Article
Medicine, Research & Experimental
Yu Long, Songyu Liu, Jinyan Wan, Yulu Zhang, Dan Li, Shuang Yu, Ai Shi, Nan Li, Fei He
Summary: This study investigated the effect of BO-BA-LP on improving blood-brain barrier integrity. The results showed that BO-BA-LP could increase the ability of BA to penetrate the cell membrane, leading to increased concentrations of BA in plasma and brain tissues. BO-BA-LP also improved neurological function and histopathology in CIRI mice.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Cardiac & Cardiovascular Systems
Maarja A. Mae, Liqun He, Sofia Nordling, Elisa Vazquez-Liebanas, Khayrun Nahar, Bongnam Jung, Xidan Li, Bryan C. Tan, Juat Chin Foo, Amaury Cazenave-Gassiot, Markus R. Wenk, Yvette Zarb, Barbara Lavina, Susan E. Quaggin, Marie Jeansson, Chengua Gu, David L. Silver, Michael Vanlandewijck, Eugene C. Butcher, Annika Keller, Christer Betsholtz
Summary: Through single-cell RNA sequencing and other methods, the study revealed the transcriptional, morphological, and functional changes in brain endothelial cells in response to pericyte deficiency. Endothelial cells without pericyte contact maintain a BBB-specific gene expression profile and acquire a venous-shifted molecular pattern.
CIRCULATION RESEARCH
(2021)
Article
Nanoscience & Nanotechnology
Xin Xin, Wei Liu, Zhe-Ao Zhang, Ying Han, Ling-Ling Qi, Ying-Ying Zhang, Xin-Tong Zhang, Hong-Xia Duan, Li-Qing Chen, Ming-Ji Jin, Qi-Ming Wang, Zhong-Gao Gao, Wei Huang
Summary: RVG15-Lipo is a promising brain-targeted nanovehicle with tumor-specificity, showing efficient BBB penetration and enhanced drug permeability and selectivity at tumor sites. In vivo experiments demonstrated that PTX-CHO-RVG15-Lipo significantly inhibited glioma growth, improving the survival rate of mice.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Pharmacology & Pharmacy
Zhuqing Song, Xiuxian Huang, Jieqiong Wang, Feiyan Cai, Ping Zhao, Fei Yan
Summary: The ultrasound-mediated BBB opening combined with liposomal temozolomide formulation has been successfully applied in the treatment of glioblastoma, significantly inhibiting tumor growth and prolonging animal survival time without significant side effects.
Article
Physiology
Ping Yu, Yanyu Li, Gaoliang Zhong, Wen Li, Bing Chen, Jingjing Zhang
Summary: This study found that loss of membranous Claudin-5 led to hypoxia-induced autophagy in cerebrovascular endothelial cells, partially attenuating endothelial cell apoptosis. Mechanism studies showed that membranous Claudin-5 affected the stimulation of HIF-1a and iNOS under hypoxic conditions, leading to suppressed endothelial autophagy. Loss of Claudin-5 also influenced the generation of ROS and expression of Bnip3, contributing to the inhibition of endothelial autophagy under hypoxia.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Bin Yu, Yao Yao, Xiaofeng Zhang, Ming Ruan, Zhennian Zhang, Li Xu, Tao Liang, Jinfu Lu
Summary: LCH and borneol have a complementary effect in attenuating brain ischemia, with the former promoting neural stem cell proliferation, neurogenesis, and mature neuron preservation, possibly related to astrocyte transformation, while the latter focuses on maintaining BBB integrity to support neurogenesis in a homeostatic environment.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Immunology
Nuria Villalba, Yonggang Ma, Sarah A. Gahan, Aurelie Joly-Amado, Sam Spence, Xiaoyuan Yang, Kevin R. Nash, Sarah Y. Yuan
Summary: This study investigated the effects of lung infection on blood-brain barrier disruption and behavioral changes, and found that systemic bacterial infection may contribute to lung-brain axis inflammatory response through cytokine release.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Chemistry, Physical
Beatrice Simonis, Domenico Vignone, Odalys Gonzalez Paz, Enrica Donati, Maria Laura Falchetti, Cecilia Bombelli, Antonella Cellucci, Giulio Auciello, Ivan Fini, Luciano Galantini, Rudaba Zaman Syeda, Marco Mazzonna, Maria Patrizia Mongiardi, Francesco Buonocore, Francesca Ceccacci, Annalise Di Marco, Giovanna Mancini
