Article
Cell Biology
Yang Liao, Mingxin Wu, Yingjie Jia, Ruiyu Mou, Xiaojiang Li
Summary: This study provides novel insights into the tumorigenesis mechanism of prostate cancer (PCa) and highlights EpCAM as a potential prognostic biomarker. Through analysis of mRNA expression profiles and methylation data, as well as the construction of a ceRNA network, EpCAM's association with favorable overall survival, DNA methylation, and tumor-infiltrating immune cells was identified.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Endocrinology & Metabolism
Song Yi Bae, Hannah E. Bergom, Abderrahman Day, Joseph T. Greene, Zoi E. Sychev, Gabrianne Larson, Eva Corey, Stephen R. Plymate, Tanya S. Freedman, Justin H. Hwang, Justin M. Drake
Summary: Neuroendocrine prostate cancer (NEPC) is an aggressive subtype characterized by loss of androgen receptor signaling and transdifferentiation toward small-cell neuroendocrine phenotypes. Using SCN phenotype scores and gene depletion screens, ZBTB7A was identified as a candidate promoting NEPC progression. High SCN phenotype scores correlated with reliance on RET kinase activity and dependence on ZBTB7A. ZBTB7A showed distinct gene networking patterns in NEPC compared to prostate adenocarcinoma, with a strong association with genes promoting cell cycle progression. Silencing ZBTB7A suppressed cell growth and induced apoptosis in NEPC cell lines.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Medicine, Research & Experimental
Qiancheng He, Qiongyu Hao, Yanyuan Wu, Jaydutt V. Vadgama, Yiyan Jiang
Summary: The long-term prognosis for breast cancer patients with metastasis is very poor, and genetic alterations in tumor cells lead to cellular heterogeneity, promoting cancer cell invasion and colonization. CircRNAs play an important role in identifying disease mechanisms and developing effective treatments. However, the role of aberrant circRNA expression in breast cancer progression is still largely unknown.
Article
Biochemistry & Molecular Biology
Isabel Heidegger, Georgios Fotakis, Anne Offermann, Jermaine Goveia, Sophia Daum, Stefan Salcher, Asma Noureen, Hetty Timmer-Bosscha, Georg Schaefer, Annemiek Walenkamp, Sven Perner, Aleksandar Beatovic, Matthieu Moisse, Christina Plattner, Anne Krogsdam, Johannes Haybaeck, Sieghart Sopper, Stefanie Thaler, Markus A. Keller, Helmut Klocker, Zlatko Trajanoski, Dominik Wolf, Andreas Pircher
Summary: This study provides a comprehensive analysis of prostate cancer tumor endothelial cells (TEC) and identifies potential therapeutic targets, specifically the CXCL12/CXCR4 interaction, to interfere with tumor angiogenesis in prostate cancer. Understanding the cell-to-cell communication networks in the tumor microenvironment contributes to the development of new therapeutic approaches for prostate cancer.
Article
Cell Biology
Michele Patricia Rode, Adny Henrique Silva, Julia Cisilotto, Daiane Rosolen, Tania Beatriz Creczynski-Pasa
Summary: This study evaluated exosomal miRNAs derived from metastatic prostate cancer cell lines LNCaP and PC-3, identifying 14 candidates for prognostic biomarkers. miR-425-5p was associated with residual tumor, pathological staging, and TP53 status in prostate cancer samples.
CELLULAR SIGNALLING
(2021)
Article
Oncology
Rocio B. Duca, Cintia Massillo, Guillermo N. Dalton, Paula L. Farre, Karen D. Grana, Kevin Gardner, Adriana De Siervi
Summary: This research identified the association between a high fat diet and prostate cancer, pinpointing the potential importance of two miRNAs in the diagnosis and prognosis of prostate cancer. Further investigations revealed the significant relevance of these miRNAs in distinguishing tumor types and metastatic status.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Galina Gritsina, Jindan Yu
Summary: Chemokines and their cognate receptors play a crucial role in tumor growth and dissemination, and ACKR3, also known as CXCR7, is a promising target for therapeutic intervention. Unlike CXCR4, CXCR7 activates beta-arrestin instead of G proteins upon binding to its ligand CXCL12, leading to rapid internalization and degradation of CXCL12 as a scavenger receptor. Recent evidence suggests that CXCR7 may have essential roles in cancer progression, independent of CXCR4 and its ligands. Constitutively active CXCR7 forms a protein complex with beta-arrestin, which assembles and activates various cytoplasmic kinases necessary for cell survival and tumor growth. This review discusses the current understanding of CXCR7 regulation and function, with a focus on prostate cancer.
