Review
Endocrinology & Metabolism
Christophe E. M. De Block, Eveline Dirinck, Ann Verhaegen, Luc F. Van Gaal
Summary: Glucagon-like peptide-1 receptor agonists and dual GLP-1/glucose-dependent insulinotropic peptide RA tirzepatide have expanded the population of individuals reaching HbA1c and weight targets, showing potential therapeutic benefits. However, further research is needed to determine whether this will lead to improved cardiovascular outcomes and impact treatment guidelines.
DIABETES OBESITY & METABOLISM
(2022)
Article
Immunology
Yucheol Cheong, Minjin Kim, Jina Ahn, Hana Oh, Jongkwan Lim, Wonil Chae, Seung Won Yang, Min Seok Kim, Ji Eun Yu, Sanguine Byun, Yo Han Jang, Baik Lin Seong
Summary: The study investigated the potential use of catechins derived from green tea as adjuvants for subunit and inactivated vaccines, demonstrating their ability to enhance immune responses and provide protection against vaccines, including influenza virus.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Syed Faizan Mehdi, Suma Pusapati, Muhammad Saad Anwar, Durga Lohana, Parkash Kumar, Savitri Aninditha Nandula, Fatima Kausar Nawaz, Kevin Tracey, Huan Yang, Derek LeRoith, Michael J. Brownstein, Jesse Roth
Summary: Inflammation is involved in many chronic conditions and stimulates the release of pro-inflammatory cytokines and immune cells. GLP-1 levels are associated with disease severity and can serve as markers of inflammation. Previous studies have investigated the anti-inflammatory properties of oxytocin, hCG, ghrelin, alpha-MSH and ACTH, while the anti-inflammatory effects of GLP-1 have only recently been recognized. GLP-1 has been shown to be beneficial in treating type-2 diabetes, metabolic syndrome, and hyperglycemia by reducing inflammation and cell death.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Pengpeng Zhang, Wei Wu, Chunyu Du, Xiang Ji, Yaling Wang, Qiu Han, Hiaxia Xu, Cencen Li, Yongjie Xu
Summary: In this study, primary WAT and BAT SVF cells were isolated and induced to adipogenic differentiation in the presence or absence of EGCG. RNA-seq was used to analyze the gene regulation by EGCG in these two distinct adipose tissues and identify the key differences. The findings of this study have significant implications for obesity-related clinical and basic research.
Article
Chemistry, Applied
Jianyong Zhang, Hongchun Cui, Jiahuan Qiu, Xiaoqing Wang, Yixin Zhong, Caiping Yao, Lanying Yao, Qunxiong Zheng, ChunHua Xiong
Summary: This study aimed to improve the stability and bioavailability of EGCG in aqueous solutions and in vivo by preparing EGCG glycosylated arachin nanoparticles and EGCG glycosylated casein nanoparticles. The results showed that the DPPH scavenging activity of the nanoparticles was stable within temperature range of 25-70 degrees Celsius. EGCG enhanced the crosslinking effect of molecular particles in the glycosylation complexes solution. The glycosylated protein nanoparticles were stable to acid-base and enzymolysis in simulated gastrointestinal fluid.
Review
Endocrinology & Metabolism
Chloe Wong, Ming Hui Lee, Clyve Yu Leon Yaow, Yip Han Chin, Xin Lei Goh, Cheng Han Ng, Amanda Yuan Ling Lim, Mark Dhinesh Muthiah, Chin Meng Khoo
Summary: This meta-analysis examined the efficacy of glucagon-like peptide-1 receptor agonists on non-alcoholic fatty liver disease in patients with type 2 diabetes mellitus. Results showed significant improvements in hepatic fat content, liver biochemistry, body composition, glucose parameters, lipid parameters, insulin sensitivity, and inflammatory markers following treatment with glucagon-like peptide-1 receptor agonists. Glucagon-like peptide-1 receptor agonists were also found to significantly decrease hepatic fat content compared to other treatments, showing promise in improving both diabetes and non-alcoholic fatty liver disease phenotype.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Immunology
Cheng Zhang, Xin Li, Xiang Hu, Qirui Xu, Yanqi Zhang, Hongyan Liu, Yutao Diao, Xiaoyu Zhang, Lianlian Li, Jie Yu, Haipeng Yin, Jun Peng
Summary: The study found that EGCG inhibits caspase-1 activation and IL-1β secretion in mouse bone marrow-derived macrophages by suppressing NLRP3 inflammasome activation. Additionally, EGCG treatment improves glucose tolerance in HFD-induced T2D mice and prevents NLRP3 inflammasome-dependent inflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Satoshi Yano, Katsuhiko Suzuki, Taichi Hara
Summary: This study demonstrates that intestinal epithelial cells can secrete exosomes, and food components can regulate the secretion of these exosomes. Epigallocatechin gallate (EGCG) affects the number and size of secreted exosomes by altering their properties and protein expression. These findings contribute to a better understanding of the expression and mechanism of exosomal proteins related to food components.
