Article
Biochemistry & Molecular Biology
Ayami Saga, Masahiro Koseki, Kotaro Kanno, Jiuyang Chang, Tomoaki Higo, Daisuke Okuzaki, Takeshi Okada, Hiroyasu Inui, Masumi Asaji, Katsunao Tanaka, Takashi Omatsu, Sae Nishihara, Yinghong Zhu, Kaori Ito, Hiroaki Hattori, Ikuyo Ichi, Yoshihiro Kamada, Masafumi Ono, Toshiji Saibara, Tohru Ohama, Shungo Hikoso, Makoto Nishida, Shizuya Yamashita, Yasushi Sakata
Summary: Patients with psoriasis are more prone to nonalcoholic fatty liver disease. A cholesterol derivative called 7-ketocholesterol (7KC) may exacerbate psoriasis-like dermatitis by accelerating steatohepatitis. These findings suggest a diet-related factor linking steatohepatitis and psoriasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Benjamin Ehst, Zhiping Wang, Justin Leitenberger, Danielle McClanahan, Rachel De La Torre, Erika Sawka, Alex G. Ortega-Loayza, Jennifer Strunck, Teri Greiling, Eric Simpson, Yuangang Liu
Summary: IL-23 plays a crucial role in Th17 immunity and inflammatory responses, especially in diseases like psoriasis. While dendritic cells are considered the main source of IL-23 in psoriasis, there is controversy surrounding the expression of IL-23 in psoriatic keratinocytes. Research has shown that a combination of TNF alpha and IL-17A can induce IL-23 production in human keratinocytes, with enhanced effects in psoriatic keratinocytes and EGFR signaling.
Article
Biochemistry & Molecular Biology
Olga M. Koper-Lenkiewicz, Kinga Sutkowska, Natalia Wawrusiewicz-Kurylonek, Ewa Kowalewska, Joanna Matowicka-Karna
Summary: Studies have shown that the relationship between SNPs in proinflammatory cytokines genes and susceptibility to developing RA is inconclusive and varies among different ethnic populations. These polymorphisms also have an impact on clinicopathological features of RA and patients' response to treatment. Further research on larger cohorts and diverse populations is needed to elucidate the role of these SNPs in RA patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Yu-Huei Huang, Lun-Ching Chang, Ya-Ching Chang, Wen-Hung Chung, Shun-Fa Yang, Shih-Chi Su
Summary: Alterations in gut microbiota composition and microbial-encoded metabolic pathways were observed in patients with psoriasis, and the impact of biologics on shaping gut microbiota was explored in this study. The results showed that the gut microbial compositions changed during the treatment period, and the relative abundance of individual taxa differed between patients receiving different inhibitors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Qing-Qing Yang, Hao-Nan Li, Yu-Tong Xia, Xue Tian, Fan Feng, Jian Yang, Ya-Li Xu, Juan Guo, Xiao-Qi Li, Jun-Yang Wang, Xiao-Yan Zeng
Summary: Our study reveals that rubral interleukin-6 (IL-6) plays a role in descending facilitation and pain sensation through the activation of JAK2/STAT3 and/or ERK pathways, resulting in the upregulation of spinal pro-inflammatory cytokines and downregulation of spinal anti-inflammatory cytokines. These findings provide potential therapeutic targets for the treatment of pathological pain.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Medicine, General & Internal
Gianluca Avallone, Carlo Alberto Maronese, Giulia Murgia, Carlo Giovanni Carrera, Luca Mastorino, Gabriele Roccuzzo, Paolo Dapavo, Silvia Alberti-Violetti, Pietro Quaglino, Simone Ribero, Angelo Valerio Marzano
Summary: This study aimed to compare the efficacy of IL-17 and IL-23 inhibitors in treating pustular and erythrodermic psoriasis. The results showed that IL-17 inhibitors had higher effectiveness in treating these conditions, while the efficacy of IL-23 inhibitors remains unknown.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Evelyn Kelemen, Eva Adam, Stella Marta Sagi, Aniko Goblos, Lajos Kemeny, Zsuzsanna Bata-Csorgo, Marta Szell, Judit Danis
Summary: Psoriasis is a chronic inflammatory skin disease influenced by both genetic and environmental factors. Increased levels of free nucleic acids in psoriatic skin are associated with IL-23 expression. The study reveals that free nucleic acids regulate IL-23 mRNA expression in epithelial keratinocytes through TLR3 receptor and specific signaling pathways, contributing to the development of an inflammatory milieu favorable for psoriatic symptoms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Dermatology
Hidehisa Saeki, Tomotaka Mabuchi, Akihiko Asahina, Masatoshi Abe, Atsuyuki Igarashi, Shinichi Imafuku, Yukari Okubo, Mayumi Komine, Shigetoshi Sano, Hideshi Torii, Akimichi Morita, Hiroshi Yotsuyanagi, Akira Watanabe, Mamitaro Ohtsuki
Summary: This article provides an overview of the development of biologics for psoriasis treatment in Japan and emphasizes the importance of considering factors such as efficacy, safety, convenience, and cost when selecting biologic therapies for patients.
