Article
Urology & Nephrology
Takuto Chiba, Debora M. Cerqueira, Yao Li, Andrew J. Bodnar, Elina Mukherjee, Katherine Pfister, Yu Leng Phua, Kai Shaikh, Brandon T. Sanders, Shelby L. Hemker, Patrick J. Pagano, Yijen L. Wu, Jacqueline Ho, Sunder Sims-Lucas
Summary: miR-17 similar to miR-92 is dynamically regulated in renal endothelial cells after renal IRI and plays a role in the pathogenesis of AKI. Endothelial-specific miR-17 similar to miR-92 knockout exacerbates renal IRI, promoting renal tubular injury, reducing renal blood flow, and increasing oxidative stress in the kidneys. miR-17 similar to miR-92 is critical in the angiogenic response after renal IRI, and treatment with miR-18a and miR-19b mimics can mitigate the damage.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Article
Urology & Nephrology
Jennifer S. Y. Li, Harry Robertson, Katie Trinh, Arti M. Raghubar, Quan Nguyen, Nicholas Matigian, Ellis Patrick, Angus W. Thomson, Andrew J. Mallett, Natasha M. Rogers
Summary: Ischemia reperfusion injury is a common cause of acute kidney injury. Adoptively transferred tolerogenic dendritic cells can successfully limit kidney injury and provide protection against ischemia reperfusion injury.
KIDNEY INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Heng-Chih Pan, Yau-Hung Chen, Wei-Ching Fang, Vin-Cent Wu, Chiao-Yin Sun
Summary: KDM4C plays a critical role in kidney development and acute kidney injury (AKI). Knockdown of KDM4C leads to impaired kidney development and decreased cell survival in zebrafish and mouse models. Furthermore, KDM4C may exert a protective effect on cell survival in AKI by regulating mitochondrial dynamics and function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Benedikt Kolbrink, Friedrich Alexander von Samson-Himmelstjerna, Maja Lucia Messtorff, Theresa Riebeling, Raphael Nische, Jessica Schmitz, Jan Hinrich Brasen, Ulrich Kunzendorf, Stefan Krautwald
Summary: Ferroptosis, a type of iron-dependent programmed cell death, plays a vital role in multiple diseases. However, there are no pharmacologic inhibitors of ferroptosis in clinical use. In this study, vitamin K1 was identified as an efficient inhibitor of ferroptosis, providing a new strategy for pharmacological control of this mode of cell death.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Engineering, Biomedical
Weimin Tang, Sudipta Panja, Chinmay M. Jogdeo, Siyuan Tang, Ling Ding, Ao Yu, Kirk W. Foster, Del L. Dsouza, Yashpal S. Chhonker, Heather Jensen-Smith, Hee-Seong Jang, Erika I. Boesen, Daryl J. Murry, Babu Padanilam, David Oupicky
Summary: This study demonstrates the synthesis of a novel siRNA carrier, C-CS, which shows potential for targeted delivery to injured kidneys. The C-CS/siRNA nanoparticles effectively accumulate and deliver therapeutic siRNAs to injured kidneys through CXCR4 binding, providing a new approach for AKI therapy.
Article
Cell Biology
Izumi Nagayama, Kaori Takayanagi, Hajime Hasegawa, Akito Maeshima
Summary: In this study, the expression and localization of follistatin in normal and ischemic rat kidneys were examined, and urinary follistatin levels were measured to assess its potential as a biomarker for acute kidney injury. The results showed that follistatin was mainly localized in the distal tubules of the cortex in normal kidneys, while it was also present in the distal tubules of both the cortex and outer medulla in ischemic kidneys. Urinary follistatin levels were significantly increased in ischemic rats and correlated with the duration of ischemia, the follistatin-positive area, and the acute tubular damage area.
