Review
Chemistry, Medicinal
Min Zhao, Yuqian Tang, Jingwen Xie, Zhongxiang Zhao, Hui Cui
Summary: Meroterpenoids, derived from terpenoids, are widely distributed in plants, animals, and fungi, with complex structures and diverse bioactivities. A systematic review on meroterpenoids from higher and lower fungi has been lacking since the first summary in 2009. This review classifies and summarizes the natural meroterpenoids from fungi, highlighting their unique structures and promising bioactivities.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Review
Food Science & Technology
Ying Zhou, Minghang Chu, Farhad Ahmadi, Osman Tuncay Agar, Colin J. Barrow, Frank R. Dunshea, Hafiz A. R. Suleria
Summary: Mushrooms have been highly regarded for their unique flavor and medicinal properties since ancient times. Modern research has revealed that mushrooms are rich in various nutrients and biologically active substances. This review focuses on the nutritional components and secondary metabolites in mushrooms, particularly the bioactive functions and potential applications of mushroom polyphenols. It also briefly discusses the current challenges and future research trends in mushroom polyphenols. Mushrooms are a low-energy, healthy food that is high in protein and insoluble fiber, low in fat and sodium. They contain beneficial bioactive substances, including phenolic compounds, tocopherols, terpenoids, and phytosterols. Mushroom polyphenols have antioxidant, anti-inflammatory, anti-cancer, anti-tyrosine, antihyperglycemic, and other biological activities that are beneficial for human health and medical applications, particularly in treating degenerative diseases and cancer. However, commercial applications of phenolic compounds in mushrooms still face various research and development challenges.
FOOD REVIEWS INTERNATIONAL
(2023)
Review
Food Science & Technology
Hai-Ying Chen, Jin-Yu Lei, Shu-Li Li, Li-Qiong Guo, Jun-Fang Lin, Guang-Hong Wu, Jun Lu, Zhi-Wei Ye
Summary: Edible fungi contain terpenoids, which have both edible and medicinal functions. Terpenoids possess a wide range of biological activities and show great potential in the pharmaceutical and healthcare industries. This review summarizes the diverse biological activities of terpenoids in edible fungi, with a focus on the mechanisms of anti-cancer and anti-inflammation. The review also highlights the advances in understanding the biosynthesis of terpenoids in edible fungi, particularly in the generation of sesquiterpenes, diterpenes, and triterpenes.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Eva Pokorna, Tomas Hluska, Petr Galuszka, H. Tucker Hallmark, Petre I. Dobrev, Lenka Zaveska Drabkova, Tomas Filipi, Katarina Holubova, Ondrej Plihal, Aaron M. Rashotte, Roberta Filepova, Jiri Malbeck, Ondrej Novak, Lukas Spichal, Bretislav Brzobohaty, Pavel Mazura, Lenka Zahajska, Vaclav Motyka
Summary: The study revealed a widespread distribution of cytokinin N-glucosides across plant species, with varying proportions of N7- and N9-glucosides in different plants. Additionally, it demonstrated specific physiological effects of N-glucosides on plant growth and signaling pathways.
Review
Microbiology
Hamza Shahid, Teng Cai, Yuyang Wang, Caiqing Zheng, Yuting Yang, Ziling Mao, Ping Ding, Tijiang Shan
Summary: Duclauxin is a unique heptacyclic oligophenalenone dimer that inhibits ATP synthesis in tumor cells, showing potential in agricultural and medical applications due to its remarkable biological activities. Natural duclauxin analogs produced by various fungal species exhibit diverse properties, contributing to the understanding of their biosynthesis, mechanisms of action, and potential uses in different fields.
FRONTIERS IN MICROBIOLOGY
(2021)
Review
Agriculture, Multidisciplinary
Jianzhao Qi, Yu-Qi Gao, Shi-jie Kang, Chengwei Liu, Jin-Ming Gao
Summary: Bird's nest fungi, known as medicinal fungi in Chinese medicine, produce secondary metabolites, including 185 compounds mainly cyathane diterpenoids, with antimicrobial and antineurodegenerative activities. This review aims to provide a systematic summary of the secondary metabolites of bird's nest fungi and promote further research on their natural product chemistry.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Food Science & Technology
Rim Nasri, Ola Abdelhedi, Moncef Nasri, Mourad Jridi
Summary: Protein hydrolysates are potential sources of diverse bioactive peptides. Fermentation is an alternative approach to produce biopeptides, offering promising applications and challenges.