Article
Cell Biology
Mohammad Taheri, Arash Safarzadeh, Bashdar Mahmud Hussen, Soudeh Ghafouri-Fard, Aria Baniahmad
Summary: The construction of ceRNA network in prostate cancer and the identification of its importance in predicting patient survival were investigated in this study. The analysis of microarray data led to the identification of differentially expressed mRNAs, lncRNAs, and miRNAs. A ceRNA network consisting of miRNAs, lncRNAs, and mRNAs was constructed, and 10 hub genes were identified. The expression levels of these hub genes showed high diagnostic value. Overall, this study introduces novel diagnostic biomarkers for prostate cancer.
Article
Biochemistry & Molecular Biology
Somayeh Sedaghati Burkhani, Mahdieh Salimi
Summary: The study found that miR-888 is significantly upregulated in breast cancer patients, while E-cadherin expression is downregulated. miR-888 has an inverse correlation with E-cadherin mRNA levels and is significantly increased in nodal involvement and distant metastasis status.
GENETIC TESTING AND MOLECULAR BIOMARKERS
(2022)
Article
Biochemistry & Molecular Biology
Mohan Damodaran, Mohanapriya Chinambedu Dandapani, SimonDuraiRaj, SandhyaSundaram, S. VenkatRamanan, Ilangovan Ramachandran, Vettriselvi Venkatesan
Summary: The study found that miR-21 and miR-100 were significantly downregulated in prostate cancer patients, while miR-125a was upregulated. MiR-100 was significantly downregulated in high-grade tumors, indicating its association with prostate cancer.ROC analysis revealed that the combined analysis of all five miRNAs showed an AUC of 0.87, indicating their potential as diagnostic biomarkers for prostate cancer.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Oncology
Mauro Scaravilli, Sonja Koivukoski, Andrew Gillen, Aya Bouazza, Pekka Ruusuvuori, Tapio Visakorpi, Leena Latonen
Summary: The study demonstrates that miR-32 promotes MYC-induced prostate adenocarcinoma and identifies PDK4 as a PC-relevant metabolic target of miR-32-3p. Elevated expression of miR-32 influences prostate tumor growth and phenotype, and regulates the expression of prostate secretome and several PC-related target genes.
Article
Oncology
Maurizia Mello-Grand, Antonino Bruno, Lidia Sacchetto, Simone Cristoni, Ilaria Gregnanin, Alessandro Dematteis, Andrea Zitella, Paolo Gontero, Caterina Peraldo-Neia, Riccardo Ricotta, Douglas M. Noonan, Adriana Albini, Giovanna Chiorino
Summary: A novel minimally invasive liquid biopsy-based tool was developed to characterize new metabolites and identify potential non-invasive biomarkers for better prediction of prostate cancer, especially when PSA is uninformative for precision medicine in genitourinary cancers.
FRONTIERS IN ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Irene Cosi, Annalisa Moccia, Chiara Pescucci, Uday Munagala, Salvatore Di Giorgio, Irene Sineo, Silvestro G. G. Conticello, Rosario Notaro, Maria De Angioletti
Summary: ETV4, an overexpressed ETS protein in prostate cancer, promotes migration, invasion, and proliferation in prostate cells. This study identifies previously unknown ETV4 alternatively spliced transcripts in human prostate cell lines and confirms their presence in prostate tumors. The abundance of these transcripts may reflect tumor deranged splicing machinery and their potential interactions with canonical variants may contribute to the biology and clinics of prostate cancer. Further investigations are needed to understand the biological role of these ETV4 transcripts and their isoforms.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Tian-Yuan Zhai, Meng Dou, Yu-Bo Ma, Hong Wang, Fang Liu, Lian-Dong Zhang, Tie Chong, Zi-Ming Wang, Li Xue
Summary: This study evaluated the diagnostic value of miR-20b-5p in PCa. miR-20b-5p was found to be upregulated in PCa tissues, cells, and exosomes from prostatic fluid. It may serve as a promising early diagnostic biomarker and a tool for guiding prostate biopsy decision-making.
Article
Biochemistry & Molecular Biology
Xing Zeng, Zhiquan Hu, Yuanqing Shen, Xian Wei, Jiahua Gan, Zheng Liu
Summary: miR-5195-3p functions as a tumor suppressor in prostate cancer by targeting CCNL1, resulting in inhibition of cell proliferation and cell cycle progression.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2022)