Cryptococcal pathogenic mechanisms: a dangerous trip from the environment to the brain

Global burden of disease of HIV-associated cryptococcal meningitis: an updated analysis

(2017) Radha Rajasingham et al.   LANCET INFECTIOUS DISEASES

Characterization of C-type lectins reveals an unexpectedly limited interaction between Cryptococcus neoformans spores and Dectin-1

(2017) Naomi M. Walsh et al.   PLoS One

Trojan Horse Transit Contributes to Blood-Brain Barrier Crossing of a Eukaryotic Pathogen

(2017) Felipe H. Santiago-Tirado et al.   mBio

The Metalloprotease, Mpr1, Engages AnnexinA2 to Promote the Transcytosis of Fungal Cells across the Blood-Brain Barrier

(2017) Sarisa Na Pombejra et al.   Frontiers in Cellular and Infection Microbiology

Capsule Enlargement in Cryptococcus neoformans Is Dependent on Mitochondrial Activity

(2017) Nuria Trevijano-Contador et al.   Frontiers in Microbiology

Dectin-3 Is Not Required for Protection against Cryptococcus neoformans Infection

(2017) Althea Campuzano et al.   PLoS One

Cryptococcosis

(2016) Eileen K. Maziarz et al.   INFECTIOUS DISEASE CLINICS OF NORTH AMERICA

Cryptococcus neoformans capsular polysaccharides form branched and complex filamentous networks viewed by high-resolution microscopy

(2016) Glauber R. de S. Araújo et al.   JOURNAL OF STRUCTURAL BIOLOGY

Cryptococcal transmigration across a model brain blood-barrier: evidence of the Trojan horse mechanism and differences between Cryptococcus neoformans var. grubii strain H99 and Cryptococcus gattii strain R265

(2016) Tania C. Sorrell et al.   MICROBES AND INFECTION

Fungal morphogenetic changes inside the mammalian host

(2016) Nuria Trevijano-Contador et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Fungal colonization of the brain: anatomopathological aspects of neurological cryptococcosis

(2015) ANA CAROLINE COLOMBO et al.   ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS

The formation of titan cells inCryptococcus neoformansdepends on the mouse strain and correlates with induction of Th2-type responses

(2015) Irene García-Barbazán et al.   CELLULAR MICROBIOLOGY

Cryptococcus neoformans–Induced Macrophage Lysosome Damage Crucially Contributes to Fungal Virulence

(2015) Michael J. Davis et al.   JOURNAL OF IMMUNOLOGY

Comparative analyses of clinical and environmental populations ofCryptococcus neoformansin Botswana

(2015) Yuan Chen et al.   MOLECULAR ECOLOGY

The endosomal sorting complex required for transport machinery influences haem uptake and capsule elaboration inCryptococcus neoformans

(2015) Guanggan Hu et al.   MOLECULAR MICROBIOLOGY

Polyploid Titan Cells Produce Haploid and Aneuploid Progeny To Promote Stress Adaptation

(2015) Aleeza C. Gerstein et al.   mBio

Protein Composition of Infectious Spores Reveals Novel Sexual Development and Germination Factors in Cryptococcus

(2015) Mingwei Huang et al.   PLoS Genetics

Chitin Recognition via Chitotriosidase Promotes Pathologic Type-2 Helper T Cell Responses to Cryptococcal Infection

(2015) Darin L. Wiesner et al.   PLoS Pathogens

The fungal pathogenCryptococcus neoformansmanipulates macrophage phagosome maturation

(2014) Leanne M. Smith et al.   CELLULAR MICROBIOLOGY

Dectin-2 Deficiency Promotes Th2 Response and Mucin Production in the Lungs after Pulmonary Infection with Cryptococcus neoformans

(2014) Yuri Nakamura et al.   INFECTION AND IMMUNITY

Defect of CARD9 Leads to Impaired Accumulation of Gamma Interferon-Producing Memory Phenotype T Cells in Lungs and Increased Susceptibility to Pulmonary Infection with Cryptococcus neoformans

