☆ 4.7 Editorial Material

Stepping up HIV-1 low-level viraemia surveillance in South Africa

LANCET INFECTIOUS DISEASES (2018)

Journal

LANCET INFECTIOUS DISEASES

Volume 18, Issue 2, Pages 130-131

Publisher

ELSEVIER SCI LTD

DOI: 10.1016/S1473-3099(17)30680-1

Keywords

-

Categories

Infectious Diseases

Funding

Bristol-Myers Squibb
Gilead Sciences
ViiV Healthcare
Merck Sharp Dohme
Janssen-Cilag

Ask authors/readers for more resources

Protocol

Community support

Reagent

Community support

Authors

I am an author on this paper

Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7

Not enough ratings

Secondary Ratings

Novelty

-

Significance

-

Scientific rigor

-

Rate this paper

Recommended

Article Infectious Diseases

Feasibility and clinical relevance of HIV-1 drug resistance testing in patients with low-level viraemia in South Africa

Avania Bangalee, Lucia Hans, Kim Steegen

Summary: The study aimed to determine the feasibility of HIV genotyping at low-level viremia in a South African population and found a high prevalence of drug resistance mutations in this population, suggesting a need for adjustments to current virological failure guidelines in South Africa.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2021)

Add to Collection

Review Medicine, General & Internal

The risk of sexual transmission of HIV in individuals with low-level HIV viraemia: a systematic review

Laura N. Broyles, Robert Luo, Debi Boeras, Lara Vojnov

Summary: This article summarizes the risk of sexual transmission of HIV from individuals with low-level viral loads and emphasizes its importance in public health. The review of 8 studies shows that the risk of HIV transmission is almost zero when viral loads are below 1000 copies per mL. These findings can help destigmatize HIV and promote adherence to antiretroviral therapy.

LANCET (2023)

Add to Collection

Article Infectious Diseases

HIV-1 drug resistance mutations among individuals with low-level viraemia while taking combination ART in Botswana

Ontlametse T. Bareng, Sikhulile Moyo, Melissa Zahralban-Steele, Dorcas Maruapula, Tsotlhe Ditlhako, Baitshepi Mokaleng, Patrick Mokgethi, Wonderful T. Choga, Natasha O. Moraka, Molly Pretorius-Holme, Madisa O. Mine, Elliot Raizes, Kesaobaka Molebatsi, Modisa S. Motswaledi, Irene Gobe, Terence Mohammed, Tendani Gaolathe, Roger Shapiro, Mompati Mmalane, Joseph M. Makhema, Shahin Lockman, Max Essex, Vlad Novitsky, Simani Gaseitsiwe

Summary: A single instance of low-level viraemia (LLV) in adults receiving ART strongly predicts the risk of future virological failure (VF), suggesting the need for more intensive adherence support and frequent viral load (VL) monitoring.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2022)

Add to Collection

Article Public, Environmental & Occupational Health

Low-level viraemia among people living with HIV in Nigeria: a retrospective longitudinal cohort study

Helen M. Chun, Andrew Abutu, Kyle Milligan, Akipu Ehoche, Ray W. Shiraishi, Solomon Odafe, Ibrahim Dalhatu, Dennis Onotu, McPaul Okoye, Ademola Oladipo, Jerry Gwamna, Akudo Ikpeazu, Nseobong M. Akpan, Jahun Ibrahim, Gambo Aliyu, Sulaiman Akanmu, Mary A. Boyd, Mahesh Swaminathan, Tedd Ellerbrock, Kristen A. Stafford, Emilio Dirlikov

Summary: This study analyzed the prevalence and outcomes of low-level viremia in a cohort of people living with HIV on antiretroviral therapy in Nigeria. The results showed that patients with low-level viremia had an increased risk of virological non-suppression and failure. The monitoring benchmarks and targets should be revised to strengthen clinical outcomes and track progress to epidemic control.

