Review
Medicine, General & Internal
David Bauer, Petr Tousek
Summary: This review evaluates known outcome predictors supported by clinical data in light of the development of new treatment strategies for ACS patients during the last three decades.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Carlos A. K. Nakashima, Luis A. O. Dallan, Luiz A. F. Lisboa, Fabio B. Jatene, Ludhmila A. Hajjar, Alexandre M. Soeiro, Remo H. M. Furtado, Talia F. Dalcoquio, Luciano M. Baracioli, Felipe G. Lima, Roberto R. C. Giraldez, Bianca A. Silva, Mateus S. S. Costa, Celia M. C. Strunz, Luis R. P. Dallan, Carlos J. D. G. Barbosa, Flavia A. B. Britto, Michael E. Farkouh, Paul A. Gurbel, Jose C. Nicolau
Summary: The platelet reactivity-based strategy is as effective as the standard of care in preventing post-CABG bleeding in ACS patients, while also reducing waiting time and hospital expenses.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Review
Medicine, General & Internal
Brian A. Bergmark, Njambi Mathenge, Piera A. Merlini, Marilyn B. Lawrence-Wright, Robert P. Giugliano
Summary: Although progress has been made in diagnosing and treating acute coronary syndromes, cardiovascular disease remains a leading cause of death globally. High-sensitivity troponin assays have allowed for rapid diagnosis in suspected cases. Dual antiplatelet therapy and additional preventive measures are recommended. The diagnosis and management of acute coronary syndromes continue to evolve, especially in response to the COVID-19 pandemic.
Article
Cardiac & Cardiovascular Systems
Derek P. Chew, Karice Hyun, Erin Morton, Matt Horsfall, Graham S. Hillis, Clara K. Chow, Stephen Quinn, Mario D'Souza, Andrew T. Yan, Chris P. Gale, Shaun G. Goodman, Keith Fox, David Brieger
Summary: Routine implementation of the Global Registries of Acute Coronary Events (GRACE) risk score (GRS) in cardiology services led to an increase in early invasive treatment but did not significantly improve other aspects of care for hospitalized ACS patients. Further larger scale randomized studies are needed due to low event rates and premature study discontinuation.
Article
Health Care Sciences & Services
Jiali Wang, Wei Gao, Guanghui Chen, Ming Chen, Zhi Wan, Wen Zheng, Jingjing Ma, Jiaojiao Pang, Guangmei Wang, Shuo Wu, Shuo Wang, Feng Xu, Derek P. Chew, Yuguo Chen
Summary: This study developed a biomarker-based risk model to predict major adverse cardiovascular events in patients with acute coronary syndromes during the 12 months after hospital admission. The model incorporated clinical variables and the measurement of NT-proBNP, and demonstrated improved predictive capability compared to existing risk scores. It provides a useful tool for personalized care and risk assessment in ACS patients.
LANCET REGIONAL HEALTH-WESTERN PACIFIC
(2022)
Article
Geriatrics & Gerontology
Ahmed Ijaz Shah, Amy Alabaster, Makdine Dontsi, Jamal S. Rana, Matthew D. Solomon, Ashok Krishnaswami
Summary: Through long-term follow-up of patients with acute coronary syndrome, the study found that coronary artery bypass grafting (CABG) is superior to multivessel percutaneous coronary intervention (PCI) in improving patient quality of life and survival.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2022)
Article
Cardiac & Cardiovascular Systems
Kimon Stamatelopoulos, Matthias Mueller-Hennessen, Georgios Georgiopoulos, Pedro Lopez-Ayala, Marco Sachse, Nikolaos Vlachogiannis, Kateryna Sopova, Dimitrios Delialis, Francesca Bonini, Raphael Patras, Giorgia Ciliberti, Mehrshad Vafaie, Moritz Biener, Jasper Boeddinghaus, Thomas Nestelberger, Luca Koechlin, Simon Tual-Chalot, Ioannis Kanakakis, Aikaterini Gatsiou, Hugo Katus, Ioakim Spyridopoulos, Christian Mueller, Evangelos Giannitsis, Konstantinos Stellos
Summary: This study found that circulating CTSS levels can predict long-term mortality in NSTE-ACS patients and can improve risk stratification for patients. Combining CTSS with the GRACE score can enhance the prediction of all-cause mortality and CV death.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Letter
Medicine, General & Internal
John A. Bittl
Summary: The article discusses the preference for antithrombotic therapy in patients with acute coronary syndromes and the difference between preference and actual practice. It also mentions a new study, but does not explicitly state whether this new study can explain the discrepancy.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Review
Cardiac & Cardiovascular Systems
Sharaf Eldeen S. Mahmoud, Mohammady Shahin, Nooraldaem Yousif, Andrea Denegri, Lotfy H. Abo Dahab, Thomas F. Luscher
Summary: This study aimed to investigate the cardiovascular risk profile, clinical presentations, angiographic findings, management strategies, and outcomes of patients with previous coronary artery bypass grafting (CABG) presenting with acute coronary syndromes (ACS). The findings showed that structural changes and atherosclerotic plaques in bypass grafts, especially venous grafts, were the main causes of ACS. Most patients presented with unstable angina, followed by non-ST segment elevation myocardial infarction (NSTEMI), and a small percentage presented with ST segment elevation myocardial infarction (STEMI). The majority of events occurred after one year, particularly in patients with saphenous vein grafts. Hypertensive and obese patients, as well as those with myocardial infarction or ACS before discharge or during the first year after CABG, had higher rates of major adverse cardiovascular and cerebrovascular events (MACCE).
