Article
Polymer Science
Aftab Alam, Ahmed I. Foudah, Mohammad Ayman Salkini, Mohammad Raish, Jyotiram Sawale
Summary: Antimicrobial resistance is a significant global threat, and fennel essential oils encapsulated in nanoparticles can be used as antibacterial agents against Staphylococcus aureus, with promising drug release and antimicrobial efficacy.
Article
Infectious Diseases
Michela Galgano, Paolo Capozza, Francesco Pellegrini, Marco Cordisco, Alessio Sposato, Sabina Sblano, Michele Camero, Gianvito Lanave, Giuseppe Fracchiolla, Marialaura Corrente, Francesco Cirone, Adriana Trotta, Maria Tempesta, Domenico Buonavoglia, Annamaria Pratelli
Summary: The study found that essential oils such as lemon, pine, fennel, basil, melissa, thyme, and ginger have broad-spectrum antimicrobial activity. The activity of ginger oil against Staphylococcus aureus strains showed a dose-effect correlation, while fennel oil showed low activity. Pine, melissa, and basil oils showed bactericidal effects against S. aureus, and lemon oil had different effects on different strains. Thyme oil showed complete inhibition of growth for both E. coli and S. aureus.
Review
Pharmacology & Pharmacy
Sandra Truong, Poonam Mudgil
Summary: This systematic review examines the antibacterial properties of lavender essential oil (LEO) against Staphylococcus aureus and MRSA. The findings suggest mixed results, with some studies reporting significant effectiveness and others reporting minimal to negligible effect. However, it is noted that LEO works synergistically with other antibacterial substances, highlighting the need for further research.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Food Science & Technology
Qiao He, Lianjiao Zhang, Luyao Song, Xinhui Zhang, Donghong Liu, Yaqin Hu, Mingming Guo
Summary: The study demonstrated the synergistic antimicrobial effect of ultrasound combined with thyme essential oil nanoemulsions on the inactivation of Staphylococcus aureus. The mechanisms involved changes in membrane properties, increased exposure to essential oil, and alterations in membrane fatty acid profile. This integrated technology effectively enhanced bacterial inactivation by targeting membrane compositions.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Taehyung Lee, Woorim Yeom, Hoikyung Kim, Larry R. Beuchat, Jee-Hoon Ryu
Summary: This study evaluated the influence of chemical diluents on the antimicrobial activity of plant essential oil vapors. The results showed that ethyl ether vapor inhibited the growth of S. aureus. Cinnamon bark essential oil vapor showed significantly lower minimal inhibitory concentrations against S. aureus and S. enterica when diluted in certain diluents.
Article
Plant Sciences
Wendeo Kennedy Costa, Alisson Macario de Oliveira, Izabelly Bianca da Silva Santos, Valquiria Bruna Guimaraes Silva, Elys Karine Carvalho da Silva, Joao Victor de Oliveira Alves, Ana Paula Sant'Anna da Silva, Vera Lucia de Menezes Lima, Maria Tereza dos Santos Correia, Marcia Vanusa da Silva
Summary: The antibacterial and antivirulence activities of E. stipitata leaf essential oil (EsEO) against Staphylococcus aureus were evaluated. EsEO showed antibacterial activity, synergistic effect with antibiotics, ability to reduce hemolysis and staphyloxanthin, and impact on cell membrane integrity. Moreover, EsEO exhibited protective effects in S. aureus-infected Tenebrio mollitor larvae and no cytotoxicity on human fibroblasts and macrophages. These findings suggest that E. stipitata leaf essential oil has potential as a therapeutic agent against S. aureus infections.
SOUTH AFRICAN JOURNAL OF BOTANY
(2022)
Article
Multidisciplinary Sciences
Jianye Zeng, Dandan Chen, Chunli Lv, Kening Qin, Qin Zhou, Na Pu, Shanshan Song, Xiaomin Wang
Summary: The aqueous extract of Polygonum chinense L. has a significant bacteriostatic effect on Staphylococcus aureus and can destroy its cell wall as well as inhibit biofilm formation. Flow cytometry results show that the extract can disrupt the cell membrane and promote apoptosis. Confocal laser scanning microscopy images demonstrate the dose-dependent inhibition of biofilm formation by the extract.
SCIENTIFIC REPORTS
(2022)
Article
Infectious Diseases
Alexandra Coimbra, Sonia Miguel, Maximiano Ribeiro, Paula Coutinho, Lucia Silva, Ana Paula Duarte, Susana Ferreira
Summary: This study characterized the chemical composition and bioactive properties of T. zygis essential oil, and found that it exhibited antimicrobial and antioxidant activities against S. aureus. The essential oil also demonstrated the ability to attenuate antibiotic resistance in the bacterium.
