Article
Cardiac & Cardiovascular Systems
Qianhui Wang, Li Xu, Ying Dong, Yuan Fu, Yuxia Pan, Qianran Luan, Ye Liu, Zheng Liu, Xinchun Yang, Mulei Chen, Yuanfeng Gao
Summary: This study found that elevated plasma Gal-3 concentration is significantly associated with AF progression from PAF to PsAF, indicating its potential use for risk stratification and management guidance in PAF patients.
BMC CARDIOVASCULAR DISORDERS
(2021)
Article
Biotechnology & Applied Microbiology
Victoriano Mendieta-Carmona, Guadalupe Delgado-Lopez, Julio Reyes-Leyva, Claudia Teresita Gutierrez-Quiroz, Victor Javier Vazquez-Zamora, Denisse Alejandra Picazo-Mendoza, Alvaro Jose Montiel-Jarquin, Laura Patricia Martinez-Morales, Veronica Vallejo-Ruiz
Summary: The aim of this study was to investigate the correlation between the expression of galectin-9 gene (LGALS9) and cervical cancer progression, clinicopathological characteristics, and overall survival. The results showed that higher expression levels of LGALS9 were associated with better prognosis and early clinical stages, and were also positively correlated with immune pathways enrichment and abundance of tumor infiltrating immune cells.
ONCOTARGETS AND THERAPY
(2023)
Review
Genetics & Heredity
Grzegorz Procyk, Aleksandra Czapla, Kamila Jalocha, Agata Tyminska, Marcin Grabowski, Aleksandra Gasecka
Summary: Galectin-3 shows potential as a diagnostic, prognostic, and predictive biomarker in atrial fibrillation (AF). Patients with AF have increased levels of galectin-3, and the concentration differs between different types of AF. Galectin-3 has the potential to predict the outcome of AF ablation therapy, with higher levels indicating a higher risk of AF recurrence.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2023)
Article
Microbiology
Limin Zhang, Ziying Feng, Yinghua Li, Cuiting Lv, Chunchun Li, Yue Hu, Mingsheng Fu, Liang Song
Summary: This study investigated the differences in fecal and salivary microbiota between patients with colorectal polyps and healthy controls, and identified potential microbiota-based biomarkers for the detection of colorectal polyps.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Gastroenterology & Hepatology
Saray Duran-Sanchon, Lorena Moreno, Javier Gomez-Matas, Josep M. Auge, Miquel Serra-Burriel, Miriam Cuatrecasas, Leticia Moreira, Anna Serradesanferm, Angels Pozo, Jaume Grau, Maria Pellise, Meritxell Gironella, Antoni Castells
Summary: The miRFec algorithm can effectively identify individuals at highest risk for advanced colorectal neoplasia and differentiate patients with colorectal cancer from those with non-advanced adenomas or normal colonoscopy. By incorporating this algorithm, 34% of colonoscopies could be avoided, increasing the effectiveness and efficiency of FIT-based CRC screening programs.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Review
Medicine, Research & Experimental
Emily Capone, Stefano Iacobelli, Gianluca Sala
Summary: LGALS3BP, a secreted protein expressed in most human cells, has been identified as a potential therapeutic target for cancer treatment. Studies have shown that LGALS3BP plays a significant role in cancer, potentially impacting prognosis and functionality.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Fernando Magro, Catarina Alves, Joanne Lopes, Susana Lopes, Helena Tavares de Sousa, Jose Cotter, Vitor Macedo da Silva, Paula Lago, Ana Vieira, Mariana Brito, Maria A. M. Duarte, Francisco Portela, Joao P. Silva, Paula Ministro, Bruno Arroja, Liliana Carvalho, Joana Torres, Mafalda Santiago, Maria Manuela Estevinho, Silvio Danese, Laurent Peyrin-Biroulet, Claudia Camila Dias, Paula Borralho, Roger M. Feakins, Fatima Carneiro
Summary: The Geboes score from colon biopsies was found to be an independent risk factor for the progression of UC in the first 36 months after biopsy, with patients having higher scores at a greater risk and experiencing faster progression.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Review
Oncology
James Yu, Robin Park, Richard Kim
Summary: The systemic therapy landscape for hepatocellular carcinoma is rapidly evolving with the approval of new checkpoint inhibitor-based regimens. However, the development of biomarkers has not kept pace with the approvals of new agents. Nevertheless, recent research has focused on biomarkers for early detection, prognostication, and predictive markers to guide treatment selection.
