Article
Nanoscience & Nanotechnology
Michal Gorzkiewicz, Monika Marcinkowska, Maciej Studzian, Iwona Karwaciak, Lukasz Pulaski, Barbara Klajnert-Maculewicz
Summary: This study developed an innovative nanocarrier based on PAMAM dendrimer to increase the concentration of mesalazine in intestinal epithelial cells, thereby enhancing its anti-inflammatory potential. The covalent PAMAM-mesalazine conjugate was synthesized and characterized, and it was found that the drug successfully attached to the dendrimer. The use of PAMAM as a carrier improved cellular uptake and anti-inflammatory activity of mesalazine.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Materials Science, Ceramics
Zachary Kegley, Michael Makay, Joshua Rogers, Katrina Phelps, Colleen Malcom, David Hellmig, Anna Kroninger, Xiangdong Bi
Summary: The purpose of this research is to develop a hydrogel delivery system using PAMAM dendrimer to enhance the solubility and sustained release of hydrophobic drugs. The research shows that with the presence of PAMAM dendrimer, the solubility of diflunisal in water is significantly improved and the hydrogel system can achieve sustained release of the drug.
JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY
(2022)
Article
Polymer Science
Reza Pashaei-Sarnaghi, Faezeh Najafi, Ameneh Taghavi-Kahagh, Mehdi Salami-Kalajahi, Hossein Roghani-Mamaqani
Summary: In this study, poly(amidoamine) dendrimer with ethylenediamine core up to the fourth generation was synthesized and conjugated to different amounts of 7-(carboxymethoxy)-4-methylcoumarin. Under UV light irradiation, the crosslinked dendrimer-coumarin samples showed smaller particle sizes compared to non-crosslinked samples, with release behavior being influenced by increasing coumarin moieties.
EUROPEAN POLYMER JOURNAL
(2021)
Article
Biophysics
Bhavya Surekha, Naga Sreenu Kommana, Sunil Kumar Dubey, A. V. Pavan Kumar, Rahul Shukla, Prashant Kesharwani
Summary: PAMAM dendrimers are novel polymeric structures with defined nano-size and multiple active functional groups, ideal for cancer therapy. Their modifiable surface functionalities and high drug encapsulation rate make them widely used in drug delivery and gene therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Review
Polymer Science
Mohammad Nikzamir, Younes Hanifehpour, Abolfazl Akbarzadeh, Yunes Panahi
Summary: Dendrimers are hyper-branched organic compounds with functional groups on the surface that can be modified for enhanced functionality. They possess unique properties such as nanoscale size, globular shape, high reactivity, and water solubility, making them promising for drug delivery applications. Dendrimers can serve as carriers for therapeutic agents, reducing drug toxicity and increasing efficacy, and have received significant attention from researchers in the field of nanomedicine.
JOURNAL OF INORGANIC AND ORGANOMETALLIC POLYMERS AND MATERIALS
(2021)
Review
Chemistry, Multidisciplinary
Raji Rama Krishnan, Shine Rama Chandran, Elizabath Johnson, Prema Kakkadath Hariharan
Summary: Magnetic nanoparticles (MNPs) have great potential in the biomedical field for diagnosis and treatment of diseases. Functionalization of MNPs with dendrimers enhances their stability and dispersibility, enabling targeted drug delivery, MRI, magnetic hyperthermia treatment, and antimicrobial applications.
Article
Materials Science, Multidisciplinary
Malvika Chawla, R. D. Kaushik, Mayank Kumar Malik, Vishakha Pundir, Jaspal Singh, Hafeezur Rehmaan
Summary: This study investigates the drug release dynamics and anti-inflammatory activity of the roflumilast analogue with dendrimer. The results show that the RofA-Dendrimer complex has high encapsulation potency and loading capability, and releases the drug progressively, making it suitable for sustained delivery. Drug release kinetics analysis indicates non-Fickian diffusion. Furthermore, the solubility of roflumilast increases with different dendrimer generations and pH levels.
MATERIALS TODAY COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Jiamin Ban, Sidi Li, Qi Zhan, Xuepin Li, Huike Xing, Ning Chen, Lixia Long, Xin Hou, Jin Zhao, Xubo Yuan
Summary: The study demonstrates the use of PMPC-modified PAMAM nanoparticles as a drug delivery system for glioma treatment, showing that PMPC can reduce toxicity and effectively target brain tumors.