CURRENT PROBLEMS IN CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Klaus F. Kofoed, Thomas Engstrom, Per E. Sigvardsen, Jesper J. Linde, Christian Torp-Pedersen, Martina de Knegt, Peter R. Hansen, Thomas Fritz-Hansen, Jan Bech, Merete Heitmann, Olav W. Nielsen, Dan Hofsten, Jorgen T. Kuhl, Ilan E. Raymond, Ole P. Kristiansen, Ida H. Svendsen, M. H. Dominguez Vall-Lamora, Charlotte Kragelund, Jens D. Hove, Tem Jorgensen, Gitte G. Fornitz, Rolf Steffensen, Birgit Jurlander, Jawdat Abdulla, Stig Lyngbaek, Hanne Elming, Susette K. Therkelsen, Erik Jorgensen, Lene Klovgaard, Lia E. Bang, Steffen Helqvist, Soren Galatius, Frants Pedersen, Ulrik Abildgaard, Peter Clemmensen, Kari Saunamaki, Lene Holmvang, Gunnar Gislason, Henning Kelbaek, Lars Kober
Summary: Coronary CTA is found to be equivalent to ICA in assessing long-term risk in patients with NSTEACS, with the rate of primary endpoint being up to 1.7-fold higher in patients with obstructive CAD compared to those with nonobstructive CAD as defined by both imaging modalities.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Review
Oncology
Talha Badar, Yazan F. Madanat, Amer M. Zeidan
Summary: The majority of lower-risk myelodysplastic syndromes/neoplasms patients present with anemia. Historically, they were treated with erythropoiesis-stimulating agents (ESA) but with modest responses. Recently, luspatercept has shown better responses compared with ESAs in treatment-naive patients and imetelstat in patients refractory to ESAs. Other evaluated novel compounds have not yet shown meaningful efficacy. More needs to be done to improve outcomes, and participation in clinical trials evaluating novel therapies should be encouraged. Improving prognostication and serial monitoring will help identify high-risk patients for appropriate management.
Article
Cardiac & Cardiovascular Systems
Marianne Hartford, Hans Herlitz, Elisabeth Perers, Thomas Karlsson, Johan Herlitz, Anita Persson, Kenneth Caidahl
Summary: The study found that PRA is associated with all-cause mortality in patients with acute coronary syndromes, with higher PRA serving as an independent predictor of all-cause mortality after three years. However, PRA is not significantly associated with long-term cardiovascular events, indicating the need for further research on the prognostic/predictive role of the renin-angiotensin system in ACS.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Adriano Murrone, Fortunato Scotto di Uccio, Vincenzo Amodeo, Nadia Aspromonte, Pasquale Caldarola, Gianni Casella, Manlio Cipriani, Leonardo De Luca, Andrea Di Lenarda, Stefano Domenicucci, Giuseppina Maura Francese, Massimo Imazio, Loris Roncon, Stefano Urbinati, Serafina Valente, Giuseppe Di Pasquale, Michele Massimo Gulizia, Furio Colivicchi, Domenico Gabrielli
Summary: This study discusses the European Society of Cardiology's guidelines on non-ST-elevation acute coronary syndromes, analyzing the current issues in Italy that hinder certain revascularization strategies. The focus is on patients with a defined diagnosis of non-ST-elevation myocardial infarction.
