Article
Chemistry, Multidisciplinary
Askal Maimulyanti, Isna Nurhidayati, Bella Mellisani, Fajar Amelia Rachmawati Putri, Fitria Puspita, Anton Restu Prihadi
Summary: NADES is used as a green solvent for extracting polyphenolic compounds from coffee husk waste. The best composition of NADES solvent is choline chloride and proline in a ratio of 1:1, resulting in a polyphenol concentration of 294.02 mg/L.
ARABIAN JOURNAL OF CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Paraskevi Siamandoura, Constantina Tzia
Summary: Natural deep eutectic solvents (NADES) combined with microwave-assisted extraction (MAE), ultrasound-assisted extraction (UAE), homogenate-assisted extraction (HAE), and high hydrostatic pressure-assisted extraction (HHPAE) were used to recover olive leaf phenolic compounds. The extracts were evaluated for their total phenol content (TPC), phenolic profile, and antioxidant activity, and compared with water and ethanol-water 70% extracts. HAE was found to be the most efficient method, and the highest TPC (55.12 +/- 1.08 mg GAE/g d.w.) was obtained from CCA extracts after HAE at 60 degrees C and 12,000 rpm. The highest antioxidant activity (3.32 +/- 0.39 g d.w./g DPPH) was found in CGL extracts after UAE at 60 degrees C for 30 min. Ethanol extracts generally had higher TPCs than NADES extracts. The main phenolic compounds in the extracts were oleuropein, hydrohytyrosol, and rutin.
Review
Food Science & Technology
Teresa Pinto, Alfredo Aires, Fernanda Cosme, Eunice Bacelar, Maria Cristina Morais, Ivo Oliveira, Jorge Ferreira-Cardoso, Rosario Anjos, Alice Vilela, Berta Goncalves
Summary: Polyphenols and volatile compounds are crucial for the quality and characteristics of vegetables and medicinal and aromatic plants, possessing various bioactivities and disease prevention properties. Researchers are focusing on polyphenols, volatile compounds, and the new challenges in enhancing positive characteristics of plants.
Article
Plant Sciences
Monica Patricia Antonella Carabajal, Janet Piloto-Ferrer, Heloiza Diniz Nicollela, Iara Silva Squarisi, Ana Paula Prado Guissone, Tabata Rodrigues Esperandim, Denise Crispim Tavares, Maria Ines Isla, Iris Catiana Zampini
Summary: This study evaluated the antigenotoxic, antitumor, and anti-metastatic properties of Jarilla species from northwest Argentina and their herbal combination. The results showed that the herbal mixture exhibited cytotoxic effects against tumor cells without selective action on normal cells, and reduced tumor mass and metastatic nodules in a mouse model. These findings suggest that the combination of three Jarilla species could be a promising alternative for treating or slowing down the development of chronic diseases, such as cancer.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Hania Hamrouni, Khadija Ben Othman, Hasnia Benmoussa, Sourour Idoudi, Hanen Najjaa, Mohamed Neffati, Walid Elfalleh
Summary: Phytochemical screening of aqueous extract from six medicinal wild plants grown in South-eastern of Tunisia, including Atriplex halimus, Teucrium polium, Moricandia arvensis, Deverra tortuoa, Haplophyllum tuberculatum and Polygonum equisetiforme, was conducted using decoction and ultrasound assisted extraction methods. The antioxidant, antibacterial properties, and phenolic profiling were assessed, and the extracts of P. equisetiforme, T. polium, and H. tuberculatum showed the highest effectiveness as natural antioxidants. The ultrasonic extract of H. tuberculatum exhibited the highest antibacterial activity against P. aeruginosa and S. aureus. Additionally, 24 phenolic compounds were identified, with quinic acid, gallic acid, and protocatechuic acid being the predominant components.
CHEMISTRY & BIODIVERSITY
(2023)
Article
Chemistry, Applied
Joana Boiteux, Magdalena Espino, Silvana Azcarate, Maria Fernanda Silva, Federico J. V. Gomez, Pablo Pizzuolo, Maria de los Angeles Fernandez
Summary: Bioactive functional coatings, which reduce postharvest fruit losses and provide health benefits, have gained attention. This study optimized a bioactive coating based on Natural Deep Eutectic Solvents (NADES) and Larrea divaricata extract for managing postharvest diseases caused by Monilinia fructicola. The NADES composition was optimized using a Simplex Lattice design and response surface methodology, while the bioactive coating composition was optimized using a D-optimal mixture-mixture design. The optimal biocoating exhibited 72% in vitro antimicrobial activity against M. fructicola and had a smooth and uniform surface due to the NADES plasticizer.
