Article
Biochemistry & Molecular Biology
Botuo Zheng, Songyi Xu, Xufeng Ni, Jun Ling
Summary: This study achieved controlled NNTA polymerization in amide polar solvents by adding acetic acid as a promoter, producing polypeptoids with designable molecular weights and low dispersities. The presence of acetic acid not only accelerated polymerization, but also suppressed H2S-catalyzed decomposition, leading to preparation of high molecular weight polysarcosines.
Article
Biotechnology & Applied Microbiology
Sahana Vasudevan, Parthasarathy Srinivasan, Prasanna Neelakantan, John Bosco Balaguru Rayappan, Adline Princy Solomon
Summary: In this study, a novel photoluminescence-based assay using cysteamine-capped titanium oxide nanoparticles was developed for the rapid and sensitive diagnosis of microbial infections. The system showed a maximum relative response of 98% for AHLs produced by Pseudomonas aeruginosa, with a linear detection range of 10-160 nM in simulated host urine. The efficacy and specificity of the system in detecting AHLs produced by P. aeruginosa were confirmed in a temporal manner.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Yueming Wu, Min Zhou, Kang Chen, Sheng Chen, Ximian Xiao, Zhemin Ji, Jingcheng Zou, Runhui Liu
Summary: The study demonstrates that lithium/sodium/potassium hexamethyldisilazide can initiate polymerization on NNCAs at a substantially faster rate, especially for NNCAs with bulky N substitution groups. This accelerated polymerization can increase the structural diversity and applications of polypeptoids as synthetic mimics of polypeptides.
CHINESE CHEMICAL LETTERS
(2021)
Article
Polymer Science
Siqi Wang, Tianlun Shen, Kai Hao, Xinfeng Tao, Jihong Sun, Jun Ling
Summary: Hyperbranched poly(a-amino acid)s have attracted attention for their biocompatibility, degradability, and bioactivity. Unique polymerization reactions of di-NNPC resulted in hyperbranched polypeptoids instead of gels. The molecular weights of the hyperbranched polypeptoids were controlled by tuning the initial concentrations of monomer and basic catalyst. The residual glycine pendant groups on the polymer chains were used for Gd3+ complexation and post-modification, making the hyperbranched polypeptoids multifunctional single molecular micelles applicable as contrast agents and probes in magnetic resonance imaging and photoluminescence.
MACROMOLECULAR CHEMISTRY AND PHYSICS
(2023)
Article
Polymer Science
David Siefker, Brandon A. Chan, Meng Zhang, Ju-Woo Nho, Donghui Zhang
Summary: This study demonstrates the zwitterionic ring-opening polymerization (ZROP) of sarcosine-derived N-thiocarboxyanhydrides (Me-NNTAs) using 1,1,3,3-tetramethylguanidine (TMG) initiators, resulting in well-defined polysarcosine polymers with controlled molecular weights and narrow molecular weight distributions. The polymerization exhibits living characteristics and can be conducted in the presence of moisture.
Article
Chemistry, Multidisciplinary
Zhi-Lin Wu, Jin-Yang Chen, Xian-Zhi Tian, Wen-Tao Ouyang, Zhuo-Tao Zhang, Wei-Min He
Summary: A novel and efficient electro-chemical initiated radical strategy was developed for the preparation of both N-substituted and N-unsubstituted 4-selanylisoquinolin-1(2H)-ones through selenylation of isoquinolin-1(2H)-ones with organodiselenides under chemical oxidant-, additive-free and ambient conditions.
CHINESE CHEMICAL LETTERS
(2022)
Article
Chemistry, Organic
Suresh Kumar Yadav, Masilamani Jeganmohan
Summary: A redox-neutral [4 + 2] annulation of N-chlorobenzamides/acrylamides with substituted alkenes using Co(III) catalyst at ambient temperature is demonstrated. The reaction provides pharmaceutically important 3,4-dihydroisoquinolinone derivatives in good yields, preserving the synthetically useful functional groups.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Organic
Simon Felder, Laurent Micouin, Erica Benedetti
Summary: A simple and convenient procedure for preparing para-disubstituted [2.2]paracyclophanes was reported, utilizing regioselective formylation of N-substituted 4-amino[2.2]paracyclophanes to access a series of products with a reactive aldehyde function. These compounds can undergo a variety of late-stage derivatization processes and serve as precursors for more complex derivatives.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Kasim Ali, Gautam Panda
Summary: An efficient transition-metal-free multicomponent approach to the regioselective synthesis of highly substituted N-alkylpyrazoles through 1,6-addition of pyrazole (in situ generated from alpha,beta-unsaturated aldehyde and hydrazide) to para-Quinone Methides has been developed. The N-alkylpyrazole containing triarylmethanes having several heteroaryl rings (quinoline, pyridine, thiophene) at the central methine carbon atom was developed. This chemical process may be used for large-scale synthesis and provides a novel way to produce triarylmethanes with diverse functional groups.
