Review
Cell Biology
Yuling Hong, Yunxing Zhang, Haibo Zhao, Hailing Chen, Qing-Qing Yu, Hongxia Cui
Summary: lncRNAs may play key roles in hepatocellular carcinoma (HCC) and have the potential to serve as diagnostic and therapeutic biomarkers.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Hassan Ayaz, Nouman Aslam, Faryal Mehwish Awan, Rabea Basri, Bisma Rauff, Badr Alzahrani, Muhammad Arif, Aqsa Ikram, Ayesha B. Obaid, Anam Naz, Sadiq Noor Khan, Burton B. Yang, Azhar Nazir
Summary: Non-coding RNAs (ncRNAs), including circular RNAs (circRNAs), play important roles in genetic information control, RNA stability, and epigenetic modifications. This study aimed to explore the regulatory networks driven by SARS-CoV-2 related circRNAs, miRNAs, and mRNAs to identify potential therapeutic options. The analysis identified a circRNA-miRNA-mRNA network and suggested that two differentially expressed circRNAs could serve as potential theranostic agents for SARS-CoV-2 infection. Overall, this study sheds light on the functional role of circRNAs as ceRNAs during SARS-CoV-2 infection.
Review
Pharmacology & Pharmacy
Alina-Veronica Ghionescu, Andrei Sorop, Simona Olimpia Dima
Summary: Hepatocellular carcinoma (HCC) is a major global health problem and the leading cause of cancer-related deaths, especially in advanced stages with limited treatment options. Tumor resistance in HCC is closely associated with the activation and reversal of the EMT phenomenon, which are modulated by noncoding RNAs (ncRNAs). ncRNAs, circulating in the tumor microenvironment encapsulated in exosomes, play significant roles as both tumor suppressors and oncogenic molecules, controlling the malignant potential of HCC cells. This review highlights recent advances in ncRNAs related to EMT and categorizes the described mechanisms as direct and indirect for better summarization, and discusses the regulatory mechanisms of exosomal ncRNAs in EMT-HCC via intercellular communication pathways.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Lika Gamaev, Lina Mizrahi, Tomer Friehmann, Nofar Rosenberg, Orit Pappo, Devorah Olam, Evelyne Zeira, Keren Bahar Halpern, Stefano Caruso, Jessica Zucman-Rossi, Jonathan H. Axelrod, Eithan Galun, Daniel S. Goldenberg
Summary: The study showed that in the Mdr2-KO mouse model, the lncRNA H19 is pro-oncogenic during chronic inflammation-mediated hepatocarcinogenesis, mainly by increasing liver injury and decreasing hepatocyte polyploidy in young mice. Tumor incidence and load were significantly lower in female dKO mice compared to control Mdr2-KO mice.
Review
Medicine, Research & Experimental
Enjun Lv, Jiaqi Sheng, Chengpeng Yu, Dean Rao, Wenjie Huang
Summary: Long noncoding RNAs (lncRNAs) have gained widespread attention as new and crucial molecules involved in biological function regulation, particularly in tumor metastasis such as hepatocellular carcinoma; despite the incomplete understanding of their mechanisms, lncRNAs have been shown to be closely associated with various stages of tumor growth, invasion, and metastasis.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Cell Biology
Baofu Zhang, Wenming Bao, Sina Zhang, Bo Chen, Xiang Zhou, Jungang Zhao, Zhehao Shi, Tan Zhang, Ziyan Chen, Luhui Wang, Xiangtao Zheng, Gang Chen, Yi Wang
Summary: This study found that the expression of lncRNA HEPFAL is reduced in HCC tissues. HEPFAL can promote ferroptosis by reducing the expression of SLC7A11 and increasing the levels of ROS and iron. Additionally, HEPFAL increases the sensitivity of erastin-induced ferroptosis.
CELL DEATH & DISEASE
(2022)
Article
Oncology
Yanglan Gan, Xin Hu, Guobing Zou, Cairong Yan, Guangwei Xu
Summary: The article introduces a new computational algorithm BiRGRN for inferring gene regulatory networks (GRNs) from time-series single-cell RNA-seq data. The algorithm utilizes a bidirectional recurrent neural network to transform the inference of GRNs into a regression problem, and adopts bidirectional structure and prior knowledge filtering strategy to improve accuracy and stability.
