Article
Biochemistry & Molecular Biology
Lu Wang, Fengling Liu, Xinrang Zhai, Wei Dong, Wei Wei, Zhenhua Hu
Summary: A composite hydrogel (GelNB@SIS) was designed for the repair of skin injuries. GelNB provides photo-triggering tissue adhesive property, while SIS has a 3D microporous structure and contains high levels of growth factors and collagen. This study demonstrated that GelNB@SIS can improve the healing process by promoting vascular renewal, dermal remodeling, and epidermal regeneration, making it a promising candidate for tissue repair applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Nanoscience & Nanotechnology
Boquan Qin, Shizhou Wu, Hongxian Dong, Shu Deng, Yunjie Liu, Wanli Zhang, Guoying Feng, Lei Lei, Huiqi Xie
Summary: This study developed a dual-layered sodium alginate/carboxymethyl chitosan (SA/CMCS) adhesive film cored with an SA-bFGF microsphere-loaded small intestine submucosa (SIS) hydrogel composite dressing with a graphene oxide (GO)-based antisense transformation system to promote infected diabetic wound healing and bacterial eradication.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Review
Polymer Science
Olga Luneva, Roman Olekhnovich, Mayya Uspenskaya
Summary: A wide range of skin diseases necessitates the search for alternative and effective treatment options, particularly for various types of wounds. This review examines the advantages and methods of bilayer dressings in wound treatment and skin tissue regeneration, focusing on hydrogel-based materials. The use of such materials can provide unique properties, such as antimicrobial, adhesion, and hemostasis capabilities, as well as drug delivery and self-healing abilities.
Article
Biophysics
Miaomiao Zhang, Shixin Xu, Chen Du, Ruoying Wang, Cuicui Han, Yongan Che, Wei Feng, Chengwei Wang, Shan Gao, Wen Zhao
Summary: In this study, a novel bilayer wound dressing made of poly(L-lactate-caprolactone) copolymer (PLCL) nanofibrous and keratin hydrogel loaded with fibroblast growth factor (FGF-2) was prepared using the low-pressure filtration-assisted method. The bilayer dressing was found to mimic the dermis and epidermis. It exhibited good porosity, maximum water absorption, and tight bond at the interface. In vitro and in vivo studies demonstrated the biocompatibility, biodegradability, and ability to promote skin healing of the bilayer dressing, making it a promising biomedical wound dressing for skin tissue engineering applications.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Biochemistry & Molecular Biology
Hemant Singh, Indu Yadav, Wajid Mohammad Sheikh, Aniruddha Dan, Zenab Darban, Showkat Ahmad Shah, Narayan Chandra Mishra, Syed Shahabuddin, Shabir Hassan, Showkeen Muzamil Bashir, Mukesh Dhanka
Summary: This research focuses on fabricating biological macromolecule-based hydrogel with desirable antibacterial, antioxidant, controlled drug release, cytocompatibility, and wound healing properties. The nanocomposite hydrogel loaded with 500 mu g/ml NC exhibited excellent performance in treating full-thickness wound healing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Polymer Science
Zhenghua Sun, Hao Xiong, Tengfei Lou, Weixuan Liu, Yi Xu, Shiyang Yu, Hui Wang, Wanjun Liu, Liang Yang, Chao Zhou, Cunyi Fan
Summary: Treating chronic wounds, especially in diabetes mellitus cases, is challenging due to prolonged inflammatory responses. Macrophage polarization and the use of Quercetin (QCT) have shown potential in promoting wound healing and inhibiting inflammation. However, the limited solubility of QCT restricts its applicability. Small intestinal submucosa (SIS) has been studied as a carrier for tissue regeneration and wound healing. Researchers have developed a biosafe hydrogel dressing with self-healing, water-absorbable, and immunomodulatory properties by combining SIS and QCT. In in vivo experiments, the hydrogels significantly increased wound repair rate and showed promising results in promoting wound healing.
Article
Biochemistry & Molecular Biology
Yiyu Wang, Long Su, Yuanjing Hou, Fei Lin, Chao Xu, Yanling Xue, Jian Shi, Xinyu Wang
Summary: In this study, a bilayer sheet mimicking the hierarchical structure of the skin was developed for full-thickness skin wound dressings. The bilayer sheet showed suitable water uptake capacity and high stability, and promoted wound healing and regeneration. In vivo experiments demonstrated superior and faster healing effects of the bilayer sheets compared to other treatments.