Review
Biochemistry & Molecular Biology
Natalya Vinogradova, Elena Vinogradova, Victor Chaplygin, Saglara Mandzhieva, Pradeep Kumar, Vishnu D. Rajput, Tatiana Minkina, Chandra Shekhar Seth, Marina Burachevskaya, Dionise Lysenko, Rupesh Kumar Singh
Summary: This article analyzes the impact of anthropogenically transformed environment on the content of pharmaceutically valuable biologically active compounds in medicinal plants. The study focuses on phenolic compounds such as flavonoids, anthocyanins, tannins, and phenolic acids. The discharge of transmissible forms of heavy metals, including cadmium, lead, and mercury, from factories has led to contamination of soil. This affects the activity of enzymes involved in the biosynthesis of phenolic compounds in medicinal plants, resulting in changes in their quantity.
Article
Chemistry, Multidisciplinary
Hisako Okumura
Summary: This article emphasizes the importance of utilizing phenolic compounds derived from plants to generate green materials, discussing their potential role as adsorbents and future tools, summarizing various studies on their interactions with metal ions, and exploring research and development of new electronic devices.
CURRENT OPINION IN GREEN AND SUSTAINABLE CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Ines Mansinhos, Sandra Goncalves, Raquel Rodriguez-Solana, Jose Luis Ordonez-Diaz, Jose Manuel Moreno-Rojas, Anabela Romano
Summary: The combination of ultrasound-assisted extraction (UAE) and natural deep eutectic solvents (NADES) was found to be effective in extracting phenolic compounds from Lavandula pedunculata subsp. lusitanica, resulting in high antioxidant activity and enzyme inhibitory capacity. Organic acid-based NADES showed to be the best extractants producing extracts with considerable ability to inhibit enzymes.
Article
Biochemistry & Molecular Biology
Mariana Leal, Maria Alejandra Moreno, Patricia Liliana Albornoz, Maria Ines Mercado, Iris Catiana Zampini, Maria Ines Isla
Summary: Tobacco cultivation and industrialization generate a large amount of waste biomass every year, which has detrimental effects on the environment. This study aimed to extract bioactive compounds, such as polyphenols and alkaloids, from pre-harvest tobacco leaf waste using conventional and green solvents (NaDES), indicating their potential use in cosmetics.
Article
Plant Sciences
Mariana Leal, Maria Alejandra Moreno, Patricia Liliana Albornoz, Maria Ines Mercado, Iris Catiana Zampini, Maria Ines Isla
Summary: The production of smokeable tobacco for cigarettes leads to environmental damage due to the production of pre-harvest and post-harvest waste. However, using green solvents like Natural deep eutectic solvents (NaDESs), antioxidant molecules can be extracted from this waste, leading to potential use in cosmetics. The characterization of tobacco inflorescences and inflorescence powders shows their potential as a plant matrix for obtaining valuable metabolites.
Article
Biochemistry & Molecular Biology
Iva Rukavina, Maria Joao Rodrigues, Catarina G. Pereira, Ines Mansinhos, Anabela Romano, Sylwester Slusarczyk, Adam Matkowski, Luisa Custodio
Summary: Natural deep eutectic solvents (NADES) composed of choline chloride, sucrose, fructose, glucose, and xylose were used to extract antioxidants from sea knotgrass in this study. The NADES extracts showed higher antioxidant activity compared to conventional solvents, with ChCl:fructose being the most efficient in the radical scavenging assay. The phenolic composition of NADES extracts was less complex but contained similar proportions of major antioxidants like flavonols and flavan-3-ols compared to conventional extracts.
Article
Food Science & Technology
Beatriz H. Paschoalinotto, Maria Ines Dias, Jose Pinela, Tania C. S. P. Pires, Maria Jose Alves, Andrei Mocan, Ricardo C. Calhelha, Lillian Barros, Rafael P. Ineu, Isabel C. F. R. Ferreira
Summary: This study explored the chemical composition and bioactive properties of several medicinal and aromatic plants in tisane form, with T5 showing the highest concentration of active compounds. T2 and T4 were highlighted for their antihemolytic, antimicrobial, and cytotoxic activities.
Article
Biochemistry & Molecular Biology
Pritika Mala, Gausal A. Khan, Romila Gopalan, Desta Gedefaw, Katy Soapi
Summary: Medicinal plants are natural sources of active compounds that have the potential to alleviate various illnesses, including diabetes. This study investigated the antidiabetic potential of Fijian medicinal plants and found that some of them showed significant inhibitory effects on enzymes linked to Type 2 diabetes.
