Article
Pharmacology & Pharmacy
Hua Yin, Xiaoli Yang, Lisi Peng, Chuanchao Xia, Deyu Zhang, Fang Cui, Haojie Huang, Zhaoshen Li
Summary: This study conducted a comprehensive bibliometric analysis of published research literature on calcium silicate biomaterials (CSB) for biomedical applications. It was found that CSB has been widely reported for bone tissues and dental applications. Chang J from Chinese Academy of Sciences and Gandolfi MG from the University of Bologna were identified as the most productive authors in these two fields, respectively. China was the leading contributor to CSB research in the medical field.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Construction & Building Technology
Rakibul I. Khan, Warda Ashraf, Jan Olek
Summary: This study investigated the application of amino acids in controlling CaCO3 crystallization in carbonation cured wollastonite composites. The use of amino acids resulted in the formation of stable ACC, vaterite, and aragonite, as well as enhanced flexural and compressive strength of the composites. These improvements were attributed to the reduced critical pore size and the formation of organic-inorganic hybrid phases in the matrix.
CEMENT AND CONCRETE RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Hongjian Zhang, Chen Qin, Meng Zhang, Yahui Han, Jingge Ma, Jinfu Wu, Qingqiang Yao, Chengtie Wu
Summary: The important role of nerves in bone formation and remodeling has been overlooked in the design of bone regeneration scaffolds. This study successfully developed a biomimetic neural-bone construct using nanocomposite bioinks and multicellular 3D bioprinting technology to enhance innervated bone regeneration.
Article
Radiology, Nuclear Medicine & Medical Imaging
George Goncalves dos Santos, Izamir Resende Junior Borges Miguel, Aryon de Almeida Barbosa Junior, Willams Teles Barbosa, Katilayne Vieira de Almeida, Raul Garcia-Carrodeguas, Marcus Lia Fook, Miguel A. Rodriguez, Fulvio Borges Miguel, Roberto Paulo Correia de Araujo, Fabiana Paim Rosa
Summary: The bone repair capacity of three ceramic scaffold formulations were evaluated histomorphometrically, with the scaffold containing 20% wollastonite and 80% beta-tricalcium phosphate showing more evident bone formation. All composites exhibited notable bioactivity and promising characteristics for clinical application.
BIOMEDICAL PHYSICS & ENGINEERING EXPRESS
(2021)
Article
Materials Science, Multidisciplinary
Gehan T. El-Bassyouni, Amira M. El-Rafei, Moenis A. Azooz, Sayed H. Kenawy, Hussein Darwish, Esmat M. A. Hamzawy
Summary: Calcium silicate/calcium hexaboride composites were prepared using the wet precipitation chemical method. After heat treatment, high quartz, calcium silicate, and calcium hexaboride were detected as phases. When soaked in SBF, the samples showed the formation of nano-sized calcium phosphate particles. The analysis confirmed the biocompatibility of the prepared composites.
MATERIALS CHEMISTRY AND PHYSICS
(2022)
Article
Engineering, Multidisciplinary
Wenjuan Liu, Zhiguang Huan, Chengtie Wu, Zhihua Zhou, Jiang Chang
Summary: This study developed a composite bone cement with high compressive strength and desirable bioactivity by incorporating calcium silicate bioceramic into magnesium phosphate bone cement. The composite bone cement showed significantly higher compressive strength compared to traditional bone cements and demonstrated apatite mineralization ability and moderate degradation behavior.
COMPOSITES PART B-ENGINEERING
(2022)
Review
Engineering, Biomedical
Ilijana Kovrlija, Janis Locs, Dagnija Loca
Summary: Octacalcium phosphate (OCP) has significant advantages as a precursor to biologically formed apatite and is utilized as a carrier for biologically active substances in bone regeneration. However, research on drug delivery systems with OCP is still in its pioneering stage, and comprehensive data is lacking to fully understand the benefits it can bring. Further studies are needed to explore the potential of OCP in drug delivery systems for bone tissue engineering.
