Journal
MOLECULAR CELL
Volume 69, Issue 2, Pages 165-168Publisher
CELL PRESS
DOI: 10.1016/j.molcel.2017.11.028
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Funding
- NIBIB NIH HHS [U01 EB022546] Funding Source: Medline
- NIGMS NIH HHS [R35 GM118021, R35 GM118022] Funding Source: Medline
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Some longstanding dogmas in the circadian field warrant reexamination in light of recent studies focused on the role of post-translational modifications and intrinsic disorder in core circadian clock proteins of mice and fungi. Such dogmas include the role of turnover in circadian feedback loops and the origin myths describing evolutionary relatedness among circadian clocks. In this Essay, the authors recapitulate recent findings on circadian clock protein regulation by taking an unconventional approach in the form of a dialog between Wizard and Apprentice.
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