LANCET GLOBAL HEALTH (2022)

Add to Collection

Article Infectious Diseases

Prevalence of HIV drug resistance among adolescents receiving ART in Cameroon with low- or high-level viraemia

Armando B. D. Djiyou, Calixte Penda, Yoann Madec, Grace D. Ngondi, Astrid Moukoko, Carole E. Eboumbou, Avelin F. Aghokeng

Summary: The threshold of 1000 copies/mL is not suitable for defining virological failure in resource-limited settings. High levels of drug resistance were found in both adolescents with low-level viraemia (LLV) and those in virological failure (VF). Nucleoside reverse transcriptase inhibitors (NRTIs) and non-nucleoside reverse transcriptase inhibitors (NNRTIs) were the most affected drug classes.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2023)

Add to Collection

Article Multidisciplinary Sciences

Factors associated with low-level viraemia in people with HIV starting antiretroviral therapy: A Swedish observational study

Hanna Brattgard, Per Bjoerkman, Piotr Nowak, Carl Johan Treutiger, Magnus Gisslen, Olof Elvstam

Summary: Among Swedish PWH, low-level viremia (LLV) during antiretroviral therapy (ART) was associated with markers of HIV disease severity before starting ART, male sex, injecting drug use, and use of protease inhibitor (PI)-based or non-standard ART regimens.

PLOS ONE (2022)

Add to Collection

Article Multidisciplinary Sciences

Large age shifts in HIV-1 incidence patterns in KwaZulu-Natal, South Africa

Adam Akullian, Alain Vandormael, Joel C. Miller, Anna Bershteyn, Edward Wenger, Diego Cuadros, Dickman Gareta, Till Barnighausen, Kobus Herbst, Frank Tanser

Summary: In a hyper-epidemic region of KwaZulu-Natal, South Africa, the median age of HIV seroconversion increased in both men and women, suggesting a changing demographic of HIV risk with a focus on younger age groups. The decline in HIV incidence was more pronounced in young men and women, while older individuals showed stable or even lagging declines in incidence. These results provide direct epidemiological evidence of the impact of large-scale treatment and prevention interventions on the age distribution of HIV incidence in sub-Saharan Africa.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

Add to Collection

Article Immunology

HIV Infection a Risk Factor for Death among Hospitalized Persons with Candidemia, South Africa, 2012-2017

Nelesh P. Govender, Jim Todd, Jeremy Nel, Mervyn Mer, Alan Karstaedt, Cheryl Cohen

Summary: A study conducted in 29 hospitals in South Africa found that HIV-positive candidemia patients had a higher in-hospital mortality rate, but HIV-positive patients who received intensive care had a lower mortality rate. Therefore, outcomes of candidemia patients with HIV might be improved with intensive care.

EMERGING INFECTIOUS DISEASES (2021)

Add to Collection

Article Virology

Persistent Hepatitis B Viraemia with Polymerase Mutations among HIV/HBV Co-Infected Patients on HBV-Active ART in KwaZulu-Natal, South Africa

Nokukhanya Msomi, Raveen Parboosing, Eduan Wilkinson, Jennifer Giandhari, Kerusha Govender, Benjamin Chimukangara, Koleka P. Mlisana

Summary: This study assessed the rate of HBV virological response in HIV/HBV co-infected patients on HBV-active ART in KwaZulu-Natal, South Africa, and analyzed factors associated with persistent HBV viraemia. The findings showed a high proportion of patients on HBV-active ART were unsuppressed, which will have an impact on global elimination goals. Better monitoring and early HBV drug-resistance testing should be implemented.

