Article
Pharmacology & Pharmacy
Hongjuan Zhao, Yatong Li, Beibei Zhao, Cuixia Zheng, Mengya Niu, Qingling Song, Xinxin Liu, Qianhua Feng, Zhenzhong Zhang, Lei Wang
Summary: The physical properties of nanoparticle-based vaccines, such as their shape, play a crucial role in antigen capture, lymphatic delivery, antigen presentation, and immune response in lymph nodes. Star-shaped gold nanoparticles (AuNPs) were found to capture and retain more repetitive antigen epitopes. Rods and star-shaped nanovaccines primarily drained into the lymph node follicles region, while cage-shaped nanovaccines showed stronger paracortex retention. Surprisingly, star-shaped nanovaccines elicited potent humoral immunity, preventing tumor growth in prophylactic studies. Cage-shaped nanovaccines preferentially presented peptide-MHC I complexes and showed the strongest therapeutic efficacy when combined with PD-1 checkpoint inhibitors in established tumor studies.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Biochemistry & Molecular Biology
Iker Malaina, Lorena Gonzalez-Melero, Luis Martinez, Aiala Salvador, Ana Sanchez-Diez, Aintzane Asumendi, Javier Margareto, Jose Carrasco-Pujante, Leire Legarreta, Maria Asuncion Garcia, Martin Blas Perez-Pinilla, Rosa Izu, Ildefonso Martinez de la Fuente, Manoli Igartua, Santos Alonso, Rosa Maria Hernandez, Maria Dolores Boyano
Summary: The importance of neoantigens in personalized antitumor vaccine development has significantly increased. DNA samples from patients with cutaneous melanoma were used to study the effectiveness of bioinformatic tools in detecting neoantigens. The analysis showed that the tools were able to highlight neoantigens in HLA-II recognition, but no significant differences were found in HLA-I binding affinity and Class I immunogenicity values. A new vaccine was designed using aggregative functions and combinatorial optimization, and it demonstrated specific activation of the immune response ex vivo. This study reinforces the use of bioinformatic tools in vaccine development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Ten-Tsao Wong, Gunn-Guang Liou, Ming-Chung Kan
Summary: In this article, a novel protein nanoparticle was created and its ability to withstand extended high temperature incubation while stimulating a long-lasting immune response was assessed. The protein nanoparticle was assembled from a fusion protein composed of a derived amphipathic helical peptide and a superfolder green fluorescent protein. A gain-of-function mutant was created to enhance the stability of the nanoparticle and induce a long-lasting immune response. This thermally stable protein nanoparticle may be a promising platform for vaccine development.
Review
Immunology
Anirban Sengupta, Mohammad Azharuddin, Noha Al-Otaibi, Jorma Hinkula
Summary: The use of gold nanoparticles (GNPs) in vaccine development has gained popularity due to their excellent properties in biocompatibility, immune modulation, and antigen delivery. GNPs can effectively combat various pathogens by modulating immune responses of cells and antibodies. Despite their potential toxicity, it is worth further exploring and investing in GNPs for vaccine development.
Review
Medicine, Research & Experimental
Stephanie N. N. Johnson, Spencer D. D. Brucks, Kyle D. D. Apley, Mark P. P. Farrell, Cory J. J. Berkland
Summary: Autoimmune diseases occur when the immune system mistakenly attacks its own antigens. Current treatments lack specificity and often result in adverse effects. Multivalent immunotherapies that specifically target immune cells responsible for disease are a promising strategy to mitigate adverse effects. This article reviews the architectural properties and functional mechanisms of multivalent ligands, and evaluates four different multivalent scaffolds for autoimmune treatment.
MOLECULAR PHARMACEUTICS
(2023)
Review
Nanoscience & Nanotechnology
Anna Cifuentes-Rius, Anal Desai, Daniel Yuen, Angus P. R. Johnston, Nicolas H. Voelcker
Summary: Induced tolerogenic dendritic cells offer a promising immunotherapy for autoimmune diseases, with nanomedicine presenting an alternative approach to overcome cost and customization limitations. By targeting dendritic cells with nanoparticles, this technology has the potential to address critical issues in organ transplantation and prevalent autoimmune disorders.
