Article
Respiratory System
Shigang Li, Zhe Chen, Weifeng Yan
Summary: This study found that diaphragm thickening fraction (DTF) has higher sensitivity and specificity for predicting successful weaning in elderly patients compared to other parameters. Using a combination of rapid shallow breathing index (RSBI), lung ultrasound score (LUS), diaphragmatic excursion (DE), and DTF performed well in predicting weaning outcome, with high sensitivity and specificity. The clinical utility of these parameters in predicting extubation success may have important implications and should be further evaluated.
BMC PULMONARY MEDICINE
(2021)
Article
Respiratory System
Jia Song, Zhixian Qian, Haixiang Zhang, Minjia Wang, Yihua Yu, Cong Ye, Weihang Hu, Shijin Gong
Summary: This study found that two weaning indices determined by bedside ultrasonography, DE-RSBI (RR/DE) and DTF-RSBI (RR/DTF), were more accurate in predicting weaning outcome during a PSV SBT compared to the traditional RSBI.
BMC PULMONARY MEDICINE
(2022)
Review
Critical Care Medicine
Henry M. Parada-Gereda, Adriana L. Tibaduiza, Alejandro Rico-Mendoza, Daniel Molano-Franco, Victor H. Nieto, Wanderley A. Arias-Ortiz, Purificacion Perez-Teran, Joan R. Masclans
Summary: A systematic review and meta-analysis showed that measurement of diaphragmatic excursion and diaphragmatic thickening fraction can predict the probability of successful weaning from mechanical ventilation with satisfactory diagnostic accuracy. However, significant heterogeneity was evident in the different included studies. High-quality studies in specific subgroups of patients in intensive care units are needed to evaluate the role of diaphragmatic ultrasound as a predictor of weaning from mechanical ventilation.
Article
Critical Care Medicine
Deepti Kilaru, Nova Panebianco, Cameron Baston
Summary: A 65-year-old man with septic shock due to pneumonia was admitted to the ICU and required mechanical ventilation. After extubation, he developed increased work of breathing and was eventually reintubated. Diaphragmatic weakness was identified as the likely cause of respiratory failure after thorough evaluation.
Article
Critical Care Medicine
Fabio Varon-Vega, Luis F. Giraldo-Cadavid, Ana Maria Uribe, Adriana Rincon, Jonathan Palacios, Stephanie Crevoisier, Eduardo Tuta-Quintero, Lina Ordonez, Natalia Boada, Paola Rincon, Marcela Poveda, Pablo Monedero
Summary: The study found that objective measurements of cough and diaphragmatic contraction velocity can predict the success of the spontaneous breathing trial. The equation for predicting successful extubation, which includes values for the trial, cough, and diaphragmatic contraction velocity, showed excellent discriminative capacity.
Article
Pediatrics
Yelin Yao, Liming He, Weiming Chen, Hao Zhou, Guoping Lu, Jinhao Tao, SuJuan Wang
Summary: Diaphragmatic ultrasonography is a feasible method in guiding ventilator weaning, and the indicators of DE, DTF, and Dtei(MAX) provide more accurate guidance for the weaning process. Among them, DTF may act as a more reliable predictor by avoiding the influence of diaphragm development in children.
FRONTIERS IN PEDIATRICS
(2022)
Article
Pediatrics
Anita Duyndam, Joke Smit, Robert Jan Houmes, Leo Heunks, Jeroen Molinger, Marloes IJland, Joost van Rosmalen, Monique van Dijk, Dick Tibboel, Erwin Ista
Summary: The association between thickening fraction of the diaphragm (dTF) and extubation success in children undergoing mechanical ventilation was investigated. The study found no significant association between dTF and extubation success in ventilated children.
FRONTIERS IN PEDIATRICS
(2023)
Article
Multidisciplinary Sciences
Antuani Rafael Baptistella, Laura Maito Mantelli, Leandra Matte, Maria Eduarda da Rosa Ulanoski Carvalho, Joao Antonio Fortunatti, Iury Zordan Costa, Felipe Gabriel Haro, Vanda Lais de Oliveira Turkot, Shaline Ferla Baptistella, Diego de Carvalho, Joao Rogerio Nunes Filho
Summary: Despite efforts by ICUs, extubation failure rates remain high in mechanically ventilated patients. This study developed an Extubation Predictive Score (ExPreS) based on respiratory and non-respiratory parameters to predict likelihood of extubation success in ICU patients receiving invasive mechanical ventilation. Results showed high accuracy in predicting extubation outcomes and decreased failure rates in a validation cohort.
Article
Medicine, General & Internal
Ishita Raj, Suresh Kumar Nagaiah
Summary: This study investigated the use of bedside ultrasonography of the diaphragm to predict extubation outcome in mechanically ventilated patients. The results showed that diaphragmatic parameters, such as diaphragmatic thickening fraction (dTF) and diaphragmatic excursion (DE), can be used as additional criteria for assessing the likelihood of successful extubation. However, they should not be used as the sole criteria.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Oncology
Qiang Bao, Liang Chen, Xiaotong Chen, Ting Li, Caihong Xie, Zijun Zou, Chunrong Huan, Yaowei Zhi, Zhijie He
Summary: This study found that EDP treatment can significantly improve diaphragm function, shorten weaning time, and prolong survival time for mechanically ventilated patients.
