Journal
MOLECULAR REPRODUCTION AND DEVELOPMENT
Volume 85, Issue 8-9, Pages 720-728Publisher
WILEY
DOI: 10.1002/mrd.23041
Keywords
noncoding RNA; self-renewal; spermatogonial stem cell
Funding
- National Natural Science Foundation of China [81502136, 81503310]
- Fundamental Research Funds for the Central Universities [XJJ2015014]
- Key Scientific and Technological Research Program for Social Development of Shaanxi Province [2015SF047]
- Special Research Funds for Talents Training of the second affiliated hospital of Xi'an Jiaotong University [RC(XM)201502]
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Spermatogonial stem cells (SSCs), a unique population of male germ cells with self-renewal ability, are the foundation for maintenance of spermatogenesis throughout the life of the male. Although many regulatory molecules essential for SSC self-renewal have been identified, the fundamental mechanism underlying how SSCs acquire and maintain their self-renewal activity remains largely to be elucidated. In recent years, many types of noncoding RNAs (ncRNAs) have been suggested to regulate the SSC self-renewal through multiple ways, indicating ncRNAs play crucial roles in SSC self-renewal. In this paper, we mainly focus on four types of ncRNAs including microRNA, long ncRNA, piwi-interacting RNA, as well as circular RNAs, and reviewed their potential roles in SSC self-renewal that discovered recently to help us gain a better understanding of molecular mechanisms by which ncRNAs perform their function in regulating SSC self-renewal.
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