Editorial Material
Biochemistry & Molecular Biology
Richard Huskey
Summary: Gossip is more than just trash talk, it can influence behavior, foster cooperation, and increase group affiliation.
Article
Oncology
Saisai Guo, Linna Zhang, Na Li
Summary: This article reviews the role of ANO1 in various malignant tumors, including replication, proliferation, invasion, and apoptosis. The expression of ANO1 is controlled by various molecules and stimuli, with different regulatory mechanisms in different tumor cells. Studies have shown that ANO1 exerts its effects through multiple pathways and signaling pathways, and has functions in resisting apoptosis and promoting immune escape. Further research on the channels and protein activity mechanism of ANO1, as well as the development of ANO1 inhibitors, is of great significance for revealing its tumor-promoting mechanism.
FRONTIERS IN ONCOLOGY
(2022)
Article
Clinical Neurology
Valentina Zschernack, Stephanie T. Junger, Martin Mynarek, Stefan Rutkowski, Maria Luisa Garre, Martin Ebinger, Marie Neu, Joerg Faber, Bernhard Erdlenbruch, Alexander Claviez, Stefan Bielack, Triantafyllia Brozou, Michael C. Fruehwald, Evelyn Doerner, Verena Dreschmann, Annika Stock, Laszlo Solymosi, Juergen Hench, Stephan Frank, Christian Vokuhl, Andreas Waha, Felipe Andreiuolo, Torsten Pietsch
Summary: Two distinct genetically defined entities of ependymoma in the supratentorial compartment, characterized by a C11orf95-RELA or a YAP-MAMLD1 fusion, have been identified. However, this study shows the existence of at least two more types (RELA-like and tanycytic) of supratentorial ependymomas without these genetic features.
ACTA NEUROPATHOLOGICA
(2021)
Review
Oncology
Margarita Artemenko, Sophia S. W. Zhong, Sally K. Y. To, Alice S. T. Wong
Summary: p70(S6K) plays a critical role in protein synthesis, cell growth, and cancer progression, and its activation is associated with poor prognosis in certain cancer types. In addition to mTOR-targeted drugs, there are emerging p70(S6K)-selective drugs under development.
Article
Biochemistry & Molecular Biology
Elis Cristina Araujo Eleutherio, Rayne Stfhany Silva Magalhaes, Aline de Araujo Brasil, Jose Raphael Monteiro Neto, Luan de Holanda Paranhos
Summary: During cellular respiration, radicals like superoxide can cause cell damage, but cells use the enzyme Cu/Zn Superoxide Dismutase (SOD1) to convert superoxide into oxygen and hydrogen peroxide. In addition to its primary function, SOD1 also plays other roles, such as activating gene transcription or functioning as an RNA binding protein.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Biochemistry & Molecular Biology
Guillermo H. Jimenez Aleman, Venkatesh P. Thirumalaikumar, Georg Jander, Alisdair R. Fernie, Aleksandra Skirycz
Summary: The oxylipin 12-oxo-phytodienoic acid (OPDA) is a biosynthetic precursor of the plant hormone jasmonic acid, but also functions as a signaling molecule independent of jasmonates. OPDA is involved in various biological processes across plant species, including defense and stress responses, growth regulation, and development. This article summarizes what is known about OPDA metabolism and signaling, discussing its jasmonate dependent and independent roles, as well as open questions regarding the OPDA protein interactome and biological roles of OPDA conjugates.
Review
Immunology
Le Xiong, Stephen L. L. Nutt, Cyril Seillet
Summary: Innate lymphoid cells (ILCs) serve as a link between sensory cells and effector cells, contributing to tissue homeostasis and adaptation to changing environmental conditions. Studying the non-canonical functions of these cells provides insights into their regulation and adaptability.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Matthias W. Laschke, Thomas Spaeter, Michael D. Menger
Summary: Adipose tissue-derived microvascular fragments have the ability to rapidly reassemble into microvascular networks, exhibit angiogenic activity, and serve as a source of endothelial progenitor cells and multipotent mesenchymal stromal cells. They also play a crucial role in tissue integration of implanted biomaterials.