ACTA BIOMATERIALIA
(2021)
Article
Chemistry, Multidisciplinary
Melaku N. Seifu, Amanuel Bersisa, Ki-Yeon Moon, G. M. Kim, Jin-Sang Cho, Solmoi Park
Summary: This study investigates the effect of reaction and carbonation degrees on the reaction products of calcium silicate cement (CSC) during the hardening process in a high atmospheric CO2 concentration. The results show that stable C-S-H phase can form when the carbonation degree is less than one-third of the reaction degree. At higher carbonation degrees and depleted C-S-H, amorphous aluminosilicate and calcite become the main binding phases.
JOURNAL OF CO2 UTILIZATION
(2023)
Review
Engineering, Biomedical
Ni Su, Cassandra Villicana, Fan Yang
Summary: This review discusses the progress in immunomodulation research for bone applications using biomaterials and cell-based strategies, with a focus on different disease types. The role of the immune system in orthopedic applications, including prolonging orthopaedic implant lifetime and enhancing fracture healing, is reviewed. Recent research progress in harnessing immunomodulatory strategies for regenerating critical-sized, long bone or cranial bone defects, and treating osteolytic bone diseases is also discussed.
Review
Engineering, Biomedical
Dachuan Liu, Chen Cui, Weicheng Chen, Jiaxu Shi, Bin Li, Song Chen
Summary: This review provides an overview of commonly used biodegradable bone cements, such as calcium phosphates, calcium sulfates, and organic-inorganic composites. The possible degradation mechanism and clinical performance of these cements are summarized. The aim is to inspire and provide references for researchers in this field.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Review
Chemistry, Physical
Ilijana Kovrlija, Janis Locs, Dagnija Loca
Summary: Barium, as a bivalent cation, has potential in various biochemical reactions. Studies have shown both the advantages and disadvantages of barium compounds in vitro and in vivo settings. Questions for possible future research include whether barium can substitute for other biologically relevant divalent cations and if the benefits outweigh the harm.
Review
Materials Science, Biomaterials
Mohsen Ahmadipour, Hossein Mohammadi, Ai Ling Pang, Mohammad Arjmand, Tunmise Ayode Otitoju, Patrick U. Okoye, Beerelli Rajitha
Summary: This review discusses the influence of silicate ceramics on the mechanical, cytocompatibility, and bioactivity properties of polymer-based scaffolds for potential application in bone tissue engineering.
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
(2022)
Review
Biochemistry & Molecular Biology
Marcel Ferreira Kunrath, Christer Dahlin
Summary: This review compiles the physical-chemical-biological changes caused by early saliva interaction in dental implants and materials for oral regeneration, emphasizing the impact of early saliva interaction on biomaterials and the importance of controlling saliva exposure to minimize impairment of biomaterial properties.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Cecilia V. R. Truite, Jessica N. G. Noronha, Gabriela C. Prado, Leonardo N. Santos, Raquel S. Palacios, Adriane do Nascimento, Eduardo A. Volnistem, Thamara T. da Silva Crozatti, Carolina P. Francisco, Francielle Sato, Wilson R. Weinand, Luzmarina Hernandes, Graciette Matioli
Summary: This study evaluated the potential of fish bones as a natural source of calcium phosphate for bone regeneration in biomaterials production. The results showed that impregnation of curcumin in the calcium phosphate scaffold prolonged the release of the beta-TCP phase, with higher osteoinductive potential. However, in vivo studies did not show additional regenerative effects.
Article
Cell Biology
Jian- Lee, Hooi-Yee Ng, Yen-Hong Lin, Ting-Ju Lin, Chia-Tze Kao, Ming-You Shie
Summary: The study demonstrated the successful fabrication of CS/FGelMa auxetic bio-scaffolds using 3D printing technology. It was found that the incorporation of CS improved the mechanical properties and degradation rates of the scaffolds, as well as enhanced the adhesion and proliferation of periodontal ligament cells. Additionally, CS was shown to activate intracellular factors and enhance osteogenic capabilities.