(2014) Hideki Yamamoto et al.   INFECTION AND IMMUNITY

App1: An Antiphagocytic Protein That Binds to Complement Receptors 3 and 2

(2014) P. Stano et al.   JOURNAL OF IMMUNOLOGY

The Cryptococcus neoformans Transcriptome at the Site of Human Meningitis

(2014) Y. Chen et al.   mBio

Reciprocal functions of Cryptococcus neoformans copper homeostasis machinery during pulmonary infection and meningoencephalitis

(2014) Tian-Shu Sun et al.   Nature Communications

Correction: Cryptococcal Cell Morphology Affects Host Cell Interactions and Pathogenicity

(2014) Laura H. Okagaki et al.   PLoS Pathogens

Correction: Fungal Cell Gigantism during Mammalian Infection

(2014) Oscar Zaragoza et al.   PLoS Pathogens

Clustering of Pattern Recognition Receptors for Fungal Detection

(2014) Makoto Inoue et al.   PLoS Pathogens

Mannoprotein MP84 mediates the adhesion of Cryptococcus neoformans to epithelial lung cells

(2014) Pedro A. C. Teixeira et al.   Frontiers in Cellular and Infection Microbiology

The Intracellular Life of Cryptococcus neoformans

(2013) Carolina Coelho et al.   Annual Review of Pathology-Mechanisms of Disease

Susceptibility of Intact Germinating Arabidopsis thaliana to Human Fungal Pathogens Cryptococcus neoformans and C. gattii

(2013) Katherine M. Warpeha et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Cryptococcus neoformans Copper Detoxification Machinery Is Critical for Fungal Virulence

(2013) Chen Ding et al.   Cell Host & Microbe

Titan cells in Cryptococcus neoformans: cells with a giant impact

(2013) Oscar Zaragoza et al.   CURRENT OPINION IN MICROBIOLOGY

Cryptococcus neoformans Promotes Its Transmigration into the Central Nervous System by Inducing Molecular and Cellular Changes in Brain Endothelial Cells

(2013) Kiem Vu et al.   INFECTION AND IMMUNITY

Cryptococcosis in cats

(2013) Maria Grazia Pennisi et al.   JOURNAL OF FELINE MEDICINE AND SURGERY

Methamphetamine Alters Blood Brain Barrier Protein Expression in Mice, Facilitating Central Nervous System Infection by Neurotropic Cryptococcus neoformans

(2013) Eliseo A. Eugenin et al.   JOURNAL OF INFECTIOUS DISEASES

Cryptococcus neoformans Ex Vivo Capsule Size Is Associated With Intracranial Pressure and Host Immune Response in HIV-associated Cryptococcal Meningitis

(2013) Emma J. Robertson et al.   JOURNAL OF INFECTIOUS DISEASES

The Cryptococcus neoformans Rim101 Transcription Factor Directly Regulates Genes Required for Adaptation to the Host

(2013) T. R. O'Meara et al.   MOLECULAR AND CELLULAR BIOLOGY

Development of an Aerosol Model of Cryptococcus Reveals Humidity as an Important Factor Affecting the Viability of Cryptococcus during Aerosolization

(2013) Deborah J. Springer et al.   PLoS One

Cryptococcusinteractions with macrophages: evasion and manipulation of the phagosome by a fungal pathogen

(2012) Simon A. Johnston et al.   CELLULAR MICROBIOLOGY

The Cryptococcus neoformans Capsule: a Sword and a Shield

(2012) T. R. O'Meara et al.   CLINICAL MICROBIOLOGY REVIEWS

Thirty year retrospective evaluation of pneumonia in a bottlenose dolphin Tursiops truncatus population

(2012) S Venn-Watson et al.   DISEASES OF AQUATIC ORGANISMS

Pseudohyphal Growth of Cryptococcus neoformans Is a Reversible Dimorphic Transition in Response to Ammonium That Requires Amt1 and Amt2 Ammonium Permeases