TRENDS IN BIOTECHNOLOGY
(2021)
Review
Microbiology
J. Knisz, R. Eckert, L. M. Gieg, A. Koerdt, J. S. Lee, E. R. Silva, T. L. Skovhus, B. A. An Stepec, S. A. Wade
Summary: Microbiologically influenced corrosion (MIC) is a growing concern affecting various materials and sectors. Despite the global efforts to address MIC, there is limited interdisciplinary collaboration and information sharing. This review emphasizes the importance of non-biological aspects in understanding MIC and proposes approaches to tackle MIC-related challenges. It also highlights the need for microbiologists' expertise in advancing this field. Overall, this review aims to bridge the siloed nature of MIC research and encourage microbiologists to contribute to this important topic.
FEMS MICROBIOLOGY REVIEWS
(2023)
Editorial Material
Hematology
Bethany T. Samuelson Bannow
Summary: In the largest meta-analysis to date on the topic, Valeriani et al identified 4 clear benefits of using anticoagulation to treat splanchnic vein thrombosis (SVT), including increased recanalization, decreased thrombosis progression, decreased major bleeding, and decreased mortality.
Review
Cell Biology
Tautvydas Paskevicius, Rabih Abou Farraj, Marek Michalak, Luis B. Agellon
Summary: Calnexin is an integral ER membrane protein with distinct domains in the ER lumen and cytosol. It acts as a chaperone for folding and quality control of proteins, similar to calreticulin. Recent studies have shown that the cytosolic domain of calnexin undergoes post-translational modifications and interacts with various proteins, suggesting its role in coordinating ER functions with cytosolic events.
Editorial Material
Oncology
Song Chen, Andrew D. Luster
Summary: The study identifies that histamine released during allergic reactions and from tumor cells weakens the response to immunotherapy. Histamine H-1-receptor signaling induces a suppressive phenotype in tumor-associated macrophages and increases VISTA expression, thereby suppressing CD8(+) T cell function. Anti-histamines can reverse these effects and improve the efficacy of immunotherapy.
Review
Biochemistry & Molecular Biology
Yu-Hsuan Lee, Daan Ren, Byungsun Jeon, Hung-wen Liu
Summary: This review summarizes recent advances in the study of S-adenosyl-l-methionine (SAM) utilizing enzymes. SAM is a naturally occurring molecule that is commonly associated with methyltransfer reactions. However, it has been found that SAM can also donate other moieties during natural product biosynthetic reactions. The review focuses on the discovery of novel SAM utilizing enzymes and the role of SAM in sulfonium chemistry.
NATURAL PRODUCT REPORTS
(2023)
Review
Endocrinology & Metabolism
Hannah A. Taylor, Lena Przemylska, Eva M. Clavane, Paul J. Meakin
Summary: This review focuses on the research of beta-site amyloid precursor protein cleaving enzyme-1 (BACE1) and its role in metabolic diseases. It discusses the regulation of BACE1, its effect on metabolism, and the possibility of using BACE1 inhibitors as a treatment for obesity and its comorbidities. The study finds that BACE1 is expressed not only in the brain but also in various cell types, and its dysregulation is implicated in the development of metabolic diseases. Additionally, BACE1 knockout models and clinical trials of BACE1 inhibitors suggest a physiological role of BACE1 in energy metabolism and weight regulation.
Review
Agriculture, Multidisciplinary
Beatriz Gonzalez-Munoz, Fernanda Garrido-Vargas, Carolina Pavez, Fernando Osorio, Jianshe Chen, Edmundo Bordeu, Jose A. O'Brien, Natalia Brossard
Summary: Red wines are characterized by astringency, which is influenced by factors like tannins, salivary proteins, and anthocyanins. These interactions lead to different tactile sensations and require further research, particularly regarding the origins and development of astringency.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2022)
Article
Pathology
Juliana Mota Siqueira, Yoshitsugu Mitani, Camilla Oliveira Hoff, Flavia Bonini, Luana Guimaraes de Sousa, Mario L. Marques-Piubelli, Anurag Purushothaman, Mutsumi Mitani, Hui Dai, Shiaw-Yih Lin, Michael T. Spiotto, Ehab Y. Hanna, Daniel J. McGrail, Adel K. El-Naggar, Renata Ferrarotto
Summary: B7-H4 expression pattern varies among different types of salivary gland carcinomas, and high B7-H4 expression is associated with poor prognosis in adenoid cystic carcinoma.