JOURNAL OF HEPATOCELLULAR CARCINOMA
(2023)
Review
Oncology
Shunhao Zhang, Jing Sun, Minqi Gu, Guihua Wang, Xudong Wang
Summary: Circular RNAs, a special type of noncoding RNA, exhibit high stability and potential gene regulation effects, playing roles in various biological functions and showing associations with the development and chemotherapy resistance of CRC.
Article
Multidisciplinary Sciences
Nevena Gajovic, Sofija Sekulic Markovic, Milena Jurisevic, Marina Jovanovic, Nebojsa Arsenijevic, Zeljko Mijailovic, Marina Jovanovic, Ivan Jovanovic
Summary: Gal-3 is associated with COVID-19 severity and immune response. Patients in critical stage have higher levels of Gal-3, cytokines, and CCR5 expression, indicating more severe inflammation. Gal-3 also correlates with clinical and radiographic findings, as well as peripheral blood immune cell composition.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Yueh-Jung Wu, Siang-Ting Huang, Ya-Hui Chang, Shih-Yi Lin, Weng-Ling Lin, Ying-Jung Chen, Shang-Tao Chien
Summary: Concurrent chemoradiotherapy is an effective treatment option for low-grade colorectal cancer patients. However, approximately 20% to 30% of patients do not respond well to this treatment, highlighting the need for new biomarkers to predict prognosis. In this study, SAE1 was identified as an independent prognostic biomarker and its knockdown inhibited tumor cell proliferation and increased radiosensitivity, suggesting it as a potential therapeutic target in CRC treatment.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Qi-Shun Geng, Mei-Jia Yang, Li-Feng Li, Zhi-Bo Shen, Long-Hao Wang, Yuan-Yuan Zheng, Wen-Hua Xue, Jie Zhao
Summary: This study identified the overexpression of FATP5 in colorectal carcinoma and predicted a favorable prognosis, suggesting it as a novel appealing prognostic marker for CRC. The study also revealed the potential biological function of FATP5 and confirmed its important role in cell cycle regulation.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Oncology
Biao Yuan, Bin Ma, Jing Yu, Qingkai Meng, Tao Du, Hongyi Li, Yueyan Zhu, Zikui Sun, Siping Ma, Chun Song
Summary: CRC is one of the top five lethal malignant tumors globally and in China, and early diagnosis and treatment are crucial for improving survival rates. The gut microbiome could serve as a potential non-invasive screening tool for CRC, with a few specific bacteria genus identified as effective biomarkers for clinical use. Analysis of gut microbiome composition in CRC patients versus healthy controls showed significant differences, with 13 bacteria identified as biomarkers with high sensitivity and specificity for discriminating CRC patients. This method has the potential to be a non-invasive approach for early diagnosis of CRC.
FRONTIERS IN ONCOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Daniela A. R. Santos, Cristiana Gaiteiro, Marlene Santos, Lucio Santos, Mario Dinis-Ribeiro, Luis Lima
Summary: Colorectal cancer (CRC) is the third most common cancer globally. Early detection is crucial for better prognosis and increased survival rate. MicroRNA biomarkers have emerged as a powerful tool for CRC screening, as they are highly expressed in CRC patients and easily detectable. This review evaluates the available data on microRNAs as promising biomarkers for early CRC screening, discusses their advantages, disadvantages, and optimal study characteristics.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Health Care Sciences & Services
Mohammed Aref Kyyaly, Elena Vladimirovna Vorobeva, Dilini M. Kothalawala, Wei Chern Gavin Fong, Peijun He, Collin L. Sones, Mohammad Al-Zahrani, Tilman Sanchez-Elsner, Syed Hasan Arshad, Ramesh J. Kurukulaaratchy
Summary: This systematic review explores the potential of miRNAs as biomarkers for asthma diagnosis and severity-risk assessment. The review identifies multiple differentially expressed miRNAs, including two panels expressed in blood, which have the potential for further investigation.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Biochemical Research Methods
Massimo Caruso, Rosalia Emma, Alfio Distefano, Sonja Rust, Konstantinos Poulas, Antonio Giordano, Vladislav Volarevic, Konstantinos Mesiakaris, Silvia Boffo, Aleksandar Arsenijevic, Georgios Karanasios, Roberta Pulvirenti, Aleksandar Ilic, Angelo Canciello, Pietro Zuccarello, Margherita Ferrante, Riccardo Polosa, Giovanni Li Volti
Summary: This study confirms the importance of electronic cigarettes and heated tobacco products as harm reduction strategies for cardiovascular disease development in smokers, as they have less impact on endothelial cell migration compared to cigarette smoke.