VIRUSES-BASEL (2022)

Add to Collection

Article Microbiology

HIV-1 tropism in low-level viral load HIV-1 infections during HAART in Guangdong, China

Chuyu Zhang, Yun Lan, Linghua Li, Ruiying He, Yu Meng, Jian Li, Weilie Chen

Summary: This study investigated the factors associated with different HIV-1 tropisms in low-level viral load HIV-1 infections in China. The majority of infections in Guangdong receiving highly active antiretroviral therapy for more than 6 months were R5-tropic, and the baseline immune level was lower in X4-tropic infections. Furthermore, certain amino acid variations were associated with X4-tropic HIV-1.

FRONTIERS IN MICROBIOLOGY (2023)

Add to Collection

Article Medicine, General & Internal

The Impact of Low-Level Viraemia on Virological Failure-Results From a Multicenter HIV Antiretroviral Therapy Cohort Study in Yunnan, China

Jing An, Yunfei Lao, Songyuan Tang, Jincheng Lou, Tianshu Li, Xingqi Dong

Summary: This study investigated the long-term impact of low-level viraemia (LLV) on virological failure. The study found that LLV within the range of 200-999 copies/mL of viral load is one of the risk factors for virological failure.

FRONTIERS IN MEDICINE (2022)

Add to Collection

Article Multidisciplinary Sciences

The association between low-level viraemia and subsequent viral non-suppression among people living with HIV/AIDS on antiretroviral therapy in Uganda

Nicholus Nanyeenya, Larry William Chang, Noah Kiwanuka, Esther Nasuuna, Damalie Nakanjako, Gertrude Nakigozi, Simon P. S. Kibira, Susan Nabadda, Charles Kiyaga, Fredrick Makumbi

Summary: Uganda's efforts to end the HIV epidemic by 2030 are threatened by the increasing number of PLHIV with low-level viraemia (LLV). A retrospective cohort study was conducted to determine the prevalence of LLV and its association with viral non-suppression among PLHIV on ART in Uganda.

PLOS ONE (2023)

Add to Collection

Article Public, Environmental & Occupational Health

Effect of peer-distributed HIV self-test kits on demand for biomedical HIV prevention in rural KwaZulu-Natal, South Africa: a three-armed cluster-randomised trial comparing social networks versus direct delivery

Maryam Shahmanesh, T. Nondumiso Mthiyane, Carina Herbsst, Melissa Neuman, Oluwafemi Adeagbo, Paul Mee, Natsayi Chimbindi, Theresa Smit, Nonhlanhla Okesola, Guy Harling, Nuala McGrath, Lorraine Sherr, Janet Seeley, Hasina Subedar, Cheryl Johnson, Karin Hatzold, Fern Terris-Prestholt, Frances M. Cowan, Elizabeth Lucy Corbett

Summary: In this study conducted in KwaZulu-Natal, South Africa, two peer distribution models of HIV self-testing were compared in HIV prevention demand creation. The results showed that while incentivised social network distribution reached more people, it resulted in fewer linkages compared to PrEP/ART promotion by peer navigators.

BMJ GLOBAL HEALTH (2021)

Add to Collection

Article Immunology

Predicting the Risk of Human Immunodeficiency Virus Type 1 (HIV-1) Acquisition in Rural South Africa Using Geospatial Data

D. Allen Roberts, Diego Cuadros, Alain Vandormael, Dickman Gareta, Ruanne Barnabas, Kobus Herbst, Frank Tanser, Adam Akullian

Summary: This study evaluated the performance of HIV risk prediction models that incorporated geospatial factors. The results showed that simple models using age group and geospatial factors had similar performance to models that included detailed behavioral data.

CLINICAL INFECTIOUS DISEASES (2022)

Add to Collection

Article Public, Environmental & Occupational Health

Mobility during the post-partum period and viraemia in women living with HIV in South Africa

Jasantha Odayar, Tamsin K. Phillips, Siti Kabanda, Thokozile R. Malaba, Elton Mukonda, Nei-yuan Hsiao, Maia Lesosky, Landon Myer

Summary: A study in Cape Town, South Africa, examined the association between travel and viremia in post-partum women with HIV on antiretroviral therapy. The findings suggested that travel events were associated with an increased likelihood of higher viral load, highlighting the importance of interventions to support women on ART during travel.

