Using the inbred mouse strain SPRET/EiJ to provide novel insights in inflammation and infection research

Simultaneous Inhibition of Tumor Necrosis Factor Receptor 1 and Matrix Metalloproteinase 8 Completely Protects Against Acute Inflammation and Sepsis

(2018) Sophie Steeland et al.   CRITICAL CARE MEDICINE

Counteracting the effects of TNF receptor‐1 has therapeutic potential in Alzheimer's disease

(2018) Sophie Steeland et al.   EMBO Molecular Medicine

Genetic mapping of species differences via in vitro crosses in mouse embryonic stem cells

(2018) Stefano Lazzarano et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Complete overview of protein-inactivating sequence variations in 36 sequenced mouse inbred strains

(2017) Steven Timmermans et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TNFR1 inhibition with a Nanobody protects against EAE development in mice

(2017) Sophie Steeland et al.   Scientific Reports

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

(2016) Mervyn Singer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Efficient analysis of mouse genome sequences reveal many nonsense variants

(2016) Sophie Steeland et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glucocorticoid‐induced microRNA‐511 protects against TNF by down‐regulating TNFR1

(2015) Leen Puimège et al.   EMBO Molecular Medicine

TNF trailblazers five centuries apart

(2015) Claude Libert   NATURE

Lymphotoxin and TNF: How it all began—A tribute to the travelers

(2014) Nancy H. Ruddle   CYTOKINE & GROWTH FACTOR REVIEWS

Generation and Characterization of Small Single Domain Antibodies Inhibiting Human Tumor Necrosis Factor Receptor 1

(2014) Sophie Steeland et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Determining differentially expressed miRNAs and validating miRNA—target relationships using the SPRET/Ei mouse strain

(2014) S. Timmermans et al.   MAMMALIAN GENOME

LPS resistance of SPRET/Ei mice is mediated by Gilz, encoded by theTsc22d3gene on the X chromosome

(2013) Iris Pinheiro et al.   EMBO Molecular Medicine

Safe TNF-based antitumor therapy following p55TNFR reduction in intestinal epithelium

(2013) Filip Van Hauwermeiren et al.   JOURNAL OF CLINICAL INVESTIGATION

Severe Sepsis and Septic Shock

(2013) Derek C. Angus et al.   NEW ENGLAND JOURNAL OF MEDICINE

Profiling Circulating MicroRNA Expression in Experimental Sepsis Using Cecal Ligation and Puncture

(2013) Shao-Chun Wu et al.   PLoS One

Glucocorticoid receptor dimerization induces MKP1 to protect against TNF-induced inflammation

(2012) Sofie Vandevyver et al.   JOURNAL OF CLINICAL INVESTIGATION

Paradoxical inflammation induced by anti-TNF agents in patients with IBD

(2012) Isabelle Cleynen et al.   Nature Reviews Gastroenterology & Hepatology

Treatment of TNF mediated diseases by selective inhibition of soluble TNF or TNFR1

(2011) Filip Van Hauwermeiren et al.   CYTOKINE & GROWTH FACTOR REVIEWS

The first MMP in sepsis

(2011) Roosmarijn E. Vandenbroucke et al.   EMBO Molecular Medicine

PWD/PhJ and WSB/EiJ Mice Are Resistant to Diet-Induced Obesity But Have Abnormal Insulin Secretion

(2011) Katie T. Y. Lee et al.   ENDOCRINOLOGY

Sequence-based characterization of structural variation in the mouse genome

(2011) Binnaz Yalcin et al.   NATURE

Mouse genomic variation and its effect on phenotypes and gene regulation

(2011) Thomas M. Keane et al.   NATURE

Cecal ligation and puncture: the gold standard model for polymicrobial sepsis?

(2011) Lien Dejager et al.   TRENDS IN MICROBIOLOGY

Increased Glucocorticoid Receptor Expression and Activity Mediate the LPS Resistance of SPRET/EI Mice

(2010) Lien Dejager et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Thirty years of Mus spretus: a promising future

(2009) Lien Dejager et al.   TRENDS IN GENETICS