Journal
MICROCHIMICA ACTA
Volume 185, Issue 3, Pages -Publisher
SPRINGER WIEN
DOI: 10.1007/s00604-018-2729-2
Keywords
Pb2+ detection; Cyclic voltammetry; Electrochemical impedance spectroscopy; Bioassay; DNA template; Cu2O nanoparticles; Sensitivity; Selectivity; Reproducibility; Stability
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Funding
- Programs for the National Natural Science Foundation of China (NSFC) [U1604127, 21601161]
- Doctoral research foundation of Zhengzhou University of Light Industry [13501050056]
- Innovative Technology Team of Henan Province [CXTD2014042]
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The paper describes a one-step synthetic method to chemically reduce cupric sulfate by ascorbic acid in the presence of DNA strands to directly produce CuxO@DNA spheres. The DNA strands act as template to assist the preparation of CuxO, and also are capable of specifically binding Pb(II) ions. The CuxO@DNA spheres possess high specific surface area and strong bioaffinity. They can be directly employed as platform for detecting Pb2+ sensitively. Electrochemical impedance spectroscopy data showed that the assay exhibits high sensitivity and a wide linear analytical range that extends from 0.1 to 100 nM, and the detection limit is 6.8 pM at a signal-to-noise ratio of 3. The assay is selective, acceptably reproducible, stable, and well feasible for the detection of Pb2+ in blood serum.
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