INTERNATIONAL HEALTH (2023)

Add to Collection

Article Infectious Diseases

Rilpivirine plus cobicistat-boosted darunavir as a two-drug switch regimen in HIV-infected, virologically suppressed subjects on steady standard three-drug therapy: a randomized, controlled, non-inferiority trial (PROBE2)

F. Maggiolo, N. Gianotti, L. Comi, E. Di Filippo, L. Fumagalli, S. Nozza, L. Galli, D. Valenti, M. Rizzi, A. Castagna

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2020)

Add to Collection

Article Public, Environmental & Occupational Health

Schistosomiasis, strongyloidiasis and Chagas disease: the leading imported neglected tropical diseases in Italy

Lorenzo Zammarchi, Federico Gobbi, Andrea Angheben, Michele Spinicci, Dora Buonfrate, Guido Calleri, Mirella De Paola, Nazario Bevilacqua, Stefania Carrara, Luciano Attard, Elisa Vanino, Maurizio Gulletta, Elena Festa, Tiziana Iacovazzi, Anna Grimaldi, Alessio Sepe, Angelo Salomone Megna, Giovanni Gaiera, Antonella Castagna, Patrizia Parodi, Marco Albonico, Zeno Bisoffi, Francesco Castelli, Piero Olliaro, Alessandro Bartoloni

JOURNAL OF TRAVEL MEDICINE (2020)

Add to Collection

Review Environmental Sciences

The Role of Physical Activity for the Management of Sarcopenia in People Living with HIV

Matteo Bonato, Filippo Turrini, Laura Galli, Giuseppe Banfi, Paola Cinque

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2020)

Add to Collection

Article Public, Environmental & Occupational Health

Stranger Months: How SARS-CoV-2, Fear of Contagion, and Lockdown Measures Impacted Attendance and Clinical Activity During February and March 2020 at an Urban Emergency Department in Milan

Stefano Franchini, Marzia Spessot, Giovanni Landoni, Cecilia Piani, Chiara Cappelletti, Federica Mariani, Simona Mauri, Maria Vittoria Taglietti, Manuela Fortunato, Federico Furlan, Barbara Guglielmi, Eleonora Setti, Davide Di Napoli, Giovanni Borghi, Federico Pascucci, George Ujlaki-Formenti, Riccardo Sannicandro, Matteo Moro, Sergio Colombo, Lorenzo Dagna, Antonella Castagna, Moreno Tresoldi, Patrizia Rovere-Querini, Alberto Ambrosio, Fabio Ciceri, Alberto Zangrillo, Michele Carlucci, Roberto Faccincani

Summary: The unprecedented wave of patients with acute respiratory failure due to COVID-19 hit emergency departments in Lombardy, causing a significant drop in ED attendance and an increase in patients needing oxygen, noninvasive ventilation, ICU transfers, and in-hospital mortality. The fear of contagion led to missed or delayed diagnoses for conditions other than COVID-19.

DISASTER MEDICINE AND PUBLIC HEALTH PREPAREDNESS (2021)

Add to Collection

Letter Immunology

Cerebrospinal fluid viral replication and burden of resistance in three HIV-1-infected people taking Ibalizumab with multiple drug class-wide resistance

Camilla Muccini, Vincenzo Spagnuolo, Diana Canetti, Alba Bigoloni, Massimo Cernuschi, Michela Franzin, Michela Sampaolo, Antonella Castagna

AIDS (2020)

Add to Collection

Article Infectious Diseases

Secondary infections in patients hospitalized with COVID-19: incidence and predictive factors

Marco Ripa, Laura Galli, Andrea Poli, Chiara Oltolini, Vincenzo Spagnuolo, Andrea Mastrangelo, Camilla Muccini, Giacomo Monti, Giacomo De Luca, Giovanni Landoni, Lorenzo Dagna, Massimo Clementi, Patrizia Rovere Querini, Fabio Ciceri, Moreno Tresoldi, Adriano Lazzarin, Alberto Zangrillo, Paolo Scarpellini, Antonella Castagna

Summary: The study aimed to describe the incidence and predictive factors of secondary infections in COVID-19 patients. Risk factors identified for secondary infections included low lymphocyte count, baseline PaO2/FiO2 decrease, and ICU admission within the first 48 hours.

