Article
Cardiac & Cardiovascular Systems
Jonathan Hinton, Maclyn Augustine, Lavinia Gabara, Mark Mariathas, Rick Allan, Florina Borca, Zoe Nicholas, John Ikwoube, Neil Gillett, Chun Shing Kwok, Paul Cook, Michael P. W. Grocott, Mamas Mamas, Nick Curzen
Summary: The diagnosis and clinical implications of periprocedural myocardial infarction (PPMI) following coronary artery bypass grafting (CABG) are controversial. The study found that the diagnosis of UDMI PPMI post-CABG is independently associated with 1-year mortality, indicating its clinical and research utility.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Bahadir Simsek, Spyridon Kostantinis, Judit Karacsonyi, Khaldoon Alaswad, Oleg Krestyaninov, Dmitrii Khelimskii, Rhian Davies, Jeremy Rier, Omer Goktekin, Sevket Gorgulu, Ahmed ElGuindy, Raj H. Chandwaney, Mitul Patel, Nidal Abi Rafeh, Dimitrios Karmpaliotis, Amirali Masoumi, Jaikirshan J. Khatri, Farouc A. Jaffer, Darshan Doshi, Paul B. Poommipanit, Bavana Rangan, Yader Sandoval, James W. Choi, Basem Elbarouni, William Nicholson, Wissam A. Jaber, Stephane Rinfret, Michael Koutouzis, Ioannis Tsiafoutis, Robert W. Yeh, M. Nicholas Burke, Salman Allana, Olga C. Mastrodemos, Emmanouil S. Brilakis
Summary: This study aimed to develop risk scores for in-hospital major adverse cardiovascular events (MACE), mortality, pericardiocentesis, and acute myocardial infarction (MI) in patients undergoing CTO PCI. The risk scores were validated and showed good predictive ability.
JACC-CARDIOVASCULAR INTERVENTIONS
(2022)
Review
Medicine, General & Internal
Seung-Hyun Kim, Michael Behnes, Kambis Mashayekhi, Alexander Bufe, Markus Meyer-Gessner, Ibrahim El-Battrawy, Ibrahim Akin
Summary: Studies have shown a clear association between coronary chronic total occlusion (CTO) and adverse clinical outcomes, especially in patients with acute myocardial infarction (AMI). However, the prognostic impact of CTO-percutaneous coronary intervention (PCI) during AMI remains controversial due to the higher risk of complications compared to non-occlusive coronary lesions.
JOURNAL OF CLINICAL MEDICINE
(2021)
Editorial Material
Cardiac & Cardiovascular Systems
Samuel Heuts, Iwan C. C. van der Horst, Alma Mingels
Summary: Researchers found that CK-MB and hs-cTnT can predict PMI with high accuracy and proposed a more sensitive threshold for hs-cTnT, but further research is needed to identify appropriate cut-offs for improving the diagnosis of PMI in clinical practice.
JOURNAL OF CARDIAC SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Lei Song, Yang Wang, Changdong Guan, Tongqiang Zou, Zhongwei Sun, Lihua Xie, Rui Zhang, Kefei Dou, Weixian Yang, Yongjian Wu, Shubin Qiao, Bo Xu
Summary: The study findings suggest that postprocedural CK-MB levels are significantly associated with 5-year cardiovascular death in CTO-PCI patients, while cTnI levels do not show such correlation. Additionally, the Society for Cardiovascular Angiography and Interventions definition of periprocedural myocardial infarction is clinically relevant in predicting outcomes following CTO-PCI.
CIRCULATION-CARDIOVASCULAR INTERVENTIONS
(2021)
Article
Cardiac & Cardiovascular Systems
Yupeng Liu, Wenyao Wang, Jingjing Song, Kuo Zhang, Kaihao Wang, Chunli Shao, Ping Li, Bo Xu, Min Yang, Jing Chen, Jilin Zheng, Yi-Da Tang
Summary: This study followed 10,724 patients undergoing PCI for a median of 2.4 years and found that PMI was consistently associated with increased MACE risk regardless of definition, while the SMI group had higher risks of death and MACE.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Yasushi Ueki, Koichiro Kuwahara
Summary: Percutaneous coronary intervention (PCI) combined with guideline-directed medical therapy can reduce the risks of spontaneous myocardial infarction (MI), urgent revascularization, and angina, but it also increases the risks of periprocedural myocardial injury and MI. The definitions of periprocedural MI vary, resulting in differences in frequency and clinical significance. Accurate diagnosis of clinically-relevant periprocedural MI is crucial for patient management. In clinical trials, only clinically relevant definitions should be used to avoid obscuring meaningful outcomes. This review aims to summarize the mechanisms, predictors, frequency, and prognostic impact of periprocedural MI in patients undergoing PCI and provide the current perspective on this issue.
JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Zhuoshan Huang, Xing Shui, Yesheng Ling, Linli Zhou, Wenqi Shi, Yanting Luo, Suhua Li, Jieming Zhu, Shujie Yu, Jinlai Liu
Summary: This study found that elevated preprocedural Lp(a) levels were associated with the risk of PCI-related myocardial injury in non-AMI CHD patients.
CLINICAL CARDIOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Shao-Yong Cheng, Hao Wang, Shi-Hua Lin, Jin-Hui Wen, Ling-Ling Ma, Xiao-Ce Dai
Summary: The study evaluated the associations between admission hyperglycemia and all-cause mortality risk in patients with acute myocardial infarction, finding a significant increase in mortality risk related to admission hyperglycemia. Short-term and long-term follow-ups both indicated an increased risk of major adverse cardiac events associated with admission hyperglycemia.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Ya Li, Duanbin Li, Liding Zhao, Tian Xu, Qingbo Lv, Jialin He, Yao Wang, Wenbin Zhang
Summary: This study evaluated the association between different thresholds of post-PCI cTnI and mortality, and found that none of these thresholds were significantly associated with an increased risk of cardiac death during a 3-year follow-up period.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
You Zhou, Zhangwei Chen, Ao Chen, Jiaqi Ma, Chunfeng Dai, Danbo Lu, Yuan Wu, Su Li, Jinxiang Chen, Muyin Liu, ChenGuang Li, Hao Lu, Juying Qian, Junbo Ge
Summary: This study aimed to investigate the prognostic implications of increased post-procedural cardiac troponin levels in patients undergoing elective percutaneous coronary intervention (PCI) and to define the threshold of prognostically relevant periprocedural myocardial injury (PMI). The study found that post-PCI high-sensitivity cardiac troponin T (hs-cTnT) >8x URL was associated with an increased risk of major adverse cardiovascular events (MACEs).
EUROPEAN HEART JOURNAL-QUALITY OF CARE AND CLINICAL OUTCOMES
(2022)
Article
Cardiac & Cardiovascular Systems
Janek Salatzki, Evangelos Giannitsis, Anastasia Hegenbarth, Matthias Mueller-Hennessen, Florian Andre, Norbert Frey, Moritz Biener
Summary: This study aims to investigate the phenomenon of undetectable myocardial injury on LGE in a group of Type 1 AMI patients and provide possible explanations.
EUROPEAN HEART JOURNAL-ACUTE CARDIOVASCULAR CARE
(2023)
Article
Cardiac & Cardiovascular Systems
Yifan Pan, Min Xu, Yaosheng Mei, Yunxiang Wang, Qiongli Zhang
Summary: This retrospective cross-sectional study examined the relationship between activities of daily living (ADL) measured by Barthel index (BI) and periprocedural myocardial infarction (PMI) and injury following percutaneous coronary intervention (PCI). The study found that impaired ADL was an independent risk factor for PMI and injury among patients following PCI.
BMC CARDIOVASCULAR DISORDERS
(2023)
Article
Cardiac & Cardiovascular Systems
Heerajnarain Bulluck, Valeria Paradies, Emanuele Barbato, Andreas Baumbach, Hans Erik Botker, Davide Capodanno, Raffaele De Caterina, Claudio Cavallini, Sean M. Davidson, Dmitriy N. Feldman, Peter Ferdinandy, Sebastiano Gili, Mariann Gyongyosi, Vijay Kunadian, Sze-Yuan Ooi, Rosalinda Madonna, Michael Marber, Roxana Mehran, Gjin Ndrepepa, Cinzia Perrino, Stefanie Schupke, Johanne Silvain, Joost P. G. Sluijter, Giuseppe Tarantini, Gabor G. Toth, Linda W. Van Laake, Clemens von Birgelen, Michel Zeitouni, Allan S. Jaffe, Kristian Thygesen, Derek J. Hausenloy
Summary: The article recommends measuring baseline and post-PCI cTn values in all CCS patients undergoing PCI and confirms the prognostic relevance of post-PCI cTn elevation >5x 99th percentile URL for defining type 4a MI. In the absence of related complications, the same cTn cut-off threshold can be used to define major periprocedural myocardial injury, which are strong predictors of all-cause mortality post-PCI and can be used as quality metrics in clinical trials. Further research is needed to evaluate treatment strategies for reducing the risk of major periprocedural myocardial injury, type 4a MI, and MACE in CCS patients undergoing PCI.