FRONTIERS IN ONCOLOGY
(2022)
Editorial Material
Biochemistry & Molecular Biology
Cecilia Maria Arraiano
Summary: Science is entering a new RNA world that is reshaping our knowledge and opening up new horizons in molecular biology. Noncoding RNAs play crucial regulatory roles in various diseases and cellular functions, with vast potential applications ahead.
Review
Gastroenterology & Hepatology
Antonio Pea, Nigel B. Jamieson, Chiara Braconi
Summary: Noncoding RNAs play an essential role in regulating cellular homeostasis and are implicated in the development and progression of hepatocellular carcinoma by affecting cancer cell signaling and crosstalk with the microenvironment. They hold promise as clinical biomarkers, but further evidence is needed before their translation into clinical practice.
Article
Cell Biology
Xuan Deng, Fanyang Kong, Si Li, Haoqin Jiang, Liu Dong, Xiao Xu, Xinju Zhang, Hong Yuan, Ying Xu, Yimin Chu, Haixia Peng, Ming Guan
Summary: The study identified PiHL as a promoter of chemoresistance in CRC, with its role in activating the EZH2/HMGA2/PI3K/Akt signaling axis to confer oxaliplatin resistance. Targeting PiHL restored sensitivity to oxaliplatin in resistant CRC cells, indicating a potential novel strategy for overcoming drug resistance.
CELL DEATH & DISEASE
(2021)
Review
Oncology
Senmiao Zhang, Yanling Li, Shuyu Xin, Li Yang, Mingjuan Jiang, Yujie Xin, Yiwei Wang, Jing Yang, Jianhong Lu
Summary: This review summarizes the biological functions and clinical implications of long noncoding RNAs and circular RNAs as competitive endogenous RNAs in nasopharyngeal carcinoma (NPC). The imbalanced ceRNA networks derived from lncRNA/circRNA-miRNA-mRNA interaction are widely found to contribute to NPC development. Understanding the involvement of these ceRNAs networks provides new insights into the pathogenesis and treatment strategies of NPC.
Article
Medicine, General & Internal
Xu Huang, Xu Wang, Ge Huang, Ruotao Li, Xingkai Liu, Lidong Cao, Junfeng Ye, Ping Zhang
Summary: This study bioinformatically identified differentially expressed genes (DEGs) associated with the prognosis of hepatocellular carcinoma (HCC). The GO and KEGG analyses revealed the involvement of these DEGs in HCC-related biological processes, molecular functions, and cell components. Additionally, the PPI network analysis identified core genes associated with the HCC prognosis. These DEGs have the potential to serve as prognostic biomarkers and therapeutic targets for HCC.
Article
Plant Sciences
Saet-Byul Kim, Lisa Van den Broeck, Shailesh Karre, Hoseong Choi, Shawn A. Christensen, Guan-Feng Wang, Yeonhwa Jo, Won Kyong Cho, Peter Balint-Kurti
Summary: This study identified differentially expressed genes and metabolites associated with susceptibility and Rp1-D-mediated resistance in maize infected with Puccinia sorghi. The presence of Rp1-D gene in maize plants triggered defense responses and upregulation of specific metabolic pathways, providing insights into the mechanisms underlying resistance to common rust. Transcriptional and metabolic analyses revealed both common and specific responses to infection, with key transcription factors identified as potential signaling hubs in the resistance-specific response.
MOLECULAR PLANT PATHOLOGY
(2021)
Review
Pharmacology & Pharmacy
Yulai Zeng, Shuyu Hu, Yi Luo, Kang He
Summary: Hepatocellular carcinoma (HCC) is a common cancer with unsatisfactory early diagnosis and treatment. Exosomes, containing various components, play a crucial role in the development and prognosis of HCC. Biomarkers in exosomes show potential for novel diagnostic and prognostic tools for HCC.
Article
Oncology
Feng Yuan, Yongchang Tang, Mingbo Cao, Yupeng Ren, Yuxuan Li, Gaoyuan Yang, Qifeng Ou, Francisco Tustumi, Giovanni Battista Levi Sandri, Driss Raissi, Christine Pocha, Meihai Deng, Zhicheng Yao
Summary: This study explored the expression network of circRNAs in HCC and found that hsa_circ_0039466 promotes the expression of FOXO1 by sponging miR-96-5p, thereby inhibiting tumor progression. These findings provide important theoretical basis for further understanding of the gene expression network of HCC.
ANNALS OF TRANSLATIONAL MEDICINE
(2022)