4.6 Article

A viscous modified Gompertz model for the analysis of the kinetics of tumors under electrochemical therapy

Journal

MATHEMATICS AND COMPUTERS IN SIMULATION
Volume 151, Issue -, Pages 96-110

Publisher

ELSEVIER SCIENCE BV
DOI: 10.1016/j.matcom.2018.03.005

Keywords

Diffusion process; Modified Gompertz equation; Tumor; Electrochemical therapy

Funding

  1. MINECO [MTM2016-77735-C3-1-P]

Ask authors/readers for more resources

Knowledge of tumor growth kinetics constitutes a challenge for researchers. Different models have been used to describe data of unperturbed and perturbed tumors. The modified Gompertz equation had been proposed to describe diverse responses of direct current treated tumors (disease progression, stable disease, partial response and complete response). Nevertheless, diffusion processes involved in the tumor growth are not integrated in this equation. This paper analyzes the viscous modified Gompertz equation. It is shown that for certain input parameters the corresponding solutions decrease exponentially in appropriate time intervals. (C) 2018 International Association for Mathematics and Computers in Simulation (IMACS). Published by Elsevier B.V. All rights reserved.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.6
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

Article Biology

Dose-response study for the highly aggressive and metastatic primary F3II mammary carcinoma under direct current

Maraelys M. Gonzalez, Dasha F. Morales, Luis E. B. Cabrales, Daniel J. Perez, Juan I. Montijano, Antonio R. S. Castaneda, Victoriano G. S. Gonzalez, Oscar O. Posada, Janet A. Martinez, Arlem G. Delgado, Karina G. Martinez, Mayrel L. Mon, Kalet L. Monzon, Hector M. C. Ciria, Emilia O. Beaton, Soraida C. A. Brooks, Tamara R. Gonzalez, Manuel V. Jarque, Miguel A. O. Mateus, Jorge L. G. Rodriguez, Enaide M. Calzado

BIOELECTROMAGNETICS (2018)

Article Mathematics, Applied

On the effectiveness of spectral methods for the numerical solution of multi-frequency highly oscillatory Hamiltonian problems

Luigi Brugnano, Juan I. Montijano, Luis Randez

NUMERICAL ALGORITHMS (2019)

Article Computer Science, Interdisciplinary Applications

High-order energy-conserving Line Integral Methods for charged particle dynamics

Luigi Brugnano, Juan Montijano, Luis Randez

JOURNAL OF COMPUTATIONAL PHYSICS (2019)

Article Multidisciplinary Sciences

New formulation of the Gompertz equation to describe the kinetics of untreated tumors

Antonio Rafael Selva Castaneda, Erick Ramirez Torres, Narciso Antonio Villar Goris, Maraelys Morales Gonzalez, Juan Bory Reyes, Victoriano Gustavo Sierra Gonzalez, Maria Schonbek, Juan Ignacio Montijano, Luis Enrique Bergues Cabrales

PLOS ONE (2019)

Article Engineering, Multidisciplinary

Simulations of the electrostatic field, temperature, and tissue damage generated by multiple electrodes for electrochemical treatment

Enaide Maine Calzado, Jorge Luis Garcia Rodriguez, Luis Enrique Bergues Cabrales, Francisco Monier Garcia, Antonio Rafael Selva Castaneda, Ivelice Maria Gonzalez Delgado, Leonardo Mesa Torres, Fidel Valentin Giro Uribazo, Maraelys Morales Gonzalez, Soraida Candida Acosta Brooks, Tamara Rubio Gonzalez, Eduardo Jose Roca Oria, Leonardo Lorenzo Bravo Roger, Hugo Enrique Hernandez Figueroa, Geisa Davila Perez

APPLIED MATHEMATICAL MODELLING (2019)

Article Medicine, Research & Experimental

Efficacy of direct current generated by multiple-electrode arrays on F3II mammary carcinoma: experiment and mathematical modeling