Article
Engineering, Biomedical
Matilde Concilio, Ramon Garcia Maset, Laia Pasquina Lemonche, Vito Kontrimas, Ji-Inn Song, Santhosh Kalash Rajendrakumar, Freya Harrison, C. Remzi Becer, Sebastien Perrier
Summary: Antimicrobial-resistant pathogens have become a significant global health concern, demanding the development of new treatments. Synthetic nanoengineered antimicrobial polymers (SNAPs) show promise as an alternative to antimicrobial peptides, with high activity against Staphylococcus aureus and good biocompatibility. The lead compounds disrupt the cell membrane of S. aureus, while leaving the cell wall unaffected. In addition, there is a potential interaction of the compounds with bacterial DNA, suggesting implications on bacterial division. Finally, one of the compounds exhibits high efficacy in vivo in an insect infection model.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Biochemistry & Molecular Biology
Denis Swolana, Robert D. Wojtyczka
Summary: The article introduces the effects of Staphylococcus epidermidis and Staphylococcus aureus on human health, as well as silver nanoparticles as a potential new substance for neutralizing bacterial cells. By reviewing the data on the activity of silver nanoparticles in inhibiting bacterial growth and biofilm formation, it provides insights for future research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Editorial Material
Plant Sciences
Hazem S. Elshafie
Summary: This article summarizes the chemical composition and biological-pharmaceutical activities of plant essential oils (PEOs), and discusses their possible modes of action and influencing factors. It provides valuable insights into the application of PEOs.
Article
Infectious Diseases
Ahmed H. Abed, Esraa F. Hegazy, Sherif A. Omar, Rehab M. Abd El-Baky, Ahmed A. El-Beih, Ahmed Al-Emam, Ahmed M. S. Menshawy, Eman Khalifa
Summary: Staphylococcus species with multidrug resistance genes were found in animal and human samples in Minya Governorate, Egypt, while carvacrol essential oil demonstrated promising antibacterial effects and the ability to impact the phenotypic properties and gene expression of the bacteria even in sub-lethal doses.
Article
Chemistry, Applied
Lili Li, Ping Zhou, Yidi Wang, Ying Pan, Min Chen, Ye Tian, Hua Zhou, Baoru Yang, Hecheng Meng, Jie Zheng
Summary: Enzymatic acylation of anthocyanin with fatty acid improves its lipophilic solubility and this study demonstrates that the resulting acylated anthocyanin, C3G-LA, exhibits strong antibacterial activity against Staphylococcus aureus and moderate activity against Escherichia coli. The mechanism of action involves disruption of cell membrane integrity, intracellular ATP concentration, intracellular pH, and changes in cellular morphology.
Article
Biochemistry & Molecular Biology
Hosein Khabaz, Mehdi Rahimi-Nasrabadi, Amir Homayoun Keihan
Summary: In this study, a hierarchical machine learning model was developed to classify peptides with antimicrobial activity against Staphylococcus aureus. The final model showed high accuracy on the test set, utilizing a comprehensive set of features and feature selection steps.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Iva Sovadinova, Kenichi Kuroda, Edmund F. Palermo
Summary: Cationic and amphiphilic polymers exhibit broad-spectrum antibacterial activity by disrupting cell membranes. While nonspecific binding to hydrophobic components in serum was thought to hinder their effectiveness, it was unexpectedly found that the addition of fetal bovine serum actually enhances their antimicrobial activity against S. aureus but not E. coli.
Article
Biotechnology & Applied Microbiology
A. Soroh, L. Owen, N. Rahim, J. Masania, A. Abioye, O. Qutachi, L. Goodyer, J. Shen, K. Laird
Summary: The study developed an essential oil-loaded textile coating using a microemulsion technique to achieve antimicrobial and mosquito repellent functionalities. Tests showed strong antimicrobial activity against various microorganisms and potential mosquito repellent properties.
JOURNAL OF APPLIED MICROBIOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Lucy Owen, Lindsay Apps, Natalia Stanulewicz, Andrew Hall, Katie Laird
Summary: This study investigated the knowledge and attitudes of UK healthcare workers towards domestic laundering of uniforms during the COVID-19 pandemic. The results showed that, despite a preference for professional laundering, most healthcare workers still chose to launder their uniforms at home. However, 17% of participants failed to launder at the recommended temperature, and limited provision of uniforms and lack of changing and storage facilities were identified as major barriers to adherence.
AMERICAN JOURNAL OF INFECTION CONTROL
(2022)
Review
Biotechnology & Applied Microbiology
Lucy Owen, Katie Laird, Maitreyi Shivkumar
Summary: This article reviews the antiviral activity of plant-derived natural products against RNA viruses, highlighting their potential as broad-spectrum antiviral agents. While there is a range of plant extracts and compounds with antiviral activity, their mechanisms of action and in vivo efficacy and toxicity are not fully understood and further research is needed.
LETTERS IN APPLIED MICROBIOLOGY
(2022)
Review
Genetics & Heredity
Huw E. Jones, Philippe B. Wilson
Summary: The development of genetic and genomic technologies has played a crucial role in improving the productivity of farmed animals. By combining advanced data collection, analytics, cloud computing, appropriate infrastructure, and regulation, precision livestock farming (PLF) can be taken to an advanced level, reducing resource use, health treatments, and environmental impact, while also improving animal health and welfare.
