via ATH for drug discovery.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Review
Chemistry, Multidisciplinary
Hong-Hao Zhang, Tian-Zhen Li, Si-Jia Liu, Feng Shi
Summary: The catalytic asymmetric synthesis of atropisomers bearing multiple chiral elements has recently become an emerging research field. Chemists have devised metal-catalyzed or organocatalytic asymmetric reactions for accessing atropisomers with multiple chiral elements, such as those with center chirality, planar chirality, and helical chirality. This review summarizes the rapid developments in this field and indicated the remaining challenges.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Inorganic & Nuclear
Shinichi Iba, Kohei Iwata, Taichi Sotani, Takahiro Ishida, Natsuhiro Sano, Hiromitsu Sogawa, Fumio Sanda
Summary: In this study, platinum complexes derived from L-alanine were synthesized with azobenzene moieties, showing isomerization between trans and cis forms under UV and visible light irradiation. DFT calculations and noncovalent interaction analysis revealed the formation of intramolecular hydrogen bonds and pi-pi interactions contributing to the conformational stability. Mirror-image CD spectroscopic patterns were exhibited by the D-alanine-derived counterparts, indicating different chiroptical properties compared to the L-alanine-derived complexes.
Article
Chemistry, Medicinal
Melissa J. Buskes, Aaron Coffin, Dawn M. Troast, Rachel Stein, Maria-Jesus Blanco
Summary: The generation of multiple bonds in one reaction step has attracted massive interest in drug discovery and development. Multicomponent reactions (MCRs) offer the advantage of combining three or more reagents in a one-pot fashion to effectively yield a synthetic product. This approach significantly accelerates the synthesis of relevant compounds for biological testing.
ACS MEDICINAL CHEMISTRY LETTERS
(2023)
Article
Pharmacology & Pharmacy
Samvel N. Sirakanyan, Marcel Hrubsa, Domenico Spinelli, Patricia Dias, Victor Kartsev, Alejandro Carazo, Anush A. Hovakimyan, Jana Pourova, Elmira K. Hakobyan, Jana Karlickova, Shamima Parvin, Jaka Fadraersada, Katerina Macakova, Athina Geronikaki, Premysl Mladenka
Summary: In this study, a series of 6-oxopyrano[3,4-c]pyridines were synthesized and the 8-methyl derivative (3a) was found to be a potent inhibitor of platelet aggregation with additional vasodilatory activity.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Tzuriel S. Metzger, Harikrishna Batchu, Anil Kumar, Daniil A. Fedotov, Naama Goren, Deb Kumar Bhowmick, Israa Shioukhi, Shira Yochelis, Igor Schapiro, Ron Naaman, Ori Gidron, Yossi Paltiel
Summary: Chirality is a fundamental property in nature, and chiral molecules exist in two forms, each being a mirror image of the other. The chirality of molecules is related to their optical activity, and circular dichroism is often used to determine the chirality of chiral molecules. Recently, the chiral induced spin selectivity (CISS) effect was discovered, showing that electron transfer within chiral molecules depends on the electron's spin. This study found that the CISS properties are similar for the two enantiomers when adsorbed on a metal substrate, while on a nonmetallic surface, the preferred spin depends on the molecule's chirality. The correlation between optical activity and CISS effect suggests a relation to the global polarizability of the molecule.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Review
Critical Care Medicine
Patrick M. Wieruszewski, Ashish K. Khanna
Summary: This article is a review selected from the Annual Update in Intensive Care and Emergency Medicine 2022, providing links to other selected articles in different areas and information about the Annual Update itself.
Article
Biochemistry & Molecular Biology
Elzbieta Zmudzka, Klaudia Lustyk, Agata Siwek, Malgorzata Wolak, Adam Galuszka, Jolanta Jaskowska, Marcin Kolaczkowski, Jacek Sapa, Karolina Pytka
Summary: Cardiovascular diseases remain a leading cause of death globally, and developing new drug candidates is crucial. In this study, we investigated the cardiovascular effects of six novel arylpiperazine alkyl derivatives of salicylamide. The compounds showed high affinity for alpha(1)-adrenergic receptors and demonstrated potential antiarrhythmic and hypotensive activities.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Chemistry, Medicinal
Zheyi Wang, Liying Meng, Xinxin Liu, Lingzi Zhang, Zongjiang Yu, Guanzhao Wu
Summary: Atropisomers are axially chiral stereoisomers resulting from restricted rotation around a single bond, and they exhibit remarkable biological activity. In this review, we comprehensively summarize the bioactive compounds of atropisomers, including those bonded with C-C, C-N, and N-N bonds, and provide examples along with their biological activity.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)