MACROMOLECULAR BIOSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Nahideh Asadi, Ahmad Mehdipour, Marjan Ghorbani, Mehran Mesgari-Abbasi, Abolfazl Akbarzadeh, Soodabeh Davaran
Summary: A bilayer wound dressing with multifunctional properties was designed in this study, showing enhanced wound healing performance, including antibacterial, free radical scavenging, and biocompatibility properties. Through a full thickness wound model study, it was found that this scaffold had a faster wound closure rate, effective collagen deposition, quick re-epithelialization, and regulation of transforming growth factor-β1 (TGF-β1) and tumor necrosis factor-alpha (TNF-α).
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Engineering, Biomedical
Ying Shen, Xinyu Wang, Yiyu Wang, Xiaodong Guo, Keda Yu, Kuo Dong, Yajin Guo, Cuiling Cai, Binbin Li
Summary: An ideal wound dressing for full-thickness wound regeneration should have desirable biocompatibility, mechanical properties, barrier function, and cellular regulation. In this study, a bilayer scaffold resembling the hierarchical structure of human skin was developed. The combination of a nonporous upper membrane and a porous lower scaffold improved the tensile strength and protected the wound from dehydration. The bilayer scaffold facilitated wound closure, granulation tissue formation, re-epithelialization, and skin component transition. This off-the-shelf and cell-free wound dressing is promising for full-thickness wound regeneration.
Article
Materials Science, Multidisciplinary
Jiawei Lu, Xiaokun Fan, Jiawei Hu, Jie Li, Jingjing Rong, Weijia Wang, Ying Chen, Wenyong Liu, Jin Chen, Yi Chen
Summary: The study reveals that a double-layer hydrogel can be used as an independent wound dressing. The first layer, C-A, has moderate adhesion and the ability to promote solution absorption, while the second layer, P-A, has good water-locking ability and high strength. The double-layer hydrogel dressing exhibits excellent comprehensive performance, promoting wound healing and possessing antibacterial effects.
MATERIALS & DESIGN
(2023)
Article
Chemistry, Applied
Asghar Eskandarinia, Mosayeb Gharakhloo, Paria Khaloo Kermani, Sepehr Navid, Mohammad Ali Salami, Darioush Khodabakhshi, Ali Samadi
Summary: This study investigated the effect of a bilayer hydrogel wound dressing on wound-healing rate. A self-healing hydrogel was synthesized using chitosan and arginine, and its characteristics were evaluated through various tests. The bilayer wound dressing showed desirable properties like self-healing and adhesiveness. It also had antibacterial efficacy and potential applications in analyzing healthcare data and detecting body movement.
CARBOHYDRATE POLYMERS
(2023)
Article
Materials Science, Biomaterials
Shijie Qiu, Lijin Liang, Peng Zou, Qi Chen
Summary: The study developed a bi-layer composite scaffold using decellularized small intestine submucosa and polylactic-co-glycolic acid, with minimal residual DNA in the former and satisfactory mechanical properties in the scaffold. Cellular interactions within the scaffold showed desirable cell proliferation and phenotypic behaviors, laying a solid foundation for future in vivo studies and clinical applications.
REGENERATIVE BIOMATERIALS
(2021)
Article
Biotechnology & Applied Microbiology
Feng Wang, Shuguang Wang, Liping Nan, Jiawei Lu, Ziqi Zhu, Jintao Yang, Dong Zhang, Junjian Liu, Xiao Zhao, Desheng Wu
Summary: Wound injuries can lead to serious consequences, and the use of biomedical hydrogels as wound dressings has shown great potential in accelerating wound healing.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Wencheng Liang, Mingli Jiang, Junyong Zhang, Xiaoming Dou, Yan Zhou, Yun Jiang, Li Zhao, Meidong Lang
Summary: In this study, novel antibacterial composite scaffolds were prepared with improved water absorption rate, water retention rate, and mechanical strength compared to traditional scaffolds. The addition of hyaluronic acid enhanced the biocompatibility of the scaffolds, and the positive charge in the scaffolds contributed to their antibacterial activity. The scaffolds showed potential for wound healing and could be used as wound dressings.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2021)
Article
Engineering, Multidisciplinary
Rong Nie, Qing-Yi Zhang, Jie Tan, Zi-Yuan Feng, Kai Huang, Ning Sheng, Yan-Lin Jiang, Yu-Ting Song, Chen-Yu Zou, Long-Mei Zhao, He-Xi Li, Rui Wang, Xing-Li Zhou, Juan-Juan Hu, Chen-Yu Wu, Li-Ling Jesse, Hui-Qi Xie
Summary: This study demonstrates that epigallocatechin gallate (EGCG) modification of decellularized porcine small intestinal submucosa (SIS) improves its antioxidant and immunomodulatory capacities, thereby enhancing its therapeutic potential for wound healing.
