Journal
MICROFLUIDICS AND NANOFLUIDICS
Volume 22, Issue 3, Pages -Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s10404-018-2049-1
Keywords
Valve; Point-of-care; Nitinol; Sel-actuated; PDMS
Funding
- MedEl Corporate Grant [FK2350]
- NIH [R01NS092726]
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Various microfluidic architectures designed for in vivo and point-of-care diagnostic applications require larger channels, autonomous actuation, and portability. In this paper, we present a normally closed microvalve design capable of fully autonomous actuation for wide diameter microchannels (tens to hundreds of mu m). We fabricated the multilayer plunger-membrane valve architecture using the silicone elastomer, poly-dimethylsiloxane (PDMS) and optimized it to reduce the force required to open the valve. A 50-mu m Nitinol (NiTi) shape memory alloy wire is incorporated into the device and can operate the valve when actuated with 100-mA current delivered from a 3-V supply. We characterized the valve for its actuation kinetics using an electrochemical assay and tested its reliability at 1.5-s cycle duration for 1 million cycles during which we observed no operational degradation.
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