MACROMOLECULAR BIOSCIENCE
(2021)
Article
Chemistry, Multidisciplinary
E. Murugan, V. Yogaraj
Summary: In this study, poly (amidoamine) dendrimers (generation G2 and G3) were synthesized as drug carriers to enhance the solubility and sustained release of furosemide (FRSD). The dendrimers significantly increased the solubility and release time of FRSD compared with pure FRSD. Cytotoxicity studies indicated reduced toxicity and improved bioavailability of FRSD when delivered using these dendrimer-based drug carriers. The results suggest that the dendrimer-based drug carriers are promising for poorly soluble drugs and could be used for real-time drug delivery applications.
FRONTIERS IN CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Magdalena Szota, Pawel Wolski, Cristina Carucci, Flaminia Cesare Marincola, Jacek Gurgul, Tomasz Panczyk, Andrea Salis, Barbara Jachimska
Summary: This study investigates the effect of the protonation degree of G4PAMAM dendrimer and the anticancer drug 5-fluorouracil (5FU) on the efficiency of complex formation. The most favorable conditions for constructing the G4PAMAM-5FU complex are a low degree of protonation of the dendrimer molecule with the drug simultaneously present in a deprotonated form. The formation of the stable complex is confirmed by fluorine components in the XPS spectra.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Shugo Yamashita, Hidemasa Katsumi, Toshiyasu Sakane, Akira Yamamoto
Summary: The aim of this study was to develop a new drug carrier for the treatment of bone diseases using a polyethylene glycol (PEG)-conjugated polyamidoamine dendrimer (PAMAM). The results showed that the carrier could efficiently target the osteoid surfaces and exhibit excellent performance in bone pathogenesis mechanisms.
MOLECULAR PHARMACEUTICS
(2022)
Review
Chemistry, Multidisciplinary
Vidhi Patel, Princy Patel, Jigar Patel, Pravinkumar M. Patel
Summary: Dendrimer chemistry is a rapidly expanding field with potential applications in nanotechnology, pharmaceuticals, and medicinal chemistry. Dendrimers are highly branched polymers with multiple peripheral groups and interior cavities, which allow for adjustment of surface properties and incorporation of biologically active agents.
JOURNAL OF THE INDIAN CHEMICAL SOCIETY
(2022)
Review
Chemistry, Organic
Luis Daniel Pedro-Hernandez, Marcos Martinez-Garcia
Summary: Nanotechnology has become crucial in research and development in recent years, with dendrimers offering unique properties that make them attractive for new technology development. The physical and chemical properties of dendrimers depend on their generation number or size.
CURRENT ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Physical
Jia-Si Wu, Jia-Xian Li, Na Shu, Qi-Jia Duan, Qi-Song Tong, Jing-Yang Zhang, Yong-Cong Huang, Si-Yu Yang, Zhi-Bin Zhao, Jin-Zhi Du
Summary: The study developed a novel polymer capable of polarizing TAMs into M1 phenotype, which efficiently loaded TLR7/8 agonist to remodel the tumor immunosuppressive microenvironment, enhancing the efficacy of cancer immunotherapy.
Article
Chemistry, Multidisciplinary
Dinesh Dhumal, Bar Maron, Einav Malach, Zhenbin Lyu, Ling Ding, Domenico Marson, Erik Laurini, Aura Tintaru, Brigino Ralahy, Suzanne Giorgio, Sabrina Pricl, Zvi Hayouka, Ling Peng
Summary: The urgent need for innovative antibacterial agents due to the antibiotic resistance crisis is addressed in this study. The researchers developed antibacterial candidates based on self-assembled supramolecular dendrimer nanosystems, which exhibited strong antibacterial activity and prevented biofilm formation.
Article
Chemistry, Applied
Elianaso Elimbinzi, Stephen S. Nyandoro, Egid B. Mubofu, Jinesh C. Manayil, Adam F. Lee, Karen Wilson
MICROPOROUS AND MESOPOROUS MATERIALS
(2020)
Article
Plant Sciences
Gasper Maeda, Joan J. E. Munissi, Sofia Lindblad, Sandra Duffy, Jerry Pelletier, Vicky M. Avery, Stephen S. Nyandoro, Mate Erdelyi
JOURNAL OF NATURAL PRODUCTS
(2020)
Article
Plant Sciences
Gasper Maeda, Jelle van der Wal, Arvind Kumar Gupta, Joan J. E. Munissi, Andreas Orthaber, Per Sunnerhagen, Stephen S. Nyandoro, Mate Erdelyi
JOURNAL OF NATURAL PRODUCTS
(2020)
Article
Chemistry, Applied
Robert Christopher, Quintino A. Mgani, Stephen S. Nyandoro, Amanda L. Rousseau, Michelle Isaacs, Heinrich C. Hoppe
Summary: Phytochemical investigation of Monodora minor and Uvaria tanzaniae yielded new compounds and known compounds, with compound 4 showing remarkable activities against Trypanosoma brucei brucei and Plasmodium falciparum in both antitrypanosomal and antiplasmodial assays.
