Article
Nanoscience & Nanotechnology
Arun Teotia, Isabella Lauren, Sedigheh Borandeh, Jukka Seppala
Summary: Cationic polysaccharides, specifically quaternary chitosans (QCs), have shown significant antimicrobial properties and can be potential antiviral agents. This study aimed to develop metal-free and environmentally friendly QCs with long-lasting virucidal activity. The influence of quaternary functional group, charge density, and molecular weight on the antiviral properties of QCs was investigated. The findings demonstrated that heterogeneously functionalized chitosan derivatives exhibited excellent antiviral activity and have promising potential in various biomedical applications.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Review
Polymer Science
Kamla Pathak, Shashi Kiran Misra, Aayush Sehgal, Sukhbir Singh, Simona Bungau, Agnieszka Najda, Robert Gruszecki, Tapan Behl
Summary: Chitosan, a natural polymer, is extensively used for versatile drug delivery systems, with quaternized chitosan being preferred in pharmaceutical industries due to its superior properties. Quaternized chitosan has been widely applied in tissue engineering, wound healing, gene, and vaccine delivery.
Article
Food Science & Technology
Bianca-Iustina Andreica, Alexandru Anisiei, Irina Rosca, Luminita Marin
Summary: This paper presents a new design of nanofibers tailored for food packaging applications. By electrospinning chitosan, quaternized chitosan, vanillin, and poly(ethylene oxide) into fibrous materials, the nanofibers were able to provide benefits such as natural origin bioactive components, high surface-to-volume ratio, and dynamic nature of imine bonds. The study confirmed the bonding of vanillin via dynamic imine units and the formation of fibers with an average diameter of 140 nm. The nanofibers exhibited high mechanical properties, thermal stability, and good moisture adsorption. With the covalent imine bonds encapsulating vanillin and the inclusion of quaternized chitosan, the nanofibers showed high antioxidant, antibacterial, and antifungal activity. Application on raspberries significantly extended their shelf life, and the components promoted fast biodegradation in soil.
FOOD PACKAGING AND SHELF LIFE
(2023)
Article
Polymer Science
Tatsiana V. Shakola, Vasili V. Rubanik, Vasili V. Rubanik-Jr, Aleh V. Kurliuk, Anatoly A. Kirichuk, Alexander G. Tskhovrebov, Anton R. Egorov, Andreii S. Kritchenkov
Summary: In this study, electrochemical N-arylation of chitosan was successfully achieved, providing a straightforward and convenient method for chemical modification of chitosan without depolymerization. The synthesized chitosan derivatives exhibited excellent water solubility across a broad pH range and showed potential antimicrobial activity. Moreover, the nanoparticles formed by these derivatives displayed strong antibacterial effects, comparable to commercially available antibiotics. This study highlights the significance of electrochemical N-arylation in modifying chitosan for various applications, particularly in antimicrobial and nanomedicine domains.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Wanwen Chen, Hao Cheng, Qixing Jiang, Wenshui Xia
Summary: Synthesis of sNCCS, a selenium polysaccharide with potential bioactivity, showed excellent bile acid binding capacity and antioxidative properties, without apparent cytotoxic effects on cells, suggesting its potential as an effective ingredient in the fields of food or medicine.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Medicinal
Yan Sun, Jingmin Cui, Liguang Tian, Yingqi Mi, Zhanyong Guo
Summary: Fourteen novel phenolic acid functional chitooligosaccharide derivatives were successfully prepared and characterized in this study. The derivatives showed strong antioxidant and antimicrobial activities, making them potentially useful in various industries.