EUROPEAN HEART JOURNAL SUPPLEMENTS
(2021)
Review
Cardiac & Cardiovascular Systems
Hourmazd Haghbayan, Chris P. Gale, Derek P. Chew, David Brieger, Keith A. Fox, Shaun G. Goodman, Andrew T. Yan
Summary: This article highlights the importance of risk assessment in patients with ACS and the necessity of establishing and applying clinical risk scores for structured risk stratification. It also explores the role of risk scores in guiding clinical decision-making, particularly in the timing of invasive coronary angiography.
EUROPEAN HEART JOURNAL-QUALITY OF CARE AND CLINICAL OUTCOMES
(2021)
Article
Medicine, Research & Experimental
Sriram Navuluri, James Reed Gardner, Donald Vickers, Samantha Mohler, Deanne King, Alissa Kanaan
Summary: This study aimed to identify objective perioperative diagnostic factors for acute invasive fungal rhinosinusitis (AIFS) and create a diagnostic scoring system. The study found measurable differences in lab values and standard imaging between patients with hematologic malignancy-related AIFS and non-hematologic malignancy-related AIFS. A novel scoring system was proposed for diagnostic probability of AIFS. Prospective validation is needed.
Article
Cardiac & Cardiovascular Systems
Shantanu P. Sengupta, Bernard Prendergast, Cecile Laroche, Shumaila Furnaz, Ricardo Ronderos, Abdallah Almaghraby, Federico M. Asch, Kamila Blechova, Hosam Zaky, Jacob Strahilevitz, Rafal Dworakowski, Yoko Miyasaka, Igal Sebag, Chisato Izumi, Olivier Axler, Abdulrahman Jamiel, Mary Philip, Marcelo Luiz Campos Vieira, Patrizio Lancellotti, Gilbert Habib
Summary: Socioeconomic factors influence the clinical profile of patients presenting with infective endocarditis (IE) worldwide. Patients from lower-middle income countries are younger and have a higher risk of complications and mortality, associated with delayed diagnosis and lower use of surgery, compared to patients from high-income and upper-middle income countries.
EUROPEAN HEART JOURNAL-QUALITY OF CARE AND CLINICAL OUTCOMES
(2023)
Article
Cardiac & Cardiovascular Systems
Jeremie Abtan, Deepak L. Bhatt, Yedid Elbez, Gregory Ducrocq, Shinya Goto, Sidney C. Smith, E. Magnus Ohman, Kim A. Eagle, Kim Fox, Robert A. Harrington, Lawrence A. Leiter, Shamir R. Mehta, Tabassome Simon, Ivo Petrov, Peter R. Sinnaeve, Prem Pais, Eli Lev, Hector Bueno, Peter Wilson, Philippe Gabriel Steg
Summary: This study aimed to describe the proportion of eligible and ineligible patients for the THEMIS trial in a population with diabetes and stable coronary artery disease. 64.1% of patients did not meet THEMIS eligibility criteria, mainly due to prior myocardial infarction and use of oral anticoagulation. 28.1% of patients were eligible for the trial.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Ramesh Nadarajah, Peter Ludman, Yolande Appelman, Salvatore Brugaletta, Andrzej Budaj, Hector Bueno, Kurt Huber, Vijay Kunadian, Sergio Leonardi, Maddalena Lettino, Dejan Milasinovic, Chris P. Gale
Summary: The aim of this study is to identify international patterns in the management of NSTEMI and compare them with the 2015 ESC Guidelines. By collecting data from 3620 NSTEMI patients in 287 centers across 59 countries, this study will provide unique insights into the contemporary management of NSTEMI patients.
EUROPEAN HEART JOURNAL-QUALITY OF CARE AND CLINICAL OUTCOMES
(2023)
Article
Cardiac & Cardiovascular Systems
Andre Lamy, John Eikelboom, Wesley Tong, Fei Yuan, Shrikant Bangdiwala, Jackie Bosch, Stuart Connolly, Eva Lonn, Gilles R. Dagenais, Kelley R. H. Branch, Wei-Jhih Wang, Deepak L. Bhatt, Jeff Probstfield, Georg Ertl, Stefan Stoerk, P. Gabriel Steg, Victor Aboyans, Isabelle Durand-Zaleski, Lars Ryden, Salim Yusuf
Summary: The addition of rivaroxaban 2.5 mg BID to aspirin in patients with stable coronary artery disease or peripheral artery disease was found to reduce direct healthcare costs. In Canada, France, and Germany, the combination of rivaroxaban and aspirin was highly cost-effective in terms of lifetime cost-effectiveness.
