Review
Oncology
Pingping Su, Lirui Yu, Xiaodan Mao, Pengming Sun
Summary: Oxygen is crucial for energy metabolism in tumors, which often occur in a hypoxic microenvironment. The interaction between HIF-1 alpha and ERR alpha plays a key role in regulating the metabolic and functional changes in cancer cells. This review gives an overview of the tumor metabolic reprogramming involving HIF-1 alpha/ERR alpha and explores their role in promoting tumor growth adaptation and pyroptosis resistance.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Yangyang Yang, Shujing Li, Bowen Li, Yanan Li, Kangkai Xia, Sattout Aman, Yuxi Yang, Bashir Ahmad, Binggong Zhao, Huijian Wu
Summary: The study identified the interaction between orphan nuclear receptor ERR alpha and FBXL10 in breast cancer, showing that FBXL10 stabilized ERR alpha protein levels by reducing polyubiquitylation and promoting mono-ubiquitylation, resulting in increased transcriptional activity and proliferation of breast cancer cells. This study revealed a novel molecular mechanism underlying the regulation of ERR alpha and FBXL10 in breast cancer tumorigenesis.
Article
Oncology
Pingping Su, Xiaodan Mao, Jincheng Ma, Lixiang Huang, Lirui Yu, Shuting Tang, Mingzhi Zhuang, Zhonglei Lu, Kelvin Stefan Osafo, Yuan Ren, Xinrui Wang, Xite Lin, Leyi Huang, Xiaoli Huang, Elena Ioana Braicu, Jalid Sehouli, Pengming Sun
Summary: ERR alpha inhibits pyroptosis in a NLRP3-dependent manner and induces glycolytic metabolism, resulting in cisplatin resistance in EC cells.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Oncology
Min Zhang, Qinsheng Lu, Huomei Hou, Dingqian Sun, Miaojuan Chen, Fen Ning, Peihuang Wu, Dan Wei, Yaoyun Duan, Yue Pan, Gendie E. Lash
Summary: Garcinol demonstrates significant inhibitory effects on cell proliferation and cell cycle in endometrial cancer cells, making it a promising candidate for endometrial cancer chemotherapy.
Article
Environmental Sciences
Ruipu Chen, Jing Liu, Jun Hu, Chunxia Li, Yanhua Liu, Weiwei Pan
Summary: DLGAP5 is highly expressed in endometrial cancer (EC) and is associated with poor prognosis. Silencing DLGAP5 inhibits proliferation and invasion of EC cells by inactivating the Wnt/β-catenin pathway.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Shuting Tang, Jincheng Ma, Pingping Su, Huifang Lei, Yao Tong, Liangzhi Cai, Shuxia Xu, Xiaodan Mao, Pengming Sun
Summary: This study investigates the role of ERR alpha and HMGCS1 in promoting intracellular cholesterol metabolism for endometrial cancer progression, and suggests that they could be potential targets to suppress EC progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell & Tissue Engineering
Isabel Falke, Fabian M. Troschel, Heike Palenta, Maria T. Loeblein, Kathrin Brueggemann, Katrin Borrmann, Hans Theodor Eich, Martin Goette, Burkhard Greve
Summary: This study demonstrated that Musashi-1 is aberrantly expressed in primary endometrial tumor tissues, and its silencing resulted in decreased cell proliferation, reduced radioresistance, and unchanged chemoresistance. The anti-proliferative effect was associated with downregulation of key genes and pathways, providing potential therapeutic implications.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Oncology
Dario R. Roque, Lu Zhang, Weiya Z. Wysham, Jianjun Han, Wenchuan Sun, Yajie Yin, James N. Livingston, Ken W. Batchelor, Chunxiao Zhou, Victoria L. Bae-Jump
Summary: The study found that NT-1044 suppressed endometrial cancer cell growth by inducing apoptosis, inhibiting cell cycle progression, activating AMPK, and inhibiting the mTOR pathway. In vivo experiments also showed inhibition of endometrial cancer tumor growth in mice, suggesting potential benefits for women with endometrial cancer, a disease affected by obesity and diabetes.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Xia Fang, Jinhua Wang, Lingying Chen, Xiaochun Zhang
Summary: In endometrial cancer, circ_POLA2 was found to be highly expressed and it may promote cancer cell proliferation by increasing miR-31 methylation.