Article
Biochemistry & Molecular Biology
Ya-Ming Ge, Xue-Fang Zhao, Jia-Hui Xu, Jun-Zhi Liu, Jia-Shun Yang, Shi-Jie Li
Summary: A new type of magnetic microparticles, Sr3.8Fe25.7O70.4-chitosan, was synthesized and found to efficiently remove toxic dyes at a fast rate. The microparticles follow Langmuir isotherm and pseudo-second-order model, making them a promising material for wastewater treatment.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Tomasz Urbaniak, Gabriela S. Garcia-Briones, Alexander Zhigunov, Sviatoslav Hladysh, Edyta Adrian, Volodymyr Lobaz, Tereza Krunclova, Olga Janouskova, Ognen Pop-Georgievski, Dana Kubies
Summary: This study investigated layer-by-layer polyelectrolyte coatings with the ability to release heparin-binding proteins. The use of tannic acid as a physical crosslinker resulted in more stable films during assembly and increased protein release. The proteins released more when they were part of the heparin layers rather than as individual protein layers.
Review
Chemistry, Multidisciplinary
Iyyakkannu Sivanesan, Nazim Hasan, Syed Kashif Ali, Juhyun Shin, Judy Gopal, Manikandan Muthu, Jae-Wook Oh
Summary: This review comprehensively lists the available novel chitosan derivatives and summarizes their biological applications. It points out the selective focus on bio functions and the lack of exploration in other biomedical and antiviral applications, while highlighting the profound impact of synthesized chitosan derivatives on unexplored biological aspects.
APPLIED SCIENCES-BASEL
(2022)
Article
Biochemistry & Molecular Biology
Wenchao Li, Zhengnan Su, Yanru Hu, Lihui Meng, Fang Zhu, Bin Xie, Jiangling Wan, Qingzhi Wu
Summary: This work developed a novel strategy to prepare Methacrylated Gelatin-Dopamine (GelMA-DA)/Quaternized Chitosan (QCS)/Glycerol (Gly) composite sponges, which exhibited good biocompatibility, tissue self-adhesion, antibacterial activity, and hemostatic ability. The sponges showed high water absorption capacity and excellent lap shear strength against skin, liver, muscle, and fat. They also demonstrated better antibacterial activity and hemostasis efficiency compared to commercial Gelatin and CS hemostatic sponges in animal experiments. These results suggest the potential of GelMA-DA/QCS/Gly sponges as effective wound dressings for clinical surgery and emergency treatment.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Pharmacology & Pharmacy
Ali M. Nasr, Salama M. Aboelenin, Mohammad Y. Alfaifi, Ali A. Shati, Serag Eldin Elbehairi, Reda F. M. Elshaarawy, Nashwa H. Abd Elwahab
Summary: This study evaluated the chemical composition of virgin olive oil and improved its bioactivity by formulating it into a nanoemulsion. The results showed that the inclusion of a protective hydrogel network stabilized the physicochemical properties of the oil and enhanced its antimicrobial, anti-biofilm, and antioxidant potentials. These findings are important for the development of biological applications for virgin olive oil.
Article
Chemistry, Applied
Shujun Zhao, Wen-Chin Tsen, Chunli Gong
Summary: In this study, a composite anion exchange membrane was prepared to enhance the ion conductivity and stability of the membrane through structural design and material synthesis. The membrane exhibited superior performance, laying a foundation for applications in fuel cells and other fields.
CARBOHYDRATE POLYMERS
(2021)
Article
Polymer Science
Lili Deng, Kangkang Ou, Jiaxin Shen, Baoxiu Wang, Shiyan Chen, Huaping Wang, Song Gu
Summary: A natural self-healing hydrogel based on methacrylated chitosan (CSMA) and dialdehyde bacterial cellulose (DABC) was developed in this study. The hydrogel showed good self-healing properties and cytocompatibility, indicating its potential in wound healing and tissue repair.
Article
Chemistry, Physical
Xiudong Liu, Huofei Zhou, Weiting Yu, Xin Xiong, Rumen Krastev, Xiaojun Ma
Summary: The study successfully prepared polymeric micelle-like nanoparticles capable of delivering DOX by modifying chitosan to HT-CS-DCA, and further demonstrated the inhibitory activity of these nanoparticles on MCF-7 cells.
Article
Chemistry, Applied
Wanwen Chen, Hao Cheng, Lingyun Chen, Xiaobei Zhan, Wenshui Xia
Summary: This study introduces selenodiacetic acid to synthesize O-selenodiacetyl chitosan and chitosan-ammonium selenodiacetate, which show higher antioxidant activity and anticancer effect compared to chitosan.
