Article
Oncology
Alessandro Salvalaggio, Erica Silvestri, Giulio Sansone, Laura Pinton, Sara Magri, Chiara Briani, Mariagiulia Anglani, Giuseppe Lombardi, Vittorina Zagonel, Alessandro Della Puppa, Susanna Mandruzzato, Maurizio Corbetta, Alessandra Bertoldo
Summary: This study combines MRI with flow cytometry analysis to measure the infiltration of different leukocyte populations in glioblastoma (GBM) tumor tissues. The MRI features are significantly correlated with different myeloid cell populations, providing a potential new tool for investigating the microenvironment of GBM.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jescelica Ortiz Rivera, Grace Velez Crespo, Mikhail Inyushin, Yuriy Kucheryavykh, Lilia Kucheryavykh
Summary: In this study, the researchers found that there was significant upregulation of Pyk2 and FAK phosphorylation levels in recurrent tumors after surgical resection, compared with primary implanted tumors. They further demonstrated that the use of Pyk2/FAK inhibitors can suppress tumor growth and prolong survival in recurrent tumors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Xinyue Dong, Jun Ren, Zohreh Amoozgar, Somin Lee, Meenal Datta, Sylvie Roberge, Mark Duquette, Dai Fukumura, Rakesh K. Jain
Summary: Chimeric antigen receptor (CAR)-T cells have limited efficacy in treating glioblastoma (GBM) and other solid tumors due to the immunosuppressive tumor microenvironment (TME). Previous studies have shown that blocking vascular endothelial growth factor (VEGF) signaling can improve tumor vessel normalization and enhance the delivery of CD8+ T cells for effective immunotherapy. In this study, the researchers tested the hypothesis that anti-VEGF therapy can improve the delivery and efficacy of CAR-T cells in mice with GBM tumors, and found that it indeed enhanced CAR-T cell infiltration, delayed tumor growth, and prolonged survival.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Oncology
Joel R. Garbow, Tanner M. Johanns, Xia Ge, John A. Engelbach, Liya Yuan, Sonika Dahiya, Christina I. Tsien, Feng Gao, Keith M. Rich, Joseph J. H. Ackerman
Summary: The study showed that previous radiation can lead to aggressive tumor growth and decreased response to PD-L1 therapy in a mouse model. The (RIM)-M-2 model highlights the impact of radiation on subsequent tumor growth and immunotherapy response, emphasizing the need for further investigation into the effects of radiation on therapeutic efficacy.
FRONTIERS IN ONCOLOGY
(2021)
Review
Cell Biology
Joseph H. Garcia, Saket Jain, Manish K. Aghi
Summary: Glioblastoma is a deadly brain tumor with poor prognosis largely due to cellular invasion and metabolic adaptations. Recent studies have shown that metabolic reprogramming plays a role in GBM invasion and may offer novel therapeutic targets.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Oncology
Chen Zhao, Ronald N. Germain
Summary: Multiplex imaging is a valuable tool for studying the interactions among immune cells, stroma, and malignant cells within the tumor microenvironment. It holds significant promise for discovering biomarkers and therapeutic targets. However, challenges exist in study design, experiment optimization, and data analysis.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Biochemistry & Molecular Biology
Lucia Villamanan, Laura Martinez-Escardo, Carles Arus, Victor J. Yuste, Ana P. Candiota
Summary: In vitro experiments demonstrated that combined treatment may simultaneously release two potent immunogenic signals, potentially explaining its superior performance over single treatments in vivo.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Moloud Sooreshjani, Shashwat Tripathi, Corey Dussold, Hinda Najem, John de Groot, Rimas V. Lukas, Amy B. Heimberger
Summary: Glioblastoma, a highly infiltrative tumor, often recurs despite multi-modal treatment. Novel strategies incorporating cytokines as potential therapeutic options, including virotherapy, systemic cytokine therapy, and cellular and gene therapy, are being explored to improve treatment outcomes in glioblastoma patients.