CURRENT OPINION IN FOOD SCIENCE
(2022)
Review
Environmental Sciences
Qiqi Wan, Gang Wen, Yuhong Cui, Ruihua Cao, Xiangqian Xu, Gehui Wu, Jingyi Wang, Tinglin Huang
Summary: Recently, the contamination of fungi in water has become a matter of concern due to its potential threat to water quality, safety, and the increased risk of diseases in immunocompromised individuals. This review summarizes the characteristics and different physiological states of fungi in water and provides a comprehensive evaluation of the control efficiency and mechanism of commonly used disinfection methods. It also discusses the security strategies against fungal contamination in terms of water sources, treatment plants, and pipe networks. The review suggests future research directions, including the development of rapid detection methods, understanding the production and control of mycotoxins, and investigating outbreak conditions of fungi in water. Exploring efficient, safe, and economical disinfection technologies, particularly advanced disinfection processes, is highlighted as the main direction for future studies in fungal disinfection. This review is valuable for filling the knowledge gap and providing guidance for future research.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Review
Biochemistry & Molecular Biology
Camila Luiz Gomes, Victor de Albuquerque Wanderley Sales, Camila Gomes de Melo, Rosali Maria Ferreira da Silva, Rodolfo Hideki Vicente Nishimura, Larissa Araujo Rolim, Pedro Jose Rolim Neto
Summary: beta-Lapachone, an ortho-naphthoquinone, is known for its anticancer, antifungal, and antibacterial activities, as well as its low toxicity. Its potential therapeutic effects extend to various diseases such as tumors, infections, and inflammatory conditions.
Review
Biochemistry & Molecular Biology
Yeni Mulyani, Siska Elisahbet Sinaga, Unang Supratman
Summary: Meliaceae plants are globally distributed in tropical or subtropical climates and are significant in ethnobotany as traditional medicine sources. Previous research indicates that microorganisms, particularly endophytic fungi, play a vital role in producing diverse secondary metabolites. This comprehensive review provides an overview of the ethnobotanical uses and secondary metabolites derived from Meliaceae endophytic fungi.
Article
Chemistry, Physical
Arpita Roy, Amin Elzaki, Vineet Tirth, Samih Kajoak, Hamid Osman, Ali Algahtani, Saiful Islam, Nahla L. Faizo, Mayeen Uddin Khandaker, Mohammad Nazmul Islam, Talha Bin Emran, Muhammad Bilal
Summary: Bioinspired synthesis of nanocatalysts is an eco-friendly and cost-effective method that utilizes microorganisms as "factories" for synthesis, with wide potential applications in various fields.
Review
Biochemistry & Molecular Biology
Sabrin R. M. Ibrahim, Alaa Sirwi, Basma G. Eid, Shaimaa G. A. Mohamed, Gamal A. Mohamed
Summary: This review provides an overview of fungal depsides from 1975 to 2020, including their sources, biosynthesis, physical and spectral data, and bioactivities. A total of 110 metabolites and more than 122 references have been confirmed in this first review of these multi-faceted metabolites from fungi.
Article
Chemistry, Medicinal
Joko Tri Wibowo, Peni Ahmadi, Siti Irma Rahmawati, Asep Bayu, Masteria Yunovilsa Putra, Anake Kijjoa
Summary: Novel secondary metabolites from marine macroorganisms and marine-derived microorganisms have been extensively studied. Indole alkaloids, as one of the most promising compounds, possess diverse biological/pharmacological activities. This review summarizes the indole alkaloids isolated from 2016 to 2021 and their relevant biological/pharmacological activities, describing a total of 186 indole alkaloids.
Review
Chemistry, Medicinal
Salar Hafez Ghoran, Fatemeh Taktaz, Emilia Sousa, Carla Fernandes, Anake Kijjoa
Summary: Marine-derived fungi are unique sources of bioactive secondary metabolites, particularly peptides, with diverse structures and biological activities. This review summarizes the literature on marine fungal peptides from January 1991 to June 2023, covering their chemical characteristics, sources, and biological and pharmacological activities. Among 30 genera, Aspergillus was found to produce the highest number of peptides, followed by Penicillium, Acremonium, Eurotium, Trichoderma, Simplicillium, and Beauveria. The predominant activity of the reported marine peptides was cytotoxicity against human cancer cell lines, followed by antibacterial, antifungal, antiviral, anti-inflammatory, and enzyme inhibition activities.