(2012) Soo Chan Lee et al.   EUKARYOTIC CELL

Titan Cells Confer Protection from Phagocytosis in Cryptococcus neoformans Infections

(2012) Laura H. Okagaki et al.   EUKARYOTIC CELL

Cryptococcus neoformans Requires the ESCRT Protein Vps23 for Iron Acquisition from Heme, for Capsule Formation, and for Virulence

(2012) Guanggan Hu et al.   INFECTION AND IMMUNITY

Long-term surveillance and treatment of subclinical cryptococcosis and nasal colonization byCryptococcus neoformansandC. gattiispecies complex in captive koalas (Phascolarctes cinereus)

(2012) Nobuhide Kido et al.   MEDICAL MYCOLOGY

Capsular Material of Cryptococcus neoformans: Virulence and Much More

(2012) A. Vecchiarelli et al.   MYCOPATHOLOGIA

Comparison and Temporal Trends of Three Groups with Cryptococcosis: HIV-Infected, Solid Organ Transplant, and HIV-Negative/Non-Transplant

(2012) Emily W. Bratton et al.   PLoS One

Hidden Killers: Human Fungal Infections

(2012) G. D. Brown et al.   Science Translational Medicine

The Primary Target Organ of Cryptococcus gattii Is Different from That of Cryptococcus neoformans in a Murine Model

(2012) P. Ngamskulrungroj et al.   mBio

DNA Mutations Mediate Microevolution between Host-Adapted Forms of the Pathogenic Fungus Cryptococcus neoformans

(2012) Denise A. Magditch et al.   PLoS Pathogens

Aimless mutants of Cryptococcus neoformans: Failure to disseminate

(2012) E.J. Griffiths et al.   Fungal Biology Reviews

pH Response Pathways in Fungi: Adapting to Host-derived and Environmental Signals

(2012) Kyla Selvig et al.   MYCOBIOLOGY

Environmental prevalence ofCryptococcus neoformansandCryptococcus gattiiin India: An update

(2011) Anuradha Chowdhary et al.   CRITICAL REVIEWS IN MICROBIOLOGY

Cryptococcal Titan Cell Formation Is Regulated by G-Protein Signaling in Response to Multiple Stimuli

(2011) Laura H. Okagaki et al.   EUKARYOTIC CELL

Cryptococcus neoformansgalactoxylomannan is a potent negative immunomodulator, inspiring new approaches in anti-inflammatory immunotherapy

(2011) Anna Vecchiarelli et al.   Immunotherapy

Cryptococcus gattii: an emerging fungal pathogen infecting humans and animals

(2011) Edmond J. Byrnes et al.   MICROBES AND INFECTION

Evidence for branching in cryptococcal capsular polysaccharides and consequences on its biological activity

(2011) Radames J. B. Cordero et al.   MOLECULAR MICROBIOLOGY

SEC14 is a specific requirement for secretion of phospholipase B1 and pathogenicity of Cryptococcus neoformans

(2011) Methee Chayakulkeeree et al.   MOLECULAR MICROBIOLOGY

The copper regulon of the human fungal pathogen Cryptococcus neoformans H99

(2011) Chen Ding et al.   MOLECULAR MICROBIOLOGY

Evidence that the Human Pathogenic Fungus Cryptococcus neoformans var. grubii May Have Evolved in Africa

(2011) Anastasia P. Litvintseva et al.   PLoS One

Cryptococcus neoformans Capsular Enlargement and Cellular Gigantism during Galleria mellonella Infection

(2011) Rocío García-Rodas et al.   PLoS One

Nonlytic Exocytosis of Cryptococcus neoformans from Macrophages Occurs In Vivo and Is Influenced by Phagosomal pH

(2011) A. M. Nicola et al.   mBio

Phospholipids Trigger Cryptococcus neoformans Capsular Enlargement during Interactions with Amoebae and Macrophages