Article
Cell Biology
Sonia Sahvieh, Ahmad Oryan, Shadi Hassanajili, Amir Kamali
Summary: The study found that stem cell-loaded PLA/PCL/HA scaffolds showed better results in bone healing, assisting in bone tissue regeneration and healing. The experimental results demonstrated significant improvements in biomechanics, immunohistochemistry, and radiological evaluations in the BMSCs-loaded scaffold group, indicating higher levels of bone regeneration.
CELL AND TISSUE RESEARCH
(2021)
Article
Cell & Tissue Engineering
Ahmad Oryan, Shadi Hassanajili, Sonia Sahvieh
Summary: This study tested the effects of a scaffold made of different materials on the regeneration of critical bone defects in rats, finding that the cell-seeded scaffold group showed significantly better regeneration outcomes compared to the untreated group. Additionally, the cell-seeded scaffold group and autograft group demonstrated comparable results on day 80 post-treatment.
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2021)
Review
Medicine, Research & Experimental
Ahmad Oryan, Sonia Sahvieh
Summary: Osteoporosis mainly affects older individuals and postmenopausal women, with bisphosphonates (BPs) being the most effective medication for treatment. The use of zoledronate (Zol) within the BPs family shows promising results in improving bone density and preventing fractures, making it a potential treatment option for osteoporosis.
Correction
Parasitology
Fatemeh Khadir, Tahereh Taheri, Sima Habibzadeh, Farnaz Zahedifard, Elham Gholami, Maryam Heidari-Kharaji, Ahmad Oryan, Sima Rafati
VETERINARY PARASITOLOGY
(2021)
Review
Immunology
Maryam Akbari, Ahmad Oryan, Gholamreza Hatam
Summary: Leishmaniasis is a parasitic disease transmitted by sand fly vectors, causing a range of clinical features. Current treatments lack an effective vaccine, with chemotherapy being toxic and expensive. Immunotherapy has emerged as an alternative treatment option, aiming to reduce the toxicity of drugs and drug resistance.
IMMUNOLOGY LETTERS
(2021)
Retraction
Cell Biology
Ahmad Oryan, Mohamadreza Baghaban Eslaminejad, Amir Kamali, Samaneh Hosseini, Ali Moshiri, Hossein Baharvand
CELL AND TISSUE RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Anousheh Shasttiri, Misagh Moridi, Abbas Safari, Sayed Haidar Abbas Raza, Mostafa Ghaderi-Zefrehei, Massoud Houshmand, Ahmad Oryan, Mohammad Hossein Sanati, Jacqueline Smith, Motahareh Amjadi
Summary: The Iranian gene pool exhibits high haplogroup diversities and admixture of exotic groups, with the Arab subpopulation being independent from the others. Thalassemia patients showed some significant differences in their HVS2 sequence.
BIOCHEMICAL GENETICS
(2022)
Article
Biochemistry & Molecular Biology
Sogand Sasan Moghadam, Maryam Ghahramani, Kazem Khoshaman, Ahmad Oryan, Ali Akbar Moosavi-Movahedi, Boris Kurganov, Reza Yousefi
Summary: This study evaluated the impact of peroxynitrite (PON) and methylglyoxal (MGO) on alpha A-crystallin (alpha A-Cry) and found that the reaction of these compounds led to the formation of new chromophores, changes in protein structure, reduction in oligomer size, and increased chaperone activity of alpha A-Cry. Ascorbic acid and glutathione were able to reverse these effects. The results suggest that the lens antioxidant defense system, particularly glutathione, can provide strong protection against diabetic cataract.
BIOCHEMISTRY-MOSCOW
(2022)
Review
Cell Biology
Ahmad Oryan, Effat Alemzadeh, Esmat Alemzadeh, Maryam Barghi, Mohammad Zarei, Hamid Salehiniya
Summary: Adipose stem cell therapy can enhance the healing rate of burn wounds, especially when combined with hydrogels to significantly increase the viability of adipose stem cells. However, more clinical studies are needed to further explore the role of adipose stem cells in burn wound healing.