Article
Plant Sciences
Qianjin Xie, Xiaqiang Cai, Xu Dong, Ying Wang, Minghui Sun, Lingling Tai, Yan Xu
Summary: The combination of EGCG with Vc and glycerol could effectively increase its stability and uric acid-lowering activity, which sheds light on the development and application of EGCG in the fields of food and medicine.
PHARMACEUTICAL BIOLOGY
(2021)
Review
Endocrinology & Metabolism
Carmen M. Labandeira, Arturo Fraga-Bau, David Arias Ron, Ana Munoz, Gema Alonso-Losada, Antonio Koukoulis, Jesus Romero-Lopez, Ana Rodriguez-Perez
Summary: Parkinson's disease and diabetes mellitus are two chronic disorders associated with aging that are increasingly prevalent worldwide. Research has shown that insulin plays a role in the brain that may affect the development of Parkinson's disease, and some antidiabetic treatments may have a certain impact on this disease.
FRONTIERS IN NEUROENDOCRINOLOGY
(2021)
Article
Chemistry, Applied
Xin Luo, Jiankang Lu, Yongyan Wu, Wenshan Duan, Fengping An, Qun Huang, Lei Chen, Shaofeng Wei
Summary: The potential allergenicity of amandin was reduced by binding it with EGCG using different methods, such as alkaline, free radical, ultrasound-assisted alkaline, and ultrasound-assisted free radical methods. The binding of amandin to EGCG was found to be covalent or non-covalent, and was mainly through cysteine and glutamate residues. This study provides a new method and theoretical basis for developing hypoallergenic almond food.
Article
Chemistry, Applied
Qing-Qing Ye, Gen-Sheng Chen, Weichun Pan, Qing-Qing Cao, Liang Zeng, Jun-Feng Yin, Yong-Quan Xu
Summary: The study focused on the contribution of EGCG to astringency, the impact of mucin as a protein, and developed a predictive model to estimate the intensity of EGCG astringency.
Article
Immunology
Jun Chen, Aihua Mei, Xinxin Liu, Zachary Braunstein, Yingying Wei, Biao Wang, Lihua Duan, Xiaoquan Rao, Sanjay Rajagopalan, Lingli Dong, Jixin Zhong
Summary: This study confirms the expression of GLP-1R in macrophages in inflammatory diseases. Deficiency of GLP-1R reduces macrophage migration and enhances interleukin-6 expression. In a gout model, recruitment of macrophages is suppressed in GLP-1R knockout mice.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Food Science & Technology
Yabo Dong, Tian Lan, Guo Huang, Lianzhou Jiang, Yan Zhang, Xiaonan Sui
Summary: This study investigated the feasibility of using ESPN as an emulsifier, showing that emulsions stabilized by ESPN exhibited exceptional stability, smaller droplet size, and higher viscosity and modulus. This work demonstrates the potential of ESPN to enhance the value of SPA in various applications.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Adriana Elena Bulboaca, Alina Silvia Porfire, Vasile Rus, Cristina Ariadna Nicula, Corneliu Angelo Bulboaca, Sorana D. Bolboaca
Summary: This study aimed to evaluate the effect of liposomal epigallocatechin-gallate (LEGCG) compared with epigallocatechin-gallate (EGCG) solution on hepatic toxicity induced by gentamicin administration in rats. The results showed that LEGCG had better efficacy than EGCG in improving the oxidant/antioxidant balance, reducing inflammation, and protecting the liver from gentamicin-induced damage.