COMPOSITES PART B-ENGINEERING
(2023)
Article
Materials Science, Biomaterials
Mohammadreza Kasravi, Alireza Yaghoobi, Tahereh Tayebi, Mahsa Hojabri, Abdolkarim Talebi Taheri, Fatemeh Shirzad, Bahram Jambar Nooshin, Radman Mazloomnejad, Armin Ahmadi, Fatemeh A. Tehrani, Ghasem Yazdanpanah, Mohammad Hadi Farjoo, Hassan Niknejad
Summary: As a promising approach in translational medicine, the decellularization of discarded livers to produce bioscaffolds that support recellularization has potential in overcoming the limitations of conventional liver transplantation. In this study, the researchers investigated the use of matrix metalloproteinase (MMP) inhibition to preserve the extracellular matrix (ECM) during liver decellularization. The results demonstrated that the application of an MMP inhibitor significantly improved the preservation of ECM components and mechanical properties of the bioscaffolds, which supported cell viability and function in vitro. The study also confirmed that the MMP inhibition led to the inhibition of MMP2 and MMP9, providing a novel method to enhance ECM preservation during liver decellularization.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Mohammadsadegh Nadimifar, Weiguang Jin, Clara Coll-Satue, Gizem Bor, Paul Joseph Kempen, Ali Akbar Moosavi-Movahedi, Leticia Hosta-Rigau
Summary: This study presents a metal-phenolic self-assembly approach that can prepare nanoparticles fully made of hemoglobin. The nanoparticles exhibit good oxygen binding and releasing capabilities.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jyoti Kumari, Roel Hammink, Jochem Baaij, Frank A. D. T. G. Wagener, Paul H. J. Kouwer
Summary: Fibrosis is the formation of fibrous connective tissue in response to injury, leading to organ dysfunction. A novel hybrid hydrogel combining synthetic polyisocyanide with hyaluronic acid has been developed, showing strong antifibrotic properties.
BIOMATERIALS ADVANCES
(2024)
Letter
Materials Science, Biomaterials
Melissa Machado Rodrigues, Cristian Padilha Fontoura, Charlene Silvestrin Celi Garcia, Sandro Tomaz Martins, Joao Antonio Pegas Henriques, Carlos Alejandro Figueroa, Mariana Roesch Ely, Cesar Aguzzoli
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jessica Polak, David Sachs, Nino Scherrer, Adrian Suess, Huan Liu, Mitchell Levesque, Sabine Werner, Edoardo Mazza, Gaetana Restivo, Mirko Meboldt, Costanza Giampietro
Summary: Human skin equivalents (HSEs) play a crucial role in tissue engineering. This study introduces a 3D-printed culture insert to apply a static radial constraint on HSEs and examines its effects on tissue characteristics. The results show that the diameter of the culture insert significantly influences tissue contraction, fibroblast and matrix organization, keratinocyte differentiation, epidermal stratification, and basement membrane formation. This study provides important insights for the design of skin tissue engineering.
BIOMATERIALS ADVANCES
(2024)
Review
Materials Science, Biomaterials
Shiliang Chen, Tianming Du, Hanbing Zhang, Jing Qi, Yanping Zhang, Yongliang Mu, Aike Qiao
Summary: This paper reviewed the primary methods for improving the overall properties of biodegradable zinc stents. It discussed the mechanical properties, degradation behavior, and biocompatibility of various improvement strategies. Alloying was found to be the most common, simple, and effective method for improving mechanical properties. Deformation processing and surface modification further improved the mechanical properties and biological activity of zinc alloys. Meanwhile, structural design could endow stents with special properties. Manufacturing zinc alloys with excellent properties and exploring their interaction mechanism with the human body are areas for future research.
BIOMATERIALS ADVANCES
(2024)