Article
Behavioral Sciences
Juliano Viana Borges, Vivian Naziaseno Pires, Betania Souza de Freitas, Gabriel Ruebensam, Vitoria Correa Vieira, Cristophod de Souza dos Santos, Nadja Schroder, Elke Bromberg
Summary: Social deprivation can cause stress in group-living mammals, but they have an amazing response of seeking social contact as a form of protection. This study explored the effects of social isolation and support on behavioral and epigenetic responses to chronic stress in middle-aged adult rats. The results showed that isolation led to decreased corticosterone levels, impaired long-term memory, and decreased BDNF gene expression, along with altered epigenetic markers. The chronic unpredictable stress protocol had different effects, mainly on epigenetic alterations, but social support prevented the adverse effects on HPA axis functioning and gene expressions.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Neurosciences
Orie Muta, Minayu Odaka, Yasuyuki Fujii, Taiki Fushimi, Hiroki Sato, Naomi Osakabe
Summary: This study compared the stress response in metabolic cages between single- and paired-housing by assessing changes in urinary stress hormones and behavior. Results showed that single-housing led to weight loss and increased stress hormones in urine, while paired-housing did not. Therefore, it is suggested to house two mice together in metabolic cages to reduce stress-related interference.
NEUROSCIENCE LETTERS
(2023)
Article
Medicine, Research & Experimental
Jee Hyun Yi, Se Jin Jeon, Huiyoung Kwon, Eunbi Cho, Jieun Jeon, Somin Moon, A. Young Park, Hyun-Ji Kwon, Ye Hee Lee, Kyoung Ja Kwon, Chan Young Shin, Dong Hyun Kim
Summary: Stress is a common part of life and can cause various neurological and psychiatric disorders. Proper stress management is important for maintaining a healthy life. This study investigated the impact of ethyl pyruvate (EP) on stress-induced cognitive decline and found that EP can block the inhibitory effect of the stress hormone corticosterone on synaptic plasticity. Administration of EP improved cognitive decline caused by stress by regulating Akt/GSK-3β signaling and improving neurogenesis and synaptic function deficits.
Article
Biochemistry & Molecular Biology
Zubeyde Ercan, Ozgur Bulmus, Emine Kacar, Ihsan Serhatlioglu, Gokhan Zorlu, Haluk Kelestimur
Summary: This study found that chronic treadmill exercise can effectively reverse behavioral impairments caused by CRS and induce molecular changes in the brain. This suggests that exercise has positive effects on emotion and mood and can improve stress-induced anomalies.
JOURNAL OF MOLECULAR NEUROSCIENCE
(2023)
Article
Psychiatry
Davy Vancampfort, Andreas Heissel, Aline Waclawovsky, Brendon Stubbs, Joseph Firth, Ryan L. McGrath, Tine Van Damme, Felipe B. Schuch
Summary: This meta-analysis examined the existence of true interindividual differences in the anxiolytic effects of exercise among adults with anxiety-and stress-related disorders. The results showed significant anxiolytic effects of both aerobic exercise and resistance training. However, there is currently a lack of convincing evidence to support the notion that true interindividual differences exist for the anxiolytic effects of exercise in this population. Therefore, clinical practice should focus on general population physical activity guidelines rather than highly specific, individualized recommendations.
PSYCHIATRY RESEARCH
(2022)
Article
Biology
Zhihua Luo, Junlin Chen, Yelin Dai, Kwok-Fai So, Li Zhang
Summary: Aerobic exercise effectively improves mental disorders by promoting adult neurogenesis. This study reveals that chronic restraint stress leads to overexcitation of the mPFC-BLA pathway, and 14-day treadmill exercise reverses these abnormalities. Chemogenetic studies demonstrate that the mPFC-BLA circuit is necessary for preventing anxiety-like behaviors in stressed mice. These findings suggest a neural circuitry mechanism by which exercise enhances resilience against environmental stress.
COMMUNICATIONS BIOLOGY
(2023)
Article
Geriatrics & Gerontology
Badrah Saeed Alghamdi
Summary: This study investigates the potential of melatonin and exercise in improving behavioral changes related to social isolation. The results suggest that the combination of melatonin and exercise shows promise in improving physical activity, anxiety, and cognitive functions in aging rats.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Critical Care Medicine
Kate Karelina, Katarina Schneiderman, Sarthak Shah, Julie Fitzgerald, Ruth Velazquez Cruz, Robin Oliverio, Bailey Whitehead, Jingzhen Yang, Zachary M. Weil
Summary: Despite the common practice of prescribed rest after traumatic brain injury (TBI), research shows little to no benefit of it on patient outcomes, with prolonged rest potentially interfering with patient well-being. In contrast, animal models consistently indicate that exercise is neuroprotective and promotes recovery after brain injury, suggesting carefully titrated physical activity may be a safe and effective approach to promoting recovery.