NATURAL PRODUCT RESEARCH
(2021)
Article
Green & Sustainable Science & Technology
Cecilia Rolence China, Askwar Hilonga, Stephen S. Nyandoro, Michaela Schroepfer, Swarna Kanth, Michael Meyer, Karoli N. Njau
JOURNAL OF CLEANER PRODUCTION
(2020)
Review
Infectious Diseases
Reuben Maghembe, Donath Damian, Abdalah Makaranga, Stephen Samwel Nyandoro, Sylvester Leonard Lyantagaye, Souvik Kusari, Rajni Hatti-Kaul
Review
Environmental Sciences
Cecilia Rolence China, Mihayo Musabila Maguta, Stephen Samwel Nyandoro, Askwar Hilonga, Swarna Kanth, Karoli N. Njau
Article
Plant Sciences
Linda Zandi, Marco Makungu, Joan J. E. Munissi, Sandra Duffy, Rakesh Puttreddy, Daniel von der Heiden, Kari Rissanen, Vicky M. Avery, Stephen S. Nyandoro, Mate Erdelyi
JOURNAL OF NATURAL PRODUCTS
(2020)
Article
Plant Sciences
Thobias M. Kalenga, Monica M. Ndoile, Yoseph Atilaw, Pieter J. Gilissen, Joan J. E. Munissi, Anastasia Rudenko, Catarina Bourgard, Per Sunnerhagen, Stephen S. Nyandoro, Mate Erdelyi
Summary: Two new biflavanones and three new bichalconoids were isolated from the stem bark extract of Ochna holstii. Holstiinone A exhibited moderate antibacterial activity, while lophirone F showed cytotoxicity against MCF-7.
JOURNAL OF NATURAL PRODUCTS
(2021)
Article
Biochemistry & Molecular Biology
Daniel M. Shadrack, Lucy W. Kiruri, Hulda Swai, Stephen S. Nyandoro
Summary: The polarity of solvents significantly affects the unbinding rate of TouA, with DMSO leading to faster unbinding than water. DMSO weakens the interaction between chitosan and TouA by reducing the transition state, while water sustains a strong interaction, resulting in longer residence time. Thermodynamic integration suggests greater stability of the chitosan-TouA complex in water compared to DMSO.
JOURNAL OF MOLECULAR MODELING
(2021)
Article
Chemistry, Medicinal
Thobias M. Kalenga, Monica M. Ndoile, Yoseph Atilaw, Joan J. E. Munissi, Pieter J. Gilissen, Anastasia Rudenko, Catarina Bourgard, Per Sunnerhagen, Stephen S. Nyandoro, Mate Erdelyi
Summary: New isoflavonoid and biflavonoid compounds, kirkinone A and kirkinone B, were isolated from Ochna kirkii root bark methanolic extract, showing antibacterial and cytotoxic activities but no activity against Escherichia coli.
Article
Biochemical Research Methods
Daniel M. Shadrack, Geradius Deogratias, Lucy W. Kiruri, Hulda S. Swai, John-Mary Vianney, Stephen S. Nyandoro
Summary: The study identified natural compounds such as Diosmin, Isoquercetin, and Rutin as potential inhibitors of SARS-CoV-2, which act on the virus through different mechanisms and offer an alternative solution for treating COVID-19.
JOURNAL OF MOLECULAR GRAPHICS & MODELLING
(2021)
Article
Biochemistry & Molecular Biology
Daniel M. Shadrack, Geradius Deogratias, Lucy W. Kiruri, Isaac Onoka, John-Mary Vianney, Hulda Swai, Stephen S. Nyandoro
Summary: The study suggests that luteolin from Tetradenia riparia extract could be an effective blocker of SARS-CoV-2 cell entry, potentially serving as a therapeutic option for COVID-19. Computational methods were used to investigate the mechanism of action, shedding light on the identification of more bioactive constituents from plant sources.
JOURNAL OF MOLECULAR MODELING
(2021)
Article
Microbiology
Reuben Maghembe, Angelina Michael, Ajith Harish, Stephen S. Nyandoro, Sylvester L. Lyantagaye, Rajni Hati-Kaul
Summary: The genome of Limnospira sp. BM01 from Tanzania's Big Momela Lake is characterized by its length, protein and RNA gene count, making it suitable for industrial production of dietary supplements and nutraceutical agents.
MICROBIOLOGY RESOURCE ANNOUNCEMENTS
(2021)
Article
Biochemistry & Molecular Biology
Joan J. E. Munissi, Sani M. Isyaka, Eduard Mas-Claret, Molly Brabner, Moses K. Langat, Stephen S. Nyandoro, Dulcie A. Mulholland