ANNALS OF TRANSLATIONAL MEDICINE
(2022)
Article
Oncology
Qiang Bao, Liang Chen, Xiaotong Chen, Ting Li, Caihong Xie, Zijun Zou, Chunrong Huang, Yaowei Zhi, Zhijie He
Summary: This study examined the effects of external diaphragmatic pacing (EDP) in mechanically ventilated patients. The results showed that EDP treatment improved diaphragm function, shortened weaning time, and prolonged average survival time compared to patients who did not receive EDP therapy. The improvement was more significant in cases with difficult weaning.
ANNALS OF TRANSLATIONAL MEDICINE
(2022)
Article
Pediatrics
Eslam Bahgat, Hanan El-Halaby, Ashraf Abdelrahman, Nehad Nasef, Hesham Abdel-Hady
Summary: Sonographic assessment of diaphragmatic thickness and excursion is an accurate tool in predicting successful extubation of preterm infants from invasive mechanical ventilation. Diaphragmatic excursion is a useful indicator for successful extubation of preterm infants from mechanical ventilation.
EUROPEAN JOURNAL OF PEDIATRICS
(2021)
Review
Nursing
Aymeric Le Neindre, Francois Philippart, Marta Luperto, Johan Wormser, Johanna Morel-Sapene, Serge L. Aho, Silvia Mongodi, Francesco Mojoli, Belaid Bouhemad
Summary: Diaphragm ultrasound shows moderate-to-high specificity in predicting extubation failure in critically ill patients. However, its sensitivity is low due to the influence of non-diaphragm-related factors on weaning outcomes. Further research with homogeneous definitions and measures is needed to assess the accuracy of diaphragm ultrasound.
INTERNATIONAL JOURNAL OF NURSING STUDIES
(2021)
Review
Pediatrics
Poletto Elisa, Cavagnero Francesca, Pettenazzo Marco, Visentin Davide, Zanatta Laura, Zoppelletto Fabrizio, Pettenazzo Andrea, Daverio Marco, Bonardi Claudia Maria
Summary: Ventilation is crucial for critically ill children in pediatric intensive care units, however prolonged mechanical ventilation may increase the risks of infection and mortality. Extubation failure is associated with worse patient outcomes. Currently, there is insufficient clear evidence supporting the best strategies for weaning and readiness assessment in pediatrics.
FRONTIERS IN PEDIATRICS
(2022)
Review
Anesthesiology
Ata Mahmoodpoor, Shahnaz Fouladi, Ali Ramouz, Kamran Shadvar, Zohreh Ostadi, Hassan Soleimanpour
Summary: Proper timing for discontinuation of mechanical ventilation is crucial, especially in patients with previous weaning failures. Ultrasonographic examination of the diaphragm muscle can provide accurate diagnostic indices for weaning success. This systematic review found that diaphragm thickening fraction (DTF) had superior diagnostic accuracy compared to diaphragmatic excursion (DE) and the rapid shallow breathing index (RSBI). Diaphragmatic ultrasound is a cost-effective and feasible tool for evaluating diaphragm function.
ANAESTHESIOLOGY INTENSIVE THERAPY
(2022)
Letter
Critical Care Medicine
Yunuen Aguilera Garcia, Luis Quintero, Karan Singh, Viera Lakticova, AnnaMaria Iakovou, Seth Koenig, Paul H. Mayo, Mangala Narasimhan
Article
Critical Care Medicine
Atul Palkar, Mangala Narasimhan, Harly Greenberg, Karan Singh, Seth Koenig, Paul Mayo, Eric Gottesman
Review
Critical Care Medicine
Karan Singh, Paul Mayo
CURRENT OPINION IN CRITICAL CARE
(2018)
Editorial Material
Critical Care Medicine
Karan Singh, Paul Mayo
INTENSIVE CARE MEDICINE
(2018)
Editorial Material
Critical Care Medicine
Karan Singh, Maksim Korotun, Priyanka Bhat, Seth Koenig
Editorial Material
Critical Care Medicine
Maksim Korotun, Karan Singh, Priyanka Bhat, Seth Koenig
Letter
Critical Care Medicine
Karan Singh, Priyanka Bhat, Seth Koenig
Review
Medicine, General & Internal
Dhan Bahadur Shrestha, Yub Raj Sedhai, Sagun Dawadi, Bishal Dhakal, Jurgen Shtembari, Karan Singh, Roshan Acharya, Soney Basnyat, Irfan Waheed, Mohammad Saud Khan, Mohammed Kazimuddin, Nimesh K. Patel, Gautham Kalahasty, Prashant Dattatraya Bhave, Patrick Whalen, Ghanshyam Shantha
Summary: This study compared the outcomes of in-hospital cardiac arrest (IHCA) between COVID-19 and non-COVID-19 patients. The results showed that COVID-19 patients had lower rates of return of spontaneous circulation (ROSC), higher 30-day mortality, and lower odds of cardiac arrest caused by a shockable rhythm compared to non-COVID-19 IHCA patients. COVID-19 was identified as an independent risk factor for poor outcomes in IHCA patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Meeting Abstract
Critical Care Medicine
K. Singh, R. Steff, A. S. Qadir
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2020)
Meeting Abstract
Critical Care Medicine
R. Shah, M. Korotun, L. D. Quintero, K. Singh, S. Koenig
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2018)
Meeting Abstract
Critical Care Medicine
K. Singh, T. He, S. Verma, M. Narasimhan, A. Agrawal, R. Shah, N. Kohn, S. Khanijo, P. Bhat, P. H. Mayo, A. Talwar
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2018)
Meeting Abstract
Critical Care Medicine
K. Singh, A. Hilewitz, P. Bhat, A. Talwar, M. Makaryus
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2018)
Meeting Abstract
Critical Care Medicine
M. Korotun, Z. Hasan, K. Singh
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2018)