Article
Materials Science, Multidisciplinary
Yifei Gu, Yiwen Liu, Reinhilde Jacobs, Lingfei Wei, Yi Sun, Lei Tian, Yuelian Liu, Constantinus Politis
Summary: Porous scaffolds can have improved biocompatibility and osteoconductivity by using coating technique to create micro-and nanostructures on the surfaces. This study employed a biomimetic approach to coat porous titanium scaffolds with a bone morphogenetic protein-2 (BMP-2) integrated calcium phosphate (CaP) coating. In vitro characterizations demonstrated that the coated scaffolds exhibited mechanical properties similar to human cortical bone and released BMP-2 effectively. In vivo experiments on beagle dogs with mandibular defects showed that the biomimetic coating significantly promoted bone formation in the titanium scaffolds.
MATERIALS & DESIGN
(2023)
Article
Chemistry, Physical
Qusai Alkhasawnah, Sera Elmas, Keywan Sohrabi, Sameh Attia, Sascha Heinemann, Thaqif El Khassawna, Christian Heiss
Summary: The study demonstrated the feasibility of using calcium phosphate cement paste in oral rehabilitation and the possibility of monitoring healing progression and material retention through CBCT. The flowable paste allowed for simultaneous placement of implants and prosthetics, showing good clinical feasibility.
Article
Materials Science, Multidisciplinary
Yifei Gu, Lingfei Wei, Zheru Zhang, Jeroen Van Dessel, Ronald B. Driesen, Ivo Lambrichts, Reinhilde Jacobs, Lei Tian, Yi Sun, Yuelian Liu, Constantinus Politis
Summary: In this study, a porous Ti6Al4V scaffold with a biomimetic coating was designed and implanted in beagle dogs. The results showed that the coating induced ectopic bone formation and increased biocompatibility of the scaffold. This combination has the potential for bone reconstruction, but further clinical studies are needed.
MATERIALS & DESIGN
(2022)
Article
Orthopedics
Nikola Stokovic, Natalia Ivanjko, Viktorija Rumenovic, Anita Breski, Kuber T. Sampath, Mihaela Peric, Marko Pecina, Slobodan Vukicevic
Summary: This study evaluated different commercially available synthetic ceramic particles as compression-resistant matrix (CRM) added to Osteogrow implants. The results showed that Osteogrow-C implants with different ceramic particles induced the formation of bone-ceramic structure and promoted bone formation. Highly porous Vitoss ceramic demonstrated the highest bone volume, while Vitoss and ChronOs ceramics increased the number of trabeculae, and BAM and Dongbo ceramics increased the thickness of trabeculae.
INTERNATIONAL ORTHOPAEDICS
(2022)
Article
Materials Science, Biomaterials
Peiming Liu, Tianyi Bao, Lian Sun, Zeyi Wang, Jin Sun, Wan Peng, Donglin Gan, Guoyong Yin, Pingsheng Liu, Wei-Bing Zhang, Jian Shen
Summary: The study introduces a novel mineralized PLGA/PSBMA scaffold as a carrier for rhBMP-2 with high efficiency sustained release leading to successful healing of critical-sized bone defects in rats at an ultralow dosage. This finding suggests promising potential for bone defect repair utilizing the mineralized scaffold.
BIOMATERIALS SCIENCE
(2022)
Article
Multidisciplinary Sciences
Shinichi Nakagawa, Rintaro Okada, Junichi Kushioka, Joe Kodama, Hiroyuki Tsukazaki, Zeynep Bal, Daisuke Tateiwa, Yuichiro Ukon, Hiromasa Hirai, Takahiro Makino, Shota Takenaka, Seiji Okada, Takashi Kaito
Summary: This study developed a novel composite material NP that can sustainably release BMP-2 and reduce side effects, and found that NP showed better fusion rates and fewer side effects compared to CS.
SCIENTIFIC REPORTS
(2022)
Article
Nanoscience & Nanotechnology
Masahiro Yamada, Tsuyoshi Kimura, Naoko Nakamura, Jun Watanabe, Nadia Kartikasari, Xindie He, Watcharaphol Tiskratok, Hayato Yoshioka, Hidenori Shinno, Hiroshi Egusa
Summary: Researchers have successfully created a smart titanium nanosurface that mimics the surface properties of tooth root cementum, leading to the regeneration of periodontal tissues. This nanosurface induces the formation of dentoalveolar fibrous joints, resulting in the regeneration of functional periodontium.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Engineering, Multidisciplinary
Ali Temelci, Hasan Gueney Yilmaz, Guerkan uensal, Lokman Onur Uyanik, Dilek Yazman, Aysa Ayali, Giuseppe Minervini
Summary: This study aimed to compare the contact angles and wettability of implant surfaces between beta-thalassemia major (BTM) patients and healthy individuals. The results showed that the decreased deformability of BTM patients did not affect the wettability of implant surfaces in vitro. Considering the lack of in-depth studies on dental implant success in BTM patients and the high prevalence of BTM in Cyprus, this study aimed to enrich the literature.