NATURE NANOTECHNOLOGY
(2021)
Article
Multidisciplinary Sciences
Lousineh Arakelian, Julien Lion, Guillaume Churlaud, Rezlene Bargui, Briac Thierry, Evelyne Mutabazi, Patrick Bruneval, Antonio Jose Alberdi, Christelle Doliger, Maeva Veyssiere, Jerome Larghero, Nuala Mooney
Summary: Endothelial cells play crucial roles in blood transport, vessel homeostasis, inflammatory responses, transendothelial migration, and blood vessel formation. CD34 is commonly used as an endothelial marker, but its expression and function vary in different organs and pathological conditions. This study investigates the expression and function of CD34 in endothelial cells, revealing that CD34(high) cells have lower proliferation but higher expression of IL-33 and Angiopoietin 2 compared to CD34(low) cells. CD34(high) endothelial cells also enhance the proliferation of regulatory T lymphocytes, suggesting their immunogenic ability and potential role in tolerogenic response.
SCIENTIFIC REPORTS
(2023)
Review
Immunology
Aleksandra J. Ozga, Melvyn T. Chow, Andrew D. Luster
Summary: Chemokines play a critical role in directing immune cell migration and are involved in shaping the tumor-promoting microenvironment.
Article
Chemistry, Multidisciplinary
Byungji Kim, Ryan R. Hosn, Tanaka Remba, Dongsoo Yun, Na Li, Wuhbet Abraham, Mariane B. Melo, Manuel Cortes, Bridget Li, Yuebao Zhang, Yizhou Dong, Darrell J. Irvine
Summary: The optimal storage conditions for LNPs loaded with RNA drugs have received limited attention. This study shows that LNPs stored under specific conditions can maintain long-term stability and activity, which is significant for vaccine development.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Microbiology
Idoia Buldain, Leire Martin-Souto, Aitziber Antoran, Maialen Areitio, Leire Aparicio-Fernandez, Aitor Rementeria, Fernando L. Hernando, Andoni Ramirez-Garcia
Summary: Infections caused by opportunistic pathogens Scedosporium/Lomentospora are increasing, posing challenges in diagnosis and treatment in the clinic. Understanding the immune response against these fungi is crucial for developing effective strategies. While progress has been made, many aspects remain unclear and further research is needed to elucidate the immune response to Scedosporium/Lomentospora.
Article
Medicine, Research & Experimental
Mengqi Yu, Hardeep S. Oberoi, Hitesh S. Purohit, Craig A. Fowler, Devalina Law
Summary: Amorphous solid dispersions (ASDs) are a formulation approach that enhances the bioavailability of poorly water-soluble molecules in oral drug products. Directly delivering drug-rich amorphous nanoparticles can reduce polymer quantities without sacrificing bioavailability. This study demonstrates the importance of understanding the impact of stabilizing agents on nanoparticle behavior and redispersion in designing high-drug-load amorphous formulations for poorly water-soluble compounds.
MOLECULAR PHARMACEUTICS
(2023)
Article
Immunology
Irene Gonzalez-Dominguez, Elianet Lorenzo, Alice Bernier, Laura Cervera, Francesc Godia, Amine Kamen
Summary: A flexible purification method for Gag VLPs was developed, allowing for their storage at room temperature for two months. The four-step downstream process successfully removed contaminants such as HCP, DNA, and EVs. Furthermore, this purification method could be easily scaled up and applied to purify other enveloped viruses and vesicles.
Article
Biochemistry & Molecular Biology
Sonja Scharf, Joerg Ackermann, Leonie Bender, Patrick Wurzel, Hendrik Schaefer, Martin-Leo Hansmann, Ina Koch
Summary: In this study, a semi-quantitative mathematical model of lymph nodes is constructed using the Petri net formalism. The model encompasses the major cellular processes of the immune response and fulfills the formal requirements of Petri net models. Through simulations, the model describes the dynamic modes of the immune response, its adaption to antigens, and its loss of memory.