EUROPEAN HEART JOURNAL
(2021)
Review
Biotechnology & Applied Microbiology
Johannes Mair, Allan Jaffe, Bertil Lindahl, Nicholas Mills, Martin Moeckel, Louise Cullen, Evangelos Giannitsis, Ola Hammarsten, Kurt Huber, Konstantin Krychtiuk, Christian Mueller, Kristian Thygesen
Summary: This review aims to illustrate the application of the Fourth Universal Definition of Myocardial Infarction (UDMI) for diagnosing peri-procedural myocardial infarction (MI) after percutaneous coronary interventions (PCI) in clinical practice. The study findings show that increases in cardiac troponin (cTn) concentrations are common after elective PCI in patients with chronic coronary syndrome (CCS). Diagnosing peri-procedural PCI-related MI in CCS patients requires an increase in cTn concentrations of >5-times the 99th percentile upper reference limit (URL), along with evidence of new peri-procedural myocardial ischemia.
Article
Medicine, General & Internal
Julia Isbister, Christopher Semsarian
INTERNAL MEDICINE JOURNAL
(2019)
Review
Cardiac & Cardiovascular Systems
Julia C. Isbister, Andrew D. Krahn, Christopher Semsarian, Raymond W. Sy
HEART LUNG AND CIRCULATION
(2020)
Editorial Material
Cardiac & Cardiovascular Systems
Kevin Liou, Sze-Yuan Ooi
HEART LUNG AND CIRCULATION
(2020)
Article
Cardiac & Cardiovascular Systems
Alexandra Butters, Julia C. Isbister, Caroline Medi, Hariharan Raju, Christian Turner, Raymond W. Sy, Christopher Semsarian, Jodie Ingles
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
(2020)
Review
Health Care Sciences & Services
Praveen Indraratna, Daniel Tardo, Jennifer Yu, Kim Delbaere, Matthew Brodie, Nigel Lovell, Sze-Yuan Ooi
JMIR MHEALTH AND UHEALTH
(2020)
Article
Cardiac & Cardiovascular Systems
Johanne Silvain, Michel Zeitouni, Valeria Paradies, Huili L. Zheng, Gjin Ndrepepa, Claudio Cavallini, Dimitri N. Feldman, Samin K. Sharma, Julinda Mehilli, Sebastiano Gili, Emanuele Barbato, Giuseppe Tarantini, Sze Y. Ooi, Clemens von Birgelen, Allan S. Jaffe, Kristian Thygesen, Gilles Montalescot, Heerajnarain Bulluck, Derek J. Hausenloy
Summary: The prognostic importance of cardiac procedural myocardial injury and myocardial infarction (MI) in chronic coronary syndrome (CCS) patients undergoing elective percutaneous coronary intervention (PCI) is still debated. Post-PCI cTn elevation of >= 5 x 99th percentile URL used to define Type 4a MI is associated with increased 1-year mortality in CCS patients with normal baseline cTn levels.
EUROPEAN HEART JOURNAL
(2021)
Article
Computer Science, Information Systems
Nan Ji, Ting Xiang, Paolo Bonato, Nigel H. Lovell, Sze-Yuan Ooi, David A. Clifton, Metin Akay, Xiao-Rong Ding, Bryan P. Yan, Vincent Mok, Dimitrios Fotiadis, Yuan-Ting Zhang
Summary: Prompt diagnosis and treatment are crucial in reducing mortality and morbidity in acute cardiovascular diseases, especially ST segment elevation myocardial infarction. During the COVID-19 pandemic, it is essential to balance cardiovascular emergencies with infectious risk. Utilizing wearable devices for early screening and real-time monitoring may improve patient management efficiency and effectiveness while reducing infection risk.
IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS
(2021)
Article
Geriatrics & Gerontology
Benjumin Hsu, Rosemary Korda, Vasi Naganathan, Peter Lewis, Sze-Yuan Ooi, David Brieger, Louisa Jorm
Summary: This study aimed to quantify the burden of cardiovascular diseases in older adults using community and residential care services. The findings showed a higher prevalence of major CVD among those using these services, emphasizing the importance of optimizing cardiovascular care for older adults.
Review
Cardiac & Cardiovascular Systems
Ben Ng, Sachin Nayyar, Vijay S. Chauhan
Summary: In recent years, the application of artificial intelligence (AI) in cardiology, specifically in the field of cardiac electrophysiology (EP), has increased due to large digitized data sets and advancements in high-performance computing. AI has the potential to automate the diagnosis and management of arrhythmias and has also been instrumental in discovering new EP concepts. Deep learning, a subdomain of AI, has shown groundbreaking performance surpassing traditional statistical analysis. However, there are still challenges to be overcome before AI can be widely adopted in clinical EP practice, including prospective validation and seamless integration of data.
CANADIAN JOURNAL OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Heerajnarain Bulluck, Valeria Paradies, Emanuele Barbato, Andreas Baumbach, Hans Erik Botker, Davide Capodanno, Raffaele De Caterina, Claudio Cavallini, Sean M. Davidson, Dmitriy N. Feldman, Peter Ferdinandy, Sebastiano Gili, Mariann Gyongyosi, Vijay Kunadian, Sze-Yuan Ooi, Rosalinda Madonna, Michael Marber, Roxana Mehran, Gjin Ndrepepa, Cinzia Perrino, Stefanie Schupke, Johanne Silvain, Joost P. G. Sluijter, Giuseppe Tarantini, Gabor G. Toth, Linda W. Van Laake, Clemens von Birgelen, Michel Zeitouni, Allan S. Jaffe, Kristian Thygesen, Derek J. Hausenloy
Summary: The article recommends measuring baseline and post-PCI cTn values in all CCS patients undergoing PCI and confirms the prognostic relevance of post-PCI cTn elevation >5x 99th percentile URL for defining type 4a MI. In the absence of related complications, the same cTn cut-off threshold can be used to define major periprocedural myocardial injury, which are strong predictors of all-cause mortality post-PCI and can be used as quality metrics in clinical trials. Further research is needed to evaluate treatment strategies for reducing the risk of major periprocedural myocardial injury, type 4a MI, and MACE in CCS patients undergoing PCI.
EUROPEAN HEART JOURNAL
(2021)
Editorial Material
Cardiac & Cardiovascular Systems
Julia C. Isbister, Hariharan Raju
CIRCULATION-GENOMIC AND PRECISION MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Md Shajedur Rahman Shawon, Oluwadamisola Temilade Sotade, Michelle Hill, Liesl Strachan, Gabrielle Challis, Sze-Yuan Ooi, Louisa R. Jorm
Summary: This study from New South Wales, Australia, found a significant association between cardiac implantable electronic device infection and mortality rates in both short-term and long-term follow-up, highlighting the importance of infection prevention in CIED procedures.
Article
Cardiac & Cardiovascular Systems
Julia C. Isbister, Belinda Gray, Sophie Offen, Laura Yeates, Chris Naoum, Caroline Medi, Hariharan Raju, Christopher Semsarian, Rajesh Puranik, Raymond W. Sy
Summary: This study utilized cardiac magnetic resonance imaging to longitudinally assess patients with Brugada syndrome. It found that structural changes, specifically focal fibrosis, can develop over time in a significant proportion of patients. These findings have implications for understanding the pathological substrate and longitudinal evaluation of Brugada syndrome patients.
Meeting Abstract
Cardiac & Cardiovascular Systems
P. Indraratna, D. Tardo, J. Yu, K. Delbaere, M. Brodie, N. Lovell, S. Ooi
EUROPEAN HEART JOURNAL
(2020)
Article
Medicine, General & Internal
Julia Isbister, Christopher Semsarian
AUSTRALIAN JOURNAL OF GENERAL PRACTICE
(2019)