Article
Oncology
Xiangrong Wang, Tianquan Chen
Summary: The study found that CUL4A was highly expressed in endometrial cancer cells, and knockdown of CUL4A significantly inhibited cell proliferation, invasion, and migration. However, overexpression of CSN6 alleviated the effects of CUL4A knockdown on the cells.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Oncology
Jing Liu, Ying Zuo, Gui-Mei Qu, Xiao Song, Zhong-Hui Liu, Ting-Guo Zhang, Zhu-Hua Zheng, Hong-Kun Wang
Summary: The study found that CypB is upregulated in endometrial cancer, and inhibiting CypB expression can significantly suppress cell proliferation, metastasis, and migration. Gene ontology and KEGG pathway enrichment analysis indicated that genes related to CypB are mainly enriched in cell cycle, glycosphingolipid biosynthesis, adherens junctions, and metabolism pathways.
Article
Oncology
Lindsey Buckingham, Tianran Hao, Jillian O'Donnell, Ziyi Zhao, Xin Zhang, Yali Fan, Wenchuan Sun, Yingao Zhang, Hongyan Suo, Angeles Alvarez Secord, Chunxiao Zhou, Victoria Bae-Jump
Summary: IPAT is an effective inhibitor in the treatment of uterine serous carcinoma (USC), as it inhibits cell proliferation and invasion, induces cell cycle arrest and apoptosis, and enhances the anti-tumor activity of paclitaxel. It also shows promising results in primary USC cultures.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Environmental Sciences
Ping Deng, Miduo Tan, Wei Zhou, Chunhai Chen, Yu Xi, Peng Gao, Qinlong Ma, Yidan Liang, Mengyan Chen, Li Tian, Jia Xie, Mengyu Liu, Yan Luo, Yanqi Li, Lei Zhang, Liting Wang, Youlong Zeng, Huifeng Pi, Zhengping Yu, Zhou Zhou
Summary: The study found that BPA exposure significantly promoted the proliferation and migration of MCF-7 cells by affecting the cell cycle pathway. Screening differentially expressed genes identified PTTG1 and CDC20 as key targets associated with BPA-induced cell proliferation and migration.
Article
Oncology
Stuart R. Pierce, Ziwei Fang, Yajie Yin, Lindsay West, Majdouline Asher, Tianran Hao, Xin Zhang, Katherine Tucker, Allison Staley, Yali Fan, Wenchuan Sun, Dominic T. Moore, Chang Xu, Yi-Hsuan Tsai, Joel Parker, Varun Vijay Prabhu, Joshua E. Allen, Douglas Lee, Chunxiao Zhou, Victoria Bae-Jump
Summary: ONC201 is a DRD2 antagonist that inhibits tumor growth through ClpP activation. DRD2 expression is associated with endometrial cancer progression. ONC201 shows anti-tumorigenic effects in both endometrial cancer cells and mouse models. The study supports DRD2 antagonism as a promising therapeutic strategy for endometrial cancer.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Multidisciplinary Sciences
Haining Lv, Guangfeng Zhao, Peipei Jiang, Huiyan Wang, Zhiyin Wang, Simin Yao, Zhenhua Zhou, Limin Wang, Dan Liu, Wenbo Deng, Jianwu Dai, Yali Hu
Summary: This study provides insights into the pathogenesis of thin endometrium, identifying decreased numbers of macrophages and natural killer cells, cellular senescence, and collagen overdeposition as key factors contributing to endometrial thinness. It also uncovers aberrant signaling pathways as potential causes for insufficient endometrial proliferation, thus offering therapeutic strategies for treating thin endometrium.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)