Review
Cell Biology
Nicole A. Lynn, Emily Martinez, Hieu Nguyen, Jorge Z. Torres
Summary: The katanin family of microtubule-severing enzymes plays a critical role in cytoskeletal rearrangements that impact various cellular processes. Dysregulation of katanins is associated with developmental, proliferative, and neurodegenerative disorders in humans. This review provides insights into the evolutionary conservation, functional domain organization, and mechanisms regulating katanin activity, as well as the implications of katanin dysfunction on cellular processes and disease development. Future research on katanins is highlighted to enhance our understanding of these disease-associated enzymes.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Akira Noga, Mao Horii, Yumi Goto, Kiminori Toyooka, Takashi Ishikawa, Masafumi Hirono
Summary: The study reveals the importance of centriolar protein Bld10p in the formation of centriole structural symmetry, particularly in the cartwheel-independent mechanism. Bld10p plays a role in determining the inter-triplet distance and regulating the centriole structure in the absence of the cartwheel.
Review
Cell Biology
Sarah K. Suciu, Tamara Caspary
Summary: Neural development involves a series of cellular events including cell specification, proliferation, and migration, with anomalies potentially leading to malformation of the nervous system. The primary cilium plays a critical role in neurodevelopment, with mutations in cilia-associated proteins causing human diseases and highlighting the essential nature of cilia in multiple neural processes. Further research is needed to explore the potential roles of cilia regulation in neural development and whether cilia-associated proteins function outside the cilium in certain aspects of neurodevelopment.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2021)
Article
Environmental Sciences
Michael A. Wulder, David P. Roy, Volker C. Radeloff, Thomas R. Loveland, Martha C. Anderson, David M. Johnson, Sean Healey, Zhe Zhu, Theodore A. Scambos, Nima Pahlevan, Matthew Hansen, Noel Gorelick, Christopher J. Crawford, Jeffrey G. Masek, Txomin Hermosilla, Joanne C. White, Alan S. Belward, Crystal Schaaf, Curtis E. Woodcock, Justin L. Huntington, Leo Lymburner, Patrick Hostert, Feng Gao, Alexei Lyapustin, Jean-Francois Pekel, Peter Strobl, Bruce D. Cook
Summary: Since 1972, the Landsat program has provided 50 years of digital, multispectral, medium spatial resolution observations, playing a crucial role in scientific and technical advancements. The program's early years brought technological breakthroughs and established a template for global Earth observation missions. The knowledge gained from Landsat has been recognized for its economic and scientific value, leading to continuous improvement and increased usage through the introduction of free and open access to data.
REMOTE SENSING OF ENVIRONMENT
(2022)
Review
Pharmacology & Pharmacy
Carlo Patrono
Summary: This passage describes the significant impact of Sir John Vane's publication on the pharmacological effects of aspirin and similar drugs, as well as the subsequent discovery of the platelet arachidonic acid metabolism pathway. It also emphasizes the importance of low-dose aspirin as an antiplatelet drug.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Developmental Biology
Mia J. Konjikusic, Ryan S. Gray, John B. Wallingford
Summary: This review highlights the specific developmental roles of kinesins, linking them to cellular functions reported in vitro, and points out the remaining gaps in our understanding of how this important family of proteins contributes to animal development and morphogenesis.
DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Meredith K. Bartelstein, Patrick J. Boland
Summary: There have been significant advances in the treatment of bone tumors, with limb salvage surgery replacing amputation as the standard of care. Progress has also been made in the management of benign and metastatic bone tumors.
JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Shintaroh Kubo, Shun Kai Yang, Corbin S. Black, Daniel Dai, Melissa Valente-Paterno, Jacek Gaertig, Muneyoshi Ichikawa, Khanh Huy Bui
Summary: Cilia are thin microtubule-based protrusions found in eukaryotic cells, responsible for propelling the movement of ciliated protists and sperm cells, as well as facilitating mucus flow in the trachea to protect the human body from viral infections. The main force generators of ciliary beating are the outer dynein arms (ODAs), which attach to the doublet microtubules and induce bending through conformational changes driven by ATP hydrolysis. The structure of the native ODA complex attached to the doublet microtubule has been revealed through cryo-electron microscopy, showing how the ODA complex is attached to the doublet microtubule via the docking complex in its native state, leading to remodeling and activation.
Article
Economics
Ye Yao, Huibin Du, Hongyang Zou, Peng Zhou, Carlos Henggeler Antunes, Anne Neumann, Sonia Yeh
Summary: This paper provides a retrospective overview of the journal Energy Policy during the period 1973-2022 using bibliometric data. The results show that Energy Policy has a high annual publication volume and citation rate, covering a wide range of topics. The United States and its institutions are the major contributors to the journal.
Review
Cell Biology
Ewa Joachimiak, Dorota Wloga
Summary: Protists, a diverse group of single-celled eukaryotes, have different levels of sophistication in the organization of their microtubular cytoskeleton. The tubulin post-translational modifications (PTMs) in these organisms play a crucial role in building complex structures and have been studied using protists as model organisms. This article provides a brief summary of the current knowledge on tubulin PTMs in unicellular eukaryotes and highlights key findings in protists.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2023)
Article
Oncology
Daniel G. Coit, Vivian E. Strong
Summary: This article summarizes the important changes in gastric cancer management and the supporting data. These changes have been derived from randomized controlled trials, prospective databases, and in-depth analysis of individual patients.
JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Thuy N. Vien, My C. Ta, Louise F. Kimura, Tuncer Onay, Paul G. DeCaen
Summary: In this study, the researchers found that PKD2L1 localizes and functions as a Ca2+ channel in the primary cilia of hippocampal neurons. Loss of PKD2L1 expression disrupts primary ciliary maturation, weakens neuronal high-frequency excitability, and leads to seizure susceptibility and autism spectrum disorder-like behavior in mice. The disproportionate impairment of interneuron excitability suggests that circuit disinhibition underlies the neurophenotypic features of these mice. These findings identify PKD2L1 channels as regulators of hippocampal excitability and the neuronal primary cilia as organelle mediators of brain electrical signaling.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Geosciences, Multidisciplinary
Lingyu Tang, Caiming Shen, Houyuan Lu, Chuanhai Li, Qingfeng Ma
Summary: Quaternary palynology research in the Tibetan Plateau has undergone different stages, from developing new methods to international cooperation, improving the quality of research. In recent years, new pollen records have revealed vegetation changes in the Tibetan Plateau since the Last Glacial Maximum, especially the changes in the paleomonsoon under the influence of solar insolation.
SCIENCE CHINA-EARTH SCIENCES
(2021)
Article
Cell Biology
Daniel Hlavaty, Terry Lechler
Summary: Recent studies have expanded research on microtubule dynamics and organization to tissues ex vivo and organisms in vivo, demonstrating the important roles microtubules play in stratified epithelia of the epidermis. These findings not only reveal the various roles of microtubules in supporting epidermal function, but also uncover new principles of microtubule regulation.
CURRENT OPINION IN CELL BIOLOGY
(2021)
Article
Cell Biology
Caroline Shak, Laura Vuolo, Borhan Uddin, Yohei Katoh, Tom Brown, Aakash G. Mukhopadhyay, Kate Heesom, Anthony J. Roberts, Nicola Stevenson, Kazuhisa Nakayama, David J. Stephens
Summary: The primary cilium is a sensory organelle that receives signals from the external environment and transports them into the cell. Mutations in proteins required for transport in the primary cilium result in ciliopathies, which lead to the malformation of organs and skeletal dysplasias. WDR34, a dynein-2 intermediate chain, is necessary for the maintenance of cilia function.
JOURNAL OF CELL SCIENCE
(2023)