Narciso Antonio Villar Goris, Jorge Luis Garcia Rodriguez, Maraelys Morales Gonzalez, Beatriz Olivares Borges, Dasha Fuentes Morales, Enaide Maine Calzado, Antonio Rafael Selva Castaneda, Leonardo Mesa Torres, Juan Ignacio Montijano, Victoriano Gustavo Sierra Gonzalez, Daniel Jay Perez, Oscar Ortiz Posada, Janet Avellanet Martinez, Arlem Garcia Delgado, Karina Garcia Martinez, Mayrel Labrada Mon, Kalet Leon Monzon, Hector Manuel Camue Ciria, Luis Enrique Bergues Cabrales

JOURNAL OF TRANSLATIONAL MEDICINE (2020)

Article Physics, Multidisciplinary

Correspondence between formulations of Avrami and Gompertz equations for untreated tumor growth kinetics

N. A. Villar Goris, A. R. Selva Castaneda, E. E. Ramirez-Torres, J. Bory Reyes, L. Randez, L. E. Bergues Cabrales, J. Montijano

REVISTA MEXICANA DE FISICA (2020)

Article Computer Science, Interdisciplinary Applications

A note on the stability of time-accurate and highly-stable explicit operators for stiff differential equations

M. Calvo, J. Montijano, L. Randez

Summary: A family of TASE operators for stiff IVPs is proposed, with the order of the TASE operator depending on multiple free parameters for different stability and accuracy requirements. A study on A-stability properties for explicit RK schemes supplemented with TASE operators is conducted, providing specific schemes suitable for stiff problems.

JOURNAL OF COMPUTATIONAL PHYSICS (2021)

Article Computer Science, Interdisciplinary Applications

Spatio temporal dynamics of direct current in treated anisotropic tumors

Antonio Rafael Selva Castaneda, Josue Marino del Pozo, Erick Eduardo Ramirez-Torres, Eduardo Jose Roca Oria, Sorangel Bolanos Vaillant, Juan Montijano, Luis Enrique Bergues Cabrales

Summary: By extending the Gompertz equation, this study simulated the spatiotemporal behavior of anisotropic tumors and conducted a theoretical analysis. The results showed that direct current treatment is most effective for highly heterogeneous, anisotropic, aggressive, and hypodense malignant solid tumors.

MATHEMATICS AND COMPUTERS IN SIMULATION (2023)

Article Mathematics, Applied

Singly TASE Operators for the Numerical Solution of Stiff Differential Equations by Explicit Runge-Kutta Schemes

Manuel Calvo, Lin Fu, Juan I. Montijano, Luis Randez

Summary: This paper proposes new explicit integrators for numerical solution of stiff evolution equations. The new integrators have simpler computation process and better stability properties compared to previous methods. A series of numerical experiments demonstrates that the new integrators provide a simple and stable solver for stiff systems.

JOURNAL OF SCIENTIFIC COMPUTING (2023)

Article Mathematics, Applied

Modified SEIR epidemic model including asymptomatic and hospitalized cases with correct demographic evolution

Antonio Rafael Selva Castaneda, Erick Eduardo Ramirez-Torres, Luis Eugenio Valdes-Garcia, Hilda Maria Morandeira-Padron, Diana Sedal Yanez, Juan I. Montijano, Luis Enrique Bergues Cabrales

Summary: The study proposes a modified SEIR model to describe the behavior of symptomatic, asymptomatic, and hospitalized patients in an epidemic, considering the effect of demographic evolution. The growth ratio is assumed to be proportional to the total population, following a Logistic law. Theoretical analysis, computation of the basic reproduction number R0, and numerical simulations are conducted to validate the model and its properties. The model is fitted to experimental data on COVID-19 in Cuba, providing a correct estimation of asymptomatic cases. Overall, the model is deemed an appropriate tool for studying and controlling infectious diseases.

APPLIED MATHEMATICS AND COMPUTATION (2023)

Article Computer Science, Interdisciplinary Applications

The numerical solution of the free-boundary cell motility problem

Vitaly Chernik, Pavel Buklemishev

Summary: The paper introduces a simple 2D model for describing the cell motility on a homogeneous isotropic surface. The model incorporates the dynamics of complex actomyosin liquid, which affects the boundary dynamics and cell motility. It consists of a system of equations with a free boundary domain and includes a non-local term. The numerical solution of this model is presented in this work.