BIOSCIENCE REPORTS
(2022)
Review
Agriculture, Multidisciplinary
Ali Ali Redha
Summary: This literature review discusses the extraction of phenolic compounds using green deep eutectic solvents, including their composition, factors affecting extraction, and extraction conditions.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Chemistry, Applied
Nadjama B. do Prado, Claudia B. de Abreu, Cyndi S. Pinho, Manoel M. de N. Junior, Mariana D. Silva, Magdalena Espino, Maria F. Silva, Fabio de S. Dias
Summary: This study evaluated the effects of metals aluminum, lead, and cadmium on the synthesis of phenolic compounds and dry mass in basil plants grown in a hydroponic system. The metals promoted a stress condition in the plants, reducing dry matter mass and increasing the synthesis of phenolic compounds according to metal type and concentration.
Review
Chemistry, Analytical
Rodrigo F. da Silva, Candice N. Carneiro, Cheila B. do C. de Sousa, Federico J. Gomez, Magdalena Espino, Joana Boiteux, Maria de los A. Fernandez, Maria F. Silva, Fabio de S. Dias
Summary: This review article provides an overview of the green procedures applied in the extraction of bioactive compounds in medicinal plants using environmentally friendly solvents and assisted techniques. The aim of green procedures is to design safer and higher quality extraction methods with less negative impact on the environment.
MICROCHEMICAL JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Ricardo Elia Dazat, Ezequiel Vidal, Anabela S. Lorenzetti, Carlos D. Garcia, Claudia Domini, Maria F. Silva, Federico J. Gomez
Summary: Natural Deep Eutectic Solvents (NADES) are one of the greenest solvents, but their synthesis typically requires access to power. This report describes a method using a 3D-printed solar concentrator for on-site preparation of NADES, which not only provides a simple way to adjust synthetic conditions but also represents the greenest method reported to date.
Article
Biotechnology & Applied Microbiology
Neuls Mayer Morgana, Espino Magdalena, Maria de los Angeles Fernandez, Silva Maria Fernanda
Summary: There is an urgent need to replace synthetic food additives with natural-based alternatives, and utilizing biocompounds from byproducts as bioadditives in the food industry represents a significant opportunity.
FOOD AND BIOPRODUCTS PROCESSING
(2022)
Article
Food Science & Technology
Silvana M. Azcarate, Ricardo Elia Dazat, Jose M. Camina, Maria Fernanda Silva, Federico J. V. Gomez
Summary: This study presents a smart approach using Natural Deep Eutectic Solvents (NADES) to modify the electrolyte and obtain an array of sensors, which improve the electrochemical detection. Four NADES electrochemical sensors were applied for honey heat alteration detection, achieving an optimal performance with an accuracy of 0.97 through data fusion strategies.
Article
Chemistry, Physical
Brenda V. Canizo, Pamela Y. Quintas, Rodolfo G. Wuilloud, Maria Fernanda Silva, Federico J. V. Gomez
Summary: This research provides the first comprehensive study on the fluorescence characteristics of melatonin and its derivatives in natural deep eutectic solvents. The results show differential fluorescence behavior of melatonin and its metabolic precursors in these solvents, which could inspire the development of new analytical approaches.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Biochemistry & Molecular Biology
Candice N. Carneiro, Federico J. Gomez, Adrian Spisso, Maria Fernanda Silva, Jorge L. O. Santos, Fabio de S. Dias
Summary: Microwave-induced plasma optical emission spectrometry was used to determine multiple elements in South American wine samples. Logistic regression, support vector machine, and decision tree algorithms were applied to differentiate red wine samples by region of origin. The method's accuracy was evaluated by comparing the results with ICP OES analysis.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Chemistry, Applied
Joana Boiteux, Magdalena Espino, Silvana Azcarate, Maria Fernanda Silva, Federico J. V. Gomez, Pablo Pizzuolo, Maria de los Angeles Fernandez
Summary: Bioactive functional coatings, which reduce postharvest fruit losses and provide health benefits, have gained attention. This study optimized a bioactive coating based on Natural Deep Eutectic Solvents (NADES) and Larrea divaricata extract for managing postharvest diseases caused by Monilinia fructicola. The NADES composition was optimized using a Simplex Lattice design and response surface methodology, while the bioactive coating composition was optimized using a D-optimal mixture-mixture design. The optimal biocoating exhibited 72% in vitro antimicrobial activity against M. fructicola and had a smooth and uniform surface due to the NADES plasticizer.
