Add-on tocilizumab versus conventional treatment for systemic sclerosis, and cytokine analysis to identify an endotype to tocilizumab therapy

Safety and efficacy of subcutaneous tocilizumab in adults with systemic sclerosis (faSScinate): a phase 2, randomised, controlled trial

(2016) Dinesh Khanna et al.   LANCET

Serum chemokine levels as prognostic markers in patients with early systemic sclerosis: a multicenter, prospective, observational study

(2014) Minoru Hasegawa et al.   Modern Rheumatology

Expansion of range of joint motion following treatment of systemic sclerosis with tocilizumab

(2014) Yoshihito Shima et al.   Modern Rheumatology

Synovial phenotypes in rheumatoid arthritis correlate with response to biologic therapeutics

(2014) Glynn Dennis et al.   ARTHRITIS RESEARCH & THERAPY

Baseline levels of soluble interleukin-6 receptor predict clinical remission in patients with rheumatoid arthritis treated with tocilizumab: implications for molecular targeted therapy

(2013) Naoshi Nishina et al.   ANNALS OF THE RHEUMATIC DISEASES

Tocilizumab monotherapy versus adalimumab monotherapy for treatment of rheumatoid arthritis (ADACTA): a randomised, double-blind, controlled phase 4 trial

(2013) Cem Gabay et al.   LANCET

Interleukin-13-producing CD8+ T cells mediate dermal fibrosis in patients with systemic sclerosis

(2012) Patrizia Fuschiotti et al.   ARTHRITIS AND RHEUMATISM

T cells in systemic sclerosis: a reappraisal

(2012) S. O'Reilly et al.   RHEUMATOLOGY

Blockade of Interleukin-6 Receptor Alleviates Disease in Mouse Model of Scleroderma

(2011) Shun Kitaba et al.   AMERICAN JOURNAL OF PATHOLOGY

Interstitial lung disease in systemic sclerosis

(2010) Guillaume Bussone et al.   AUTOIMMUNITY REVIEWS

The skin of patients with systemic sclerosis softened during the treatment with anti-IL-6 receptor antibody tocilizumab

(2010) Y. Shima et al.   RHEUMATOLOGY

Effector CD8+ T cells in systemic sclerosis patients produce abnormally high levels of interleukin-13 associated with increased skin fibrosis

(2009) Patrizia Fuschiotti et al.   ARTHRITIS AND RHEUMATISM

Plasma cytokine profiles in systemic sclerosis: associations with autoantibody subsets and clinical manifestations

(2009) Pravitt Gourh et al.   ARTHRITIS RESEARCH & THERAPY