CHEMISTRY-AN ASIAN JOURNAL
(2023)
Article
Chemistry, Applied
Sifeng Li, Xingchen Li, Taimin Wang, Qingjing Yang, Zijun Ouyang, Jieyu Chen, Hongbin Zhai, Xiao Li, Bin Cheng
Summary: An electrochemical decarboxylative aminomethylation reaction of imidazo[1,2-alpha]pyridines with various N-substituted glycines in acetonitrile at room temperature has been developed. The reaction proceeds under light-free, catalyst-free, oxidant-free, and air conditions, resulting in good to high yields of C3-aminomethylated imidazo[1,2-alpha]pyridines. Notably, N-aryl, N,N-dialkyl, and N-alkyl-N-aryl glycines are all compatible with this easily conducted protocol, expanding the chemical space of bioactive imidazo[1,2-alpha]pyridine derivatives.
ADVANCED SYNTHESIS & CATALYSIS
(2022)
Article
Chemistry, Multidisciplinary
Jin Huang, Guang-xun Li, Gao-feng Yang, Ding-qiang Fu, Xiao-kang Nie, Xin Cui, Jin-zhong Zhao, Zhuo Tang
Summary: N-Substituted tetrahydroquinoxalines were efficiently synthesized in good yield and enantioselectivity using readily available substrates. The reaction involves a regioselective Heyns rearrangement/enantioselective transfer hydrogenation in one pot, and both the substrate scope and reaction mechanism were systematically investigated.
Article
Chemistry, Applied
V Murugesh, Apurba Ranjan Sahoo, Mathieu Achard, Gangavaram V. M. Sharma, Christian Bruneau, Surisetti Suresh
Summary: In this study, a ruthenium-catalyzed regioselective beta-C(sp(3))-H bond functionalization on the piperazine core using aldehydes as alkylating agents was disclosed. The transformation involves dehydrogenation of piperazine to enamine in situ, nucleophilic addition to aldehyde, and hydrogenation to achieve regioselective beta-C(sp(3))-H alkylation. Various aromatic, heteroaromatic, and aliphatic aldehydes were employed for the C-3 alkylation of N-alkyl-N'-p-nitrophenyl substituted piperazines.
ADVANCED SYNTHESIS & CATALYSIS
(2021)
Article
Chemistry, Multidisciplinary
Galla V. Karunakar, Chittala Emmaniel Raju, Karra Sai Bhavani Nagasri Himaja, Perla Bharath Kumar, Balasubramanian Sridhar
Summary: N-aryl-1H-pyrazolyl substituted benzenesulfonamide derivatives were regioselectively obtained from ynamides and pyrazoles through silver-catalyzed reaction. In this intermolecular organic transformation, several substituted benzenesulfonamides were obtained in good to excellent yields by forming a new C-N bond under mild reaction conditions.
CHEMISTRY-AN ASIAN JOURNAL
(2023)
Article
Chemistry, Applied
Ramanna Jatoth, Praveen Kumar Naikawadi, Boyapally Bhaskar, Kishan Gugulothu, Peramalla Edukondalu, K. Shiva Kumar
Summary: Metal-free TFA promoted arylation/heteroarylation was achieved under mild conditions via the reaction of chloro-derivatives of nitrogen heterocycles with electron rich arenes/heteroarenes. It was also observed that TFA was able to facilitate other reactions, resulting in the formation of fused N-heterocycles.
