The synaptotagmin C2B domain calcium-binding loops modulate the rate of fusion pore expansion

Slow fusion pore expansion creates a unique reaction chamber for co-packaged cargo

(2017) Kevin P. Bohannon et al.   JOURNAL OF GENERAL PHYSIOLOGY

Synaptotagmin isoforms confer distinct activation kinetics and dynamics to chromaffin cell granules

(2017) Tejeshwar C. Rao et al.   JOURNAL OF GENERAL PHYSIOLOGY

The primed SNARE–complexin–synaptotagmin complex for neuronal exocytosis

(2017) Qiangjun Zhou et al.   NATURE

Exceptionally tight membrane-binding may explain the key role of the synaptotagmin-7 C2A domain in asynchronous neurotransmitter release

(2017) Rashmi Voleti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interactions Between SNAP-25 and Synaptotagmin-1 Are Involved in Vesicle Priming, Clamping Spontaneous and Stimulating Evoked Neurotransmission

(2016) Melanie Schupp et al.   JOURNAL OF NEUROSCIENCE

The calcium sensor synaptotagmin 7 is required for synaptic facilitation

(2016) Skyler L. Jackman et al.   NATURE

Signaling through C2 domains: More than one lipid target

(2014) Senena Corbalan-Garcia et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Distinct fusion properties of synaptotagmin-1 and synaptotagmin-7 bearing dense core granules

(2014) Tejeshwar C. Rao et al.   MOLECULAR BIOLOGY OF THE CELL

SWISS-MODEL: modelling protein tertiary and quaternary structure using evolutionary information

(2014) Marco Biasini et al.   NUCLEIC ACIDS RESEARCH

Synaptotagmin-7 Is an Asynchronous Calcium Sensor for Synaptic Transmission in Neurons Expressing SNAP-23

(2014) Jens P. Weber et al.   PLoS One

Synaptotagmin Interaction with SNAP-25 Governs Vesicle Docking, Priming, and Fusion Triggering

(2013) R. Mohrmann et al.   JOURNAL OF NEUROSCIENCE

A molecular machine for neurotransmitter release: synaptotagmin and beyond

(2013) Thomas C Südhof   NATURE MEDICINE

Synaptotagmin-1 and Synaptotagmin-7 Trigger Synchronous and Asynchronous Phases of Neurotransmitter Release

(2013) Taulant Bacaj et al.   NEURON

Hydrophobic Contributions to the Membrane Docking of Synaptotagmin 7 C2A Domain: Mechanistic Contrast between Isoforms 1 and 7

(2012) Devin S. Brandt et al.   BIOCHEMISTRY

A new role for the dynamin GTPase in the regulation of fusion pore expansion

(2011) Arun Anantharam et al.   MOLECULAR BIOLOGY OF THE CELL

Release mode of large and small dense-core vesicles specified by different synaptotagmin isoforms in PC12 cells

(2011) Zhen Zhang et al.   MOLECULAR BIOLOGY OF THE CELL

Localized topological changes of the plasma membrane upon exocytosis visualized by polarized TIRFM

(2010) Arun Anantharam et al.   JOURNAL OF CELL BIOLOGY

Regulation of Exocytosis and Fusion Pores by Synaptotagmin-Effector Interactions

(2010) Zhen Zhang et al.   MOLECULAR BIOLOGY OF THE CELL

Membrane Fusion: Grappling with SNARE and SM Proteins

(2009) T. C. Sudhof et al.   SCIENCE

How Does Synaptotagmin Trigger Neurotransmitter Release?

(2008) Edwin R. Chapman   Annual Review of Biochemistry

Synaptotagmin-1 Utilizes Membrane Bending and SNARE Binding to Drive Fusion Pore Expansion

(2008) Kara L. Lynch et al.   MOLECULAR BIOLOGY OF THE CELL

Synaptotagmin-1 and -7 are functionally overlapping Ca2+ sensors for exocytosis in adrenal chromaffin cells

(2008) J.-S. Schonn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic analysis of synaptotagmin-7 function in synaptic vesicle exocytosis

(2008) A. Maximov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystallographic identification of Ca2+ and Sr2+ coordination sites in synaptotagmin I C2B domain

(2004) Yuan Cheng et al.   PROTEIN SCIENCE