EUROPEAN HEART JOURNAL-QUALITY OF CARE AND CLINICAL OUTCOMES
(2023)
Article
Economics
Manon Belhassen, Olivier Hanon, Philippe Gabriel Steg, Isabelle Mahe, Melanie Nee, Flore Jacoud, Faustine Dalon, Francois-Emery Cotte, Dominique Guitard-Dehoux, Claire Marant-Micallef, Eric Van Ganse, Nicolas Danchin
Summary: This study compared the costs of healthcare resource use, stroke/systemic thromboembolism, and major bleedings between non-valvular atrial fibrillation patients who initiated apixaban and other oral anticoagulants. The results showed that patients initiating apixaban had lower costs in terms of healthcare resource use and event-related costs compared to other oral anticoagulants. Apixaban may be cost-saving compared to VKAs and cheaper than other DOACs, although the cost differences are limited.
EUROPEAN JOURNAL OF HEALTH ECONOMICS
(2023)
Article
Cardiac & Cardiovascular Systems
Batric Popovic, Gregory Ducrocq, Yedid Elbez, Christoph Bode, Shamir. R. Mehta, Charles Pollack, Manel Sabate, Sunil Rao, Alexander Parkhomenko, Laurent J. Feldman, Neila Sayah, Marc S. Sabatine, Philippe Gabriel Steg
Summary: In patients with non-ST-elevation myocardial infarction (NSTEMI), total occlusion of the culprit coronary artery (OCA) is not uncommon. This study aimed to determine the frequency and clinical impact of OCA at presentation in a large population of patients with NSTEMI who underwent early invasive management. The results showed that patients with OCA had earlier coronary angiography, less involvement of the left anterior descending artery, higher prevalence of angiographic thrombus, higher mortality at 7 days, but similar mortality rates at 6 months.
AMERICAN JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Judith S. Hochman, Rebecca Anthopolos, Harmony. R. Reynolds, Sripal Bangalore, Yifan Xu, Sean M. O'Brien, Stavroula Mavromichalis, Michelle Chang, Aira Contreras, Yves Rosenberg, Ruth Kirby, Balram Bhargava, Roxy Senior, Ann Banfield, Shaun G. Goodman, Renato D. Lopes, Radoslaw Pracon, Jose Lopez-Sendon, Aldo Pietro Maggioni, Jonathan D. Newman, Jeffrey S. Berger, Mandeep S. Sidhu, Harvey D. White, Andrea B. Troxel, Robert A. Harrington, William E. Boden, Gregg W. Stone, Daniel B. Mark, John A. Spertus, David J. Maron
Summary: The ISCHEMIA trial compared the outcomes of initial invasive strategy versus initial conservative strategy in patients with chronic coronary disease and moderate or severe ischemia. The trial found no major difference in most outcomes, but there was lower risk of cardiovascular mortality and higher risk of noncardiovascular mortality with the invasive strategy.
Editorial Material
Cardiac & Cardiovascular Systems
Philippe Gabriel Steg, John Kikoine
Article
Cardiac & Cardiovascular Systems
Josephine Harrington, Anthony P. Carnicelli, Kaiyuan Hua, Lars Wallentin, Manesh R. Patel, Stefan H. Hohnloser, Robert P. Giugliano, Keith A. A. Fox, Ziad Hijazi, Renato D. Lopes, Sean D. Pokorney, Hwanhee Hong, Christopher B. Granger
Summary: Through meta-analysis of multiple research databases, it was found that standard-dose DOACs are safer and more effective than warfarin in patients with kidney dysfunction. While lower-dose DOACs do not significantly lower the incidence of bleeding or intracranial hemorrhage compared to standard-dose DOACs, they are associated with a higher incidence of stroke and systemic embolism as well as death. Therefore, these findings support the use of standard-dose DOACs over warfarin in patients with kidney dysfunction.