ADVANCED SYNTHESIS & CATALYSIS
(2022)
Article
Chemistry, Organic
Shuaibo Zhang, Dong Li, Bangzhong Wang, Wuding Sun, Haojun Ma, Kai Di, Luyang Sun, Jinfeng Zhao, Jingping Qu, Yuhan Zhou
Summary: An efficient strategy for asymmetric trifluoromethylated allylic alkylation of easily available N-substituted glycine ethyl esters with a-(trifluoromethyl)alkenyl acetates has been developed. Catalyzed by a [Pd(C3H5)Cl](2)/(R)-BINAP, various trifluoromethyl-containing N-substituted glycine ethyl ester derivatives are afforded with good yields and excellent enantioselectivities. The product can be readily converted into diverse fluoro-substituted species, which shows the practicability of this method.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Huan Qiu, Ting Shen, Zhening Yang, Feng Wu, Xiaohong Li, Yingfeng Tu, Jun Ling
Summary: Janus polymerization was utilized to synthesize multiblock copolymers with self-assembly capabilities, good shape memory properties, and potential applications in biomedical devices. The distinguishable chemical structures and thermal properties between Janus MBCPs and cationic random copolymers were confirmed, providing insights into the unique features of Janus polymerization for advanced material design and applications.
CHINESE JOURNAL OF CHEMISTRY
(2022)
Article
Engineering, Biomedical
Jingya Xia, Liying Wang, Tianlun Shen, Ping Li, Peiyun Zhu, Shengnan Xie, Zhenyan Chen, Fei Zhou, Jingfeng Zhang, Jun Ling, Xiangrui Liu, Hong Yu, Jihong Sun
Summary: Despite the initial promise of photothermal ablation (PTA) therapy, the inability to completely ablate large tumors is problematic. This study developed a smart photothermal nanosystem (PBM) based on FDA-approved Prussian blue (PB) nanoparticles, doped with Mn (III) to address this issue. The PBM nanosystem amplified the PTA-induced cGAS-STING pathway, leading to a robust immune response and suppression of both local residual and distant tumors.
ACTA BIOMATERIALIA
(2023)
Article
Chemistry, Multidisciplinary
Yixuan Mei, Kaihao Chen, Jiayu Gu, Jun Ling, Xufeng Ni
Summary: This study reports the successful synthesis of a copolymer of 2-methyltetrahydrofuran (2-MeTHF) and beta-butyrolactone (BBL) through Sc(OTf)(3)-catalysed cationic ring-opening copolymerization. The possibility of copolymerization was verified by density functional theory (DFT) calculations. The obtained copolymer, poly(2-MeTHF-co-BBL), showed promising properties and potential as an environmentally friendly material.
Article
Polymer Science
Song Zuo, Weisheng Feng, Fan Liu, Xuepei Xu, Xinfeng Tao, Liquan Wang, Honglai Liu, Shaoliang Lin
Summary: This study reveals the relationship between the PISA behavior and polymerization kinetics of side-chain liquid crystal copolymers through simulation and experimental comparison. The effects of PISA time, copolymer concentration, and structural parameters on the morphology of the assemblies are investigated, achieving low polydispersity of the produced copolymers.
Article
Nanoscience & Nanotechnology
Kai Hao, Ronglu Cui, Lifeng Fang, Jun Ling, Baoku Zhu
Summary: In this study, a neutral surface of polysarcosine (PSar), a hydrophilic polypeptoid, was successfully synthesized and modified to enhance its compatibility with water, reduce protein adsorption and cytotoxicity, and demonstrate good hemocompatibility and antifouling properties.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Yanli Zhao, Xinfeng Tao, Jiaping Lin, Shaoliang Lin
Summary: A simple and robust template-free solvothermal strategy is reported to obtain azobenzene-dangled COFs. The crystallinity, specific surface area, and morphology of Azo-COFs can be controlled by changing the ratio of amine to aldehyde monomers. The reversible trans-to-cis isomerization of the dangled azobenzene units inside the pores allows for intelligent regulation of surface wettability and enhanced adsorption capacity.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Xiaoyan Yang, Haibao Jin, Xinfeng Tao, Yuan Yao, Yufeng Xie, Shaoliang Lin
Summary: A simple strategy for the preparation of photo-responsive azobenzene-containing inverse opal (AzoIO) films with adjustable structural colors in wide visible wavelength is reported. The study demonstrates the potential for developing promising optical anti-counterfeiting materials.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Polymer Science
Siqi Wang, Tianlun Shen, Kai Hao, Xinfeng Tao, Jihong Sun, Jun Ling
Summary: Hyperbranched poly(a-amino acid)s have attracted attention for their biocompatibility, degradability, and bioactivity. Unique polymerization reactions of di-NNPC resulted in hyperbranched polypeptoids instead of gels. The molecular weights of the hyperbranched polypeptoids were controlled by tuning the initial concentrations of monomer and basic catalyst. The residual glycine pendant groups on the polymer chains were used for Gd3+ complexation and post-modification, making the hyperbranched polypeptoids multifunctional single molecular micelles applicable as contrast agents and probes in magnetic resonance imaging and photoluminescence.
