4.7 Review

Seaweed Bioactive Compounds against Pathogens and Microalgae: Potential Uses on Pharmacology and Harmful Algae Bloom Control

Journal

MARINE DRUGS
Volume 16, Issue 2, Pages -

Publisher

MDPI
DOI: 10.3390/md16020055

Keywords

cyanobacteria; harmful algae bloom; control; microalgae; macroalgae; bioactive compounds

Funding

  1. FCT Project [UID/Multi/04423/2013]
  2. Structured Program of R&D&I INNOVMAR-Innovation and Sustainability in the Management and Exploitation of Marine Resources [NORTE-01-0145-FEDER-000035]
  3. Northern Regional Operational Program (NORTE2020) through the European Regional Development Fund (ERDF)
  4. project CVMar+I - program Interreg V A Espanha-Portugal (POCTEP) [0302_CVMAR_I_1_P]

Ask authors/readers for more resources

Cyanobacteria are found globally due to their adaptation to various environments. The occurrence of cyanobacterial blooms is not a new phenomenon. The bloom-forming and toxin-producing species have been a persistent nuisance all over the world over the last decades. Evidence suggests that this trend might be attributed to a complex interplay of direct and indirect anthropogenic influences. To control cyanobacterial blooms, various strategies, including physical, chemical, and biological methods have been proposed. Nevertheless, the use of those strategies is usually not effective. The isolation of natural compounds from many aquatic and terrestrial plants and seaweeds has become an alternative approach for controlling harmful algae in aquatic systems. Seaweeds have received attention from scientists because of their bioactive compounds with antibacterial, antifungal, anti-microalgae, and antioxidant properties. The undesirable effects of cyanobacteria proliferations and potential control methods are here reviewed, focusing on the use of potent bioactive compounds, isolated from seaweeds, against microalgae and cyanobacteria growth.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

Article Environmental Sciences

Multi-Soil-Layering Technology: A New Approach to Remove Microcystis aeruginosa and Microcystins from Water

Richard Mugani, Roseline Prisca Aba, Abdessamad Hejjaj, Fatima El Khalloufi, Naaila Ouazzani, C. Marisa R. Almeida, Pedro N. Carvalho, Vitor Vasconcelos, Alexandre Campos, Laila Mandi, Brahim Oudra

Summary: Eutrophication caused by toxic cyanobacteria can be remedied by eco-technologies like multi-soil-layering (MSL) systems. These systems have the advantages of small space requirement, simple maintenance, and high durability. They can effectively remove various contaminants from water, including cyanotoxins, although the mechanisms involved are not fully understood.

WATER (2022)

Article Chemistry, Medicinal

Cosmetic Potential of Pigments Extracts from the Marine Cyanobacterium Cyanobium sp.

Fernando Pagels, Cintia Almeida, Vitor Vasconcelos, A. Catarina Guedes

Summary: This study evaluated the potential of marine cyanobacterium extracts as natural and sustainable ingredients in cosmetics. The extracts showed no cytotoxicity and demonstrated anti-hyaluronidase and anti-collagenase capacities, making them promising natural anti-aging ingredients. However, stability was lower at higher temperatures.

MARINE DRUGS (2022)

Review Biochemistry & Molecular Biology

Phenolic Compounds' Occurrence in Opuntia Species and Their Role in the Inflammatory Process: A Review

Walid Zeghbib, Fares Boudjouan, Vitor Vasconcelos, Graciliana Lopes

Summary: In this study, a summary of the different classes of phenolic compounds found in Opuntia species so far is provided, and their implications in the inflammatory process are explored. The use of cactus in folk medicine is supported, and its socio-economic value is evaluated.

MOLECULES (2022)

Article Food Science & Technology

In Vitro Toxicity Evaluation of Cyanotoxins Cylindrospermopsin and Microcystin-LR on Human Kidney HEK293 Cells

Leticia Diez-Quijada, Maria Puerto, Daniel Gutierrez-Praena, Maria Turkina, Alexandre Campos, Vitor Vasconcelos, Ana M. Camean, Angeles Jos

Summary: This study assessed the cytotoxic effects and gene expression changes in renal cells caused by CYN and MC-LR. The results showed that CYN upregulated gene expression, especially at high concentrations and long exposure times. Additionally, simultaneous exposure to both cyanotoxins resulted in more protein expression changes compared to single toxin exposure.