Article
Nutrition & Dietetics
Flavia E. Santiano, Maria de los Angeles Fernandez, Magdalena Espino, Leila E. Zyla, Lara Rey, Silvina E. Gomez, Flavia A. Bruna, Virginia Pistone-Creydt, Elisa Pietrobon, Rafael Perez Elizalde, Maria F. Silva, Ruben W. Caron, Constanza M. Lopez Fontana
Summary: This study aimed to examine the influence of Yerba mate (YM) intake on prostate cancer development. The results showed that YM slightly reduced body weight, delayed tumor appearance, and diminished tumor volume in both in vivo and in vitro models. YM also had anticancer effects on prostate cancer cell lines, especially the androgen-sensitive cell line.
Article
Chemistry, Multidisciplinary
Maria de los Angeles Fernandez, Joana Boiteux, Flavia Santiano, Constanza Lopez Fontana, Maria Fernanda Silva, Magdalena Espino
Summary: A THEDES based on plant extract was developed using an ultrasound-assisted approach. The optimized eutectic mixture showed a notable reduction in cell viability and proliferation, making it more effective than aqueous extract in inhibiting prostate cancer cells.
SUSTAINABLE CHEMISTRY AND PHARMACY
(2023)
Article
Chemistry, Analytical
Sabrina B. Mammana, M. Florencia Jofre, Ana C. Cohen, Federico J. V. Gomez, M. Fernanda Silva
Summary: The selective extraction and preconcentration of melatonin using HPB-NADES from PGPR cultures showed excellent selectivity, high extraction recovery, and sustainable methodology. The method exhibited favorable linearity, LOD, LOQ, and negligible matrix effects, highlighting the potential of environmentally friendly solvents and techniques in ensuring sustainability.
MICROCHEMICAL JOURNAL
(2023)
Article
Chemistry, Analytical
Michel Rocha Baqueta, Augusto Cesar Costa-Santos, Ana Paula Rebellato, Gisele Marcondes Luz, Juliana Azevedo Lima Pallone, Federico Marini, Alexsandro Lara Teixeira, Douglas N. Rutledge, Patricia Valderrama
Summary: This study reports the essential element composition of new Brazilian Canephora coffees and applies chemometric tools for analysis. The results demonstrate the suitability of this method for origin and species discrimination based on the inorganic fraction of coffee.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Mengjie Li, Jiapeng Wang, You Zhou, Yang Chen, Lingying Xia
Summary: A novel photoelectrochemical biosensor based on gold nanoparticles and specific structures was developed for highly sensitive detection of mercury ion. The multiple sandwich structures hindered electron supply and light harvesting, resulting in a weakened PEC signal, while the specific structures extinguished the PEC signal, enabling quantitative detection of Hg2+. The sensor exhibited high selectivity and stability, with potential applications in environmental detection, biological analysis, and medical research.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Mohamed A. Korany, Rasha M. Youssef, Marwa A. A. Ragab, Mostafa A. Afify
Summary: A stability-indicating fit-for-purpose method was developed for the determination of HC, TL, and PS in syrup dosage form. The method successfully separated CL from THY and quantified the analytes using HPLC-DAD. The robustness of the method was assessed through statistical analysis and self-validation.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Lingling Lin, Minyu Li, Ping Li, Chenqing Ye, Huanglong Zhuang, Shaohuang Weng, Feng Chen
Summary: This study developed a highly sensitive and selective electrochemical sensor for simultaneous detection of dopamine and uric acid. The sensor exhibited excellent anti-interference and stability, and could accurately measure dopamine and uric acid in human urine samples.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Peifang Chen, Caiyun Jiang, Zhouping Wang, Hong-zhen Lian, Xiaoyuan Ma
Summary: In this study, a high-performance SERS-active aptasensor was successfully developed for the quantitative analysis of AFB1 in cereal grains, which is of great significance in the field of food safety.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
E. Abas, C. Marina-Montes, C. Perez-Marin, J. Puimedon, J. Anzano
Summary: This study conducted a comprehensive measurement of natural and anthropogenic radionuclides in soil, water, and air in different locations around Deception Island in Antarctica. The results revealed significant levels of 210Pb and anthropogenic 137Cs in soil samples near old human settlements and facilities, as well as detectable levels of 137Cs and 60Co in water samples from old hunting areas. The findings also suggested potential resuspension processes based on higher-than-expected air quality results.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Joao Franciso Allochio, Nayara A. dos Santos, Nathalia dos S. Conceicao, Clara S. D. Baptista, Keyller B. Borges, Valdemar Lacerda Jr, Wanderson Roma
Summary: This study developed a fiber spray ionization mass spectrometry (FSI-MS) method, which shows great potential in detecting illicit drugs. Compared with paper spray ionization mass spectrometry (PSI-MS), FSI-MS demonstrates higher sensitivity in COC detection.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Dina A. Ahmed, Ola G. Hussein, Mamdouh R. Rezk, Mohamed Abdelkawy, Yasmin Rostom