Article
Endocrinology & Metabolism
Paul Denver, Victor A. Gault, Paula L. McClean
DIABETES OBESITY & METABOLISM
(2018)
Article
Biochemistry & Molecular Biology
J. Michael Conlon, Milena Mechkarska, Yasser H. Abdel-Wahab, Peter R. Flatt
Article
Pharmacology & Pharmacy
Ruta Dekeryte, Claire Hull, Kaja Plucinska, Shakil Khan, Sarah Kamli-Salino, Nimesh Mody, Nicola Morrice, Chris McLaughlin, Victor Gault, Bettina Platt, Mirela Delibegovic
BIOCHEMICAL PHARMACOLOGY
(2019)
Review
Biochemistry & Molecular Biology
Dipak Sarnobat, R. Charlotte Moffett, Victor A. Gault, Neil Tanday, Frank Reimann, Fiona M. Gribble, Peter R. Flatt, Nigel Irwin
Review
Biochemistry & Molecular Biology
Nigel Irwin, Victor A. Gault, Finbarr P. M. O'Harte, Peter R. Flatt
Article
Pharmacology & Pharmacy
Dipak Sarnobat, Charlotte R. Moffett, Neil Tanday, Frank Reimann, Fiona M. Gribble, Peter R. Flatt, Andrei I. Tarasov
BIOCHEMICAL PHARMACOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Galyna Graham, J. Michael Conlon, R. Charlotte Moffett, Yasser H. Abdel-Wahab, Peter R. Flatt
Summary: The study showed that long-acting, dual-agonist anti-diabetic peptides can induce alpha-cell to beta-cell transdifferentiation, leading to increased pancreatic insulin content and plasma insulin concentrations. This suggests therapeutic potential for using proglucagon-derived peptides from phylogenetical ancient fish in diabetes treatment.
JOURNAL OF PEPTIDE SCIENCE
(2021)
Article
Endocrinology & Metabolism
D. Sarnobat, R. C. Moffett, P. R. Flatt, A. I. Tarasov
Summary: The study showed that metformin and rosiglitazone can help slow down the reduction of beta-cell pool in streptozotocin-induced diabetes, while tolbutamide may exacerbate beta-cell apoptosis but potentially protect beta-cells from chronic hyperglycemia by increasing insulin secretion directly.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2022)
Article
Plant Sciences
Prawej Ansari, Peter R. Flatt, Patrick Harriott, J. M. A. Hannan, Yasser H. A. Abdel-Wahab
Summary: The study demonstrated the antidiabetic effects of Acacia arabica bark extract, showing potential as a treatment for diabetes. The isolated phytoconstituents, including quercetin and kaempferol, improved glucose tolerance and insulin secretion, indicating the benefits of using them as antidiabetic agents.
Article
Medicine, Research & Experimental
Julie Turbitt, Lorraine Brennan, R. Charlotte Moffett, Peter R. Flatt, Paul R. V. Johnson, Andrei I. Tarasov, Neville H. McClenaghan
Summary: The study found that taurine, alanine, and proline can promote insulin secretion through the regulation of ion transport and inhibition of the sodium-potassium-chloride cotransporter. This action of taurine may have potential value in the treatment of diabetes.
Article
Psychology, Biological
Barry Hitchen, Kelly Norwood, Victor A. Gault, Julian C. Leslie
Summary: Motivation for food reinforcers was examined in mouse models of type 2 diabetes through three experiments. The results showed differences in food preference and behavior, but there were no significant differences between mice with diabetes and the control group.
LEARNING AND MOTIVATION
(2021)
Article
Endocrinology & Metabolism
Vadivel Parthsarathy, Christopher Hogg, Peter R. Flatt, Finbarr P. M. O'Harte
DIABETES OBESITY & METABOLISM
(2018)
Review
Endocrinology & Metabolism
V. A. Gault
Article
Biochemistry & Molecular Biology
Dawood Khan, Srividya Vasu, R. Charlotte Moffett, Victor A. Gault, Peter R. Flatt, Nigel Irwin
BIOLOGICAL CHEMISTRY
(2018)
Article
Cell Biology
Karina A. Pena, Sofya Savransky, Breanna Lewis
Summary: Compartmentalization of GPCR signaling is an emerging topic that emphasizes the importance of spatial bias in signaling for physiological relevance. PTH1R was the first GPCR discovered to signal via cAMP from endosomes, challenging the conventional model of GPCR signaling. The location of cAMP generation determines the physiological outcomes of GPCR signaling.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Cheng-Xu Ma, Xiao-Ni Ma, Jin-Jin Liu, Cong-Hui Guan, Ying-Dong Li, Nan Zhao, Didac Mauricio, Song-Bo Fu
Summary: The downregulation of primary cilia (PCs) due to BRAFV600E mutation contributes to the aggressiveness and lymph node metastasis of Papillary Thyroid Cancer (PTC).
