Journal
MOLECULAR AND CELLULAR ENDOCRINOLOGY
Volume 462, Issue -, Pages 107-118Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2017.02.002
Keywords
Adipose tissue; Cancer associated adipocytes; FABP4; FABP5; Lipid metabolism
Categories
Ask authors/readers for more resources
The adipose tissue microenvironment plays a key role in tumour initiation and progression because it provides fatty acids and adipokines to tumour cells. The fatty acid-binding protein (FABP) family is a group of small proteins that act as intracellular fatty acid transporters. Adipose-derived FABPs include FABP4 and FABP5. Both have an important role in lipid-related metabolic processes and overexpressed in many cancers, such as breast, prostate, colorectal and ovarian. Moreover, their expression in peritumoural adipose tissue is deregulated, and their circulating levels are upregulated in some tumours. In this review, we discuss the role of the peritumoural adipose tissue and the related adipokines FABP4 and FABP5 in cancer initiation and progression and the possible pathways implicated in these processes. (C)2017 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available