Review
Chemistry, Medicinal
Oladapo F. Fagbohun, Jitcy S. Joseph, Olumayowa V. Oriyomi, H. P. Vasantha Rupasinghe
Summary: Frondosides are the major saponins of the North Atlantic sea cucumber. They possess amphiphilic characteristics and have been widely studied for their potential therapeutic activities. Recent studies have shown that frondoside-containing extracts from C. frondosa exhibit various biological activities, but the exact mechanism(s) of action are not clearly understood. This review discusses the different frondosides of C. frondosa, their potential therapeutic activities, and recent advances in extraction techniques.
Article
Plant Sciences
Lixiu Hou, Furui Zhang, Xincheng Yuan, Song Li, Weijun Tian, Weirong Tian, Jiaru Li
Summary: Paris species accumulate a large amount of steroidal saponins, which have numerous pharmacological activities and are important components in many patented drugs. This study investigated the composition of steroidal saponins and the molecular basis behind the differences between species. The results showed that the accumulation of steroidal saponins was tissue- and species-specific, and the differentially expressed genes related to their biosynthesis were abundantly expressed in rhizomes.
PHYSIOLOGIA PLANTARUM
(2022)
Article
Multidisciplinary Sciences
Renju Kunjumon, Anil John Johnson, Rajani Kurup Sukumaryamma Remadevi, Sabulal Baby
Summary: In this study, the major bioactive molecules in Centella asiatica and their ratios were determined in samples collected from the natural habitats in south India. The study identified distinct C6-hydroxylated and C28-glycosylated centellosides as dominant in C. asiatica. The discovery of elite lines with high concentrations of active compounds suggests their potential industrial applications.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Multidisciplinary
Jing Xie, Shi-Juan Zhang, Grace Gar-Lee Yue, Ling-Ling Yu, Hui Liu, Wen-Yi Ma, Huan Yan, Wei Ni, Clara Bik-San Lau, Hai-Yang Liu
Summary: This study isolated five new cholestane derivatives from the whole plant of Ypsilandra thibetica and determined their structures through comprehensive spectroscopic analyses and chemical methods. Compound 5 exhibited anti-angiogenic activity in zebrafish embryos.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Plant Sciences
Billy Tchegnitegni Toussie, Ruland Tchuinkeu Nguengang, Isabelle Kamga Mawabo, Remy Bertrand Teponno, Jean Jules Kezetas Bankeu, Jean Rodolphe Chouna, Celine Ngeufeu Nkenfou, Leon Azefack Tapondjou, Norbert Sewald, Bruno Ndjakou Lenta
Summary: Eleven previously undescribed arylnaphthalide lignans (1-11) and seven known compounds were isolated from the whole plant of Justicia depauperata. The structures of 1-11 were determined by spectroscopic analysis and mass spectrometry. Compounds 6 and 9 exhibited cytotoxic activity against the KB-3-1 cervical carcinoma cell line.
JOURNAL OF NATURAL PRODUCTS
(2022)
Article
Forestry
Jiayun Xu, Nan Lu, Kun Liu, Huayu Liu, Zhi Wang, Youngsoo Bae, Chuan-Ling Si, Junhui Wang
Summary: In this study, five compounds were isolated from the bark extracts of Catalpa bungei, including a new triterpene saponin derivative, as well as two known flavonoids, a known oleanane-type triterpene, and a known phytosterol. Structural elucidation of these compounds was performed based on physicochemical and spectroscopic evidence, and it is the first time that these compounds have been discovered in C. bungei.
WOOD SCIENCE AND TECHNOLOGY
(2021)
Review
Plant Sciences
Sarah T. Sakna, Yasmin R. Maghraby, Mohamed S. Abdelfattah, Mohamed A. Farag
Summary: The genus Ziziphus is cultivated worldwide for its medicinal purposes and diverse phytochemicals. In this review, scientific reports published till 2022 on Ziziphus phytochemistry and biological activities are discussed, with a focus on the last 10 years. The study highlights the presence of alkaloids, flavonoids, terpenoids, and saponins in Ziziphus, with particular emphasis on the therapeutic potential of terpenoids and saponins. The study provides a comprehensive review of the phytochemistry and biological activities of all Ziziphus species, with a special emphasis on triterpenoids/saponins as therapeutic agents.