TRENDS IN GENETICS
(2022)
Article
Critical Care Medicine
Hugh Montgomery, F. D. Richard Hobbs, Francisco Padilla, Douglas Arbetter, Alison Templeton, Seth Seegobin, Kenneth Kim, Jesus Abraham Simon Campos, Rosalinda H. Arends, Bryan H. Brodek, Dennis Brooks, Pedro Garbes, Julieta Jimenez, Gavin C. K. W. Koh, Kelly W. Padilla, Katie Streicher, Rolando M. Viani, Vijay Alagappan, Menelas N. Pangalos, Mark T. Esser
Summary: This study evaluated the safety and efficacy of tixagevimab-cilgavimab in preventing severe COVID-19 or death in non-hospitalized adults. The results showed that a single dose of tixagevimab-cilgavimab significantly reduced the risk of progression to severe COVID-19 or death, with favorable safety.
LANCET RESPIRATORY MEDICINE
(2022)
Article
Biotechnology & Applied Microbiology
J. Tarrant, L. Owen, R. Jenkins, L. J. Smith, K. Laird
Summary: This study compared the sensitivity of C. difficile spores to heat and detergent, with and without soiling, and investigated their adherence to cotton. The results showed that high temperature and detergent had an impact on the survival of C. difficile spores, and soiling provided protection. Additionally, the study found that spores increasingly adhered to cotton over time, and removal of the exosporium increased adherence.
LETTERS IN APPLIED MICROBIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Chiemela S. S. Odoemelam, Elena Hunter, Zeeshan Ahmad, Caroline Lynn Kamerlin, Samuel White, Philippe B. B. Wilson
Summary: This study investigated the interactions of selected flavonoids with cytochrome P450 enzymes and found that isorhamnetin and pedalitin had the strongest binding energies. These flavonoids may serve as potential precursors for natural product-derived therapies.
CURRENT PHARMACEUTICAL DESIGN
(2022)
Article
Green & Sustainable Science & Technology
Ashraf Alkhtib, Emily Burton, Philippe B. Wilson, Dawn Scholey, James Bentley
Summary: The goal of this study was to determine the effect of life cycle inventory (LCI) specifications on the carbon footprint (CF) of feed used to produce broiler meat. The experimental birds were allocated to three treatments and their feed consumption was recorded. The CF was calculated and analyzed using various databases and allocation methods. The results showed that the dietary treatment significantly affected the CF, depending on the LCI database and impact assessment method.
JOURNAL OF CLEANER PRODUCTION
(2023)
Article
Agriculture, Dairy & Animal Science
Ashraf Alkhtib, Philippe Wilson, Mike R. Bedford, Helen Nell Masey O'Neill, Emily Burton
Summary: This systematic review investigates the relevance of existing life cycle analysis (LCA) and environmental assessment studies in informing sustainable poultry meat production strategies. A Rapid Evidence Assessment (REA) was conducted on articles published from 2000 to 2020, covering LCA studies on meat poultry strains, poultry manure emission, and environmental assessments of plant-based feed ingredients. The review found that there is a lack of reliable in vivo data to support the use of existing studies for guiding nutritional strategies and poultry meat production.
Article
Chemistry, Physical
Khoa Minh Ta, David J. Cooke, Lisa J. Gillie, Stephen C. Parker, Sudipta Seal, Philippe B. Wilson, Roger M. Phillips, Jonathan M. Skelton, Marco Molinari
Summary: In this study, the interaction of phosphates with the surfaces of ceria was investigated using ab initio lattice-dynamics calculations. The researchers were able to predict the infrared and Raman spectral signatures of the adsorbed phosphate species. The results showed that phosphates strongly adsorb to the CeO2 surfaces and exhibit characteristic spectral fingerprints.
JOURNAL OF PHYSICAL CHEMISTRY C
(2023)
Article
Biotechnology & Applied Microbiology
Samantha L. Sewell, Lucy Owen, Katie Laird, Katherine D. Huddersman, Susannah E. Walsh
Summary: This study aimed to investigate the mechanisms of action of a novel surface-functionalized polyacrylonitrile (PAN) catalyst, which showed potent antimicrobial activity when combined with hydrogen peroxide (H2O2). The study employed various tests including disinfectant suspension, membrane potential, permeability assays, ATP and pH analysis, and tolerance to sodium chloride and bile salts to investigate the MOA. The results suggested that the catalyst enhanced H2O2-mediated cell membrane damage, leading to increased permeability and loss of membrane potential.
JOURNAL OF APPLIED MICROBIOLOGY
(2023)
Article
Veterinary Sciences
Samuel J. White, Laurent Couetil, Eric A. Richard, Eliane Marti, Philippe B. Wilson
Summary: This study analyzed 35 sports horses from France, the United States, and Canada to investigate the sensitization profiles of severe asthma-affected and healthy horses. The results showed that microarray profiling can identify specific allergenic components associated with severe asthma in horses, and mathematical modeling of this data can be used for disease classification, highlighting the variability of sensitization profiles between geographical locations and emphasizing the importance of local exposure to the prevalence of different allergens.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2023)