Article
Plant Sciences
Ismail Amri, Marwa Khammassi, Rayda Ben Ayed, Sana Khedhri, Manel Ben Mansour, Oumayma Kochti, Ylenia Pieracci, Guido Flamini, Yassine Mabrouk, Samia Gargouri, Mohsen Hanana, Lamia Hamrouni
Summary: This study analyzed the chemical composition and evaluated the antioxidant, antimicrobial, and phytotoxic properties of the essential oils from Eucalyptus falcata, E. sideroxylon, and E. citriodora in Tunisia. The essential oils exhibited significant antioxidant activity and potential as natural pesticides. They also showed efficacy in inhibiting weed germination and growth, as well as moderate fungitoxic properties against various fungal strains.
Article
Chemistry, Applied
Ali Wang, Peng Li, Peipei Han, Gan Gu, Tijiang Shan, Daowan Lai, Ligang Zhou
Summary: New nitrogen-containing metabolites and natural products were isolated from the rice false smut pathogen, Villosiclava virens UV-8b, and evaluated for antibacterial and phytotoxic activities. Some compounds showed weak inhibition against bacteria, while others displayed inhibitory activity against the radicle elongation of rice seeds.
NATURAL PRODUCT RESEARCH
(2021)
Article
Chemistry, Applied
Jiajia Meng, Siji Zhao, Pengqin Dang, Zhiyao Zhou, Daowan Lai, Ligang Zhou
Summary: Ustilaginoidin M-1, a novel bis-naphtho-gamma-pyrone isolated from the pathogenic fungus Villosiclava virens, was tested for cytotoxicity against five human cancer cell lines after its structure was elucidated through spectroscopic analysis and comparison with literature data.
NATURAL PRODUCT RESEARCH
(2021)
Article
Chemistry, Applied
Daowan Lai, Jing Li, Siji Zhao, Gan Gu, Xiao Gong, Peter Proksch, Ligang Zhou
Summary: Several compounds isolated from the endophytic fungus Xylomelasma sp. Samif07 showed significant antibacterial, antitubercular, and antioxidant activities, indicating their potential as natural products for drug development.
NATURAL PRODUCT RESEARCH
(2021)
Article
Multidisciplinary Sciences
Daowan Lai, Ziling Mao, Zhiyao Zhou, Siji Zhao, Mengyao Xue, Jungui Dai, Ligang Zhou, Dianpeng Li
SCIENTIFIC REPORTS
(2020)
Article
Microbiology
Zheng Hu, Lu Zheng, Junbin Huang, Ligang Zhou, Chunsheng Liu, Hao Liu
CURRENT MICROBIOLOGY
(2020)
Review
Food Science & Technology
Dan Xu, Mengyao Xue, Zhen Shen, Xiaowei Jia, Xuwen Hou, Daowan Lai, Ligang Zhou
Summary: Fungal phytotoxic secondary metabolites are toxic substances produced by fungi through biochemical reactions, with a high level of diversity in their properties. These metabolites are mainly isolated from phytopathogenic fungal species, with aromatic polyketides and sesquiterpenoids being the main phytotoxic compounds.
Article
Microbiology
Xuwen Hou, Xuping Zhang, Mengyao Xue, Zhitong Zhao, Huizhen Zhang, Dan Xu, Daowan Lai, Ligang Zhou
Summary: This review summarizes the structures and bioactivities of 69 sorbicillinoids newly identified from 2016 to 2021. These compounds are classified into different categories and exhibit various biological activities, including cytotoxic, antimicrobial, anti-inflammatory, and phytotoxic effects.
Article
Biochemistry & Molecular Biology
Xuping Zhang, Dan Xu, Xuwen Hou, Penglin Wei, Jiajin Fu, Zhitong Zhao, Mingpeng Jing, Daowan Lai, Wenbing Yin, Ligang Zhou
Summary: This study identified a sorbicillinoid biosynthetic gene cluster in U. virens and demonstrated that UvSorA and UvSorB are responsible for sorbicillinoid biosynthesis and play important roles in the fungal response to external stresses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Food Science & Technology
Weixuan Wang, Gan Gu, Ruya Yin, Jiajin Fu, Mingpeng Jing, Zhen Shen, Daowan Lai, Baomin Wang, Ligang Zhou
Summary: In this study, a nanobody phage display library was established and two nanobodies were selected for the development of an indirect competitive enzyme-linked immunosorbent assay (ic-ELISA) to detect ustilaginoidins in rice. Nb-B15 showed superior characteristics compared to Nb-C21 and was chosen for the detection of actual contaminated rice samples. The developed ic-ELISA based on Nb-B15 showed consistent results with HPLC-DAD analysis, suggesting it can be a rapid and effective method for detecting total ustilaginoidins in contaminated rice samples.
