Article
Immunology
Xiao-Long Zhang, Jian An, Yong-Zhi Deng, Xuan-Zheng Fang, Cai-Yun Xu, Xu-Fang Liu, Ze-Hong Bai, Gang Zhang, Ming-Yuan Cui
Summary: Severe acute lung injury (ALI) is a major cause of morbidity and mortality worldwide. MicroRNAs (miRNAs) have been identified as potential biomarkers and therapeutic targets for ALI. This study reveals a significant role for the miR-762/NFIX pathway in the pathogenesis of ALI, suggesting that targeting this pathway could be beneficial for the diagnosis, prevention, and treatment of ALI.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Immunology
Zu -An Shi, Cheng-Xiu Yu, Zhi-Chao Wu, Chang -Lin Chen, Fa -Ping Tu, Yong Wan
Summary: The study investigated the protective effect of Fingolimod in a rat model of acute lung injury induced by LPS, showing inhibition of NF-kappa B activation, reduction of inflammatory cytokines, and improvement in lung tissue injury. These results suggest a promising therapeutic potential for Fingolimod in LPS-induced ALI by regulating the inflammatory pathway and barrier dysfunction of alveolar capillaries.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Plant Sciences
Dong Zhen, Chunyan Liu, Tianpeng Huang, Danni Fu, Xue Bai, Qianqian Ma, Mingyang Jiang, Guohua Gong
Summary: Ethanol extracts of Loulu flowers alleviated LPS-induced acute lung injury by suppressing inflammatory response and enhancing antioxidation capacity, which correlated with the MAPK/NF-kappa B and Nrf2/HO-1 signaling pathways.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Cell Biology
Xiaoling Li, Riming Huang, Kaifeng Liu, Mingyue Li, Hui Luo, Liao Cui, Lei Huang, Lianxiang Luo
Summary: Fucoxanthin alleviates lipopolysaccharide-induced acute lung injury by inhibiting inflammatory responses and the TLR4/MyD88 signaling axis, indicating a potential therapeutic strategy for controlling ALI.
Article
Plant Sciences
Tian-qi Xuan, Guohua Gong, Huanhuan Du, Chunyan Liu, Yun Wu, Guilan Bao, Qianqian Ma, Dong Zhen
Summary: This study aimed to investigate the potential of pteryxin in alleviating LPS-induced lung injury and explore the underlying mechanism. The results indicated that pteryxin effectively reduced the severity of lung injury by suppressing the MAPK/NF-κB signaling pathway and NLRP3 inflammasome activation.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Plant Sciences
Weiwei Zhu, Wu Luo, Jibo Han, Qiuyan Zhang, Lijun Ji, Aleksandr V. Samorodov, Valentin N. Pavlov, Zaishou Zhuang, Daona Yang, Lina Yin, Lijiang Huang, Guang Liang, Joo Young Huh, Yi Wang
Summary: This study investigated the anti-inflammatory mechanism of Schisandrin B (Sch B) in macrophages and an animal model of acute lung injury (ALI) and found that Sch B directly binds to MyD88 to regulate inflammatory responses and inhibit the expression of inflammatory factors. The study suggests that Sch B has therapeutic potential for ALI and other MyD88-dependent inflammatory diseases.
Article
Biochemistry & Molecular Biology
Qhaweni Dhlamini, Wei Wang, Guifeng Feng, Aiping Chen, Lei Chong, Xue Li, Quan Li, Jin Wu, Depu Zhou, Jie Wang, Hailin Zhang, Jin-San Zhang
Summary: This study demonstrates the protective effects of FGF1 pretreatment against acute lung injury (ALI) and its potential mechanisms involving anti-inflammatory and antioxidant effects.
MOLECULAR MEDICINE
(2022)
Article
Plant Sciences
Won Young Jang, Hwa Pyoung Lee, Seung A. Kim, Lei Huang, Ji Hye Yoon, Chae Yun Shin, Ankita Mitra, Han Gyung Kim, Jae Youl Cho
Summary: This study evaluated the anti-inflammatory effects of Angiopteris cochinchinensis de Vriese extract (Ac-EE) on acute lung injury (ALI) and demonstrated its potential as an effective botanical drug. Ac-EE reduced nitric oxide production and inhibited the production of proinflammatory mediators and cytokines. It also showed protective effects on lung tissue by reducing edema and lung injury.
Article
Chemistry, Medicinal
Jia-Luo Huang, Run-Zhu Fan, Yi-Hong Zou, Lei Zhang, Sheng Yin, Gui-Hua Tang
Summary: The study demonstrated that SA attenuated acute lung inflammation by suppressing the NF-kappa B pathway and activating the Nrf2 pathway.
PHYTOTHERAPY RESEARCH
(2021)
Article
Cell Biology
Jia Zhou, Zhengliang Peng, Jian Wang
Summary: The study showed that the DPP-4 inhibitor Trelagliptin has protective effects against LPS-induced ALI by reducing inflammation and oxidative stress, thereby improving the pathological condition of lung injury.
Article
Cell Biology
Jing Yue, Kai Su, Guangxin Zhang, Jinghui Yang, Chengbi Xu, Xueshibojie Liu
Summary: Dihydrotanshinone (DIH) can regulate LPS-induced acute lung injury (ALI) in mice by inhibiting the NF-κB signaling pathway.
Article
Veterinary Sciences
Qiu Zhong, Yaogui Sun, Yinlan Xu, Ajab Khan, Jianhua Guo, Zhirui Wang, Na Sun, Hongquan Li
Summary: Research demonstrates that Physalin can effectively treat LPS-induced acute lung injury by regulating a series of cellular pathways and protein expression, reducing inflammation and apoptosis in alveolar epithelial cells both in vivo and in vitro.
PAKISTAN VETERINARY JOURNAL
(2021)
Article
Cell Biology
Li Du, Jinrong Zhang, Xiyue Zhang, Chunyan Li, Qi Wang, Guangping Meng, Xingchi Kan, Jie Zhang, Yuxi Jia
Summary: In this study, it was found that oxypeucedanin could alleviate LPS-induced ALI by inhibiting the activation of inflammatory pathways and maintaining the integrity of the lung air-blood barrier.
Article
Agriculture, Multidisciplinary
Xiao Liu, Pei Yue Guan, Chun Ting Yu, Hao Yang, An Shan Shan, Xing Jun Feng
Summary: In this study, the researchers investigated the mechanism of curcumin in alleviating lung damage induced by lipopolysaccharide (LPS) in ducks. The results showed that dietary supplementation of curcumin significantly relieved oxidation stress and inflammation parameters in the lungs of ducks. The remission may be attributed to the activation of the nuclear erythroid 2-related factor 2 (Nrf2)-antioxidant reaction element (ARE) and nuclear factor kappa B (NF-kappa B) signaling pathways. This study provides insights into the potential application of curcumin in waterfowl feed.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2022)
Article
Medicine, Research & Experimental
Yan-yan Yu, Xiang-qian Li, Wen-peng Hu, Shi-chao Cu, Jia-jia Dai, Ya-nan Gao, Yi-ting Zhang, Xiao-yi Bai, Da-yong Shi
Summary: The NF-kappa B inhibitor 270 showed anti-inflammatory effects in LPS-induced AKI and ALI, improving pathological changes, reducing pro-inflammation gene expression, blocking NF-kappa B and JNK pathway activation, attenuating oxidative stress and autophagy inhibition, and reducing inflammation markers in plasma.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