PHYTOCHEMISTRY REVIEWS
(2022)
Article
Chemistry, Medicinal
Liu Liu, Haobin Li, Kaiwen Hu, Qinglong Xu, Xiaoan Wen, Keguang Cheng, Caiping Chen, Haoliang Yuan, Liang Dai, Hongbin Sun
Summary: Pentacyclic triterpenes (PTs) have been found to activate AMPK, with synthesized delta-oleanolic acid saponin 29 showing significant anti-inflammatory effects and liver protection in mice with acute hepatic failure.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Review
Biology
Celia Faustino, Lidia Pinheiro, Noelia Duarte
Summary: Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease characterized by joint inflammation, swelling and pain. Triterpenes, natural compounds with anti-inflammatory properties, have shown significant anti-arthritic activity without undesirable side effects. This review covers recent studies on triterpenes as safe and promising drug candidates for RA treatment.
Article
Plant Sciences
Yunita Eka Puspitasari, Tess De Bruyne, Kenn Foubert, Aulanni'am Aulanni'am, Luc Pieters, Nina Hermans, Emmy Tuenter
Summary: Sea cucumbers, belonging to the phylum Echinodermata, are used as food and traditional medicine in Asia, with triterpene glycosides being the most predominant secondary metabolites. The Holothuria genus, known for its high number and variety of triterpene glycosides, has had 63 saponins identified in the past decade, with LC-MS and NMR being common analytical techniques. However, inconsistencies in literature were noted, prompting a review to provide clarity on NMR and MS signals and interpretation for future research on Holothuria saponins.
PHYTOCHEMISTRY REVIEWS
(2022)
Article
Biochemistry & Molecular Biology
Jungmoo Huh, Tae Kyu Park, Hee-Sung Chae, Piseth Nhoek, Young-Mi Kim, Chae-Yeong An, Shinae Lee, Jinwoong Kim, Young-Won Chin
Summary: In this study, several compounds were isolated from the fruits of Stewartia koreana, and (+)-catechin was found to potentially lower cholesterol levels by downregulating PCSK9 expression.
Review
Plant Sciences
Elia Lacchini, Jhon Venegas-Molina, Alain Goossens
Summary: Metabolic enzymes evolve towards catalytic effectiveness, precision, and speed. Ancient and conserved enzymes involved in fundamental cellular processes have limited metabolite numbers. However, sessile organisms like plants have a vast variety of specialized metabolites, which exceed primary metabolites in number and complexity. Gene duplication, positive selection, and diversifying evolution have allowed relaxed selection and accumulation of mutations in metabolic genes, broadening substrate/product specificity and lowering activation barriers and kinetics. This study showcases the structural and functional diversity of chemical signals and products in plant metabolism using oxylipins and triterpenes.
CURRENT OPINION IN PLANT BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Li-Yuan Yang, Ping Yi, Jun-Lei Chen, Yu-Huan Li, Jue-Lin Qiu, Zhao-Yang Wang, Mao Fu, Chun-Mao Yuan, Lie-Jun Huang, Xiao-Jiang Hao, Wei Gu
Summary: Two new ursane-type triterpenes, eburnealactones A and B (1 and 2), one new flavonoid, eburneatin A (6), and one new phenylethanoid glycoside, chiritoside D (7), were isolated from the whole plant of Primulina eburnea. The structures of these compounds were determined by extensive spectroscopic analysis (IR, UV, NMR, and HR-ESI-MS). The cytotoxic activities of all compounds were evaluated, with compound 1 showing significant activity against MKN-45 and 5637 cell lines, and compound 6 showing moderate activity against multiple cell lines. Compound 5 exhibited moderate activity against A549 cell lines.
CHEMISTRY & BIODIVERSITY
(2023)
Article
Chemistry, Multidisciplinary
Ana C. Zanatta, Wagner Vilegas, Ruangelie Edrada-Ebel
Summary: Seasonality affects the synthesis and accumulation of secondary metabolites in medicinal plants. Metabolomics is crucial for quality control of plant extracts to establish metabolite profiles and analyze factors influencing effectiveness. Study of Brazilian Cerrado flora species revealed significant impact of seasonal factors on metabolite production in plants.