CARBOHYDRATE POLYMERS
(2022)
Article
Chemistry, Medicinal
Qing Li, Xueqi Sun, Guodong Gu, Zhanyong Guo
Article
Polymer Science
Fang Luan, Lijie Wei, Jingjing Zhang, Yingqi Mi, Fang Dong, Qing Li, Zhanyong Guo
Article
Chemistry, Medicinal
Yingqi Mi, Wenqiang Tan, Jingjing Zhang, Lijie Wei, Yuan Chen, Qing Li, Fang Dong, Zhanyong Guo
Article
Polymer Science
Lijie Wei, Wenqiang Tan, Jingjing Zhang, Yingqi Mi, Fang Dong, Qing Li, Zhanyong Guo
Article
Polymer Science
Jingjing Zhang, Wenqiang Tan, Lijie Wei, Fang Dong, Qing Li, Zhanyong Guo
Article
Polymer Science
Yuan Chen, Yingqi Mi, Xueqi Sun, Jingjing Zhang, Qing Li, Naiyun Ji, Zhanyong Guo
Article
Polymer Science
Xueqi Sun, Jingjing Zhang, Yuan Chen, Yingqi Mi, Wenqiang Tan, Qing Li, Fang Dong, Zhanyong Guo
Article
Polymer Science
Yuan Chen, Xiguang Liu, Xueqi Sun, Jingjing Zhang, Yingqi Mi, Qing Li, Zhanyong Guo
Article
Biochemistry & Molecular Biology
Yingqi Mi, Qin Miao, Jingmin Cui, Wenqiang Tan, Zhanyong Guo
Summary: This study investigated the moisture absorption and retention properties of 2-hydroxypropyltrimethyl ammonium chitosan derivatives modified by anionic compounds via ion exchange. Results showed enhanced moisture absorption and retention properties in all target products, with HACBA exhibiting the most significant improvement.
Article
Polymer Science
Yingqi Mi, Jingjing Zhang, Lulin Zhang, Qing Li, Yuanzheng Cheng, Zhanyong Guo
Summary: Chitosan nanoparticles loaded with adriamycin exhibited a burst effect followed by steady release, and demonstrated enhanced antioxidant activities and cytotoxicities against cancer cells. With reduced cytotoxicity and enhanced biological activity, these novel nanoparticles could serve as promising candidates for drug loading/release in drug delivery systems.
Article
Chemistry, Medicinal
Yan Sun, Xia Ji, Jingmin Cui, Yingqi Mi, Jingjing Zhang, Zhanyong Guo
Summary: This study presents a series of phenolic acid chitooligosaccharide (COS) derivatives synthesized using two mild and green methods. The synthesized derivatives exhibited enhanced antioxidant activity and low cytotoxicity, making them potential candidates for non-toxic antioxidant agents in the food and cosmetics industry.
Article
Chemistry, Medicinal
Qin Miao, Qing Li, Wenqiang Tan, Yingqi Mi, Bing Ma, Jingjing Zhang, Zhanyong Guo
Summary: This study primarily synthesized glucosamine-heparin salt (GHS) and characterized its structure. The results showed that the salt exhibited enhanced antioxidant and anticoagulant activities.
Article
Chemistry, Medicinal
Jingmin Cui, Yan Sun, Linqing Wang, Qin Miao, Wenqiang Tan, Zhanyong Guo
Summary: A series of l-arginine Schiff base acylated chitosan derivatives were successfully prepared to enhance the antioxidant and antimicrobial activities. Some compounds showed promising activities, indicating potential for further development and utilization as antioxidants and antimicrobial agents.
Article
Chemistry, Medicinal
Yan Sun, Jingmin Cui, Liguang Tian, Yingqi Mi, Zhanyong Guo
Summary: Fourteen novel phenolic acid functional chitooligosaccharide derivatives were successfully prepared and characterized in this study. The derivatives showed strong antioxidant and antimicrobial activities, making them potentially useful in various industries.