Review
Microbiology
Mengyao Xue, Xuwen Hou, Jiajin Fu, Jiayin Zhang, Jiacheng Wang, Zhitong Zhao, Dan Xu, Daowan Lai, Ligang Zhou
Summary: Genomic analysis has identified cryptic biosynthetic gene clusters in fungi that are normally silenced but can be induced using chemical-epigenetic modifiers. These modifiers, such as 5-azacytidine and suberoylanilide hydroxamic acid, alter the structure of DNA and histones to activate the production of bioactive secondary metabolites. This review summarizes the research progress from 2007 to 2022 on using chemical epigenetic modifiers to trigger silent or low-expressed biosynthetic pathways in fungi, resulting in the production of over 540 fungal secondary metabolites with significant biological activities.
Article
Microbiology
Xuping Zhang, Xuwen Hou, Dan Xu, Mengyao Xue, Jiayin Zhang, Jiacheng Wang, Yonglin Yang, Daowan Lai, Ligang Zhou
Summary: In this study, the effects of environmental factors on U. virens were investigated. It was found that fructose, glucose, complex nitrogen sources, acidic conditions, and light exposure favored the production of sorbicillinoids. The relative transcript levels of sorbicillinoid biosynthesis genes were up-regulated when U. virens was exposed to these favorable environmental factors, indicating that sorbicillinoid biosynthesis is mainly regulated at the transcriptional level. Two pathway-specific transcription factor genes, UvSorR1 and UvSorR2, were identified to be involved in the regulation of sorbicillinoid biosynthesis. These findings provide valuable insights into the regulation mechanisms of sorbicillinoid biosynthesis and can contribute to the development of effective means for controlling sorbicillinoid production in U. virens.
Article
Biochemistry & Molecular Biology
Mengyao Xue, Siji Zhao, Gan Gu, Dan Xu, Xuping Zhang, Xuwen Hou, Jiankun Miao, Hai Dong, Dongwei Hu, Daowan Lai, Ligang Zhou
Summary: Rice false smut caused by Villosiclava virens is a highly destructive fungal disease that reduces the yield and quality of rice grains. This study isolated an albino strain LN02 from white false smut balls collected in China. The genome analysis revealed the deficiency of ustilaginoidin biosynthesis in strain LN02, which led to albinism. This finding highlights the potential of strain LN02 in the development and application of secondary metabolites.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Plant Sciences
Gan Gu, Xiao Gong, Dan Xu, Yonglin Yang, Ruya Yin, Jungui Dai, Kui Zhu, Daowan Lai, Ligang Zhou
Summary: Ten new diphenyl ether polyketides, rhexocerins A-D(1-4)and rhexocercosporins A-F(5-10), as well as three known congeners (11-13), were isolated from the endophytic fungus Rhexocercosporidium sp.Dzf14 from Dioscorea zingiberensis. Their structures were determined by NMR, HRESIMS, quantum chemical ECD calculations, and X-ray crystallography. Compounds 1 and 5-9 exhibited antibacterial activities against methicillin-resistant S. aureus T144 and vancomycin-resistant E. faecalis.
JOURNAL OF NATURAL PRODUCTS
(2023)
Article
Microbiology
Gan Gu, Xiaowei Jia, Weixuan Wang, Peng Li, Siji Zhao, Zhiyao Zhou, Ruya Yin, Daowan Lai, Suqin Song, Ligang Zhou
Summary: A total of 99 endophytic fungal isolates were obtained from the roots of Glycyrrhiza inflata, with 11 different genera identified, dominated by Aspergillus, Alternaria, and Fusarium. Among 22 fungi extracts, Alternaria angustiovoidea Glinf007 showed significant mycelial growth inhibitory activity against three rice fungal pathogens. The study suggests that G. inflata harbors a diverse community of endophytic fungi with potential natural antimicrobial properties beneficial for agriculture and pharmaceutical industries.
MICROBIOLOGY RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Dan Xu, Ruya Yin, Zhiyao Zhou, Gan Gu, Siji Zhao, Jin-Rong Xu, Junfeng Liu, You-Liang Peng, Daowan Lai, Ligang Zhou
Summary: Ustilaginoidins are a type of mycotoxin produced by Ustilaginoidea virens, featuring a dimeric naphtho-gamma-pyrone skeleton. The biosynthesis process involves multiple steps, including the discovery of dimeric compounds and double bond reduction. Different enzymes play roles at different stages, leading to the formation of diverse ustilaginoidins.