DRUG TESTING AND ANALYSIS
(2023)
Article
Immunology
Ana Divjak, Ivan Jovanovic, Aleksandar Matic, Aleksandra Tomic Lucic, Nevena Gajovic, Milena Jurisevic, Aleksandra Jurisic Skevin, Mirjana Veselinovic
Summary: This trial suggests that vitamin D3 has potential therapeutic and immunomodulatory effects in patients with knee osteoarthritis. Oral supplementation of vitamin D3 can significantly reduce pain and improve the quality of life in knee osteoarthritis patients. Vitamin D3 supplementation also increases systemic values of IL-33.
IMMUNOLOGIC RESEARCH
(2023)
Article
Multidisciplinary Sciences
Nevena Gajovic, Sofija Sekulic Markovic, Milena Jurisevic, Marina Jovanovic, Nebojsa Arsenijevic, Zeljko Mijailovic, Marina Jovanovic, Ivan Jovanovic
Summary: Gal-3 is associated with COVID-19 severity and immune response. Patients in critical stage have higher levels of Gal-3, cytokines, and CCR5 expression, indicating more severe inflammation. Gal-3 also correlates with clinical and radiographic findings, as well as peripheral blood immune cell composition.
SCIENTIFIC REPORTS
(2023)
Review
Biochemistry & Molecular Biology
Nevena Ladjevac, Marija Milovanovic, Andra Jevtovic, Dragana Arsenijevic, Bojana Stojanovic, Milica Dimitrijevic Stojanovic, Bojan Stojanovic, Nebojsa Arsenijevic, Aleksandar Arsenijevic, Jelena Milovanovic
Summary: Elucidating the inflammatory mechanisms underlying formation and progression of oral squamous cell carcinoma (OSCC) is crucial for discovering new targeted therapeutics. The proinflammatory cytokine IL-17 has proven roles in tumor formation, growth, and metastasis. The presence of IL-17 is demonstrated in both in vitro and in vivo models, and in OSCC patients, is mostly accompanied by enhanced proliferation and invasiveness of cancer cells. Here we review the known facts regarding the role of IL-17 in OSCC pathogenesis, namely the IL-17 mediated production of proinflammatory mediators that mobilize and activate myeloid cells with suppressive and proangiogenic activities and proliferative signals that directly induce proliferation of cancer cells and stem cells. The possibility of a potential IL-17 blockade in OSCC therapy is also discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Ana Bogut, Bojan Stojanovic, Marina Jovanovic, Milica Dimitrijevic Stojanovic, Nevena Gajovic, Bojana S. Stojanovic, Goran Balovic, Milan Jovanovic, Aleksandar Lazovic, Milos Mirovic, Milena Jurisevic, Ivan Jovanovic, Violeta Mladenovic
Summary: This review provides a comprehensive overview of the multifaceted role of Galectin-1 in Pancreatic Ductal Adenocarcinoma (PDAC), including its contributions to tumor stroma remodeling, angiogenesis, metabolic reprogramming, and potential implications for therapeutic interventions. The challenges associated with targeting Galectin-1 are discussed, and the promising prospects of Gal-1 inhibition, including the utilization of nanotechnology and theranostics, are highlighted.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Dusan M. Maric, Danilo Vojvodic, Dusica L. Maric, Gordana Velikic, Mihajlo Radomir, Ivana Sokolovac, Debora Stefik, Nemanja Ivkovic, Sonja Susnjevic, Miljan Puletic, Oliver Dulic, Dzihan Abazovic
Summary: This study investigated the changes in cytokines in the cerebrospinal fluid of autism patients before and after autologous bone marrow transplantation. The results showed significant differences in cytokine patterns and clinical outcomes, suggesting that these patterns may serve as predictive markers for clinical improvement in autism patients after transplantation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Bojan Milosevic, Bojan Stojanovic, Aleksandar Cvetkovic, Ivan Jovanovic, Marko Spasic, Milica Dimitrijevic Stojanovic, Vesna Stankovic, Marija Sekulic, Bojana S. Stojanovic, Natasa Zdravkovic, Minja Mitrovic, Jasmina Stojanovic, Darko Laketic, Maja Vulovic, Danijela Cvetkovic
Summary: This review aims to unravel the enigmatic aspects of mammaglobin and elucidate its potential role in redefining the paradigm of breast carcinoma biomarkers. The expression of mammaglobin in tumoral and peritumoral tissues and its circulating levels in the blood will be thoroughly examined, providing insights into its possible function in cancer progression and metastasis. Furthermore, the potential application of mammaglobin as a non-invasive diagnostic tool and a target for personalized treatment strategies will be discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Borge S. Petrovic, Sandra S. Jovicic Milic, Maja B. Dukic, Ivana D. Radojevic, Milena M. Jurisevic, Nevena M. Gajovic, Angela Petrovic, Nebojsa N. Arsenijevic, Ivan P. Jovanovic, Edina Avdovic, Danijela Lj. Stojkovic, Verica V. Jevtic
Summary: Four new ligands and their corresponding palladium(II) complexes were synthesized and characterized. The interaction between the complexes and human serum albumin (HSA) was studied using fluorescence spectroscopy. The most active and selective compound, ligand L4, showed potential for future in vivo testing and induced cell death mainly by apoptosis.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2023)
Article
Medicine, General & Internal
Irina Brcerevic, Radoje Doder, Danilo Vojvodic, Nenad Perisic, Stanko Petrovic
Summary: The aim of this study was to examine the potential prognostic role of peripheral blood MDSC counts in colorectal cancer (CRC) patients. The results showed that percentages and absolute numbers of CD16(low) granulocytes, as well as the absolute numbers of M-MDSC like cells, the CD16(high)/CD16(low) granulocytes ratio, monocyte/M-MDSC like cells ratio, and NLR ratio, may be reliable indicators of overall survival in CRC patients.
