Journal
MECHANISMS OF DEVELOPMENT
Volume 154, Issue -, Pages 33-43Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.mod.2018.04.004
Keywords
Sperm; Sperm-capacitation; Hyperpolarization; Membrane potential; Ion channels
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Funding
- Agencia Nacional de Promocion Cientifica y Tecnologica de Argentina [PICT 2014-2702, PICT 2015-3102]
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Mammalian sperm are unable to fertilize the egg immediately after ejaculation. In order to gain fertilization competence, they need to undergo a series of biochemical and physiological modifications inside the female reproductive tract, known as capacitation. Capacitation correlates with two essential events for fertilization: hyperactivation, an asymmetric and vigorous flagellar motility, and the ability to undergo the acrosome reaction. At a molecular level, capacitation is associated to: phosphorylation cascades, modification of membrane lipids, alkalinization of the intracellular pH, increase in the intracellular Ca2+ concentration and hyperpolarization of the sperm plasma membrane potential. Hyperpolarization is a crucial event in capacitation since it primes the sperm to undergo the exocytosis of the acrosome content, essential to achieve fertilization of the oocyte.
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