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Kejun Wu, Cuihua Huang, Wenrong Zheng, Yubin Wu, Qintao Huang, Menghua Lin, Ruonan Gao, Liqin Qi, Guanlian He, Xiaoying Liu, Xiaohong Liu, Linxi Wang, Zhou Chen, Libin Liu
Summary: Recurrent non-severe hypoglycemia in patients with diabetes is associated with cognitive impairment. This study found that this condition is associated with reduced mitophagy in the hippocampus, leading to mitochondrial dysfunction and neurological impairment.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Yifei Lv, Yizhou Huang, Huiyu Fan, Yunxiu Zhao, Linjuan Ma, Yibing Lan, Chunming Li, Peiqiong Chen, Zheng Lou, Jianhong Zhou
Summary: Before menopause, females have a lower incidence of cardiovascular disease than age-matched males, possibly due to the protective effects of sex hormones. 17 beta-E2 inhibits THBS1 expression, preventing cell senescence and apoptosis, and counteracts oxidative stress by suppressing the TGF-beta/Smad signaling pathway.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Ana C. L. Camargo, Flavia B. Constantino, Sergio A. A. Santos, Ketlin T. Colombelli, Luiz M. F. Portela, Matheus N. Fioretto, Luisa A. Barata, Guilherme T. Valente, Carlos S. Moreno, Luis A. Justulin
Summary: This study examined the effects of maternal malnutrition on the transcriptomic landscape of the ventral prostate in rats. It found that changes in molecular pathways related to cellular development and tissue morphogenesis were associated with maternal malnutrition. The Abcg1 gene was found to be deregulated in both malnourished rats and prostate cancer models and patients.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Sandra Romero-Cordoba, Mayel Chirinos, Nancy Noyola-Martinez, Nayeli Torres-Ramirez, Mitzi Garcia-Olivares, Juan Pablo Aragon-Hernandez, Ixchel Ramirez-Camacho, Rosa Zuniga, Fernando Larrea, Ali Halhali, David Barrera
Summary: This study analyzed the effects of calcitriol, TGF-131, and their combination on human trophoblast cells. The results showed that the combination treatment modified the transcriptional landscape and mainly affected the storage, activity, and metabolism of lipids, which may have an impact on placental development.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Traver J. Wright, Richard B. Pyles, Melinda Sheffield-Moore, Rachel R. Deer, Kathleen M. Randolph, Kristen A. Mcgovern, Christopher P. Danesi, Charles R. Gilkison, Weston W. Ward, Jayson A. Vargas, Peyton A. Armstrong, Sarah E. Lindsay, Mohammed F. Zaidan, Justin Seashore, Tamara L. Wexler, Brent E. Masel, Randall J. Urban
Summary: This study investigates the persistent neurologic symptoms in COVID-19 patients after recovery and explores the association between these symptoms and disrupted growth hormone secretion and gastrointestinal discomfort.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Li-Li Chen, Ya-Qin Li, Zhi-Hui Kang, Xuan Zhang, Su-Yan Gu, Na Wang, Xue-Yan Shen
Summary: Defects in trophoblastic EMT caused by dysregulation of circTNRC18's interaction with LIN28A play a vital role in the development of preeclampsia. LIN28A overexpression suppresses circTNRC18-mediated inhibition of trophoblast migration, invasion, and EMT, while LIN28A knockdown promotes them. Furthermore, circTNRC18 regulates the intracellular distribution of LIN28A and the expression of insulin-like growth factor II, affecting cell migration and invasion. Targeting the circTNRC18-LIN28A regulatory axis may provide a novel treatment approach for preeclampsia.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)