TOXINS (2022)

Article Chemistry, Analytical

A Multiplex Molecular Cell-Based Sensor to Detect Ligands of PPARs: An Optimized Tool for Drug Discovery in Cyanobacteria

Ines Pascoa, Rita Biltes, Joao Sousa, Marco Aurelio Correia Preto, Vitor Vasconcelos, Luis Filipe Castro, Raquel Ruivo, Isabel Cunha

Summary: Cyanobacteria produce secondary metabolites that can act as ligands for PPARs, making them a potential source of bioactive compounds. A cell-based PPAR transactivation activity biosensor was upgraded and used in a screening campaign for drug discovery.

SENSORS (2023)

Article Microbiology

Aeoliella straminimaris sp. nov., a novel member of the phylum Planctomycetota with an unusual filamentous structure

Ines Rosado Vitorino, Alexandre Lobo-da-Cunha, Vitor Vasconcelos, Olga Maria Lage

Summary: In this study, a novel bacterium, strain ICT_H6.2(T), was isolated from the brackish environment of the Tagus River estuary in Portugal. Through genetic analysis, it was classified as a member of the bacterial phylum Planctomycetota and family Lacipirellulaceae, with a 98.0% similarity to its closest relative Aeoliella mucimassa Pan181(T). The strain has a genome size of 7.8 Mbp and a DNA G+C content of 59.6 mol %. It is heterotrophic, aerobic and capable of microaerobic growth, and can tolerate high salt concentrations.

INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY (2023)

Review Chemistry, Medicinal

Cyanobacteria: A Promising Source of Antifungal Metabolites

Samuel Cavalcante do Amaral, Luciana Pereira Xavier, Vitor Vasconcelos, Agenor Valadares Santos

Summary: Cyanobacteria are a valuable source of secondary metabolites with diverse chemical and biological properties, including antifungal activity. This review examines the key features of these antifungal compounds, their sources, major targets, and the environmental factors involved in their production. A comprehensive analysis of 642 documents dating from 1980 to 2022, including patents, original research, review articles, and theses, was conducted for this study.

MARINE DRUGS (2023)

Article Food Science & Technology

Cytotoxic Effects and Oxidative Stress Produced by a Cyanobacterial Cylindrospermopsin Producer Extract versus a Cylindrospermopsin Non-Producing Extract on the Neuroblastoma SH-SY5Y Cell Line

Maria G. Hinojosa, Antonio Cascajosa-Lira, Ana I. Prieto, Daniel Gutierrez-Praena, Vitor Vasconcelos, Angeles Jos, Ana M. Camean

Summary: The incidence and interest of cyanobacteria have been increasing due to their ability to produce toxic secondary metabolites known as cyanotoxins. This study assessed the cytotoxicity and oxidative stress generation of different cyanobacterial extracts, and compared the effects of extracts containing and not containing cylindrospermopsin (CYN) in human neuroblastoma cells. The results showed that the CYN-containing extract was more toxic and induced oxidative stress compared to the CYN-free extract. This study highlights the importance of studying toxic effects of cyanobacteria in their natural environment.

TOXINS (2023)

Article Biology

Antioxidant, Anti-Inflammatory and Anti-Obesity Potential of Extracts Containing Phenols, Chlorophyll and Carotenoids from Mexican Wild Populations of Bacopa monnieri (L.) Wettst

Martha Martinez-Garcia, Gloria Garduno-Solorzano, Graciliana Lopes, Begona Astrain Sanchez, Ralph Urbatzka, Guilherme Scotta Hentschke, Jorge E. Campos, Vitor Manuel Oliveira Vasconcelos

Summary: Using molecular markers, we confirmed the taxonomic status of Bacopa monnieri from Mexico and analyzed its chemical content and potential bioactivity. The results show that B. monnieri has great potential as a natural source of compounds with antioxidant, anti-inflammatory, and anti-obesity properties. This plant's raw material can be effectively used as a nutritional and medicinal supplement.