CLINICAL MICROBIOLOGY AND INFECTION (2021)

Add to Collection

Article Medicine, General & Internal

Effect of Remdesivir vs Standard Care on Clinical Status at 11 Days in Patients With Moderate COVID-19 A Randomized Clinical Trial

Christoph D. Spinner, Robert L. Gottlieb, Gerard J. Criner, Jose Ramon Arribas Lopez, Anna Maria Cattelan, Alex Soriano Viladomiu, Onyema Ogbuagu, Prashant Malhotra, Kathleen M. Mullane, Antonella Castagna, Louis Yi Ann Chai, Meta Roestenberg, Owen Tak Yin Tsang, Enos Bernasconi, Paul Le Turnier, Shan-Chwen Chang, Devi SenGupta, Robert H. Hyland, Anu O. Osinusi, Huyen Cao, Christiana Blair, Hongyuan Wang, Anuj Gaggar, Diana M. Brainard, Mark J. McPhail, Sanjay Bhagani, Young Ahn, Arun J. Sanyal, Gregory Huhn, Francisco M. Marty

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

Add to Collection

Article Multidisciplinary Sciences

Residual clinical damage after COVID-19: A retrospective and prospective observational cohort study

Rebecca De Lorenzo, Caterina Conte, Chiara Lanzani, Francesco Benedetti, Luisa Roveri, Mario G. Mazza, Elena Brioni, Giacomo Giacalone, Valentina Canti, Valentina Sofia, Marta D'Amico, Davide Di Napoli, Alberto Ambrosio, Paolo Scarpellini, Antonella Castagna, Giovanni Landoni, Alberto Zangrillo, Emanuele Bosi, Moreno Tresoldi, Fabio Ciceri, Patrizia Rovere-Querini

PLOS ONE (2020)

Add to Collection

Article Surgery

Incidence of deep venous thrombosis in COVID-19 hospitalized patients during the first peak of the Italian outbreak

Domenico Baccellieri, Luca Bertoglio, Luca Apruzzi, Vincenzo Ardita, Armando D'Angelo, Matteo Bossi, Enrico Rinaldi, Victor Bilman, Stefania Calvisi, Antonella Castagna, Laura Galli, Giovanni Landoni, Germano Melissano, Patrizia Rovere Querini, Moreno Tresoldi, Francesco De Cobelli, Alberto Zangrillo, Fabio Ciceri, Roberto Chiesa

Summary: This study assessed the incidence of DVT in COVID-19 patients and found that despite receiving prophylactic treatment, the incidence of DVT in hospitalized patients was 14.5%. The study also showed that a high D-dimer level at admission was associated with DVT, and that ICU patients and age were the main predictors of in-hospital mortality.

PHLEBOLOGY (2021)

Add to Collection

Article Infectious Diseases

Prevalence and factors associated with HIV-1 multi-drug resistance over the past two decades in the Italian ARCA database

Francesca Lombardi, Andrea Giacomelli, Daniele Armenia, Alessia Lai, Alex Dusina, Antonia Bezenchek, Laura Timelli, Francesco Saladini, Francesca Vichi, Paola Corsi, Grazia Colao, Bianca Bruzzone, Roberta Gagliardini, Annapaola Callegaro, Antonella Castagna, Maria Mercedes Santoro

Summary: This study found that HIV-1 drug resistance has remained stable since 2011, although HIV-MDR still exists at a lower rate, emphasizing the need for continuous monitoring and accurate management of ART-experienced patients with HIV.

