Article
Multidisciplinary Sciences
Phuong Thao Ly, Shaohai Xu, Melissa Wirawan, Dahai Luo, Xavier Roca
Summary: The study demonstrates that different isoforms of ZAP play overlapping yet different roles in antiviral defense and other cellular processes. The regulation of host mRNA by ZAP is mostly unknown, but splice-switching antisense oligonucleotides can modulate the balance between ZAP isoforms. The study also identifies new cellular transcripts and processes regulated by ZAP isoforms, such as unfolded protein response, epithelial-mesenchymal transition, and innate immunity.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Endocrinology & Metabolism
Chengxin Li, Lewei Zheng, Gaoran Xu, Qianqian Yuan, Ziyang Di, Yalong Yang, Xingxing Dong, Jinxuan Hou, Gaosong Wu
Summary: In this study, an EMT-related lncRNA signature was constructed to predict the prognosis of breast cancer patients. A risk score signature consisting of 10 lncRNAs associated with the EMT process was developed and validated. The signature was also evaluated for its impact on drug sensitivity and tumor immune cell infiltration in breast cancer.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Cell Biology
Ying Su, Ziyan Tang, Feng Wang
Summary: The study investigated the regulation of LINC01592 on human RPE cells undergoing epithelial-mesenchymal transition induced by TGF-beta 1, finding that LINC01592 overexpression enhanced the process while its inhibition reduced it. This provides a novel treatment approach for proliferative vitreoretinopathy.
Article
Biotechnology & Applied Microbiology
Chuming Tao, Haitao Luo, Luyue Chen, Jingying Li, Xingen Zhu, Kai Huang
Summary: This study identified a nine-EMT-related lncRNA signature with prognostic value in gliomas, showing that patients in the low-risk group had longer survival and were associated with specific genetic characteristics. The findings were validated in different genomic datasets. The lncRNA-mediated ceRNA network may play a potential role in EMT progression in gliomas.
Article
Biochemistry & Molecular Biology
Qianwen Zhao, Tinghui Shao, Yuwen Zhu, Gengjie Zong, Junjie Zhang, Shifan Tang, Yanshan Lin, Hongzhen Ma, Zhifan Jiang, Yong Xu, Xiaoyan Wu, Tao Zhang
Summary: This study found that myofibroblasts play an important role in renal fibrosis. By deleting myocardin-related transcription factor A (MRTF-A), the researchers discovered that MRTF-A promotes renal fibrosis by activating the transcription of Zeb1 and IRF9. These findings reveal a potential pathway for treating renal fibrosis.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Shuai Yang, Hui Li, Haipei Yao, Yao Zhang, Huiqian Bao, Liangjing Wu, Conghui Zhang, Min Li, Le Feng, Jingfa Zhang, Zhi Zheng, Guotong Xu, Fang Wang
Summary: The study revealed that lncRNA ERLR plays a role in TGF-beta 1-induced EMT in human RPE cells and is involved in the pathogenesis of PVR, providing new insights into the mechanism and treatment of the disease.
CELL DEATH AND DIFFERENTIATION
(2021)
Article
Pathology
Yue Yang, Ting Yan, Qiang Han, Meiyu Zhang, Yijun Zhang, Yuan Luo, Lai Wei, Pengcheng Li, Enhua Wang
Summary: ZNF326 expression was higher in colorectal tumor cells compared to normal mucosa, and its high expression was positively correlated with tumor differentiation, TNM staging, and lymph node metastasis. ZNF326 overexpression promoted colorectal cancer cell invasion and altered the expression of EMT-related proteins. Upregulation of ZNF326 also increased LTBP4 and p-Smad2/3 expression, leading to TGF-beta signaling activation.
PATHOLOGY RESEARCH AND PRACTICE
(2021)
Article
Oncology
Qun Wan, Min Tang, Shi-Lei Sun, Jing Hu, Zi-Jiu Sun, Yu-Ting Fang, Tong-Chuan He, Yan Zhang
Summary: The overexpression of SNHG3 in breast cancer promotes cell migration and invasion by modulating miR-186-5p and ZEB1, leading to the induction of epithelial to mesenchymal transition.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2021)
Article
Oncology
Yongming Liu, Yuan Zhang, Jinxue Zhang, Jingchang Ma, Xuexue Xu, Yuling Wang, Ziqing Zhou, Dongxu Jiang, Shen Shen, Yong Ding, Yong Zhou, Ran Zhuang
Summary: Our study revealed that knockdown of HuR suppresses OS cell EMT by regulating the lncRNA XIST/AGO2 signaling pathway.
FRONTIERS IN ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Noriko Funato, Hiromi Yanagisawa
Summary: TBX1 regulates stem cell properties and epithelial differentiation by activating microRNAs, specifically miR-200 and miR-203, to inhibit their common targets BMI1 and ZEB2. The ablation of Tbx1 affects palatal epithelium differentiation and disrupts the expression of miR-200, miR-203, and their target genes. These findings have significant implications for understanding the mechanisms underlying tumors and cleft palate.
SCIENTIFIC REPORTS
(2022)
Review
Oncology
Barbora Kvokackova, Jan Remsik, Mohit Kumar Jolly, Karel Soucek
Summary: Epithelial-mesenchymal transition (EMT) and mesenchymal-epithelial transition (MET) play critical roles in the development of TNBC, shaping aggressive and heterogeneous biological features, but may also contribute to the progression of metastatic disease.
Article
Oncology
Cheng Chen, Na Su, Guiying Li, Yanfeng Shen, Xiaoting Duan
Summary: TMCC1-AS1 is significantly upregulated in liver cancer tissues and cell lines, and high expression is associated with advanced tumor stage and lymph node metastasis, as well as predict poor survival in patients. Knockdown of TMCC1-AS1 inhibits cell proliferation, migration, and invasion, while overexpression has the opposite effects in HepG2 and SNU-182 cells.
Article
Oncology
Adam W. Ware, Joshua J. Harris, Tania L. Slatter, Heather E. Cunliffe, Fiona J. McDonald
Summary: The study found that alpha ENaC mRNA expression is associated with breast cancer subtypes, proliferation markers, and EMT markers. Manipulating alpha ENaC expression and activity in breast cancer cells affected cell proliferation. High alpha ENaC expression was linked to less aggressive and less proliferative breast cancer subtypes, while decreased expression or activity led to increased cell proliferation in certain breast cancer cell lines.
BREAST CANCER RESEARCH AND TREATMENT
(2021)
Article
Oncology
Zhenghui Sui, Xin Sui
Summary: The study found that TMPO-AS1 was significantly upregulated in clinical GBC tissues and cell lines, with high expression in stage III+IV patients. miR-1179 was downregulated in GBC tissues and cell lines, and negatively correlated with TMPO-AS1 expression. E2F2 was identified as a direct target of miR-1179, and overexpression of miR-1179 inhibited the proliferation, migration, and invasion of GBC cells.
Article
Anatomy & Morphology
Xiaoping Wu, Qiujie Pang, Fuxiang Zhi, Xiaohong Mao, Yingbin Hu
Summary: The long non-coding RNA ACTA2 antisense RNA 1 (LncRNA ACTA2-AS1) is downregulated in colorectal cancer. Overexpression of ACTA2-AS1 can inhibit the viability, proliferation, migration, and invasion of colorectal cancer cells, while reducing the levels of PCNA, Bcl-2, MMP-2, and MMP-9.