CELL AND TISSUE BANKING
(2022)
Article
Immunology
Ahmad Oryan, Hassan Sharifi Yazdi, Soodeh Alidadi, Sedigheh Doostmohammadi
Summary: GyrB PCR-RFLP can be used for diagnosing and detecting bovine and human tuberculosis. It is an accurate and reliable method for identifying the species of Mycobacterium tuberculosis complex (MBTC) and should be considered in tuberculosis control strategies, particularly the isolation of M. bovis from human specimens.
COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES
(2022)
Article
Genetics & Heredity
Azadeh Moradi Pirbaluty, Hossein Mehrban, Saeid Kadkhodaei, Rudabeh Ravash, Ahmad Oryan, Mostafa Ghaderi-Zefrehei, Jacqueline Smith
Summary: This bioinformatics study analyzed the transcriptome of chickens after influenza A virus challenge to explore the host expression response. The study identified different gene importance in lowly and highly pathogenic avian influenza infections, which can provide a basis for future development of treatments and preventions against avian influenza in chickens.
Article
Agriculture, Dairy & Animal Science
Zahra Hasanpour, Mousa Zarrin, Ahmad Oryan, Mostafa Mohaghegh-Dolatabad, Amir Ahmadpour
Summary: This study aims to validate the impact of feed restriction and the transition period on hepatic genes related to fat metabolism in fat-tailed sheep. The results show that feed restriction does not affect the mRNA abundance of the target genes during both pre- and post-partum periods. However, parturition suppresses the mRNA abundance of these genes. Fat-tailed sheep are well adapted to feed scarcity and have a higher capacity for fat mobilization during negative energy balance.
TROPICAL ANIMAL HEALTH AND PRODUCTION
(2022)
Article
Tropical Medicine
Ahmad Oryan, Effat Bemani, Somayeh Bahrami
Summary: Objective of this study was to evaluate the in vitro and in vivo efficacy of quercetin against Leishmania major, as well as its immunomodulatory and anti-oxidative activity. The results showed that quercetin exhibited anti-leishmanial activity, immunomodulatory, anti-oxidative, and anti-inflammatory effects. Therefore, it has the potential to be further explored as an effective drug for treating leishmaniasis.
ASIAN PACIFIC JOURNAL OF TROPICAL BIOMEDICINE
(2023)
Correction
Engineering, Biomedical
A. Oryan, Baghaban M. Eslaminejad, A. Kamali, S. Hosseini, F. A. Sayahpour, H. Baharvand
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2022)
Article
Orthopedics
Effat Karimi Ghahfarrokh, Abdolhamid Meimandi-Parizi, Ahmad Oryan, Nasrollah Ahmadi
Summary: The study demonstrated that Masquelet technique enhances bone healing, and treatments with PFG-BMP7, autograft-BMP7, and autograft all have beneficial effects on bone regeneration. Autograft-BMP7 was found to be more effective in healing radial bone defects in rabbits.
ARCHIVES OF BONE AND JOINT SURGERY-ABJS
(2021)
Article
Medicine, Research & Experimental
Yuwen Zhu, Yan Guo, Yujia Xue, Anqi Zhou, Ying Chen, Yifei Chen, Xiulian Miao, Fangqiao Lv
Summary: BRG1 plays an important role in HSC-myofibroblast transition and targeting it could be a reasonable strategy for liver fibrosis intervention.
Article
Medicine, Research & Experimental
Liu Ye, Beibei Liu, Jingling Huang, Xiaolin Zhao, Yuan Wang, Yungen Xu, Shuping Wang
Summary: Doublecortin-like kinase 1 (DCLK1) is a significant prooncogenic factor that is strongly associated with the malignant progression and clinical prognosis of various cancers. DCLK1 plays important roles in stem cell marker regulation, tumor cell reprogramming, and immune evasion. However, the exact biological functions of DCLK1, especially the disparities between its alpha- and beta-form transcripts in cancer progression, remain ambiguous.