BIOLOGY-BASEL (2023)

Article Plant Sciences

Description of four new filamentous cyanobacterial taxa from freshwater habitats in the Azores Archipelago

Ruben Luz, Rita Cordeiro, Jan Kastovsky, Jeffrey R. Johansen, Elisabete Dias, Amelia Fonseca, Ralph Urbatzka, Vitor Vasconcelos, Vitor Goncalves

Summary: This study described new genera and species of filamentous cyanobacteria isolated from aquatic habitats in the Azores archipelago through morphology, genetic data, and other analyses. It emphasizes the importance of taxonomic studies on cyanobacteria from less-studied habitats and geographical regions.

JOURNAL OF PHYCOLOGY (2023)

Review Biochemistry & Molecular Biology

Tracing the Path between Mushrooms and Alzheimer's Disease-A Literature Review

Ana Margarida Silva, Marco Preto, Clara Grosso, Monica Vieira, Cristina Delerue-Matos, Vitor Vasconcelos, Mariana Reis, Lillian Barros, Rosario Martins

Summary: Alzheimer's disease is a neurodegenerative disease that causes a decline in cognitive functions. It is the most common form of dementia and has no well-defined cause. Current treatments only manage to reduce symptoms, and there are only two drugs that can partially halt its progression. Natural compounds from mushrooms have been studied for their potential use in AD treatment due to their beneficial effects on various AD-related mechanisms such as enzyme inhibition, prevention of protein aggregation and neurotoxicity, and antioxidant and anti-inflammatory potential. While there have been studies linking mushrooms to neurodegenerative diseases, there is currently no publication summarizing the data specifically focused on AD. This review aims to fill that gap by compiling the potential anti-AD effects of mushroom extracts or compounds that target known AD-related mechanisms.

MOLECULES (2023)

Article Plant Sciences

New terrestrial cyanobacteria from the Azores Islands: description of Venetifunis gen. nov. and new species of Albertania, Kovacikia and Pegethrix

Ruben Luz, Rita Cordeiro, Jan Kastovsky, Jeffrey R. Johansen, Elisabete Dias, Amelia Fonseca, Ralph Urbatzka, Vitor Vasconcelos, Vitor Goncalves

Summary: The taxonomy of cyanobacteria has been advanced through the use of molecular methods and morphology. In this study, four cyanobacterial strains from the Azores Archipelago were genetically characterized and classified as new species and genera. This research contributes to the understanding of the biogeography of cyanobacteria in remote oceanic islands and new terrestrial habitats.

PHYCOLOGIA (2023)

Review Biochemistry & Molecular Biology

Stalling the Course of Neurodegenerative Diseases: Could Cyanobacteria Constitute a New Approach toward Therapy?

Vitoria Ramos, Mariana Reis, Leonor Ferreira, Ana Margarida Silva, Ricardo Ferraz, Monica Vieira, Vitor Vasconcelos, Rosario Martins

Summary: Neurodegenerative diseases are characterized by progressive and irreversible neuronal loss, and there are currently no available cures. Cyanobacterial compounds have anti-neurodegenerative properties and can be valuable in the field of treatment.

BIOMOLECULES (2023)

Article Microbiology

First Polyphasic Study of Cheffia Reservoir (Algeria) Cyanobacteria Isolates Reveals Toxic Picocyanobacteria Genotype

Lamia Benredjem, Joao Morais, Guilherme Scotta Hentschke, Akila Abdi, Hajira Berredjem, Vitor Vasconcelos

Summary: This study isolated and identified cyanobacteria strains from the Cheffia Reservoir, revealing the importance of morphological features and the 16S rRNA gene in species determination. The research also discovered potentially toxic genotypes within this ecosystem, highlighting the need for adapted water treatment methods to prevent toxin release from picocyanobacteria.

MICROORGANISMS (2023)

Article Infectious Diseases

Effect of Hydrogen Peroxide on Cyanobacterial Biofilms

Maria Joao Romeu, Joao Morais, Vitor Vasconcelos, Filipe Mergulhao

Summary: This study evaluated the effect of hydrogen peroxide on cyanobacterial biofilms and found that these biofilms were tolerant to hydrogen peroxide treatment, which may even lead to an increase in biomass.

ANTIBIOTICS-BASEL (2023)

No Data Available