MACROMOLECULAR CHEMISTRY AND PHYSICS
(2023)
Review
Polymer Science
Ting Shen, Kaihao Chen, Yougen Chen, Jun Ling
Summary: To address the plastic waste crisis, there are efforts to develop sustainable polymer materials that can degrade through disposing and decomposing to small molecules (DDM) or via chemical recycling to monomers (CRM). Polyacetals, a type of pH-responsive polymers, can degrade under acidic conditions but remain stable under neutral and basic conditions. Their synthesis through cationic ring-opening polymerization (CROP) has challenges but recent advancements in CRM have renewed interest in this method. Polyacetals offer recyclable materials with DDM and CRM potential, expanding closed-loop recycling options and improving degradation properties of traditional polyesters and polyolefins.
MACROMOLECULAR RAPID COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Jie Zhang, Tianwen Bai, Weixi Liu, Mingzhao Li, Qiguang Zang, Canbin Ye, Jing Zhi Sun, Yaocheng Shi, Jun Ling, Anjun Qin, Ben Zhong Tang
Summary: High refractive index polymers (HRIPs) with excellent optical transparency are prepared by using organobase catalyzed polymerization. The HRIPs exhibit high refractive indices, high molecular weights, and low propagation loss. The polymers also have aggregation-induced emission feature for monitoring the uniformity and continuity of optical waveguides.
NATURE COMMUNICATIONS
(2023)
Review
Chemistry, Multidisciplinary
Kaihao Chen, Yixuan Mei, Zhuorui Zhang, Jun Ling, Xufeng Ni
Summary: As a substituted-delta-valerolactone, alpha-ethylidene-delta-vinyl-delta-valerolactone (EVL) offers a method to utilize carbon dioxide and 1,3-butadiene in producing functional polymers. Recent successful attempts in polymerizing EVL have led to the development of novel synthetic strategies and functional polymers. This review highlights the ring-opening reactions of EVL and its derivatives, as well as the ring-opening (co)polymerizations, showcasing the unique properties of the obtained functional polymers and their application potential in various fields.
Article
Polymer Science
Jianping Wang, Peng Zhou, Ting Shen, Songyi Xu, Tianwen Bai, Jun Ling
Summary: This study developed a novel method to synthesize glycine-rich poly-(amino acid)-s (PAAs) through controlled ring-opening copolymerization. The synthesized copolymers exhibited predictable molecular weights and tunable glycine incorporation, and could form nanoparticles or hydrogel in water. The beta-sheet folding of poly-(Gly-r-Lys) remained intact in a neutral environment. This strategy opens up new possibilities for engineering glycine-rich PAAs and expanding their applications.
Article
Materials Science, Biomaterials
Shangyu Chen, Peng Zhou, Wan Yang, Danni Hu, Pengfei Chen, Pengfei Sun, Jun Ling, Quli Fan
Summary: In this study, a modified near-infrared II (NIR-II) small-molecule-based polymer was prepared for efficient breast cancer pulmonary metastasis imaging. The polymer showed good solubility, high fluorescence quantum yield, and prolonged blood circulation half-life, and demonstrated better tumor accumulation capability even at low dye concentration. The successful use of this polymer in noninvasive NIR-II fluorescence imaging for breast cancer pulmonary metastasis was demonstrated.
BIOMATERIALS SCIENCE
(2023)
Article
Polymer Science
Jia-le Qi, Yuan Yao, Xin-feng Tao, Shao-liang Lin
Summary: This study focuses on the self-assembly of crystalline polypeptoids with aromatic side chains. By designing and synthesizing a novel monomer, controlled polymerization was achieved to produce block copolymers with adjustable morphologies. It was found that these copolymers exhibited good crystallinity and formed various nanostructures in alcoholic solvents.
ACTA POLYMERICA SINICA
(2022)