Review
Biochemistry & Molecular Biology
Mark L. Sowers, Lawrence C. Sowers
Summary: Glioblastoma is a deadly brain tumor with poor prognosis. Current research focuses on the dependence of glioblastoma on exogenous methionine as a potential therapeutic target. However, methionine depletion may have complex and potentially undesirable effects, requiring further study.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
John J. Walsh, Maxime Parent, Adil Akif, Lucas C. Adam, Samuel Maritim, Sandeep K. Mishra, Muhammad H. Khan, Daniel Coman, Fahmeed Hyder
Summary: The multifaceted changes in vascularity, cellularity, and metabolism in glioblastoma progression were captured using MRI and MRSI methods. Each tumor showed unique spatiotemporal patterns in tumor perfusion, permeability, cellularity, and extracellular pH, which can be useful for exploring tumorigenesis and developing targeted therapies for specific aspects of the tumor microenvironment.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Audrey Grossen, Kyle Smith, Nangorgo Coulibaly, Benjamin Arbuckle, Alexander Evans, Stefan Wilhelm, Kenneth Jones, Ian Dunn, Rheal Towner, Dee Wu, Young-Tae Kim, James Battiste
Summary: The invasive capabilities of glioblastoma (GBM) determine its aggressiveness, treatment resistance, and overall mortality. The tumor microenvironment influences the molecular behavior of cells, both epigenetically and genetically. This review outlines the advances made in understanding the physical forces involved in GBM and highlights the need for further research to target these forces and improve patient outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Susan Brandenburg, Anne Blank, Alexander D. Bungert, Peter Vajkoczy
Summary: This article summarizes current research on methods to differentiate brain resident microglia from tumor-infiltrated macrophages, as well as their proportions and functional activities in glioma tissues.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nanoscience & Nanotechnology
Qianqian Sun, Bin Liu, Ruoxi Zhao, Lili Feng, Zhao Wang, Shuming Dong, Yushan Dong, Shili Gai, He Ding, Piaoping Yang
Summary: Mitochondria play a crucial role in cell function by maintaining Ca2+ homeostasis and disrupting this balance can lead to tumor cell death. Calcium overload in tumor cells and tissue calcification inhibit tumor growth and can be used as contrast agents for computed tomography imaging.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Review
Oncology
Ashley B. B. Zhang, Khashayar Mozaffari, Brian Aguirre, Victor Li, Rohan Kubba, Nilay C. Desai, Darren Wei, Isaac Yang, Madhuri Wadehra
Summary: Glioblastoma, the most common malignant primary brain tumor, has a poor prognosis despite advancements in treatment. Angiogenesis, particularly involving vascular endothelial growth factor-A (VEGF-A), plays a critical role in the growth and invasion of glioblastoma cells. Bevacizumab, a medication targeting VEGF-A, has been approved for recurrent glioblastoma but has not significantly improved survival. Other agents with similar mechanisms of action have also shown unfavorable results. This review explores the current state and future potential of anti-angiogenesis therapeutic agents.
Review
Biochemistry & Molecular Biology
Takayuki Morimoto, Tsutomu Nakazawa, Ryosuke Maeoka, Ichiro Nakagawa, Takahiro Tsujimura, Ryosuke Matsuda
Summary: Glioblastoma (GBM) is an aggressive and malignant brain tumor with poor prognosis. Various treatment strategies have been explored, including immunotherapies. However, current immunotherapies mainly based on T cells have not achieved satisfactory outcomes. This review focuses on the potential of NK cell-based immunotherapy as a novel treatment strategy for GBM.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Richard L. Daniels, Yoshio Takashima, David D. McKemy
JOURNAL OF BIOLOGICAL CHEMISTRY
(2009)
Article
Multidisciplinary Sciences
Wendy M. Knowlton, Richard L. Daniels, Radhika Palkar, Daniel D. McCoy, David D. McKemy
Article
Multidisciplinary Sciences
Steven G. Cresawn, Welkin H. Pope, Deborah Jacobs-Sera, Charles A. Bowman, Daniel A. Russell, Rebekah M. Dedrick, Tamarah Adair, Kirk R. Anders, Sarah Ball, David Bollivar, Caroline Breitenberger, Sandra H. Burnett, Kristen Butela, Deanna Byrnes, Sarah Carzo, Kathleen A. Cornely, Trevor Cross, Richard L. Daniels, David Dunbar, Ann M. Findley, Chris R. Gissendanner, Urszula P. Golebiewska, Grant A. Hartzog, J. Robert Hatherill, Lee E. Hughes, Chernoh S. Jalloh, Carla De Los Santos, Kevin Ekanem, Sphindile L. Khambule, Rodney A. King, Christina King-Smith, Karen Klyczek, Greg P. Krukonis, Christian Laing, Jonathan S. Lapin, A. Javier Lopez, Sipho M. Mkhwanazi, Sally D. Molloy, Deborah Moran, Vanisha Munsamy, Eddie Pacey, Ruth Plymale, Marianne Poxleitner, Nathan Reyna, Joel F. Schildbach, Joseph Stukey, Sarah E. Taylor, Vassie C. Ware, Amanda L. Wellmann, Daniel Westholm, Donna Wodarski, Michelle Zajko, Thabiso S. Zikalala, Roger W. Hendrix, Graham F. Hatfull
Article
Biochemistry & Molecular Biology
Amber M. Tavener, Megan C. Phelps, Richard L. Daniels
Summary: Anthracyclines show cytotoxic effects on GL261 glioma cells, inducing apoptosis in a dose-dependent manner; however, high concentrations may lead to cell necrosis. Results support further exploration of anthracyclines as potential compounds for improved GBM treatments.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Oncology
Averey D. Strong, Richard L. Daniels
Article
Neurosciences
Yoshio Takashima, Richard L. Daniels, Wendy Knowlton, James Teng, Emily R. Liman, David D. McKemy
JOURNAL OF NEUROSCIENCE
(2007)
Article
Neurosciences
Richard L. Daniels, David D. McKemy