Synthesis of New C- and N-β-d-Glucopyranosyl Derivatives of Imidazole, 1,2,3-Triazole and Tetrazole, and Their Evaluation as Inhibitors of Glycogen Phosphorylase

van der Waals interactions govern C -β- d -glucopyranosyl triazoles’ nM inhibitory potency in human liver glycogen phosphorylase

(2017) Anastassia L. Kantsadi et al.   JOURNAL OF STRUCTURAL BIOLOGY

Glucose-derived spiro-isoxazolines are anti-hyperglycemic agents against type 2 diabetes through glycogen phosphorylase inhibition

(2016) David Goyard et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthetic, enzyme kinetic, and protein crystallographic studies of C -β- d -glucopyranosyl pyrroles and imidazoles reveal and explain low nanomolar inhibition of human liver glycogen phosphorylase

(2016) Anastassia L. Kantsadi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Glycogen phosphorylase inhibitors: a patent review (2013 - 2015)

(2016) Marion Donnier-Maréchal et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Glycogen metabolism has a key role in the cancer microenvironment and provides new targets for cancer therapy

(2016) Christos E. Zois et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Insulin Sensitivity is Modified by a Glycogen Phosphorylase Inhibitor: Glucopyranosylidene-Spiro-Thiohydantoin in Streptozotocin-Induced Diabetic Rats

(2015) Tibor Docsa et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

4(5)-Aryl-2-C-glucopyranosyl-imidazoles as New Nanomolar Glucose Analogue Inhibitors of Glycogen Phosphorylase

(2015) Éva Bokor et al.   ACS Medicinal Chemistry Letters

Glycogen metabolism in cancer

(2014) Christos E. Zois et al.   BIOCHEMICAL PHARMACOLOGY

New synthesis of 3-(β-D-glucopyranosyl)-5-substituted-1,2,4-triazoles, nanomolar inhibitors of glycogen phosphorylase

(2014) Sándor Kun et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

[Cu(OH)(TMEDA)]2Cl2-Catalyzed Regioselective 2-Arylation of 5-Substituted Tetrazoles with Boronic Acids under Mild Conditions

(2014) Takuya Onaka et al.   JOURNAL OF ORGANIC CHEMISTRY

Natural products and their derivatives as inhibitors of glycogen phosphorylase: potential treatment for type 2 diabetes

(2014) Joseph M. Hayes et al.   PHYTOCHEMISTRY REVIEWS

1,2,3-Triazoles as Amide-bond Surrogates in Peptidomimetics

(2013) Ibai E. Valverde et al.   CHIMIA

Glycogen phosphorylase inhibitors: a patent review (2008 – 2012)

(2013) Nicolas Gaboriaud-Kolar et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Glycogen Phosphorylase Inhibitor N-(3,5-Dimethyl-Benzoyl)-N’-(β-D-Glucopyranosyl)Urea Improves Glucose Tolerance under Normoglycemic and Diabetic Conditions and Rearranges Hepatic Metabolism

(2013) Lilla Nagy et al.   PLoS One

C-Glucopyranosyl-1,2,4-triazoles As New Potent Inhibitors of Glycogen Phosphorylase

(2013) Éva Bokor et al.   ACS Medicinal Chemistry Letters

Evaluation of bis-triphenylphosphano-copper(I)-butyrate (C3H7COOCu(PPh3)2) as catalyst for the synthesis of 1-glycopyranosyl-4-substituted-1,2,3-triazoles

(2012) Éva Bokor et al.   CARBOHYDRATE RESEARCH

Glucose Utilization via Glycogen Phosphorylase Sustains Proliferation and Prevents Premature Senescence in Cancer Cells

(2012) Elena Favaro et al.   Cell Metabolism

Inhibition of Glycogen Phosphorylase in the Context of Type 2 Diabetes, with Focus on Recent Inhibitors Bound at the Active Site

(2012) J.-P. Praly et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

The Prototype of Glycogen Phosphorylase

(2012) E. D.Chrysina   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Pharmacological Manipulation of Brain Glycogenolysis as a Therapeutic Approach to Cerebral Ischemia

(2012) L. Xu et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Synthesis of variously coupled conjugates of d-glucose, 1,3,4-oxadiazole, and 1,2,3-triazole for inhibition of glycogen phosphorylase

(2011) Sándor Kun et al.   CARBOHYDRATE RESEARCH

Synopsis of Some Recent Tactical Application of Bioisosteres in Drug Design

(2011) Nicholas A. Meanwell   JOURNAL OF MEDICINAL CHEMISTRY

Maslinic acid, a natural inhibitor of glycogen phosphorylase, reduces cerebral ischemic injury in hyperglycemic rats by GLT-1 up-regulation

(2011) Teng Guan et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Effect of glucopyranosylidene-spiro-thiohydantoin on glycogen metabolism in liver tissues of streptozotocin-induced and obese diabetic rats

(2011) P�l Gergely   Molecular Medicine Reports

Glucose derived inhibitors of glycogen phosphorylase

(2010) László Somsák   COMPTES RENDUS CHIMIE

Synthesis and structure–activity relationships of C-glycosylated oxadiazoles as inhibitors of glycogen phosphorylase

(2009) Marietta Tóth et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis of 1-(d-glucopyranosyl)-1,2,3-triazoles and their evaluation as glycogen phosphorylase inhibitors

(2009) Éva Bokor et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Amide-1,2,3-triazole bioisosterism: the glycogen phosphorylase case

(2009) Evangelia D. Chrysina et al.   TETRAHEDRON-ASYMMETRY

Cu-Catalyzed Azide−Alkyne Cycloaddition

(2008) Morten Meldal et al.   CHEMICAL REVIEWS

New Inhibitors of Glycogen Phosphorylase as Potential Antidiabetic Agents

(2008) L. Somsak et al.   CURRENT MEDICINAL CHEMISTRY