(2011) Cara J. Chrisman et al.   PLoS Pathogens

Real-time imaging of trapping and urease-dependent transmigration of Cryptococcus neoformans in mouse brain

(2010) Meiqing Shi et al.   JOURNAL OF CLINICAL INVESTIGATION

The Human Fungal Pathogen Cryptococcus neoformans Escapes Macrophages by a Phagosome Emptying Mechanism That Is Inhibited by Arp2/3 Complex-Mediated Actin Polymerisation

(2010) Simon A. Johnston et al.   PLoS Pathogens

How Sweet it is! Cell Wall Biogenesis and Polysaccharide Capsule Formation inCryptococcus neoformans

(2009) Tamara Lea Doering   Annual Review of Microbiology

The structure of Cryptococcus neoformans galactoxylomannan contains β-d-glucuronic acid

(2009) Christian Heiss et al.   CARBOHYDRATE RESEARCH

Isolation and Characterization ofCryptococcus neoformansSpores Reveal a Critical Role for Capsule Biosynthesis Genes in Spore Biogenesis

(2009) Michael R. Botts et al.   EUKARYOTIC CELL

Elucidating the Pathogenesis of Spores from the Human Fungal Pathogen Cryptococcus neoformans

(2009) S. S. Giles et al.   INFECTION AND IMMUNITY

Spores as Infectious Propagules of Cryptococcus neoformans

(2009) R. Velagapudi et al.   INFECTION AND IMMUNITY

Cytokine Signaling Regulates the Outcome of Intracellular Macrophage Parasitism by Cryptococcus neoformans

(2009) K. Voelz et al.   INFECTION AND IMMUNITY

A Role for the ATP7A Copper-transporting ATPase in Macrophage Bactericidal Activity

(2009) Carine White et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cryptococcosis in domestic animals in Western Australia: a retrospective study from 1995–2006

(2009) S. McGill et al.   MEDICAL MYCOLOGY

Capsule of Cryptococcus neoformans grows by enlargement of polysaccharide molecules

(2009) S. Frases et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Systematic Genetic Analysis of Virulence in the Human Fungal Pathogen Cryptococcus neoformans

(2008) Oliver W. Liu et al.   CELL

Involvement of human CD44 during Cryptococcus neoformans infection of brain microvascular endothelial cells

(2008) Ambrose Jong et al.   CELLULAR MICROBIOLOGY

Capsular polysaccharides galactoxylomannan and glucuronoxylomannan from Cryptococcus neoformans induce macrophage apoptosis mediated by Fas ligand

(2008) Suellen N. Villena et al.   CELLULAR MICROBIOLOGY

Capsular polysaccharide induction of apoptosis by intrinsic and extrinsic mechanisms

(2008) Claudia Monari et al.   CELLULAR MICROBIOLOGY

Capsule enlargement inCryptococcus neoformansconfers resistance to oxidative stress suggesting a mechanism for intracellular survival

(2008) Oscar Zaragoza et al.   CELLULAR MICROBIOLOGY

PKC1Is Essential for Protection against both Oxidative and Nitrosative Stresses, Cell Integrity, and Normal Manifestation of Virulence Factors in the Pathogenic FungusCryptococcus neoformans

(2008) Kimberly J. Gerik et al.   EUKARYOTIC CELL

Pulmonary cryptococcosis in patients without HIV infection: factors associated with disseminated disease

(2008) J. W. Baddley et al.   EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

Evidence of a Role for Monocytes in Dissemination and Brain Invasion by Cryptococcus neoformans

(2008) C. Charlier et al.   INFECTION AND IMMUNITY

Role of the Mannose Receptor in a Murine Model of Cryptococcus neoformans Infection

(2008) J. M. Dan et al.   INFECTION AND IMMUNITY

Metabolic adaptation inCryptococcus neoformansduring early murine pulmonary infection

(2008) Guanggan Hu et al.   MOLECULAR MICROBIOLOGY