The RAG-2 Inhibitory Domain Gates Accessibility of the V(D)J Recombinase to Chromatin

H3K4me3 induces allosteric conformational changes in the DNA-binding and catalytic regions of the V(D)J recombinase

(2017) John Bettridge et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Mechanism of V(D)J Recombination from Synaptic RAG1-RAG2 Complex Structures

(2015) Heng Ru et al.   CELL

Crystal structure of the V(D)J recombinase RAG1–RAG2

(2015) Min-Sung Kim et al.   NATURE

An Autoregulatory Mechanism Imposes Allosteric Control on the V(D)J Recombinase by Histone H3 Methylation

(2015) Chao Lu et al.   Cell Reports

Identification of Valid Reference Genes for the Normalization of RT-qPCR Expression Studies in Human Breast Cancer Cell Lines Treated with and without Transient Transfection

(2015) Lin-Lin Liu et al.   PLoS One

Non-homologous end joining often uses microhomology: Implications for alternative end joining

(2014) Nicholas R. Pannunzio et al.   DNA REPAIR

Modernizing the Nonhomologous End-Joining Repertoire: Alternative and Classical NHEJ Share the Stage

(2013) Ludovic Deriano et al.   Annual Review of Genetics

RAG2’s Acidic Hinge Restricts Repair-Pathway Choice and Promotes Genomic Stability

(2013) Marc A. Coussens et al.   Cell Reports

Skewed Primary Ig  Repertoire and V-J Joining in C57BL/6 Mice: Implications for Recombination Accessibility and Receptor Editing

(2012) M. Aoki-Ota et al.   JOURNAL OF IMMUNOLOGY

Localized epigenetic changes induced by DH recombination restricts recombinase to DJH junctions

(2012) Ramesh Subrahmanyam et al.   NATURE IMMUNOLOGY

Coupling of V(D)J Recombination to the Cell Cycle Suppresses Genomic Instability and Lymphoid Tumorigenesis

(2011) Li Zhang et al.   IMMUNITY

Repair of Chromosomal RAG-Mediated DNA Breaks by Mutant RAG Proteins Lacking Phosphatidylinositol 3-Like Kinase Consensus Phosphorylation Sites

(2011) E. J. Gapud et al.   JOURNAL OF IMMUNOLOGY

The In Vivo Pattern of Binding of RAG1 and RAG2 to Antigen Receptor Loci

(2010) Yanhong Ji et al.   CELL

Autoinhibition of DNA cleavage mediated by RAG1 and RAG2 is overcome by an epigenetic signal in V(D)J recombination

(2010) G. J. Grundy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A 220-nucleotide deletion of the intronic enhancer reveals an epigenetic hierarchy in immunoglobulin heavy chain locus activation

(2009) Tirtha Chakraborty et al.   JOURNAL OF EXPERIMENTAL MEDICINE

H3K4me3 Stimulates the V(D)J RAG Complex for Both Nicking and Hairpinning in trans in Addition to Tethering in cis: Implications for Translocations

(2009) Noriko Shimazaki et al.   MOLECULAR CELL

Initial Stages of V(D)J Recombination: The Organization of RAG1/2 and RSS DNA in the Postcleavage Complex

(2009) Gabrielle J. Grundy et al.   MOLECULAR CELL