JOURNAL OF NEUROTRAUMA
(2021)
Article
Clinical Neurology
Moustafa Algamal, Andrew J. Pearson, Coral Hahn-Townsend, Ioana Burca, Michael Mullan, Fiona Crawford, Joseph O. Ojo
Summary: This study assessed the impact of chronic stress on HPA axis function and fear memory deficits in a mouse model, finding that mice exposed to chronic stress exhibited exaggerated fear memory recall and weakened HPA axis functionality. Neuroendocrinal testing suggested that alterations in adrenal MC2 receptor reactivity may be related to the attenuated stress response in the model.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Agriculture, Dairy & Animal Science
Danita K. Daniel, Anuradha Bhat
Summary: Social isolation has been a common method used in experimental studies with animal models, and due to the increasing prevalence of isolation in human populations, it is important to understand its effects and find ways to alleviate them. This study used wild-caught zebrafish to investigate the impact of social cues on reducing behavioral stress caused by acute social isolation. The results showed that both visual and olfactory cues from conspecifics significantly decreased stress levels, while complete isolation led to increased stress levels. Over time, fish showed a decrease in stress levels, indicating acclimatization. There were differences in stress levels between males and females, with females exhibiting less stress. These findings highlight the importance of social cues in managing stress during unavoidable social isolation and contribute to our understanding of stress response in zebrafish, which is an important model for studying stress and anxiety in humans.
APPLIED ANIMAL BEHAVIOUR SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Saki Watanabe, Alzahra J. Al Omran, Amy S. Shao, Zeyu Zhang, Chen Xue, Jifeng Zhang, Junji Watanabe, Jing Liang
Summary: Social isolation leads to anxiety, cognitive decline, and reduced ATP levels in mice. Treatment with DHM can ameliorate these changes by restoring mitochondrial capacity to generate ATP.
NEUROCHEMISTRY INTERNATIONAL
(2022)
Article
Neurosciences
Chung-Wei Hsu, Sabrina Wang
Summary: The study suggests that activation of OX-A neurons can promote resilient behaviors under stressful situations in a learned helplessness (LH) animal model of depression, and that OX-A and OX-B neuropeptides exhibit dissimilar functions in LH behaviors.
Article
Biochemistry & Molecular Biology
Joseph O. T. Emudainohwo, Benneth Ben-Azu, Olusegun G. Adebayo, Wadioni Aduema, Christian Uruaka, Abayomi M. Ajayi, Emma Elohor Okpakpor, Ray I. Ozolua
Summary: This study found that rutin has a protective effect on neurobehavioral and neuro-biochemical changes in mice exposed to social defeat stress (SDS). Rutin restored neurobehavioral deficits, reduced acetylcholinesterase activity, attenuated adrenal hypertrophy and elevated glucose and corticosterone levels, and suppressed the release of pro-inflammatory cytokines in specific brain regions. Additionally, rutin reversed oxidative and nitrergic stress induced by SDS in the brain.
JOURNAL OF MOLECULAR NEUROSCIENCE
(2023)
Article
Physiology
Leandro Almeida da Silva, Anand Thirupathi, Mateus Cardoso Colares, Daniela Pacheco dos Santos Haupenthal, Ligia Milanez Venturini, Maria Eduarda Anastacio Borges Correa, Gustavo de Bem Silveira, Alessandro Haupenthal, Fernando Russo Costa do Bomfim, Thiago Antonio Moretti de Andrade, Yaodong Gu, Paulo Cesar Lock Silveira
Summary: The study investigated the effects of physical exercise on a treadmill and swimming in an animal model of osteoarthritis. The results showed that exercise on a treadmill was more effective in attenuating pro-inflammatory cytokines and regulating anti-inflammatory factors compared to other groups. Treadmill exercise also showed better morphological outcomes in histological evaluation.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Neurosciences
Anderson Camargo, Ana Paula Dalmagro, Daiane B. Fraga, Julia M. Rosa, Ana Lucia B. Zeni, Manuella P. Kaster, Ana Lucia S. Rodrigues
Summary: Low doses of ketamine and/or guanosine have been shown to reverse corticosterone-induced anxiety-like behavior, but were not effective in counteracting disturbances in the hippocampal NLRP3 pathway.
PSYCHOPHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Leyla Sahin, Ozge Selin Cevik, Dilan Deniz Koyuncu, Kansu Buyukafsar
Article
Anatomy & Morphology
S. Keloglan, L. Sahin, O. S. Cevik
FOLIA MORPHOLOGICA
(2019)
Article
Neurosciences
Leyla Sahin, Ozge Selin Cevik, Kenan Cevik, Celal Guven, Eylem Taskin, Sayad Kocahan
Summary: This study investigated the protective effects of mild treadmill exercise on acute sleep deprivation rats, finding that exercise can alleviate memory impairment but there is a lack of correlation between hippocampal gene expression levels and memory impairment.
Article
Developmental Biology
Sayad Kocahan, Kubra Akillioglu, Leman Sencar, Leyla Sahin, Ozge Selin Cevik, Eylem Taskin, Celal Guven, Ayper Boga, Sait Polat
Summary: The study found that postpartum depression leads to increased depressive symptoms, reduced swimming and climbing behaviors in both females and males. The stressed groups had a significantly higher number of crossings in the center area compared to the control groups. Females and males with postpartum depression spent significantly more time in the center area during the open-field test.
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
(2021)
Article
Developmental Biology
Seval Musuroglu Keloglan, Leyla Sahin, Ozge Selin Cevik
Summary: This study investigated the effect of chronic caffeine consumption on learning and memory functions in REM sleep-deprived rats. The results showed that REM sleep deprivation impaired spatial memory performance, but chronic caffeine consumption had a therapeutic effect on this impairment, possibly mediated by NR2A.
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
(2022)
Article
Developmental Biology
Seval Keloglan Musuroglu, Duygu Murat Ozturk, Leyla Sahin, Ozge Selin Cevik, Kenan Cevik
Summary: Environmental enrichment has positive effects on memory function and anxiety behavior in socially isolated rats, but it alone is insufficient to cause changes in memory performance. In addition to improving memory function, environmental enrichment also has the potential to decrease anxiety behavior.
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
(2022)
Article
Behavioral Sciences
Ozge Selin Cevik, Kenan Cevik, Gulhan Orekici Temel, Leyla Sahin
Summary: This study examined the effects of environmental enrichment on memory functions in maternally separated rats. The results showed that environmental enrichment did not affect memory performance, while maternal separation increased it. This suggests that environmental enrichment alone is not sufficient to compensate for the detrimental effects of maternal separation stress on memory.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Neurosciences
Leyla Sahin, Seval Keloglan Musuroglu, Ozge Selin Cevik, Kenan Cevik, Gulhan Orekici Temel
Summary: This study found that hyperthyroidism impairs hippocampus-dependent spatial memory, and one possible molecular mechanism is the decreased expression level of the GRIN2B gene.
Review
Geriatrics & Gerontology
Wouter A. J. Vints, Evrim Gokce, Antoine Langeard, Iuliia Pavlova, Ozge Selin Cevik, Mohammad Mosaferi Ziaaldini, Jasemin Todri, Orges Lena, Giorgos K. Sakkas, Suzanne Jak, Ioanna Zorba (Zormpa), Christina Karatzaferi, Oron Levin, Nerijus Masiulis, Yael Netz
Summary: This ongoing review aims to explore the underlying mechanisms of exercise-induced cognitive improvements, particularly focusing on the potential role of myokines. Randomized controlled studies will be collected and analyzed systematically to investigate the relationship between exercise, myokines, and cognition. The findings will contribute to a better understanding of the triad relationship and provide insights into optimizing exercise regimes for enhancing cognitive functioning in older adults.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Biology
Meryem Ilkay Karagul, Savas Aktas, Sakir Necat Yilmaz, Derya Yetkin, Havva Didem Celikcan, Ozge Selin Cevik
Article
Biochemistry & Molecular Biology
Leyla Sahin, Ozge Selin Cevik, Dilan Deniz Koyuncu, Sayad Kocahan
CELLULAR AND MOLECULAR BIOLOGY
(2019)
Meeting Abstract
Endocrinology & Metabolism
Leyla Sahin, Ozge Selin Cevik, Neriman Ezgin
NEUROENDOCRINOLOGY
(2018)
Article
Medicine, Research & Experimental
Yuwen Zhu, Yan Guo, Yujia Xue, Anqi Zhou, Ying Chen, Yifei Chen, Xiulian Miao, Fangqiao Lv
Summary: BRG1 plays an important role in HSC-myofibroblast transition and targeting it could be a reasonable strategy for liver fibrosis intervention.
