Inhibiting trophoblast PAR-1 overexpression suppresses sFlt-1-induced anti-angiogenesis and abnormal vascular remodeling: a possible therapeutic approach for preeclampsia

Impact of haemostatic mechanisms on pathophysiology of preeclampsia

(2017) Chris Gardiner et al.   THROMBOSIS RESEARCH

Protease-Activated Receptor 1 Contributes to Angiotensin II-Induced Cardiovascular Remodeling and Inflammation

(2016) Silvio Antoniak et al.   CARDIOLOGY

Thrombin receptor PAR-1 activation on endothelial progenitor cells enhances chemotaxis-associated genes expression and leukocyte recruitment by a COX-2-dependent mechanism

(2015) Clément d’Audigier et al.   ANGIOGENESIS

Activation of PAR-1/NADPH Oxidase/ROS Signaling Pathways is Crucial for the Thrombin-Induced sFlt-1 Production in Extravillous Trophoblasts: Possible Involvement in the Pathogenesis of Preeclampsia

(2015) Qi-tao Huang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Protease-activated-receptor 1 polymorphisms correlate with risk for unexplained recurrent pregnancy loss: a pilot study querying an association beyond coagulation

(2015) Sorina Grisaru-Granovsky et al.   European Journal of Obstetrics & Gynecology and Reproductive Biology

Ephrin-B2 mediates trophoblast-dependent maternal spiral artery remodeling in first trimester

(2015) Q. Luo et al.   PLACENTA

Protease-Activated Receptor 1 and 4 Signal Inhibition Reduces Preterm Neonatal Hemorrhagic Brain Injury

(2015) Tim Lekic et al.   STROKE

Resveratrol Inhibits Trophoblast Apoptosis through Oxidative Stress in Preeclampsia-Model Rats

(2014) Yanfen Zou et al.   MOLECULES

Edaravone inhibits hypoxia-induced trophoblast-soluble Fms-like tyrosine kinase 1 expression: A possible therapeutic approach to preeclampsia

(2014) Y. Zhao et al.   PLACENTA

PAR1 antagonists inhibit thrombin-induced platelet activation whilst leaving the PAR4-mediated response intact

(2014) Heather M. Judge et al.   PLATELETS

Targeting protease activated receptor-1 with P1pal-12 limits bleomycin-induced pulmonary fibrosis

(2013) Cong Lin et al.   THORAX

Thrombin enhances soluble Fms-like tyrosine kinase 1 expression in trophoblasts; possible involvement in the pathogenesis of preeclampsia

(2012) Yin Zhao et al.   FERTILITY AND STERILITY

Effects of netrin-1 and netrin-1 knockdown on human umbilical vein endothelial cells and angiogenesis of rat placenta

(2011) H. Xie et al.   PLACENTA

Activation of Proteinase-Activated Receptor 2 Stimulates Soluble Vascular Endothelial Growth Factor Receptor 1 Release via Epidermal Growth Factor Receptor Transactivation in Endothelial Cells

(2010) Bahjat Al-Ani et al.   HYPERTENSION

Protease activated receptor-1, PAR1, promotes placenta trophoblast invasion and β-catenin stabilization

(2008) Sorina Grisaru-Granovsky et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Over-expression of the thrombin receptor (PAR-1) in the placenta in preeclampsia: A mechanism for the intersection of coagulation and inflammation

(2008) Offer Erez et al.   Journal of Maternal-Fetal & Neonatal Medicine