Article
Plant Sciences
Meng-yuan Qin, Song-qing Huang, Xiao-qin Zou, Xiao-bin Zhong, Yu-fang Yang, Yu-ting Zhang, Zheng-cheng Mi, Yan-song Zhang, Zhen-guang Huang
Summary: The study found that the drug-containing serum of rhubarb-astragalus can effectively inhibit the epithelial-mesenchymal transformation of HK-2 cells, and achieve this effect by downregulating the TGF-fi1/p38 MAPK/Smad2/3 pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Chemistry, Medicinal
Dali Ding, Xuebin Shen, Lizhen Yu, Yueyue Zheng, Yao Liu, Wei Wang, Li Liu, Zitong Zhao, Sihui Nian, Limin Liu
Summary: Timosaponin BII (TS BII), a main constituent of Anemarrhena asphodeloides Bunge, was found to restore lung structure, inhibit collagen deposition, and reverse abnormal expression of EMT-related marker proteins in a bleomycin-induced pulmonary fibrosis (PF) model. Furthermore, TS BII suppressed EMT by inhibiting the TGF-beta/Smad pathway both in vivo and in vitro. Therefore, TS BII may be a promising candidate for PF treatment.
PHYTOTHERAPY RESEARCH
(2023)
Article
Oncology
Yu Xie, Shuai Zhu, Jinglei Zang, Guanlin Wu, Yuheng Wen, Yu Liang, Ying Long, Weiming Guo, Chuanbing Zang, Xiang Hu, Gang Fan, Shuanglin Xiang, Jian Zhang
Summary: ADNP is overexpressed in BC tissues of patients with tumor progression, and high ADNP expression is associated with shorter tumor-free survival in BC patients. Downregulation of ADNP increases sensitivity to cisplatin in BC, while overexpression of ADNP has the opposite effect. ADNP promotes cell migration and EMT, leading to cisplatin resistance, possibly through the TGF-β/Smad signaling pathway.
Article
Chemistry, Medicinal
Yonghui Hu, Wangna Tang, Wenjie Liu, Zhibo Hu, Congqing Pan
Summary: This study found that AS-IV can alleviate renal tubular EMT in DKD patients by regulating CX3CL1, thereby reducing renal pathological damage.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2022)
Article
Biotechnology & Applied Microbiology
Baiyang Song, Li Fang, Xufeng Mao, Xianwang Ye, Zejun Yan, Qi Ma, Zewen Shi, Yiwei Hu, Yabin Zhu, Yue Cheng
Summary: This study investigates the use of gelatin-grafted tubular scaffolds for ureteral repair. The grafting of gelatin improves the adhesion and proliferation of urothelial cells, leading to enhanced ureteral regeneration. Animal experiments demonstrate good biocompatibility and urethra regeneration with the gelatin-grafted scaffold.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Oncology
Feifeng Lan, Menghua Chen, Xiaowei Xie, Yanyan Mo, Fengti Chen, Renbin Huang, Wenqi Liu
Summary: YLSPS, derived from the root of Millettia pulchra var. laxior, exhibits anticancer effects in lung cancer cells by reversing EMT and inhibiting the TGF-beta 1-induced ERK signaling pathway. YLSPS significantly inhibits the growth of xenograft tumors and reduces the levels of proteins associated with EMT. Importantly, YLSPS has fewer toxic side effects than cisplatin.