Article
Biotechnology & Applied Microbiology
Ziyang Yang, Li Xie, Boqing Zhang, Gang Zhang, Fangjun Huo, Changchun Zhou, Xi Liang, Yujiang Fan, Weidong Tian, Yinghui Tan
Summary: This study demonstrates the potential of the BMP-2/PDA-BCP scaffold for the treatment of small craniofacial bone defects requiring high accuracy. The scaffold, constructed using DLP-based 3D printing, showed excellent properties and effectively promoted bone regeneration both in vitro and in vivo.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Nansi Lopez-Valverde, Javier Aragoneses, Cinthia Rodriguez, Juan Manuel Aragoneses
Summary: This study compared the bone in contact with titanium implant surfaces treated with bone morphogenetic protein 2 (BMP-2) and carboxyethylphosphonic acid (CEPA) with those treated with conventional etched surface. The results showed that dental implant surfaces treated with CEPA and BMP-2 improved their biological response to osseointegration.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Nansi Lopez-Valverde, Javier Aragoneses, Antonio Lopez-Valverde, Cinthia Rodriguez, Juan Manuel Aragoneses
Summary: The aim of this study was to analyze and compare the effect of bone morphogenetic protein-7 (BMP-7) on biological parameters related to implant osseointegration in an experimental animal model. The results showed that dental implant surfaces treated with carboxyethylphosphonic acid and BMP-7 improved the biological response of dental implants to osseointegration.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Menghong Li, Mingjie Wang, Lingfei Wei, Arie Werner, Yuelian Liu
Summary: This study aimed to improve the biocompatibility of stainless steel (SSL) by coating its surface with a bio-mimetic calcium phosphate (BioCaP). The results showed that the BioCaP coating improved the roughness and wettability of SSL surface, and increased cell adhesion and proliferation.
Article
Engineering, Biomedical
Liisa T. Kuhn, Tao Peng, Gloria Gronowicz, Marja M. Hurley
Summary: Endogenous levels of fibroblast growth factor-2 (FGF-2) decrease with age, and a personalized medicine approach should guide FGF-2 supplementation to avoid excessive bone resorption and cartilage formation, which both inhibit calvarial bone repair.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2021)
Review
Biochemistry & Molecular Biology
Fan Qi, Haofei Huang, Ming Wang, Weifeng Rong, Jing Wang
Summary: With the increasing attention to dental health, various dental treatment procedures have emerged. However, these procedures often result in the production of a large number of free radicals, causing oxidative stress and damage. This article reviews the origin of these free radicals, the types of antioxidants, and their mechanisms. The delivery of antioxidants in dental procedures and their feasibility for clinical applications are also discussed. Additionally, the importance of safety assessment for these materials and future challenges in antioxidant development are highlighted.
Article
Polymer Science
Rafael Silva Bonato, Gustavo Vicentis de Oliveira Fernandes, Monica Diuana Calasans-Maia, Alexandre Mello, Alexandre Malta Rossi, Ana Claudia Oliveira Carreira, Mari Cleide Sogayar, Jose Mauro Granjeiro
Summary: This study investigates the effect of rhBMP-7 on the osseointegration of titanium implants coated with a thin film of hydroxyapatite. The results show that rhBMP-7 promotes bone formation, particularly in over-instrumented implant sites.
Article
Materials Science, Ceramics
Ipek Karacan, Oguzhan Gunduz, L. Sevgi Ozyegin, Hasan Gokce, Besim Ben-Nissan, Sibel Akyol, Faik N. Oktar
JOURNAL OF THE AUSTRALIAN CERAMIC SOCIETY
(2018)
Article
Biochemical Research Methods
Fatma Gizem Avci, Fatma Ece Altinisik, Ipek Karacan, Duygu Senturk Karagoz, Serhat Ersahin, Ayse Eren, Nihat Alpagu Sayar, Didem Vardar Ulu, Elif Ozkirimli, Berna Sariyar Akbulut
JOURNAL OF MOLECULAR GRAPHICS & MODELLING
(2018)
Article
Materials Science, Ceramics
S. Akyol, B. Ben Nissan, I. Karacan, M. Yetmez, H. Gokce, D. J. Suggett, F. N. Oktar
JOURNAL OF THE AUSTRALIAN CERAMIC SOCIETY
(2019)
Article
Materials Science, Biomaterials
Ipek Karacan, Besim Ben-Nissan, Hang Andy Wang, Arion Juritza, Michael Swain, Wolfgang H. Mueller, Joshua Chou, Artemis Stamboulis, Innocent J. Macha, Valerio Taraschi
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2019)
Article
Materials Science, Ceramics
Ipek Karacan, Nathan Cox, Annette Dowd, Razi Vago, Bruce Milthorpe, Sophie Cazalbou, Besim Ben-Nissan
Summary: Artificially grown coral species, such as Millepora dichotoma, can be used to produce hydroxyapatite bioceramics for drug delivery systems and tissue engineering. Analysis showed that the hydrothermally treated coral was completely converted to hydroxyapatite, with a nanocrystalline structure suitable for biomedical applications like bone growth and repair.
JOURNAL OF THE AUSTRALIAN CERAMIC SOCIETY
(2021)
Article
Cell & Tissue Engineering
Ipek Karacan, Besim Ben-Nissan, Jerran Santos, Stanley Yiu, Peta Bradbury, Stella M. Valenzuela, Joshua Chou
Summary: The study aimed to improve current implant treatments by using a localized and controlled antibiotic delivery-based coating system. The results showed that the coating effectively prevented biofilm formation caused by Staphylococcus aureus and did not have adverse effects on human cells.
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2022)
Article
Chemistry, Multidisciplinary
M. Sayahi, J. Santos, H. El-Feki, C. Charvillat, F. Bosc, I Karacan, B. Milthorpe, C. Drouet
MATERIALS TODAY CHEMISTRY
(2020)
Article
Multidisciplinary Sciences
Innocent J. Macha, Ipek Karacan, Besim Ben-Nissan, Sophie Cazalbou, Wolfgang H. Mueller
SN APPLIED SCIENCES
(2019)
Meeting Abstract
Biochemistry & Molecular Biology
F. Ece Altinisik, F. Gizem Avci, Berna Sariyar Akbulut, Elif Ozkirimli Olmez, Didem Vardar Ulu, Ipek Karacan, Duygu Senturk