JOURNAL OF DERMATOLOGY
(2022)
Article
Dermatology
Xingyu Zhu, Ruomei Han, Xiaoxue Tian, Mathias Hochgerner, Hui Li, Jiucun Wang, Jingjing Xia
Summary: Tapinarof has different effects on different types of psoriasis, inhibiting the development of IMQ-induced psoriatic dermatitis while aggravating the IL-23-injection model. This suggests that Tapinarof may have varying effects on different psoriasis subtypes.
EXPERIMENTAL DERMATOLOGY
(2023)
Article
Plant Sciences
Ying Feng, Han Dong, Liyan Zheng
Summary: Ligustrazine was found to inhibit inflammation in Endometriosis (EMs) by regulating the STAT3/IGF2BP1/RELA axis. These findings propose a new agent against EMs and support the development of ligustrazine-based treatment strategies for EMs.
PHARMACEUTICAL BIOLOGY
(2023)
Article
Dermatology
Jiao Chen, Jiaxi Du, Yiyang Han, Zhiping Wei
Summary: The serum levels of IL-35, IL-36 gamma, and CCL27 cytokines were evaluated in patients with psoriasis, showing correlations with disease severity. IL-36 gamma and CCL27 may act as pro-inflammatory factors in the pathogenesis of psoriasis, while IL-35 may function as an anti-inflammatory factor.
JOURNAL OF DERMATOLOGICAL TREATMENT
(2021)
Article
Immunology
Daiki Takezaki, Shin Morizane, Kenta Ikeda, Masanori Iseki, Yuma Sakamoto, Yoshio Kawakami, Taishi Hashiguchi, Yuka Shirakata, Sohji Nishina, Tomoyuki Mukai
Summary: This study explored the bidirectional association between non-alcoholic steatohepatitis (NASH) and psoriasis using a murine model. The results showed that NASH exacerbates psoriatic skin changes, accompanied by increased inflammatory cytokine levels and decreased adiponectin levels. Therefore, therapeutic intervention for co-occurring NASH is crucial for achieving a favorable prognosis of psoriasis in clinical practice.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Anissa Fries, Fanny Saidoune, Francois Kuonen, Isabelle Dupanloup, Nadine Fournier, Ana Cristina Guerra de Souza, Muzlifah Haniffa, Feiyang Ma, Johann E. Gudjonsson, Lennart Roesner, Yang Li, Thomas Werfel, Curdin Conrad, Raphael Gottardo, Robert L. Modlin, Jeremy Di Domizio, Michel Gilliet
Summary: This study establishes the role of interleukin 26 (IL-26) in the generation of IL-17A producing Th17 CD4(+) T cells, indicating its involvement in the pathogenic response of psoriasis. IL-26-producing cells infiltrate psoriatic skin and promote their own differentiation into IL17A-producing T(H)17 cells through epithelial crosstalk involving paracrine production of TGF-& beta;1.
NATURE COMMUNICATIONS
(2023)
Article
Medicine, General & Internal
Iwona Szydlowska, Marta Grabowska, Jolanta Nawrocka-Rutkowska, Andrzej Kram, Malgorzata Piasecka, Andrzej Starczewski
Summary: This study found that a good response to UPA treatment may be associated with a decrease of inflammatory markers, but it does not influence myoma vascularization.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Health Care Sciences & Services
Malgorzata Galecka, Katarzyna Blizniewska-Kowalska, Agata Orzechowska, Janusz Szemraj, Michael Maes, Michael Berk, Kuan-Pin Su, Piotr Galecki
Summary: This research study found that in depressed patients without coexisting inflammatory diseases, the gene expression levels of specific immune-inflammatory factors such as IL-17, IL-21, IL-23, and IL-35 were higher, while Foxp3 expression was lower. The duration of the disease appears to be more important than the severity of depression in relation to the expression of these genes. These findings suggest that specific inflammatory genes may play a role in the etiopathogenesis of depressive disorders.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Immunology
Carlos Henrique Camargo, Amanda Yaeko Yamada, Andreia Rodrigues de Souza, Claudio Tavares Sacchi, Alex Domingos Reis, Marlon Benedito Nascimento Santos, Denise Brandao de Assis, Eneas de Carvalho, Elizabeth Harummyy Takagi, Marcos Paulo Vieira Cunha, Monique Ribeiro Tiba-Casas
Summary: This study reveals the silent spread of New Delhi metallo-beta-lactamase (NDM) carbapenemase in Brazil, particularly in Enterobacterales other than Klebsiella spp. It highlights the diverse species and coexistence of important resistance genes in these NDM-producing strains. Prompt detection and effective measures are crucial to mitigate the further dissemination of NDM carbapenemase and preserve antimicrobial therapy options in hospital settings.
MICROBIOLOGY AND IMMUNOLOGY
(2024)