Preclinical evaluation of the selective small-molecule UBA1 inhibitor, TAK-243, in acute myeloid leukemia
Published 2018 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Preclinical evaluation of the selective small-molecule UBA1 inhibitor, TAK-243, in acute myeloid leukemia
Authors
Keywords
-
Journal
LEUKEMIA
Volume -, Issue -, Pages -
Publisher
Springer Nature
Online
2018-06-08
DOI
10.1038/s41375-018-0167-0
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Midostaurin plus Chemotherapy for Acute Myeloid Leukemia with a FLT3 Mutation
- (2017) Richard M. Stone et al. NEW ENGLAND JOURNAL OF MEDICINE
- Positive First Trial of Enasidenib for AML
- (2017) Cancer Discovery
- Constitutive NF-κB activation in AML: Causes and treatment strategies
- (2016) Matthieu Cornelis Johannes Bosman et al. CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
- Inhibition of HSP90 by AUY922 Preferentially Kills Mutant KRAS Colon Cancer Cells by Activating Bim through ER Stress
- (2016) C. Y. Wang et al. MOLECULAR CANCER THERAPEUTICS
- Regulation of DNA double-strand break repair by ubiquitin and ubiquitin-like modifiers
- (2016) Petra Schwertman et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- The role of the proteasome in AML
- (2016) C M Csizmar et al. Blood Cancer Journal
- Acute myeloid leukaemia
- (2016) Asim Khwaja et al. Nature Reviews Disease Primers
- Acute Myeloid Leukemia
- (2015) Hartmut Döhner et al. NEW ENGLAND JOURNAL OF MEDICINE
- The demographics of the ubiquitin system
- (2015) Michael J. Clague et al. TRENDS IN CELL BIOLOGY
- UBA1: At the Crossroads of Ubiquitin Homeostasis and Neurodegeneration
- (2015) Ewout J.N. Groen et al. TRENDS IN MOLECULAR MEDICINE
- An inhibitor of ubiquitin conjugation and aggresome formation
- (2015) Heeseon An et al. Chemical Science
- The unfolded protein response governs integrity of the haematopoietic stem-cell pool during stress
- (2014) Peter van Galen et al. NATURE
- The cellular thermal shift assay for evaluating drug target interactions in cells
- (2014) Rozbeh Jafari et al. Nature Protocols
- Cleaning up in the endoplasmic reticulum: ubiquitin in charge
- (2014) John C Christianson et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Acute myeloid leukaemia in adults
- (2013) Felicetto Ferrara et al. LANCET
- Oral Treatment Targeting the Unfolded Protein Response Prevents Neurodegeneration and Clinical Disease in Prion-Infected Mice
- (2013) J. A. Moreno et al. Science Translational Medicine
- Treatment-Emergent Mutations in NAEβ Confer Resistance to the NEDD8-Activating Enzyme Inhibitor MLN4924
- (2012) Michael A. Milhollen et al. CANCER CELL
- Cleaning Up: ER-Associated Degradation to the Rescue
- (2012) Jeffrey L. Brodsky CELL
- Governance of Endocytic Trafficking and Signaling by Reversible Ubiquitylation
- (2012) Michael J. Clague et al. DEVELOPMENTAL CELL
- Nelfinavir inhibits regulated intramembrane proteolysis of sterol regulatory element binding protein-1 and activating transcription factor 6 in castration-resistant prostate cancer
- (2012) Min Guan et al. FEBS Journal
- The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule
- (2012) B. C. S. Cross et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A Gatekeeper Residue for NEDD8-Activating Enzyme Inhibition by MLN4924
- (2012) Julia I. Toth et al. Cell Reports
- Mechanistic Studies of Substrate-assisted Inhibition of Ubiquitin-activating Enzyme by Adenosine Sulfamate Analogues
- (2011) Jesse J. Chen et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Road to Ruin: Targeting Proteins for Degradation in the Endoplasmic Reticulum
- (2011) M. H. Smith et al. SCIENCE
- The antihelmintic flubendazole inhibits microtubule function through a mechanism distinct from Vinca alkaloids and displays preclinical activity in leukemia and myeloma
- (2010) P. A. Spagnuolo et al. BLOOD
- The ubiquitin-activating enzyme E1 as a therapeutic target for the treatment of leukemia and multiple myeloma
- (2010) G. W. Xu et al. BLOOD
- The ubiquitous role of ubiquitin in the DNA damage response
- (2010) Abdallah Al-Hakim et al. DNA REPAIR
- Substrate-Assisted Inhibition of Ubiquitin-like Protein-Activating Enzymes: The NEDD8 E1 Inhibitor MLN4924 Forms a NEDD8-AMP Mimetic In Situ
- (2010) James E. Brownell et al. MOLECULAR CELL
- Ubiquitin-like protein conjugation and the ubiquitin–proteasome system as drug targets
- (2010) Lynn Bedford et al. NATURE REVIEWS DRUG DISCOVERY
- Ubiquitin signalling in DNA replication and repair
- (2010) Helle D. Ulrich et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Nonproteolytic Functions of Ubiquitin in Cell Signaling
- (2009) Zhijian J. Chen et al. MOLECULAR CELL
- An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer
- (2009) Teresa A. Soucy et al. NATURE
- Targeting the ubiquitin system in cancer therapy
- (2009) Daniela Hoeller et al. NATURE
- Ubiquitin-like protein activation by E1 enzymes: the apex for downstream signalling pathways
- (2009) Brenda A. Schulman et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Histone Ubiquitination: Triggering Gene Activity
- (2008) Vikki M. Weake et al. MOLECULAR CELL
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now