Article
Immunology
Pablo Juanes-Velasco, Alicia Landeira-Vinuela, Marina L. Garcia-Vaquero, Quentin Lecrevisse, Raquel Herrero, Antonio Ferruelo, Rafael Gongora, Fernando Corrales, Javier De Las Rivas, Jose A. Lorente, Angela-Patricia Hernandez, Manuel Fuentes
Summary: This study analyzed the immune profile of severe ARDS in COVID-19 patients using functional proteomics approaches. It found that the autoimmune profiles were correlated with disease severity and clinical progression, providing new perspectives for therapeutic development and biomarker identification in COVID-19 patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Chaoran Zang, Yan Zhao, Ling Qin, Guihai Liu, Jianping Sun, Kang Li, Yanan Zhao, Shoupeng Sheng, Honghai Zhang, Ning He, Peng Zhao, Qi Wang, Xi Li, Yanchun Peng, Tao Dong, Yonghong Zhang
Summary: The study revealed specific T cell responses against CTAs and TAAs in HCC patients. In early-stage HCC patients, SALL4-specific response was the most prominent, followed by MAGE-A3, NY-ESO-1, MAGE-A1, and SSX2. The protective role of CTA-specific responses was suggested for one-year recurrence-free survival after treatment. As HCC progressed, CTA and SALL4-specific T cell responses decreased while AFP-specific response increased, indicating the potential of immunotherapy at an early stage of HCC.
Article
Biophysics
Ting Wang, Yuanyuan Zhen, Xiaoyu Ma, Biao Wei, Shuqin Li, Ning Wang
COLLOIDS AND SURFACES B-BIOINTERFACES
(2015)
Article
Pharmacology & Pharmacy
Ting Wang, Ning Wang
CURRENT PHARMACEUTICAL DESIGN
(2015)
Review
Pharmacology & Pharmacy
Ning Li, Ning Wang, Xueting Wang, Yuanyuan Zhen, Ting Wang
Meeting Abstract
Nanoscience & Nanotechnology
Ting Wang, Yuanyuan Zhen, Ning Li, Zhixuan Wang, Ning Wang
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2016)
Article
Biotechnology & Applied Microbiology
Xueting Wang, Ning Wang, Ning Li, Yuanyuan Zhen, Ting Wang
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2016)
Meeting Abstract
Chemistry, Multidisciplinary
Ning Wang, Yuanyuan Zhen, Ning Li, Xueting Wang, Ting Wang
JOURNAL OF CONTROLLED RELEASE
(2017)
Article
Chemistry, Multidisciplinary
Ning Wang, Yuanyuan Zhen, Yiguang Jin, Xueting Wang, Ning Li, Shaohong Jiang, Ting Wang
JOURNAL OF CONTROLLED RELEASE
(2017)
Article
Chemistry, Medicinal
Ning Li, Ning Wang, Tingni Wu, Changlu Qiu, Xueting Wang, Shaohong Jiang, Zina Zhang, Ting Liu, Chunliu Wei, Ting Wang
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
(2018)
Review
Chemistry, Multidisciplinary
Ning Wang, Minnan Chen, Ting Wang
JOURNAL OF CONTROLLED RELEASE
(2019)
Article
Immunology
Ning Wang, Changlu Qiu, Minnan Chen, Ting Liu, Ting Wang
Article
Polymer Science
Ning Wang, Chunliu Wei, Zina Zhang, Ting Liu, Ting Wang
JOURNAL OF INORGANIC AND ORGANOMETALLIC POLYMERS AND MATERIALS
(2020)
Article
Materials Science, Biomaterials
Yuanyuan Qi, Can Wang, Rui Qian, Minnan Chen, Pingping Jiang, Ting Wang, Ning Wang
Summary: The novel TUDC procedure allows for efficient loading of poorly water-soluble drugs into liposome interiors, with improved drug encapsulation efficiency. When combined with mathematical equations and thermodynamic process, it can accurately predict loading results, reducing experimental workload and enhancing liposome development efficiency.
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2021)
Article
Polymer Science
Jiale Li, Conghui Li, Hui Zhang, Xiang Gao, Ting Wang, Zengming Wang, Aiping Zheng
Summary: In this study, hot-melt extrusion was used to prepare azithromycin amorphous solid dispersion, solving the issues of bitter taste and low solubility. The selection of a suitable polymer was based on solubility parameter calculations, and the formulation and process were optimized using design of experiments.
Review
Pharmacology & Pharmacy
Ning Wang, Rui Qian, Ting Liu, Tingni Wu, Ting Wang
CRITICAL REVIEWS IN THERAPEUTIC DRUG CARRIER SYSTEMS
(2019)