MATHEMATICS AND COMPUTERS IN SIMULATION (2024)

Article Computer Science, Interdisciplinary Applications

A well-balanced and positivity-preserving numerical model for overland flow under vegetation effects

Hasan Karjoun, Abdelaziz Beljadid

Summary: In this study, we developed a numerical model based on the depth-averaged shallow water equations to simulate flows through vegetation field. The model takes into account the drag and inertia forces induced by vegetation, using different formulations for the stem drag coefficient. Turbulence induced by vegetation is also considered through the addition of diffusion terms in the momentum equations. The proposed numerical model is validated through numerical simulations and shows good accuracy in simulating overland flows under vegetation effects.

MATHEMATICS AND COMPUTERS IN SIMULATION (2024)

Article Computer Science, Interdisciplinary Applications

A Branch and Bound algorithm for multidimensional Holder optimization: Estimation of the age-dependent viral hepatitis A infection force

Bechir Naffeti, Hamadi Ammar, Walid Ben Aribi

Summary: This paper proposes a branch and bound multidimensional Holder optimization method, which converts a multivariate objective function into a single variable function and minimizes it using an iterative optimization method. The method is applied to solve a parameters identification problem resulting from the increase in infections, providing information about the prevalence and infection force.

MATHEMATICS AND COMPUTERS IN SIMULATION (2024)

Article Computer Science, Interdisciplinary Applications

Autonomous bonobo optimization algorithm for power allocation in wireless networks

Heba F. Eid, Erik Cuevas, Romany F. Mansour

Summary: The proposed modified Bonobo optimizer algorithm dynamically adjusts the trajectory of each search agent to overcome the flaw of the original algorithm and improve the performance and solution quality by exploring and exploiting different regions of the solution space.

MATHEMATICS AND COMPUTERS IN SIMULATION (2024)

Article Computer Science, Interdisciplinary Applications

Valuation of option price in commodity markets described by a Markov-switching model: A case study of WTI crude oil market

Farshid Mehrdoust, Idin Noorani, Juho Kanniainen

Summary: This paper proposes a Markov-switching model to evaluate the dynamics of commodity futures and spot prices, and introduces a hidden Markov chain to model the sudden jumps in commodity prices. The model is calibrated using the crude oil spot price and estimation-maximization algorithm. The study also evaluates European call options written on crude oil futures under the regime-switching model and derives Greek formulas for risk assessment. The importance of this paper is rated at 8 out of 10.

MATHEMATICS AND COMPUTERS IN SIMULATION (2024)

Article Computer Science, Interdisciplinary Applications

Predictive Power Control of PMSG based WECS: Development and Implementation for Smooth Grid Synchronisation, Balanced and Unbalanced Grid

Rupa Mishra, Tapas Kumar Saha

Summary: This paper presents a control scheme for distributed generation units to operate in stand-alone and grid-connected modes, with a smooth transition between the two. The control strategy includes predictive control for voltage and frequency regulation in stand-alone mode, and power control for symmetrical and unbalanced grid voltage conditions in grid-connected mode. The proposed control method improves power factor, reduces grid current harmonics, and eliminates grid frequency ripple.

MATHEMATICS AND COMPUTERS IN SIMULATION (2024)

Article Computer Science, Interdisciplinary Applications

Active torque-based gait adjustment multi-level control strategy for lower limb patient-exoskeleton coupling system in rehabilitation training

Yu Wang, Yang Tian, Yida Guo, Haoping Wang

Summary: This paper proposes a multi-level control strategy for lower limb patient-exoskeleton coupling system (LLPECS) in rehabilitation training based on active torque. The controller consists of three sub-controllers: gait adjustment layer, interaction torque design layer, and trajectory tracking layer. The effectiveness of the proposed control strategy is demonstrated through co-simulations in the SimMechanics environment using an exoskeleton virtual prototype developed in SolidWorks.

MATHEMATICS AND COMPUTERS IN SIMULATION (2024)

Article Computer Science, Interdisciplinary Applications

Monte Carlo simulation for Barndorff-Nielsen and Shephard model under change of measure

Takuji Arai, Yuto Imai

Summary: The Barndorff-Nielsen and Shephard model is a jump-type stochastic volatility model, and this paper proposes two simulation methods for computing option prices under a representative martingale measure. The performance of these methods is evaluated through numerical experiments.