Article
Cardiac & Cardiovascular Systems
Agnieszka Kaplon-Cieslicka, Lina Benson, Ovidiu G. Chioncel, Maria Crespo-Leiro, Andrew J. S. D. Coats, Stefan Anker, Frank Ruschitzka, Camilla Hage, Jaroslaw Drozdz, Petar Seferovic, Giuseppe M. C. Rosano, Massimo Piepoli, Alexandre Mebazaa, Theresa McDonagh, Mitja Lainscak, Gianluigi Savarese, Roberto Ferrari, Wilfried Mullens, Antoni P. Bayes-Genis, Aldo H. Maggioni, Lars Lund
Summary: This study comprehensively assessed the prevalence, associations, hospital course, and post-discharge outcomes of hyponatremia in acute heart failure (AHF). Of the patients hospitalized for AHF, 20% had hyponatremia. Independent predictors of hyponatremia included lower systolic blood pressure, estimated glomerular filtration rate, and hemoglobin level, as well as certain comorbidities and medications. In-hospital mortality rate was 3.3%.
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Jasper M. Tromp, Alice M. Jackson, Magdy Abdelhamid, Doaa Fouad, Ghada C. Youssef, Mark C. Petrie, Johann Bauersachs, Karen Sliwa, Peter van Der Meer, ESC EORP PPCM Registry
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Article
Medicine, General & Internal
Philip Joseph, Ambuj Roy, Eva Lonn, Stefan Stoerk, John Floras, Lisa Mielniczuk, Jean-Lucien Rouleau, Jun Zhu, Anastase Dzudie, Kumar Balasubramanian, Kamilu Karaye, Khalid F. AlHabib, Juan Esteban Gomez-Mesa, Kelley R. Branch, Abel Makubi, Andrzej Budaj, Alvaro Avezum, Thomas Wittlinger, Georg Ertl, Charles Mondo, Nana Pogosova, Aldo Pietro Maggioni, Andres Orlandini, Alexander Parkhomenko, Ahmed ElSayed, Patricio Lopez-Jaramillo, Alex Grinvalds, Ahmet Temizhan, Camilla Hage, Lars H. Lund, Khawar Kazmi, Fernando Lanas, Sanjib Kumar Sharma, Keith Fox, John J. V. McMurray, Darryl Leong, Hisham Dokainish, Aditya Khetan, Gerald Yonga, Kristian Kragholm, Kerolos Wagdy Shaker, Julius Chacha Mwita, Arif Abudullatif Al Mulla, Francois Alla, Albertino Damasceno, Jose Silva-Cardoso, Antonio L. Dans, Karen Sliwa, Martin O'Donnell, Nooshin Bazargani, Antoni Bayes-Genis, Tara McCready, Jeffrey Probstfield, Salim Yusuf
Summary: This study examines the differences in heart failure (HF) etiology, treatment, and outcomes between countries with different levels of economic development. The findings highlight the importance of understanding these differences in order to improve HF prevention and treatment globally.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Editorial Material
Peripheral Vascular Disease
Pawel Lewandowski, Anna Zuk, Andrzej Budaj
Summary: We present a case series of four patients with radial artery occlusion who were scheduled for coronary angiography. We discuss the challenges of finding suitable vascular access in patients with a history of coronary angiography and percutaneous coronary intervention and highlight the benefits of using preprocedural ultrasound examination to detect radial artery occlusion. Our findings suggest that the transulnar approach could be a safe alternative for these patients if the anterior interosseous artery provides collateral circulation to the hand.
JOURNAL OF VASCULAR ACCESS
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Florian A. Wenzl, Keith A. A. Fox, Thomas F. Luescher
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Alexandre Gautier, Fabien Picard, Gregory Ducrocq, Yedid Elbez, Kim M. Fox, Roberto Ferrari, Ian Ford, Jean-Claude Tardif, Michal Tendera, Philippe Gabriel Steg
Summary: This study found that new-onset atrial fibrillation (NOAF) is common among patients with chronic coronary syndromes (CCS) and is associated with increased risk of cardiovascular adverse events. Age, body mass index, glomerular filtration rate, ethnicity, alcohol intake, and left ventricular ejection fraction were identified as predictors of NOAF. The study suggests that more intensive preventive measures and systematic screening for atrial fibrillation should be considered in this patient population.
EUROPEAN HEART JOURNAL
(2023)