FRONTIERS IN CHEMISTRY
(2021)
Article
Integrative & Complementary Medicine
Yu Zhao, Xin Dong, Zhi Wang, Rui Dong, Ren Bu, Qianxi Feng, Peifeng Xue, Bi Qu
Summary: A new method was established to quickly and effectively identify and quantify compounds in MTBD, successfully applied to evaluate its quality. This enhances our understanding of the molecular composition of MTBD, improves quality control, and promotes the development and utilization of ethnic medicine.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Walid Khitri, Dalila Smati, Anne-Claire Mitaine-Offer, Thomas Paululat, Marie-Aleth Lacaille-Dubois
BIOCHEMICAL SYSTEMATICS AND ECOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Bastien Petit, Anne-Claire Mitaine-Offer, Feliciana Real Fernandez, Anna Maria Papini, Clement Delaude, Tomofumi Miyamoto, Chiaki Tanaka, Paolo Rovero, Marie-Aleth Lacaille-Dubois
Article
Plant Sciences
Duc Hung Nguyen, Anne-Claire Mitaine-Offer, Tomofumi Miyamoto, Chiaki Tanaka, Pierre-Simon Bellaye, Bertrand Collin, Odile Chambin, Marie-Aleth Lacaille-Dubois
PHYTOCHEMISTRY LETTERS
(2020)
Article
Plant Sciences
Amina Dahmoune, Dalila Smati, Anne-Claire Mitaine-Offer, Tomofumi Miyamoto, Chiaki Tanaka, Thomas Paululat, Marie-Aleth Lacaille-Dubois
PHYTOCHEMISTRY LETTERS
(2020)
Article
Environmental Sciences
Delaram Poorasadollah, Tayebe Bagheri Lotfabad, Amir Heydarinasab, Soheila Yaghmaei, Farzaneh Aziz Mohseni
Summary: The study shows that the biological activated carbon (BAC) process is an efficient method for the degradation of azo dye Carmoisine. Klebsiella spp. demonstrated the capability to remove Carmoisine. Various analyses indicated that the porosity of activated carbons and the age of biological beds are crucial factors influencing the efficiency of the degradation process.
ENVIRONMENTAL TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Bastien Petit, Anne-Claire Mitaine-Offer, Jochen Fischer, Anja Schuffler, Clement Delaude, Tomofumi Miyamoto, Chiaki Tanaka, Eckhard Thines, Marie-Aleth Lacaille-Dubois
Summary: Chemical analysis and biological screening of Chytranthus macrobotrys and Radlkofera calodendron led to the discovery of new terpenoid glycosides and their antimicrobial activity was tested against fifteen phytopathogens.
Article
Biochemistry & Molecular Biology
David Pertuit, Anne-Claire Mitaine-Offer, Tomofumi Miyamoto, Chiaki Tanaka, Christine Belloir, Loic Briand, Marie-Aleth Lacaille-Dubois
Summary: Four oleanane-type glycosides were isolated from the endemic Pittosporum tenuifolium cultivar Green Elf in New Zealand: three from the leaves and one from the roots. The structures were elucidated using spectroscopic methods, and their inhibitory activities on sweet taste receptors were evaluated based on structural similarities.
Article
Biochemistry & Molecular Biology
Duc Hung Nguyen, Anne-Claire Mitaine-Offer, Tomofumi Miyamoto, Chiaki Tanaka, Pierre-Simon Bellaye, Bertrand Collin, Odile Chambin, Marie-Aleth Lacaille-Dubois
Summary: A phytochemical study of Cordyline fruticosa Fairchild red from Vietnam led to the isolation of fourteen steroidal glycosides, including twelve previously undescribed and two known ones. The structures of these compounds, mainly spirostanol and furostanol glycosides, were elucidated through spectroscopic analysis. The isolated compounds were evaluated for their cytotoxicity against 4T1 cell line derived from a mouse mammary gland tissue.
Article
Chemistry, Medicinal
David Pertuit, Anne-Claire Mitaine-Offer, Tomofumi Miyamoto, Chiaki Tanaka, Clement Delaude, Pierre-Simon Bellaye, Bertrand Collin, Marie-Aleth Lacaille-Dubois
Summary: Seven previously unknown oleanane-type glycosides were isolated from the trunk barks of a Central African tree named Millettia laurentii, and their structures were determined using NMR and mass spectrometry. The cytotoxicity of six of these glycosides were evaluated against 4 T1 cell line.
