Article
Cell Biology
Maria Likhatcheva, Roben G. Gieling, James A. L. Brown, Constantinos Demonacos, Kaye J. Williams
Summary: Genotoxic stress can activate the ATM kinase, with potential involvement of Suv39H1 and Tip60 in ATM activation under hypoxic conditions.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Goutham Narayanan Subramanian, Abrey Jie Yeo, Magtouf Hnaidi Gatei, David John Coman, Martin Francis Lavin
Summary: The ATM protein kinase has diverse functions in the cell, including protecting DNA, maintaining cellular homeostasis, and safeguarding against external and internal damage.
Article
Oncology
Zun-Yan Zhou, Ji-Yuan Yang, Cheng-Ze Shao, Fei Luo, Wei Du
Summary: By regulating the expression of E2F-1 and ATM, the resistance of human nasopharyngeal carcinoma cells to cisplatin can be reversed.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Immunology
Geraldine Blanchard-Rohner, Anna Peirolo, Ludivine Coulon, Christian Korff, Judit Horvath, Pierre R. Burkhard, Fabienne Gumy-Pause, Emmanuelle Ranza, Peter Jandus, Harpreet Dibra, Alexander Malcolm R. Taylor, Joel Fluss
Summary: Ataxia-telangiectasia (A-T) is a neurodegenerative and primary immunodeficiency disorder characterized by various symptoms. This study presents a case series highlighting the phenotypic variability of A-T and emphasizes the importance of early diagnosis of variant A-T and classical A-T.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cell Biology
Venturina Stagni, Alessandra Ferri, Claudia Cirotti, Daniela Barila
Summary: There is a strong interplay between autophagy and genomic stability, with recent evidence linking DNA Damage Response (DDR) and autophagy in influencing cell fate. ATM kinase plays a crucial role in balancing senescence and apoptosis in response to stimuli, and its aberrant deregulation is linked to the development of pathologies like cancer and neurodegeneration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Genetics & Heredity
Motohiro Yamauchi
Summary: Chromosome rearrangements are structural variations in chromosomes and are associated with a variety of human diseases. Ataxia-telangiectasia (A-T) is an autosomal recessive disorder characterized by chromosome rearrangements at the cellular level, particularly in T lymphocytes. The defective gene in A-T is ataxia-telangiectasia mutated (ATM), which plays a central role in cellular response to DNA damage, including suppressing chromosome rearrangements.
Article
Oncology
Jingyu Xun, Hideo Ohtsuka, Katsuya Hirose, Daisuke Douchi, Shun Nakayama, Masaharu Ishida, Takayuki Miura, Kyohei Ariake, Masamichi Mizuma, Kei Nakagawa, Takanori Morikawa, Toru Furukawa, Michiaki Unno
Summary: This study reveals the impact of ATM expression on the prognosis of pancreatic cancer patients. Loss of ATM expression enhances tumor development, suppresses apoptosis, and reduces sensitivity to gemcitabine. Additionally, loss of phosphorylated ATM is associated with poor prognosis in pancreatic cancer patients.
Review
Pharmacology & Pharmacy
Bhanu Priya, Srimadhavi Ravi, Sivapriya Kirubakaran
Summary: The DNA Damage and Response (DDR) pathway is crucial for maintaining genome integrity and preventing cancer development. The DDR pathway, particularly the ATM and ATR kinases, plays a vital role in recognizing and repairing DNA double-strand breaks (DSBs), a severe DNA damage that can lead to genomic instability. Cancer cells, with a high burden of DSBs, heavily rely on efficient DSB repair mechanisms for their survival. Therefore, targeting DSB repair pathways, such as ATM and ATR, can enhance the efficacy of DNA-damaging agents in cancer treatment. This review focuses on the roles of ATM and ATR in the DDR pathway, challenges in targeting these kinases, and current clinical trials of their inhibitors.
DRUG DISCOVERY TODAY
(2023)
Article
Physiology
Rachel Warren, Andrew M. Dylag, Molly Behan, William Domm, Min Yee, Margot Mayer-Proschel, Luis Martinez-Sobrido, Michael A. O'Reilly
Summary: Children and young adults with mutant forms of the ATM gene, which is involved in DNA damage signaling and mitochondrial homeostasis, suffer from respiratory infections, immune deficiencies, and obstructive airways disease associated with disorganized airway epithelium. A study on mice showed that ATM is required for the regeneration of injured airway epithelium after influenza virus infection. Mice lacking ATM exhibited increased airway resistance and reduced lung compliance during infection, and their lungs developed an abnormal proximal airway epithelium containing cells lacking expression of the immunomodulatory protein Scgb1a1. Restoration of Scgb1a1 expression in the airways required ATM and failure to efficiently restore it may contribute to the respiratory diseases seen in individuals with ataxia telangiectasia.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2022)
Article
Cell Biology
Zhentai Huang, Chi-Wei Chen, Raquel Buj, Naveen Kumar Tangudu, Richard S. S. Fang, Kelly E. E. Leon, Erika S. S. Dahl, Erika L. L. Varner, Eliana von Krusenstiern, Aidan R. R. Cole, Nathaniel W. W. Snyder, Katherine M. M. Aird
Summary: Inhibition of ATM increases macropinocytosis, promoting cancer cell survival under nutrient-poor conditions, and macropinocytosis is a metabolic vulnerability of cancer cells treated with ATM inhibitors.