Article
Biochemistry & Molecular Biology
Johanna Stoermer, Wilfried Gwinner, Katja Derlin, Stephan Immenschuh, Song Rong, Mi-Sun Jang, Nelli Shushakova, Hermann Haller, Faikah Gueler, Robert Greite
Summary: This study investigated the effects of diclofenac on the progression of AKI and long-term renal consequences in the setting of pre-existing subclinical AKI. The results showed that diclofenac aggravated renal injury in a dose and time-dependent manner and even a single dose can cause progression to chronic kidney disease.
Article
Immunology
Jiefu Zhu, Yafei Zhang, Lang Shi, Yao Xia, Hongchu Zha, Huimin Li, Zhixia Song
Summary: This study reveals the protective role of RP105 in ischemic and septic acute kidney injury (AKI). Overexpression of RP105 alleviated renal structural injuries and dysfunction caused by ischemic and septic AKI. RP105 suppressed inflammatory responses mediated by the TLR4 signaling pathway. These findings suggest that RP105 could be a potential target for preventing and treating ischemic and septic AKI.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Immunology
Lijuan Ma, Xueqi Liu, Mengya Zhang, Lang Zhou, Ling Jiang, Li Gao, Xian Wang, Yuebo Huang, Hanxu Zeng, Yonggui Wu
Summary: This article discusses the complicated pathophysiological mechanism of acute kidney injury (AKI) and the lack of effective drugs. It also introduces a newly discovered cell death mode called ferroptosis, which is involved in the progression of AKI. Paeoniflorin (PF), a traditional Chinese medicine, has protective effects on kidney diseases including AKI, but the mechanism of PF in attenuating AKI is unclear.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Chih-Chao Yang, Pei-Hsun Sung, John Y. Chiang, Han-Tan Chai, Chih-Hung Chen, Yi-Ching Chu, Yi-Chen Li, Hon-Kan Yip
Summary: Combined tacrolimus and melatonin therapy was more effective than either single treatment in protecting the kidney from IR injury by suppressing inflammation and oxidative stress.
Article
Nanoscience & Nanotechnology
Chenguang Ding, Bo Wang, Jin Zheng, Mingzhen Zhang, Yang Li, Hsin-Hui Shen, Yingcong Guo, Bingxuan Zheng, Puxun Tian, Xiaoming Ding, Wujun Xue
Summary: Ischemia/reperfusion (I/R) injury leads to excessive oxidative events and destructive inflammatory responses, playing a key role in various pathological conditions. Ferroptosis, a type of iron-dependent nonapoptotic cell death, is associated with I/R injury diseases. Excessive production of inflammatory cytokines contributes to the development of acute kidney injury. In this study, neutrophil membrane-coated copper-based nanoparticles (N-Cu5.4O@DFO NPs) demonstrated excellent antioxidant and iron ion scavenging abilities, effectively reducing oxidative damage and inflammatory response in the kidney, presenting a potential therapeutic strategy for renal I/R injury. This work also promotes the development of nanoantioxidant agents for the treatment of other I/R injury diseases.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Pharmacology & Pharmacy
Jiajia Li, Yupeng Jiang, Qin Dai, Yue Yu, Xin Lv, Yan Zhang, Xiaohua Liao, Liyun Ao, Gaoyun Hu, Jie Meng, Zhangzhe Peng, Lijian Tao, Yanyun Xie
Summary: In this study, the protective effect of Mefunidone on ischemia-reperfusion injury-induced acute kidney injury was investigated. The results showed that Mefunidone can protect the kidney by relieving kidney tubular injury, suppressing oxidative stress, and inhibiting cell apoptosis. Furthermore, Mefunidone reduced mitochondrial damage and protected mitochondrial function.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Physical
Xishao Xie, Yunjing Zhang, Xinwan Su, Junni Wang, Xi Yao, Dou Lv, Qin Zhou, Jianhua Mao, Jianghua Chen, Fei Han, Yangyang Li, Weiqiang Lin
Summary: This study synthesized gallic acid-gallium polyvinyl pyrrolidone nanoparticles (GGP NPs) as a potential iron-scavenging agent and demonstrated their good biocompatibility and protective effects in inhibiting ferroptosis. Treatment with GGP NPs significantly ameliorated renal injury and mitochondrial damage, making them a potential candidate for AKI treatment.