Summary: The main goal of this study was to develop two green chromatographic techniques, HPLC and TLC, for the determination of alcaftadine (ALF) in pharmaceutical formulation and biological samples. The developed HPLC technique showed high efficiency and minimal environmental impact, successfully identifying ALF in the presence of its degradate. The TLC method provided a stability indicating study for ALF and was determined to be safe, green, and eco-friendly.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Abdullah Taner Bisgin
Summary: A green, speedy, and handy method for separation and determination of four commonly used food colorants was established using vortex assisted sequential-simultaneous liquid phase micro-extraction (VA-SS-LPME). The method does not require any instrumental chromatographic techniques. The procedure includes sequential separation steps using different extractants and simultaneous UV-vis spectrophotometric determination steps. The method is environmentally friendly and applicable for determination of colorants in food and pharmaceuticals.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Yifan Zhang, Tong Zhang, Wenjing Ba, Li Liu, Yuan Rao, Xiaodan Zhang, Hanhan Zhang, Xiu Jin
Summary: This paper proposes a novel spectral transfer modelling method based on neural network architecture searching for the asymptomatic prediction of Akizuki pear cork spot disorder. The experiments show that the model by this method is more effective, achieving an accuracy of 82.61%.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Krzysztof Greda, Maja Welna, Anna Szymczycha-Madeja, Pawel Pohl
Summary: For the first time, a dispersive micro-solid phase extraction (D-mu SPE) based on graphene oxide was used for the ultrasensitive determination of Cd. With this method, Cd can be efficiently extracted from a mixture of alkali and alkaline earth metals without the need for an elution step. The combination of D-mu SPE and SAGD OES significantly reduces matrix effects and improves the tolerance of Cd to alkali metals. The method shows simplicity in the measurement system and the commercially available nanosorbent used.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
P. K. Fathima Anjila, G. R. Tharani, Anand Sundaramoorthy, Venkat Kumar Shanmugam, Karthikeyan Subramani, Shanmugavel Chinnathambi, Ganesh N. Pandian, Vimala Raghavan, Andrews Nirmala Grace, Singaravelu Ganesan, Mangaiyarkarasi Rajendiran
Summary: This work proposes a rapid and sensitive spectroscopic method for detecting melamine in food products using rare-earth Terbium-doped Graphene Quantum Dots (Tb-GQDs) synthesized by microwave and simple chemical conjugation methods. The synthesized Tb-GQDs show a spherical shape with a size of approximately 6 nm and a quantum yield of 52%. The maximum detection limit for melamine concentration in milk and milk products is found to be 0.31 μM. The dual emitting Tb-GQDs provide a sensitive and effective platform for real-time detection of melamine in food samples, particularly in milk, and show promising potential in the food industry.
MICROCHEMICAL JOURNAL
(2024)
Review
Chemistry, Analytical
Piyush Dey, Mandeep Kaur, Akhil Khajuria, Dilmeet Kaur, Manpreet Singh, Hema Kumari Alajangi, Neha Singla, Gurpal Singh, Ravi Pratap Barnwal
Summary: Environmental issues, such as the uncontrolled release of dangerous pollutants, have significant impacts on human health. Traditional methods for detecting pollutants require specialized personnel and equipment, but nanotechnology has improved the performance of biosensors. This article discusses the use of nanotechnology in pollutant detection and the associated techniques.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Sa Dong, Qiuyun Shi, Lingjun Guan, Yulong Wang, Pengyan Liu, Cunzheng Zhang, Jianguo Feng
Summary: In this study, a highly sensitive indirect competitive chemiluminescence enzyme immunoassay (icCLEIA) method was developed for the determination of sodium pentachlorophenolate (PCP-Na) and its metabolite pentachlorophenol (PCP). The method showed high specificity and affinity with a detection limit of 0.0032 ng/mL for PCP-Na and 0.0192 ng/mL for PCP. The method had no cross reaction with other chlorophenols compounds except for PCP. The average recoveries in chicken, pork and fish samples were 81.3-105.8% with low coefficient of variation (CV).
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Palaniappan Ilayaraja, Murugan Manivannan, Paramasivam Parthiban
Summary: Nirmatrelvir, an antiviral drug used for the treatment of COVID-19, has been recommended by the World Health Organization. We developed an optimized analytical method for the quantification of Nirmatrelvir and its products, with high sensitivity and a wide linear range. The method also meets the requirements for greenness evaluation.
MICROCHEMICAL JOURNAL
(2024)