Summary: This study found that the addition of diasteromeric cationic gemini amphiphiles in liposomes promoted the crossing of the blood-brain barrier. The stereochemistry and pegylation of the gemini amphiphiles affected the permeability, and the use of iPSC-derived BBB models represented an important advancement in drug discovery research.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Adam Juhasz, Ditta Ungor, Norbert Varga, Gabor Katona, Gyorgy T. Balogh, Edit Csapo
Summary: The encapsulation possibilities of neuroprotective drug KYNA using lipid-based nanocarriers to increase BBB permeability were studied. Preparation conditions and characterization of liposomes were optimized. The drug-loaded liposomes showed improved BBB penetration and lipid membrane retention compared to the unformatted drug.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
David J. Lundy, Helen Nguyen, Patrick C. H. Hsieh
Summary: Treatment of brain tumors is challenging due to the blood-brain tumor barrier, but nanomedicines show promise despite being underutilized in clinical settings. Liposomes, extracellular vesicles, and biomimetic strategies are the most clinically feasible nano-carrier strategies for improving brain drug delivery. Numerous obstacles in translation of these technologies include pre-clinical models, analytical methods, and regulatory issues.
Article
Chemistry, Multidisciplinary
Zhou Ye, Benjamin D. Gastfriend, Benjamin J. Umlauf, David M. Lynn, Eric Shusta
Summary: A receptor-mediated antibody-targeted liposomal system was developed and evaluated for targeted delivery of therapeutics into the brain. The system showed increased brain accumulation by targeting the brain vasculature through the blood-brain barrier. These findings indicate the potential of this system for transporting therapeutic molecules into the central nervous system.
PHARMACEUTICAL RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Anne Mahringer, Elena Puris, Gert Fricker
Summary: The blood-brain barrier presents challenges in drug delivery to the central nervous system, but surface modified nanocarrier systems are being explored as a potential solution. Liposomes and solid nanoparticles are the main systems being tested currently.
NEUROCHEMISTRY INTERNATIONAL
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Zixuan Lin, Dengrong Jiang, Peiying Liu, Yulin Ge, Abhay Moghekar, Hanzhang Lu
Summary: This study used non-contrast MRI technique to dynamically monitor the effect of caffeine on blood-brain barrier (BBB) permeability to water. The results showed that caffeine ingestion led to decreased cerebral blood flow and venous oxygenation, but did not affect BBB permeability to water. These findings provide important insights into the effects of caffeine on the nervous system.
MAGNETIC RESONANCE IN MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Maj Schneider Thomsen, Kasper Bendix Johnsen, Krzysztof Kucharz, Martin Lauritzen, Torben Moos
Summary: Liposomes and other nanoparticles can be used as good candidates for delivering biologics across brain endothelial cells. Antibodies targeting the transferrin receptor can enhance the uptake of nanoparticles by endothelial cells and facilitate transport across the blood-brain barrier. Reducing antibody density or using monovalent antibodies can increase the uptake of nanoparticles by brain endothelial cells and promote further transport across the blood-brain barrier.
Article
Pharmacology & Pharmacy
Richard Nii Lante Lamptey, Chengwen Sun, Jagdish Singh
Summary: Functionalized liposomes can safely deliver losartan potassium to the brain, blocking angiotensin receptor type 1 activity and preventing the occurrence of hypertension in spontaneously hypertensive rats.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)