Review
Food Science & Technology
Maria C. Tenuta, Brigitte Deguin, Monica R. Loizzo, Claire Cuyamendous, Marco Bonesi, Vincenzo Sicari, Lorenza Trabalzini, Anne-Claire Mitaine-Offer, Jianbo Xiao, Rosa Tundis
Summary: Cornus species, including Cornus mas and Cornus officinalis, are widely distributed in Europe, Africa, Asia, and America, and their edible fruits are known for their nutritional and medicinal values. These fruits contain various secondary metabolites with nutritional and functional properties. Although there is limited information available on the phytochemicals and biological activities of Cornus species, their potential for applications in the food industry and traditional medicine is of growing interest.
Article
Plant Sciences
Samir Hobloss, Antoine Bruguiere, Anne-Sophie Champy-Tixier, Tomofumi Miyamoto, Chiaki Tanaka, Simon Dessertaine, Marc Sautour, Marie-Aleth Lacaille-Dubois, Anne-Claire Mitaine-Offer
Summary: Sixteen oleanane-type glycosides were extracted from three Weigela hybrids and cultivars, four of which were previously undescribed. Extensive 1D and 2D NMR experiments, as well as mass spectrometry analysis, were used for their full structural elucidation. Six compounds among the known ones were tested for their antifungal and antibacterial activities.
PHYTOCHEMISTRY LETTERS
(2022)
Article
Pharmacology & Pharmacy
Duc Hung Nguyen, Tihana Baric, Gaelle Roudaut, Philippe Cayot, Marie-Aleth Lacaille-Dubois, Anne-Claire Mitaine-Offer, Odile Chambin
Summary: The aim of this study was to encapsulate curcumin in pectin beads using ionotropic gelation method, and to evaluate its solubility, bioavailability and antioxidant activity in the presence of various surfactants. The results showed successful production of different beads, with encapsulation efficiency above 75% in all cases. Curcumin was transformed from crystalline to amorphous state during the manufacturing process with Kolliphor (R) and TPGS (R) beads, leading to a rapid release in simulated intestinal fluids. The antioxidant activity of curcumin showed slight changes after encapsulation and dissolution with these surfactants. On the other hand, release was lower and antioxidant capacity decreased with BLG and control beads without any surfactant. The study demonstrated the significant effectiveness of surfactants in enhancing solubility and preserving antioxidant capacity of curcumin, and the importance of their choices.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Biochemical Research Methods
Nasim Rezaee, Pedram Hasanvand, Tayebe Bagheri Lotfabad, Amir Heydarinasab, Mahvash Khodabandeh, Soheila Yaghmaei
Summary: In this study, bovine blood was used to obtain a protein hydrolysate as a peptone for microbial growth medium. Physico-chemical features and amino acid compositions of the protein hydrolysate were compared to a commercial peptone from meat. The growth of test microbial strains in culture media based on the protein hydrolysate was comparable to that in media based on commercial peptone.
PREPARATIVE BIOCHEMISTRY & BIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Samir Hobloss, Antoine Bruguiere, David Pertuit, Tomofumi Miyamoto, Chiaki Tanaka, Christine Belloir, Marie-Aleth Lacaille-Dubois, Loic Briand, Anne-Claire Mitaine-Offer
Summary: The phytochemical study of the Chinese Wisteria led to the discovery of seven oleanane-type glycosides from the roots, including two previously unreported saponins. The effects of these glycosides on the sweet taste receptor were evaluated based on their similarity to glycyrrhizin from licorice.
Article
Environmental Sciences
Fatemeh Darbandi, Azadeh Mousavi, Tayebe Bagheri Lotfabad, Amir Heydarinasab, Soheila Yaghmaei
Summary: The study focuses on utilizing PVDF membranes manipulated by surfactants to improve dye removal efficacy. The addition of Tween surfactants at specific concentrations resulted in changes in membrane properties, including pore size, hydrophobicity, and dye removal efficiency. Overall, surfactant-mediated modifications enhanced the performance of PVDF membranes in dye removal.
ENVIRONMENTAL HEALTH ENGINEERING AND MANAGEMENT JOURNAL
(2021)