Article
Medicine, Research & Experimental
Liu Ye, Beibei Liu, Jingling Huang, Xiaolin Zhao, Yuan Wang, Yungen Xu, Shuping Wang
Summary: Doublecortin-like kinase 1 (DCLK1) is a significant prooncogenic factor that is strongly associated with the malignant progression and clinical prognosis of various cancers. DCLK1 plays important roles in stem cell marker regulation, tumor cell reprogramming, and immune evasion. However, the exact biological functions of DCLK1, especially the disparities between its alpha- and beta-form transcripts in cancer progression, remain ambiguous.
Article
Medicine, Research & Experimental
Jiahui Yang, Xiaoyu Chen, Tianjing Liu, Yongyan Shi
Summary: This article reviews the role of bile acids in necrotizing enterocolitis (NEC) and their potential therapeutic value. The dysregulation of bile acids is associated with intestinal injury, and inflammatory factors in the liver also play a crucial role in regulating bile acid transport. The bile acid metabolic pathway is important for regulating intestinal microbiota, cell proliferation, and barrier protection.
Review
Medicine, Research & Experimental
Zhenzheng Zhu, Yuemiao Xu, Yuwei Xia, Xinru Jia, Yixin Chen, Yuyue Liu, Leyin Zhang, Hui Chai, Leitao Sun
Summary: Bile acid, as the final product of cholesterol breakdown, plays a complex regulatory and signaling role in human metabolism. Research suggests that it has the potential to enhance metabolism and regulate chronic metabolic diseases through various pathways. The interaction between bile acid and gut microbiota is also of great significance.
Article
Medicine, Research & Experimental
Xin He, Hong-Xu Zhou, Xian Fu, Kai-Di Ni, Ai-Zhi Lin, Ling-Tong Zhang, Hou-Hua Yin, Qing Jiang, Xue Zhou, Yi-Wen Meng, Jun-Yan Liu
Summary: DON exposure causes an increase in deoxycholic acid (DCA), which contributes to intestinal injury. DCA may be a potential therapeutic target for DON enterotoxicity.
Article
Medicine, Research & Experimental
Zhitao Wang, Heng Ma, Abdul Nasir, Sufang Liu, Zhisong Li, Feng Tao, Qian Bai
Summary: This study reveals the involvement of TET1-mediated epigenetic regulation in chronic TMJ pain through trigeminal TNF alpha signaling.
Article
Medicine, Research & Experimental
Lu Yu, Hao Ran, Yaru Lu, Qian Ma, Huan Huang, Weibin Liu
Summary: This study found that the HIF-1 alpha inhibitor BAY 87-2243 can alleviate the symptoms of the Experimental Autoimmune Myasthenia Gravis (EAMG) inflammation model. BAY 87-2243 can restore the balance of CD4(+)T cell subsets, reduce the production of pro-inflammatory cytokines, and act as both an immune imbalance regulator and anti-inflammatory.
Article
Medicine, Research & Experimental
Alex Peralvarez-Marin, Montse Sole, Judith Serrano, Alice Taddeucci, Belen Perez, Clara Penas, Gemma Manich, Marcel Jimenez, Pilar D'Ocon, Francesc Jimenez-Altayo
Summary: This study provides the first evidence that TRPV2 channels may modulate vascular tone by balancing opposing inputs from the endothelium and smooth muscle, leading to net vasodilation. The amplification of TRPV2 channel-induced activity by NO emphasizes the pathophysiological relevance of these findings.
Article
Medicine, Research & Experimental
Amin Ullah, Jing Zhao, Jiakun Li, Rajeev K. Singla, Bairong Shen
Summary: Gastric cancer is the fifth-most prevalent and second-most deadly cancer worldwide. Late onset of symptoms makes early detection important. CXC chemokines play an important role in the pathological process of gastric cancer, but their exact role in diagnosis and prognosis is not fully understood. Inhibiting CXC chemokines shows promise as a targeted therapy.
Article
Medicine, Research & Experimental
Menna S. Zeyada, Salma M. Eraky, Mamdouh M. El-Shishtawy
Summary: The current study demonstrates the prophylactic and antifibrotic effects of Trig against BLM-induced PF by targeting multiple signaling pathways. The combination of Trig and Pirf may be a promising approach to enhance Pirf's anti-fibrotic effect.