MATHEMATICS AND COMPUTERS IN SIMULATION (2024)

Article Computer Science, Interdisciplinary Applications

Quadrature-free forms of discontinuous Galerkin methods in solving compressible flows on triangular and tetrahedral grids

Wanai Li

Summary: This paper proposes a new framework that combines quadrature-based and quadrature-free discontinuous Galerkin methods and applies them to triangular and tetrahedral grids. Four different DG schemes are derived by choosing specific test functions and collocation points, improving computational efficiency and ease of code implementation.

MATHEMATICS AND COMPUTERS IN SIMULATION (2024)

Article Computer Science, Interdisciplinary Applications

A novel dimensionality reduction approach by integrating dynamics theory and machine learning

Xiyuan Chen, Qiubao Wang

Summary: This paper introduces a technique that combines dynamical mechanisms and machine learning to reduce dimensionality in high-dimensional complex systems. The method utilizes Hopf bifurcation theory to establish a model paradigm and utilizes machine learning to train location parameters. The effectiveness and robustness of the proposed method are tested and validated through experiments and simulations.

MATHEMATICS AND COMPUTERS IN SIMULATION (2024)

Article Computer Science, Interdisciplinary Applications

Analysis and controllability of diabetes model for experimental data by using fractional operator

Muhammad Farman, Aqeel Ahmad, Anum Zehra, Kottakkaran Sooppy Nisar, Evren Hincal, Ali Akgul

Summary: Diabetes is a significant public health issue that affects millions of people worldwide. This study proposes a mathematical model to understand the mechanisms of glucose homeostasis, providing valuable insights for diabetes management. The model incorporates fractional operators and analyzes the impact of a new wave of dynamical transmission on equilibrium points, offering a comprehensive understanding of glucose homeostasis.

MATHEMATICS AND COMPUTERS IN SIMULATION (2024)

Article Computer Science, Interdisciplinary Applications

Improved MPS models for simulating free surface flows

Gholamreza Shobeyri

Summary: This study introduces two improved Laplacian models for more accurate simulation of free surface flows in the context of the MPS method. The higher accuracy of these models compared to the traditional methods is verified through solving 2D Poisson equations and solving three benchmark free surface flow problems. These models can also resolve the issue of wave damping in the original MPS computations.

MATHEMATICS AND COMPUTERS IN SIMULATION (2024)

Article Computer Science, Interdisciplinary Applications

Nonfragile state estimation for semi-Markovian switching CVNs with general uncertain transition rates: An event-triggered scheme

Qiang Li, Jinling Liang, Weiqiang Gong, Kai Wang, Jinling Wang

Summary: This paper addresses the problem of nonfragile state estimation for semi-Markovian switching complex-valued networks with time-varying delay. By constructing an event-triggered generator and solving matrix inequalities, less conservative criteria are obtained, and the gains of the nonfragile estimator are explicitly designed. A numerical example is provided to demonstrate the effectiveness of the proposed estimation scheme.

MATHEMATICS AND COMPUTERS IN SIMULATION (2024)

Article Computer Science, Interdisciplinary Applications

A class of unconditionally energy stable relaxation schemes for gradient flows

Gengen Zhang, Jingyu Li, Qiong-Ao Huang

Summary: In this paper, a novel class of unconditionally energy stable schemes are constructed for solving gradient flow models by combining the relaxed scalar auxiliary variable (SAV) approach with the linear multistep technique. The proposed schemes achieve second-order temporal accuracy and strictly unconditional energy stability.

MATHEMATICS AND COMPUTERS IN SIMULATION (2024)

Article Computer Science, Interdisciplinary Applications

Stencil and kernel optimisation for mesh-free very high-order generalised finite difference method

S. Clain, J. Figueiredo

Summary: This study proposes a detailed construction of a very high-order polynomial representation and introduces a functional to assess the quality of the reconstruction. Several optimization techniques are implemented and their advantages in terms of accuracy and stability are demonstrated.

MATHEMATICS AND COMPUTERS IN SIMULATION (2024)