Journal
MOLECULAR IMMUNOLOGY
Volume 93, Issue -, Pages 125-132Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.molimm.2017.11.016
Keywords
Extracellular vesicle; Rheumatoid arthritis; Signal communication; Pathogenesis; Inflammation; microRNA
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Funding
- Beijing Nova program [Z171100001117110]
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Cell-derived extracellular vesicles (EVs) are involved in the pathogenesis of rheumatoid arthritis (RA), playing, important roles in antigen presentation, inflammation, angiogenesis, cell cell signal communication, thrombosis, and articular cartilage extracellular matrix degradation. Understanding the pathogenic mechanism of RA is important for developing therapies. The pathogenic indicators of RA, such as submicron-sized EVs, represent promising biomarkers for evaluating RA activity. This review summarizes the recent advances in understanding the pathogenesis of RA, and sheds light on the pathogenic as well as anti-inflammatory or immunosuppressive roles of EVs. We suggest that EVs could be harnessed as tools for drug delivery or targets for RA therapies.
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