Article
Pharmacology & Pharmacy
Zengying Liu, Chen Guan, Chenyu Li, Ningxin Zhang, Chengyu Yang, Lingyu Xu, Bin Zhou, Long Zhao, Hong Luan, Xiaofei Man, Yan Xu
Summary: This study found that tilianin has a protective effect on I/R-induced AKI through the ERK/EGR1/BCL2L1 pathway by using bioinformatics analysis. It provides new insights into the protective effect and underlying molecular mechanisms of tilianin on I/R-induced AKI.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Qian Chen, Fei Ding, Shuangye Zhang, Qian Li, Xiaoguo Liu, Haiyun Song, Xiaolei Zuo, Chunhai Fan, Shan Mou, Zhilei Ge
Summary: The development of a renal-accumulating DNA nanodevice in this study offers promising protection for acute kidney injury patients in different stages, with potential for providing durable and pathogenic treatment for kidney dysfunction based on the pathophysiological events caused by ischemia-reperfusion.
Review
Pharmacology & Pharmacy
Saifu Yin, Turun Song, Xingxing Li, Hanyue Xu, Xueling Zhang, Yamei Jiang, Tao Lin
CURRENT PHARMACEUTICAL DESIGN
(2019)
Article
Medical Laboratory Technology
Saifu Yin, Turun Song, Yamei Jiang, Xingxing Li, Yu Fan, Tao Lin
THERAPEUTIC DRUG MONITORING
(2019)
Article
Immunology
Turun Song, Saifu Yin, Yamei Jiang, Zhongli Huang, Jinpeng Liu, Zhiling Wang, Linde Li, Jun Zeng, Yu Fan, Xianding Wang, Xingxing Li, Tao Lin
FRONTIERS IN IMMUNOLOGY
(2019)
Review
Immunology
Turun Song, Saifu Yin, Xingxing Li, Yamei Jiang, Tao Lin
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Andrology
Yang Qiu, Jinpeng Liu, Yamei Jiang, Turun Song, Zhongli Huang, Yu Fan, Xianding Wang, Tao Lin
TRANSLATIONAL ANDROLOGY AND UROLOGY
(2020)
Article
Cell Biology
Ruochen Qi, Jiyan Wang, Yamei Jiang, Yue Qiu, Ming Xu, Ruiming Rong, Tongyu Zhu
Summary: This study investigated the correlation between partial EMT and cell cycle arrest in renal fibrosis, revealing the crucial role of NF-kappa B-mediated inflammatory response. Targeting NF-kappa B might disrupt the reciprocal loop between partial EMT and G2/M arrest, potentially alleviating renal fibrosis.
CELL DEATH & DISEASE
(2021)
Review
Immunology
Yongsheng Luo, Jingjing Guo, Pingbao Zhang, Yin Celeste Cheuk, Yamei Jiang, Jiyan Wang, Shihao Xu, Ruiming Rong
Summary: The increase in Th17-mediated pro-inflammatory response and decrease in Treg-mediated anti-inflammatory effect aggravate renal tubular epithelial cell injury. MSC can control the imbalance between Th17 and Treg by inhibiting mTOR signaling, promoting Treg generation while restraining Th17 differentiation. This suggests that MSC-mediated Th17-to-Treg polarization could serve as a new immunotherapy approach for kidney injury.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Xianding Wang, Fan Zhang, Yamei Jiang, Zilin Xu, Xiaobing Feng, Linde Li, Yu Fan, Turun Song, Yunying Shi, Zhongli Huang, Tao Lin
Summary: Research on the quantitative distribution of ABO antigens in different organs and tissues is limited. The expression of blood group glycoprotein A and B antigens showed certain trends and distinct distribution in the kidney, liver, and vessels among individuals, as well as differences among various donors and regions within the same individual, influenced by age and sex.