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2021)

Add to Collection

Article Infectious Diseases

Viral resistance burden and APOBEC editing correlate with virological response in heavily treatment-experienced people living with multi-drug resistant HIV

Daniele Armenia, Maria Mercedes Santoro, Maria Concetta Bellocchi, Luca Carioti, Laura Galli, Andrea Galli, Rossana Scutari, Eleonora Salsi, Cristina Mussini, Gaetana Sterrantino, Leonardo Calza, Barbara Rossetti, Maurizio Zazzi, Antonella Castagna

Summary: The study found that heavily treatment-experienced individuals with multidrug-resistant HIV had high levels of drug resistance mutational load but less pronounced APOBEC editing. Patients who failed treatment showed higher levels of DNA resistance and mutational load compared to those who responded.

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2022)

Add to Collection

Letter Geriatrics & Gerontology

Benefits of a 12 week physical activity programme on muscle and bone health in people living with HIV

Matteo Bonato, Laura Galli, Simona Bossolasco, Cecilia Bertocchi, Giuseppe Balconi, Marco Borderi, Pierluigi Viale, Gaspare Pavei, Giampiero Merati, Antonio La Torre, Adriano Lazzarin, Giuseppe Banfi, Paola Cinque

JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE (2021)

Add to Collection

Article Oncology

Levels of Alpha-Fetoprotein and Association with Mortality in Hepatocellular Carcinoma of HIV-1-Infected Patients

Giulia Morsica, Laura Galli, Emanuela Messina, Alessandro Cibarelli, Sabrina Bagaglio, Andrea Poli, Martina Ranzenigo, Antonella Castagna, Hamid Hasson, Caterina Uberti-Foppa

Summary: The study evaluated the impact of alpha-fetoprotein (AFP) levels on mortality in HIV-1-infected patients with hepatocellular carcinoma (HCC). The results suggest that AFP levels greater than 28.8 ng/mL, HBV coinfection, and treatment allocation are predictive markers for death in this patient population.

JOURNAL OF ONCOLOGY (2022)

Add to Collection

Article Infectious Diseases

Antibiotic appropriateness for Gram-negative bloodstream infections: impact of infectious disease consultation

Valentina Da Prat, Laura Galli, Paola Cichero, Barbara Castiglioni, Chiara Oltolini, Chiara Tassan Din, Andrea Andolina, Elena Bruzzesi, Andrea Poli, Matteo Moro, Nicasio Mancini, Massimo Clementi, Moreno Tresoldi, Antonella Castagna, Paolo Scarpellini, Marco Ripa

Summary: In a setting with high antibiotic resistance, IDC and RDTs are associated with earlier prescription of appropriate therapy in GNBSIs, without impact on mortality.

INFECTIOUS DISEASES (2023)

Add to Collection

Article Infectious Diseases

Evaluation of HIV-DNA and residual viremia levels through week 96 in HIV-infected individuals who continue a two-drug or switch to a three-drug integrase strand transfer inhibitor-based regimen

Rossana Scutari, Laura Galli, Claudia Alteri, Andrea Poli, Lorenzo Piermatteo, Alba Bigoloni, Carlo Federico Perno, Adriano Lazzarin, Francesca Ceccherini-Silberstein, Antonella Castagna, Maria Mercedes Santoro, Nicola Gianotti

Summary: This study investigated HIV-DNA and residual viremia levels over 96 weeks in virologically-suppressed HIV-1-infected individuals. The results showed a small reduction in HIV-DNA and RV levels at W96 in individuals who switched to the E/C/F/TAF arm compared to those who remained on the DTG + 1 RTI arm. However, there were no significant differences between the two arms in the changes in HIV-DNA and HIV-RNA over time.

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2023)

Add to Collection

No Data Available

© Peeref 2019-2024. All rights reserved.