Article
Pathology
Basile Tessier-Cloutier, Felix K. F. Kommoss, David L. Kolin, Kristyna Nemejcova, Dupreez Smith, Jennifer Pors, Colin J. R. Stewart, W. Glenn Mccluggage, William D. Foulkes, Andreas von Deimling, Martin Kobel, Cheng-Han Lee
Summary: This study provides a detailed analysis of the clinical, pathological, immunohistochemical, and molecular features of DDOC/UDOC. The majority of patients presented with extraovarian disease and had rapid disease progression resulting in high mortality rate.
Review
Pathology
Sophia J. Wagner, Christian Matek, Sayedali Shetab Boushehri, Melanie Boxberg, Lorenz Lamm, Ario Sada, Dominik J. E. Winter, Carsten Marr, Tingying Peng
Summary: Computational pathology research driven by deep learning faces challenges in reproducibility and reusability. Codebase with good documentation and robustness and generalizability of models are crucial. The reuse of computational pathology algorithms is limited, and their application in clinical settings is even rarer. This study evaluates 160 peer-reviewed articles, providing criteria for data and code availability and statistical analysis of results.
Article
Pathology
Andres M. Acosta, Lynette M. Sholl, Fiona Maclean, Chia-Sui Kao, Thomas M. Ulbright
Summary: This study assessed the clinicopathologic and genomic features of 14 cases of testicular sex cord-stromal tumors. The results showed that CTNNB1 mutations are rare in these tumors, and most of them have genomic alterations similar to testicular sex cord-stromal tumors with pure or predominant spindle cell components.
Article
Pathology
Toru Odate, Kaishi Satomi, Takashi Kubo, Yuko Matsushita, Toshihide Ueno, Akira Kurose, Kohei Shomori, Tokiko Nakai, Reiko Watanabe, Keiko Segawa, Shusa Ohshika, Naritomo Miyake, Sayaka Kudo, Tatsunori Shimoi, Eisuke Kobayashi, Motokiyo Komiyama, Seiichi Yoshimoto, Fumihiko Nakatani, Akira Kawai, Yasushi Yatabe, Shinji Kohsaka, Koichi Ichimura, Hitoshi Ichikawa, Akihiko Yoshida
Summary: Inflammatory rhabdomyoblastic tumors (IRMTs) are newly recognized skeletal muscle tumors with uncertain malignant potential. This study investigated 13 IRMTs using clinicopathologic, genetic, and epigenetic methods. The results showed specific histologic features and genetic mutations in these tumors, and most of them exhibited benign behavior.
Article
Pathology
Dale L. Davis, Adam C. Lechner, David B. Chapel, Jonathan C. Slack, Chrystalle Katte Carreon, Bradley J. Quade, Carlos Parra-Herran
Summary: The Amsterdam Consensus Statement introduced the term maternal vascular malperfusion (MVM) to classify a group of findings related to impaired maternal-placental circulation. The study found that features such as low placental weight, accelerated villous maturation, decidual arteriopathy, and infarcts are associated with adverse obstetrical outcomes, while the role of other features like distal villous hypoplasia, excess multinucleated trophoblast, and retroplacental hemorrhage needs further research.
Review
Pathology
Alain C. Borczuk
Summary: COVID-19 is an acute respiratory illness that can progress to acute respiratory distress syndrome. While most patients recover completely, some may experience persistent respiratory dysfunction, known as long COVID. The pathogenesis involves immune and cellular disturbances.
Article
Pathology
Annikka Weissferdt, Cheuk H. Leung, Heather Lin, Boris Sepesi, William N. William, Stephen G. Swisher, Tina Cascone, J. Jack Lee, Abujiang Pataer
Summary: Neoadjuvant treatment of non-small cell lung cancer challenges traditional processing of pathology specimens, and accurate evaluation of residual tumor is crucial for assessing treatment efficacy.