JOURNAL OF CELL BIOLOGY
(2022)
Article
Oncology
Venturina Stagni, Archontia Kaminari, Claudia Contadini, Daniela Barila, Rosario Luigi Sessa, Zili Sideratou, Spiros A. Vlahopoulos, Dimitris Tsiourvas
Summary: Doxorubicin is commonly used in breast cancer treatment but resistance is a problem. Breast cancer stem cells (BCSCs) are particularly resistant. Researchers have developed a polymeric nanocarrier that targets BCSCs and enhances sensitivity to chemotherapy drugs by inhibiting ATM kinase.
Article
Immunology
Raissa Bernardes da Silva, Willian dos Reis Bertoldo, Lucila Langoni Naves, Fernanda Bernadelli de Vito, Jeziel Dener Damasceno, Luiz Ricardo Orsini Tosi, Carlos Renato Machado, Andre Luiz Pedrosa
Summary: In this study, the DNA damage response pathways in promastigote forms of L. major were investigated. The overexpression of LmjEXO1 made the cells more susceptible to genotoxic damage, while ATR-specific inhibition made the control cells more susceptible to oxidative damage.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Chaoyi Qin, Yiheng Zan, Liang Xie, Hanmin Liu
Summary: ATM plays an important role in the PDGF-BB-induced proliferation of PASMCs through ROS formation. Inhibition of ATM promotes the proliferation of PASMCs under excessive levels of PDGF-BB and H2O2.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Allergy
Ismail Ogulur, Tugce Ertuzun, Burcu Kocamis, Yasemin Kendir Demirkol, Emel Uyar, Ayca Kiykim, Dilek Baser, Gozde Yesil, Hacer Akturk, Ayper Somer, Ahmet Ozen, Elif Karakoc-Aydiner, Meltem Muftuoglu, Safa Baris
Summary: Heterozygous relatives of ataxia-telangiectasia (AT) patients are at increased risk for certain AT-related manifestations, and parents of AT patients show an increase in infection frequency. It is hypothesized that parents may exhibit immune alterations similar to their affected children.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2021)
Article
Immunology
Maria Giovanna Desimio, Andrea Finocchi, Gigliola Di Matteo, Silvia Di Cesare, Carmela Giancotta, Francesca Conti, Luciana Chessa, Maria Piane, Davide Montin, Marta Dellepiane, Paolo Rossi, Caterina Cancrini, Margherita Doria
Summary: NK cells in A-T patients show reduced NKG2D expression, possibly contributing to increased susceptibility. The abnormal expression of NKG2D in A-T patients may be associated with disease progression.
CLINICAL IMMUNOLOGY
(2021)
Article
Oncology
Jin Zhu, Sugui Wang, Wenyu Zhang, Junyi Qiu, Yuxi Shan, Dongrong Yang, Bairong Shen
Article
Biotechnology & Applied Microbiology
Yachen Zang, Jin Zhu, Qin Li, Jian Tu, Xiaoqing Li, Rongkuan Hu, Dongrong Yang
ONCOTARGETS AND THERAPY
(2020)
Article
Andrology
Qiliang Peng, Yibin Zhou, Lu Jin, Cheng Cao, Cheng Gao, Jianfang Zhou, Dongrong Yang, Jin Zhu
TRANSLATIONAL ANDROLOGY AND UROLOGY
(2020)
Article
Oncology
Meng Lu, Fu-kun Wei, Chuang Wu, Zi-yang Xu, Li-jun Mao, Dong-rong Yang
Summary: In this study, a new oncolytic adenovirus, DD3-ZD55-SPAG9, was constructed to enhance the efficacy and safety of adenovirus using the DD3 promoter. The combined use of DD3-ZD55-SPAG9 and docetaxel significantly improved the anti-tumor efficacy of docetaxel in prostate cancer both in vitro and in vivo, possibly due to the induction of tumor cell apoptosis and the inhibition of tumor cell invasion.
JOURNAL OF ONCOLOGY
(2022)