AMERICAN JOURNAL OF CANCER RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Huiwen Wang, Jian Zhang, Xiaoxun Zhang, Nan Zhao, Zongtao Zhou, Lijian Tao, Lei Fu, Shifang Peng, Jin Chai
Summary: This study found that AKF-PD effectively ameliorates cholestasis and hepatic fibrosis, significantly reducing liver function indicators and bile salt levels in a mouse model. It also attenuates hepatic inflammation and fibrosis. Mechanistic analyses revealed that AKF-PD acts through multiple pathways to exert anti-inflammatory and anti-fibrotic effects.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Min Mo, Yao Zeng, Yiqun Zeng, Shuting Li, Xiaoyang He, Xiaowen Chen, Qimei Luo, Mi Liu, Congwei Luo, Xianrui Dou, Fenfen Peng, Haibo Long
Summary: This study investigated the antifibrotic effects of NMPDOva in peritoneal fibrosis (PF) and its underlying mechanisms. NMPDOva treatment significantly alleviated PF and decreased extracellular matrix accumulation. Moreover, NMPDOva inhibited the TGF-beta 1/Smad and JAK/STAT signaling pathways to prevent PF.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Pharmacology & Pharmacy
Linqing Wu, Zengbin Wang, Xiaoli He, Yayuan Jiang, Ruizhu Pan, Shi Chen, Yizhong Chen, Yanfei Han, Huahui Yu, Tao Zhang
Summary: Arsenic is a known carcinogen, and GJA1, a multifunctional protein, plays an important role in cancer recurrence and metastasis. This study demonstrated that chronic exposure to sodium arsenite promotes epithelial-mesenchymal transition (EMT) and reduces GJA1 expression. Forced expression of GJA1 inhibits EMT induced by sodium arsenite by suppressing the MAPK/ERK signaling pathway. In addition, chronic exposure to sodium arsenite increases autophagy flux, which decreases GJA1 expression. These findings suggest that GJA1 restrains the carcinogenic effect of sodium arsenite by limiting MAPK/ERK signaling, and interventions targeting GJA1 may have preventive and therapeutic potential for cancer treatment.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2022)
Article
Cell Biology
Hanlin Ma, Gonghua Qi, Fang Han, Panpan Gai, Jiali Peng, Beihua Kong
Summary: HMGB3 promotes the proliferation and metastasis of ovarian cancer through the MAPK/ERK signaling pathway. Targeting HMGB3 is a promising strategy for the treatment of ovarian cancer and can improve the prognosis of patients.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Pharmacology & Pharmacy
Shuai Wang, Yazhou Guo, Chen Yang, Ruijie Huang, Yuting Wen, Chunyan Zhang, Chenchen Wu, Baoyu Zhao
Summary: Swainsonine induces cell paraptosis through ER stress and MAPK signaling pathway, instead of autophagy or apoptosis, laying a theoretical foundation for the study of its toxicity mechanism.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell & Tissue Engineering
Gang Wang, Fengbin Wang, Lecheng Zhang, Chao Yan, Yuelei Zhang
Summary: miR-133a is strongly associated with GIO and similar disorders induced by glucocorticoids in MSCs. Silencing miR-133a resulted in positive effects on GC-treated MSCs and on bone loss in GIO animal models. Moreover, the FGFR1-MAPK/ERK signaling may be involved in the protective effect of miR-133a silencing.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Medicine, Research & Experimental
Minmin Gong, Yujin Guo, Hui Dong, Wenbin Wu, Fan Wu, Fuer Lu
Summary: This study demonstrates that trigonelline can attenuate tubular epithelial-mesenchymal transition and renal fibrosis in diabetic mice, potentially by upregulating Smad7 in proximal tubule epithelial cells. These findings suggest the potential of trigonelline as a promising medicine against diabetic kidney disease.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Agriculture, Multidisciplinary
Guokun Zhang, Yunyao Jiang, Xin Liu, Yongyan Deng, Bin Wei, Liyan Shi
Summary: Phytochemicals from lingonberry, particularly lingonberry anthocyanins (LA), have been found to regulate hepatic stellate cell activation and liver fibrogenesis, reducing cell proliferation and fibrosis-related markers. LA alleviated CCl4-induced liver fibrosis in rats by reducing collagen production, decreasing hydroxyproline and malondialdehyde levels, and improving antioxidant enzyme levels. Additionally, LA promoted hepatocyte proliferation and inhibited TGFβ/Smad/ERK signaling pathway-related gene expression, demonstrating its potential as a novel strategy for treating liver fibrosis.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Allergy
Wenxin Wang, Zhaochuan Yang, Meixiang Li, Zhenhong Wang, Yanchun Shan, Zhenghai Qu
Summary: The study reveals that Six1 and TGFβ1 may be part of an autocrine feedback loop inducing EMT, which can be reduced by blocking the TGFβ1/Smad signaling pathway. These factors represent a promising novel therapeutic target for airway remodelling in asthma.
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
(2021)
