Article
Biochemistry & Molecular Biology
Agnieszka Krawczyk-Lebek, Monika Dymarska, Tomasz Janeczko, Edyta Kostrzewa-Suslow
Summary: The study successfully synthesized and biotransformed 2'-hydroxy-2-methylchalcone to obtain various glycosylated dihydrochalcones, with the most products produced by B. bassiana KCH J1.5. These compounds show potential as bioactive substances with improved stability and bioavailability, and can be used as flavor enhancers and sweeteners.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Martyna Perz, Agnieszka Krawczyk-Lebek, Monika Dymarska, Tomasz Janeczko, Edyta Kostrzewa-Suslow
Summary: Combining chemical and microbiological methods using entomopathogenic filamentous fungi enables the production of flavonoid glycosides. In this study, biotransformations were performed using the strains Beauveria bassiana KCH J1.5, Isaria fumosorosea KCH J2, and Isaria farinosa KCH J2.6 on six flavonoid compounds synthesized chemically. Various flavonoid derivatives were obtained through these biotransformations. These derivatives show potential in combating antibiotic-resistant bacteria. The substrates and products mentioned in this study are novel compounds and are reported for the first time.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Agnieszka Krawczyk-Lebek, Monika Dymarska, Tomasz Janeczko, Edyta Kostrzewa-Suslow
Summary: The biotransformation of methylated flavonoids using cultures of entomopathogenic filamentous fungi is an effective method to obtain glycosylated derivatives with increased solubility. In this study, chemical synthesis and biotransformation were combined to produce novel glycosylated flavonoid derivatives. These derivatives, obtained from both 2'-methylflavanone and 2'-methylflavone, show promise as potential drugs and require further investigation into their biological activity and pharmacological efficacy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Mateusz Luzny, Tomasz Tronina, Ewa Kozlowska, Monika Dymarska, Jaroslaw Poplonski, Jacek Lyczko, Edyta Kostrzewa-Suslow, Tomasz Janeczko
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Chemistry, Physical
Agnieszka Krawczyk-Lebek, Monika Dymarska, Tomasz Janeczko, Edyta Kostrzewa-Suslow
Article
Biochemistry & Molecular Biology
Monika Dymarska, Tomasz Janeczko, Edyta Kostrzewa-Suslow
Article
Agriculture, Multidisciplinary
Mateusz Luzny, Tomasz Tronina, Ewa Kozlowska, Edyta Kostrzewa-Suslow, Tomasz Janeczko
Summary: The biotransformation of methoxy derivatives of flavonoids was studied using entomopathogenic fungal strains, showing that the amount and position of the methoxy group influenced transformation rate and product formation. The structures of the products and semi-products indicate cascading transformations. The strains demonstrated the ability to selectively glycosylate the methoxy substituent and demethylate/hydroxylate specific carbons in the substrates' B ring.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Agnieszka Krawczyk-Lebek, Monika Dymarska, Tomasz Janeczko, Edyta Kostrzewa-Suslow
Summary: The study successfully synthesized and biotransformed 2'-hydroxy-2-methylchalcone to obtain various glycosylated dihydrochalcones, with the most products produced by B. bassiana KCH J1.5. These compounds show potential as bioactive substances with improved stability and bioavailability, and can be used as flavor enhancers and sweeteners.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Agnieszka Krawczyk-Lebek, Monika Dymarska, Tomasz Janeczko, Edyta Kostrzewa-Suslow
Summary: The biotransformation of methylated flavonoids using cultures of entomopathogenic filamentous fungi is an effective method to obtain glycosylated derivatives with increased solubility. In this study, chemical synthesis and biotransformation were combined to produce novel glycosylated flavonoid derivatives. These derivatives, obtained from both 2'-methylflavanone and 2'-methylflavone, show promise as potential drugs and require further investigation into their biological activity and pharmacological efficacy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Aleksandra Wloch, Paulina Strugala-Danak, Hanna Pruchnik, Agnieszka Krawczyk-Lebek, Karolina Szczecka, Tomasz Janeczko, Edyta Kostrzewa-Suslow
Summary: The study aimed to compare the effects of three synthesized chemical compounds derived from methylated flavonoids on red blood cell membranes, phosphatidylcholine model membranes, and human serum albumin. The compounds were found to be non-toxic and to influence the hydrophilic and hydrophobic regions of membranes, with different compounds having varying impacts depending on the membrane type. The compounds also bind with human serum albumin through a process of static quenching, involving hydrogen bonding interactions and van der Waals forces.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, Research & Experimental
Joanna Bronikowska, Malgorzata Klosek, Tomasz Janeczko, Edyta Kostrzewa-Suslow, Zenon P. Czuba
Summary: The study evaluated the effects of methoxy-derivatives of 2'-hydroxychalcones on the release of various factors by colon cancer cells. The compounds showed significant modulation on certain factors released by the cancer cells, indicating a potential therapeutic effect on colon cancer.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Agnieszka Krawczyk-Lebek, Monika Dymarska, Tomasz Janeczko, Edyta Kostrzewa-Suslow
Summary: In this study, flavonoid compounds were synthesized and transformed using entomopathogenic filamentous fungi as glycosylation biocatalysts. The obtained compounds showed improved physicochemical properties and potential biological activities such as antimicrobial, anticarcinogenic, hepatoprotective, and cardioprotective effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Agnieszka Krawczyk-Lebek, Monika Dymarska, Tomasz Janeczko, Edyta Kostrzewa-Suslow
Summary: Flavonoid compounds have significant impact on human health and can be modified to improve their biological activities. This study successfully synthesized and biotransformed 4'-methylflavanone, resulting in several derivatives with potential anticarcinogenic, antimicrobial, and hepatoprotective activities.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Mateusz Luzny, Dagmara Kaczanowska, Barbara Gawdzik, Alicja Wzorek, Aleksandra Pawlak, Bozena Obminska-Mrukowicz, Monika Dymarska, Ewa Kozlowska, Edyta Kostrzewa-Suslow, Tomasz Janeczko
Summary: This study aimed to select yeast strains for the biotransformation of selected 2'-hydroxybromochalcones. The position of the bromine atom was found to significantly influence the substrate conversion by the tested yeast strains. The biotransformation resulted in the production of high-potential precursors of sweet substances.
Article
Multidisciplinary Sciences
Marcelina Mazur, Tomasz Janeczko
Summary: This work presents the method and results of chemo-enzymatic Baeyer-Villiger oxidation of alpha-benzylcyclopentanones in ester solvents and deep eutectic solvents (DES).
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Tomasz Tronina, Mateusz Luzny, Monika Dymarska, Monika Urbaniak, Ewa Kozlowska, Michal Piegza, Lukasz Stepien, Tomasz Janeczko
Summary: Quercetin, the most abundant flavonoid in food products, has various biological activities and is used for medical applications. However, its low water solubility may limit its therapeutic potential.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)