Article
Medicine, Research & Experimental
Jiahui Yang, Xiaoyu Chen, Tianjing Liu, Yongyan Shi
Summary: This article reviews the role of bile acids in necrotizing enterocolitis (NEC) and their potential therapeutic value. The dysregulation of bile acids is associated with intestinal injury, and inflammatory factors in the liver also play a crucial role in regulating bile acid transport. The bile acid metabolic pathway is important for regulating intestinal microbiota, cell proliferation, and barrier protection.
Review
Medicine, Research & Experimental
Zhenzheng Zhu, Yuemiao Xu, Yuwei Xia, Xinru Jia, Yixin Chen, Yuyue Liu, Leyin Zhang, Hui Chai, Leitao Sun
Summary: Bile acid, as the final product of cholesterol breakdown, plays a complex regulatory and signaling role in human metabolism. Research suggests that it has the potential to enhance metabolism and regulate chronic metabolic diseases through various pathways. The interaction between bile acid and gut microbiota is also of great significance.
Article
Medicine, Research & Experimental
Xin He, Hong-Xu Zhou, Xian Fu, Kai-Di Ni, Ai-Zhi Lin, Ling-Tong Zhang, Hou-Hua Yin, Qing Jiang, Xue Zhou, Yi-Wen Meng, Jun-Yan Liu
Summary: DON exposure causes an increase in deoxycholic acid (DCA), which contributes to intestinal injury. DCA may be a potential therapeutic target for DON enterotoxicity.
Article
Medicine, Research & Experimental
Zhitao Wang, Heng Ma, Abdul Nasir, Sufang Liu, Zhisong Li, Feng Tao, Qian Bai
Summary: This study reveals the involvement of TET1-mediated epigenetic regulation in chronic TMJ pain through trigeminal TNF alpha signaling.
Article
Medicine, Research & Experimental
Lu Yu, Hao Ran, Yaru Lu, Qian Ma, Huan Huang, Weibin Liu
Summary: This study found that the HIF-1 alpha inhibitor BAY 87-2243 can alleviate the symptoms of the Experimental Autoimmune Myasthenia Gravis (EAMG) inflammation model. BAY 87-2243 can restore the balance of CD4(+)T cell subsets, reduce the production of pro-inflammatory cytokines, and act as both an immune imbalance regulator and anti-inflammatory.
Article
Medicine, Research & Experimental
Alex Peralvarez-Marin, Montse Sole, Judith Serrano, Alice Taddeucci, Belen Perez, Clara Penas, Gemma Manich, Marcel Jimenez, Pilar D'Ocon, Francesc Jimenez-Altayo
Summary: This study provides the first evidence that TRPV2 channels may modulate vascular tone by balancing opposing inputs from the endothelium and smooth muscle, leading to net vasodilation. The amplification of TRPV2 channel-induced activity by NO emphasizes the pathophysiological relevance of these findings.
Article
Medicine, Research & Experimental
Amin Ullah, Jing Zhao, Jiakun Li, Rajeev K. Singla, Bairong Shen
Summary: Gastric cancer is the fifth-most prevalent and second-most deadly cancer worldwide. Late onset of symptoms makes early detection important. CXC chemokines play an important role in the pathological process of gastric cancer, but their exact role in diagnosis and prognosis is not fully understood. Inhibiting CXC chemokines shows promise as a targeted therapy.
Article
Medicine, Research & Experimental
Menna S. Zeyada, Salma M. Eraky, Mamdouh M. El-Shishtawy
Summary: The current study demonstrates the prophylactic and antifibrotic effects of Trig against BLM-induced PF by targeting multiple signaling pathways. The combination of Trig and Pirf may be a promising approach to enhance Pirf's anti-fibrotic effect.