VOJNOSANITETSKI PREGLED
(2023)
Article
Medicine, General & Internal
Irina Brcerevic, Radoje Doder, Nenad Perisic, Stanko Petrovic, Danilo Vojvodic
Summary: This study analyzed the frequency and significance of MDSC-like cells in different stages of colorectal cancer patients. The results showed a significant increase in the number and proportion of PMN-MDSC-like cells in all patients with CRC compared to the healthy control group. The absolute and relative numbers of PMN-MDSC-like cells significantly correlated with the stages of CRC disease and the number of organs affected by metastases.
VOJNOSANITETSKI PREGLED
(2023)
Article
Oncology
Andjela R. Petrovic, Ivan P. Jovanovic, Milena M. Jurisevic, Marina Z. Jovanovic, Marina M. Jovanovic, Sladjana P. Pavlovic, Nebojsa N. Arsenijevic, Gordana M. Supic, Danilo V. Vojvodic, Milan M. Jovanovic, Nevena M. Gajovic
Summary: The study found that metformin can directly enhance the activation and cytotoxicity of natural killer (NK) cells. This finding may contribute to dissecting key mechanisms of metformin exerting antitumor activity and advancing the use of metformin as an antitumor agent.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2023)
Article
Medicine, General & Internal
Sofija I. Lugonja, Ivana L. Pantic, Tamara M. Milovanovic, Vesna M. Grbovic, Bojana M. Djokovic, Zeljko D. Todorovic, Stefan M. Simovic, Rasa H. Medovic, Nebojsa D. Zdravkovic, Natasa D. Zdravkovic
Summary: The aim of this study was to investigate the relationship between biochemical, haemostatic, and immune parameters of atherosclerosis and ulcerative colitis patients and platelet aggregation. The results showed higher levels of inflammatory markers and platelet aggregation in ulcerative colitis patients, as well as lower levels of total cholesterol and LDL. Inflammatory markers and platelet aggregation could be potential discrimination markers for ulcerative colitis patients with a higher risk of atherosclerosis.
MEDICINA-LITHUANIA
(2023)
Article
Medicine, General & Internal
Marina Jovanovic, Sofija Sekulic, Miodrag Jocic, Milena Jurisevic, Nevena Gajovic, Marina Jovanovic, Nebojsa Arsenijevic, Milan Jovanovic, Milan Mijailovic, Milos Milosavljevic, Ivan Jovanovic
Summary: This study aimed to determine the transcriptional activity and functional phenotype of T cells and the relationship between pro-and anti-inflammatory cytokines and clinical parameters of COVID-19 severity. The results showed a significant elevation of IL-12, IFN-gamma, IL-17, and IL-23 in stage IV of the disease, with a strong intercorrelation between these cytokines. CD4+ T cells displayed increased transcriptional activity and an increased percentage of IFN-gamma and IL-17 producing T cells.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Bojan Stojanovic, Nevena Gajovic, Milena Jurisevic, Milica Dimitrijevic Stojanovic, Marina Jovanovic, Ivan Jovanovic, Bojana S. Stojanovic, Bojan Milosevic
Summary: IL-33 plays a critical role in breast cancer biology, influencing cancer progression and immune response, and may serve as a therapeutic target.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