Article
Medicine, General & Internal
Tian Chen, Yamei Jiang, Shihao Xu, Yin Celeste Cheuk, Jiyan Wang, Cheng Yang, Ruiming Rong
Summary: The study investigated the protective effect and mechanism of different subpopulations of mesenchymal stem cells on acute kidney injury using a mouse model of renal ischemia-reperfusion injury. It was found that mesenchymal stem cells treated with poly(I:C) exhibited better protection of renal function, alleviation of tissue damage, reduction of circulating inflammation levels, and enhancement of antioxidant capacity. These effects were achieved through the TLR3/PI3K pathway.
FRONTIERS IN MEDICINE
(2021)
Article
Andrology
Yin Celeste Cheuk, Pingbao Zhang, Shihao Xu, Jiyan Wang, Tian Chen, Yongxin Mao, Yamei Jiang, Yongsheng Luo, Jingjing Guo, Weixi Wang, Ruiming Rong
Summary: This study used bioinformatic analysis to reveal the transcriptional features of macrophages in murine models of lupus nephritis, renal crystal formation, and ischemia-reperfusion injury, identifying common signaling pathways altered in these renal disorders. These findings may serve as promising targets for mechanistic research and clinical treatment of multiple renal diseases.
TRANSLATIONAL ANDROLOGY AND UROLOGY
(2021)
Article
Urology & Nephrology
Yamei Jiang, Chengzhe Cai, Pingbao Zhang, Yongsheng Luo, Jingjing Guo, Jiawei Li, Ruiming Rong, Yi Zhang, Tongyu Zhu
Summary: This study found that 18 beta-Glycyrrhetinic acid (GA) may alleviate renal fibrosis by inhibiting the inflammatory response. GA is a promising therapy that may be used in treating renal fibrosis and CKD.
Article
Immunology
Yamei Jiang, Siting Hong, Xiangyang Zhu, Lei Zhang, Hui Tang, Kyra L. Jordan, Ishran M. Saadiq, Weijun Huang, Amir Lerman, Alfonso Eirin, Lilach O. Lerman
Summary: Extracellular vesicles derived from adipose tissue mesenchymal stem cells exhibit potential immunomodulatory and tissue repair properties, with a specific focus on kidney function and myocardial injury alleviation. The anti-inflammatory cytokine IL-10 is thought to mediate the reparative effects of these vesicles in cardiovascular complications associated with metabolic syndrome and renovascular hypertension. Early intervention with IL-10-containing extracellular vesicles may hold promise in preventing adverse cardiovascular outcomes in such conditions.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Peripheral Vascular Disease
Yamei Jiang, Logan M. Glasstetter, Amir Lerman, Lilach O. Lerman
Summary: TSG-6 plays a pivotal role in anti-inflammation in various renal diseases by regulating inflammatory response, cell migration, and repair.
Article
Cell & Tissue Engineering
Siting Hong, Xiang-Yang Zhu, Yamei Jiang, Lei Zhang, Hui Tang, Kyra L. Jordan, Ishran M. Saadiq, Weijun Huang, Amir Lerman, Alfonso Eirin, Lilach O. Lerman
Summary: This study found that intrarenal delivery of autologous extracellular vesicles (EVs) can attenuate cardiac injury in experimental RVD more effectively than their parent mesenchymal stem cells (MSCs), including improving diastolic dysfunction and reducing myocardial fibrosis.
STEM CELL REVIEWS AND REPORTS
(2023)
Article
Physiology
Turun Song, Xiang-Yang Zhu, Alfonso Eirin, Yamei Jiang, James D. Krier, Hui Tang, Kyra L. Jordan, Amir Lerman, Lilach O. Lerman
Summary: Our study demonstrates the potential therapeutic role of renal pericytes in subjects with ischemic kidney disease. Xenogeneic pericyte delivery ameliorates the loss of perfusion, glomerular filtration rate, and atrophy in stenotic kidneys, and protects against renal inflammation, fibrosis, oxidative stress, apoptosis, and senescence. The beneficial effects of pericyte delivery may be mediated by improving tissue hypoxia, vascular loss, and tubular atrophy.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2022)